Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TTC21B (tetratricopeptide repeat domain 21B)

Identity

Alias (NCBI)ATD4
FAP60
FLA17
IFT139
IFT139B
JBTS11
NPHP12
Nbla10696
SRTD4
THM1
HGNC (Hugo) TTC21B
HGNC Alias symbFLJ11457
JBTS11
NPHP12
IFT139B
THM1
LocusID (NCBI) 79809
Atlas_Id 75272
Location 2q24.3  [Link to chromosome band 2q24]
Location_base_pair Starts at 165873362 and ends at 165953776 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TTC21B (2q24.3) / DOCK1 (10q26.2)TTC21B (2q24.3) / FKBP8 (19p13.11)TTC21B (2q24.3) / SLC38A11 (2q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TTC21B   25660
Cards
Entrez_Gene (NCBI)TTC21B    tetratricopeptide repeat domain 21B
AliasesATD4; FAP60; FLA17; IFT139; 
IFT139B; JBTS11; NPHP12; Nbla10696; SRTD4; THM1
GeneCards (Weizmann)TTC21B
Ensembl hg19 (Hinxton)ENSG00000123607 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123607 [Gene_View]  ENSG00000123607 [Sequence]  chr2:165873362-165953776 [Contig_View]  TTC21B [Vega]
ICGC DataPortalENSG00000123607
TCGA cBioPortalTTC21B
AceView (NCBI)TTC21B
Genatlas (Paris)TTC21B
SOURCE (Princeton)TTC21B
Genetics Home Reference (NIH)TTC21B
Genomic and cartography
GoldenPath hg38 (UCSC)TTC21B  -     chr2:165873362-165953776 -  2q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTC21B  -     2q24.3   [Description]    (hg19-Feb_2009)
GoldenPathTTC21B - 2q24.3 [CytoView hg19]  TTC21B - 2q24.3 [CytoView hg38]
ImmunoBaseENSG00000123607
Genome Data Viewer NCBITTC21B [Mapview hg19]  
OMIM612014   613819   613820   
Gene and transcription
Genbank (Entrez)AB073395 AK057268 AK096451 AK292942 BC035767
RefSeq transcript (Entrez)NM_024753
Consensus coding sequences : CCDS (NCBI)TTC21B
Gene ExpressionTTC21B [ NCBI-GEO ]   TTC21B [ EBI - ARRAY_EXPRESS ]   TTC21B [ SEEK ]   TTC21B [ MEM ]
Gene Expression Viewer (FireBrowse)TTC21B [ Firebrowse - Broad ]
GenevisibleExpression of TTC21B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79809
GTEX Portal (Tissue expression)TTC21B
Human Protein AtlasENSG00000123607-TTC21B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z4L5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z4L5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z4L5
PhosPhoSitePlusQ7Z4L5
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat    TTC21A/TTC21B   
Domain families : Pfam (Sanger)TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)TTC21B
SuperfamilyQ7Z4L5
AlphaFold pdb e-kbQ7Z4L5   
Human Protein Atlas [tissue]ENSG00000123607-TTC21B [tissue]
HPRD07752
Protein Interaction databases
DIP (DOE-UCLA)Q7Z4L5
IntAct (EBI)Q7Z4L5
BioGRIDTTC21B
STRING (EMBL)TTC21B
ZODIACTTC21B
Ontologies - Pathways
QuickGOQ7Z4L5
Ontology : AmiGOchromatin binding  cytoplasm  cytoskeleton  cilium  regulation of transcription by RNA polymerase II  smoothened signaling pathway  regulation of smoothened signaling pathway  positive regulation of gene expression  ventricular system development  cerebellar Purkinje cell differentiation  forebrain dorsal/ventral pattern formation  intraciliary transport particle A  intraciliary transport particle A  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  Bergmann glial cell differentiation  protein localization to cilium  protein localization to cilium  positive regulation of canonical Wnt signaling pathway  protein localization to non-motile cilium  ciliary tip  negative regulation of eating behavior  regulation of intraciliary retrograde transport  
Ontology : EGO-EBIchromatin binding  cytoplasm  cytoskeleton  cilium  regulation of transcription by RNA polymerase II  smoothened signaling pathway  regulation of smoothened signaling pathway  positive regulation of gene expression  ventricular system development  cerebellar Purkinje cell differentiation  forebrain dorsal/ventral pattern formation  intraciliary transport particle A  intraciliary transport particle A  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  Bergmann glial cell differentiation  protein localization to cilium  protein localization to cilium  positive regulation of canonical Wnt signaling pathway  protein localization to non-motile cilium  ciliary tip  negative regulation of eating behavior  regulation of intraciliary retrograde transport  
NDEx NetworkTTC21B
Atlas of Cancer Signalling NetworkTTC21B
Wikipedia pathwaysTTC21B
Orthology - Evolution
OrthoDB79809
GeneTree (enSembl)ENSG00000123607
Phylogenetic Trees/Animal Genes : TreeFamTTC21B
Homologs : HomoloGeneTTC21B
Homology/Alignments : Family Browser (UCSC)TTC21B
Gene fusions - Rearrangements
Fusion : QuiverTTC21B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC21B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC21B
dbVarTTC21B
ClinVarTTC21B
MonarchTTC21B
1000_GenomesTTC21B 
Exome Variant ServerTTC21B
GNOMAD BrowserENSG00000123607
Varsome BrowserTTC21B
ACMGTTC21B variants
VarityQ7Z4L5
Genomic Variants (DGV)TTC21B [DGVbeta]
DECIPHERTTC21B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTC21B 
Mutations
ICGC Data PortalTTC21B 
TCGA Data PortalTTC21B 
Broad Tumor PortalTTC21B
OASIS PortalTTC21B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC21B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTC21B
Mutations and Diseases : HGMDTTC21B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTC21B
DgiDB (Drug Gene Interaction Database)TTC21B
DoCM (Curated mutations)TTC21B
CIViC (Clinical Interpretations of Variants in Cancer)TTC21B
Cancer3DTTC21B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612014    613819    613820   
Orphanet283    12426   
DisGeNETTTC21B
MedgenTTC21B
Genetic Testing Registry TTC21B
NextProtQ7Z4L5 [Medical]
GENETestsTTC21B
Target ValidationTTC21B
Huge Navigator TTC21B [HugePedia]
ClinGenTTC21B
Clinical trials, drugs, therapy
MyCancerGenomeTTC21B
Protein Interactions : CTDTTC21B
Pharm GKB GenePA134882767
PharosQ7Z4L5
Clinical trialTTC21B
Miscellaneous
canSAR (ICR)TTC21B
HarmonizomeTTC21B
DataMed IndexTTC21B
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTC21B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 16:27:15 CEST 2021

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