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TSSK4 (testis specific serine kinase 4)

Identity

Alias (NCBI)C14orf20
STK22E
TSK-4
TSK4
TSSK5
HGNC (Hugo) TSSK4
HGNC Alias namechromosome 14 open reading frame 20
HGNC Previous nameC14orf20
 STK22E
HGNC Previous nameserine/threonine kinase 22E
LocusID (NCBI) 283629
Atlas_Id 43546
Location 14q12  [Link to chromosome band 14q12]
Location_base_pair Starts at 24205696 and ends at 24208248 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TSSK4   19825
Cards
Entrez_Gene (NCBI)TSSK4    testis specific serine kinase 4
AliasesC14orf20; STK22E; TSK-4; TSK4; 
TSSK5
GeneCards (Weizmann)TSSK4
Ensembl hg19 (Hinxton)ENSG00000139908 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000139908 [Gene_View]  ENSG00000139908 [Sequence]  chr14:24205696-24208248 [Contig_View]  TSSK4 [Vega]
ICGC DataPortalENSG00000139908
TCGA cBioPortalTSSK4
AceView (NCBI)TSSK4
Genatlas (Paris)TSSK4
SOURCE (Princeton)TSSK4
Genetics Home Reference (NIH)TSSK4
Genomic and cartography
GoldenPath hg38 (UCSC)TSSK4  -     chr14:24205696-24208248 +  14q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TSSK4  -     14q12   [Description]    (hg19-Feb_2009)
GoldenPathTSSK4 - 14q12 [CytoView hg19]  TSSK4 - 14q12 [CytoView hg38]
ImmunoBaseENSG00000139908
Genome Data Viewer NCBITSSK4 [Mapview hg19]  
OMIM610711   
Gene and transcription
Genbank (Entrez)AF542390 AK131042 AY461663 BC029918 BC111088
RefSeq transcript (Entrez)NM_001184739 NM_001308067 NM_174944
Consensus coding sequences : CCDS (NCBI)TSSK4
Gene ExpressionTSSK4 [ NCBI-GEO ]   TSSK4 [ EBI - ARRAY_EXPRESS ]   TSSK4 [ SEEK ]   TSSK4 [ MEM ]
Gene Expression Viewer (FireBrowse)TSSK4 [ Firebrowse - Broad ]
GenevisibleExpression of TSSK4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)283629
GTEX Portal (Tissue expression)TSSK4
Human Protein AtlasENSG00000139908-TSSK4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6SA08   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6SA08  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6SA08
PhosPhoSitePlusQ6SA08
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TSSK4
SuperfamilyQ6SA08
AlphaFold pdb e-kbQ6SA08   
Human Protein Atlas [tissue]ENSG00000139908-TSSK4 [tissue]
HPRD12642
Protein Interaction databases
DIP (DOE-UCLA)Q6SA08
IntAct (EBI)Q6SA08
BioGRIDTSSK4
STRING (EMBL)TSSK4
ZODIACTSSK4
Ontologies - Pathways
QuickGOQ6SA08
Ontology : AmiGOmagnesium ion binding  magnesium ion binding  acrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  protein phosphorylation  protein phosphorylation  multicellular organism development  spermatid development  fertilization  peptidyl-serine phosphorylation  flagellated sperm motility  positive regulation of CREB transcription factor activity  intracellular signal transduction  sperm flagellum  protein homodimerization activity  protein-containing complex binding  protein serine kinase activity  protein threonine kinase activity  peptidyl-threonine autophosphorylation  
Ontology : EGO-EBImagnesium ion binding  magnesium ion binding  acrosomal vesicle  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  ATP binding  nucleus  cytoplasm  protein phosphorylation  protein phosphorylation  protein phosphorylation  multicellular organism development  spermatid development  fertilization  peptidyl-serine phosphorylation  flagellated sperm motility  positive regulation of CREB transcription factor activity  intracellular signal transduction  sperm flagellum  protein homodimerization activity  protein-containing complex binding  protein serine kinase activity  protein threonine kinase activity  peptidyl-threonine autophosphorylation  
NDEx NetworkTSSK4
Atlas of Cancer Signalling NetworkTSSK4
Wikipedia pathwaysTSSK4
Orthology - Evolution
OrthoDB283629
GeneTree (enSembl)ENSG00000139908
Phylogenetic Trees/Animal Genes : TreeFamTSSK4
Homologs : HomoloGeneTSSK4
Homology/Alignments : Family Browser (UCSC)TSSK4
Gene fusions - Rearrangements
Fusion : QuiverTSSK4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTSSK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TSSK4
dbVarTSSK4
ClinVarTSSK4
MonarchTSSK4
1000_GenomesTSSK4 
Exome Variant ServerTSSK4
GNOMAD BrowserENSG00000139908
Varsome BrowserTSSK4
ACMGTSSK4 variants
VarityQ6SA08
Genomic Variants (DGV)TSSK4 [DGVbeta]
DECIPHERTSSK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTSSK4 
Mutations
ICGC Data PortalTSSK4 
TCGA Data PortalTSSK4 
Broad Tumor PortalTSSK4
OASIS PortalTSSK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTSSK4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTSSK4
Mutations and Diseases : HGMDTSSK4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTSSK4
DgiDB (Drug Gene Interaction Database)TSSK4
DoCM (Curated mutations)TSSK4
CIViC (Clinical Interpretations of Variants in Cancer)TSSK4
Cancer3DTSSK4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610711   
Orphanet
DisGeNETTSSK4
MedgenTSSK4
Genetic Testing Registry TSSK4
NextProtQ6SA08 [Medical]
GENETestsTSSK4
Target ValidationTSSK4
Huge Navigator TSSK4 [HugePedia]
ClinGenTSSK4
Clinical trials, drugs, therapy
MyCancerGenomeTSSK4
Protein Interactions : CTDTSSK4
Pharm GKB GenePA134908318
PharosQ6SA08
Clinical trialTSSK4
Miscellaneous
canSAR (ICR)TSSK4
HarmonizomeTSSK4
DataMed IndexTSSK4
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTSSK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:42 CEST 2021

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