TTC1 (tetratricopeptide repeat domain 1)

2014-11-01  

Identity

HGNC
LOCATION
5q33.3
LOCUSID
ALIAS
TPR1
FUSION GENES

Other Information

Locus ID:

NCBI: 7265
MIM: 601963
HGNC: 12391
Ensembl: ENSG00000113312

Variants:

dbSNP: 7265
ClinVar: 7265
TCGA: ENSG00000113312
COSMIC: TTC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113312ENST00000231238Q99614
ENSG00000113312ENST00000518560H0YB37
ENSG00000113312ENST00000522793Q99614

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127482872003Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras.15
230673412012Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint).10
145038502003Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation.6
227114982012Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.5
214864972011Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling.2

Citation

Dessen P

TTC1 (tetratricopeptide repeat domain 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75267/ttc1