Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TTC21B (tetratricopeptide repeat domain 21B)

Identity

Alias_symbol (synonym)FLJ11457
JBTS11
NPHP12
IFT139B
THM1
Other aliasATD4
IFT139
Nbla10696
SRTD4
HGNC (Hugo) TTC21B
LocusID (NCBI) 79809
Atlas_Id 75272
Location 2q24.3  [Link to chromosome band 2q24]
Location_base_pair Starts at 165873362 and ends at 165953838 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TTC21B (2q24.3) / DOCK1 (10q26.2)TTC21B (2q24.3) / FKBP8 (19p13.11)TTC21B (2q24.3) / SLC38A11 (2q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TTC21B   25660
Cards
Entrez_Gene (NCBI)TTC21B  79809  tetratricopeptide repeat domain 21B
AliasesATD4; IFT139; IFT139B; JBTS11; 
NPHP12; Nbla10696; SRTD4; THM1
GeneCards (Weizmann)TTC21B
Ensembl hg19 (Hinxton)ENSG00000123607 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123607 [Gene_View]  chr2:165873362-165953838 [Contig_View]  TTC21B [Vega]
ICGC DataPortalENSG00000123607
TCGA cBioPortalTTC21B
AceView (NCBI)TTC21B
Genatlas (Paris)TTC21B
WikiGenes79809
SOURCE (Princeton)TTC21B
Genetics Home Reference (NIH)TTC21B
Genomic and cartography
GoldenPath hg38 (UCSC)TTC21B  -     chr2:165873362-165953838 -  2q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTC21B  -     2q24.3   [Description]    (hg19-Feb_2009)
EnsemblTTC21B - 2q24.3 [CytoView hg19]  TTC21B - 2q24.3 [CytoView hg38]
Mapping of homologs : NCBITTC21B [Mapview hg19]  TTC21B [Mapview hg38]
OMIM612014   613819   613820   
Gene and transcription
Genbank (Entrez)AB073395 AK057268 AK096451 AK292942 BC035767
RefSeq transcript (Entrez)NM_024753
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTC21B
Cluster EST : UnigeneHs.310672 [ NCBI ]
CGAP (NCI)Hs.310672
Alternative Splicing GalleryENSG00000123607
Gene ExpressionTTC21B [ NCBI-GEO ]   TTC21B [ EBI - ARRAY_EXPRESS ]   TTC21B [ SEEK ]   TTC21B [ MEM ]
Gene Expression Viewer (FireBrowse)TTC21B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79809
GTEX Portal (Tissue expression)TTC21B
Human Protein AtlasENSG00000123607-TTC21B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ7Z4L5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ7Z4L5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ7Z4L5
Splice isoforms : SwissVarQ7Z4L5
PhosPhoSitePlusQ7Z4L5
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)TTC21B
DMDM Disease mutations79809
Blocks (Seattle)TTC21B
SuperfamilyQ7Z4L5
Human Protein Atlas [tissue]ENSG00000123607-TTC21B [tissue]
Peptide AtlasQ7Z4L5
HPRD07752
IPIIPI00178386   IPI00847349   IPI00873191   
Protein Interaction databases
DIP (DOE-UCLA)Q7Z4L5
IntAct (EBI)Q7Z4L5
FunCoupENSG00000123607
BioGRIDTTC21B
STRING (EMBL)TTC21B
ZODIACTTC21B
Ontologies - Pathways
QuickGOQ7Z4L5
Ontology : AmiGOnuclear chromatin  cytoplasm  cytoskeleton  cilium  regulation of transcription from RNA polymerase II promoter  smoothened signaling pathway  regulation of smoothened signaling pathway  ventricular system development  forebrain dorsal/ventral pattern formation  intraciliary transport particle A  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  protein localization to cilium  ciliary tip  
Ontology : EGO-EBInuclear chromatin  cytoplasm  cytoskeleton  cilium  regulation of transcription from RNA polymerase II promoter  smoothened signaling pathway  regulation of smoothened signaling pathway  ventricular system development  forebrain dorsal/ventral pattern formation  intraciliary transport particle A  intraciliary retrograde transport  intraciliary transport involved in cilium assembly  protein localization to cilium  ciliary tip  
NDEx NetworkTTC21B
Atlas of Cancer Signalling NetworkTTC21B
Wikipedia pathwaysTTC21B
Orthology - Evolution
OrthoDB79809
GeneTree (enSembl)ENSG00000123607
Phylogenetic Trees/Animal Genes : TreeFamTTC21B
HOVERGENQ7Z4L5
HOGENOMQ7Z4L5
Homologs : HomoloGeneTTC21B
Homology/Alignments : Family Browser (UCSC)TTC21B
Gene fusions - Rearrangements
Tumor Fusion PortalTTC21B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC21B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC21B
dbVarTTC21B
ClinVarTTC21B
1000_GenomesTTC21B 
Exome Variant ServerTTC21B
ExAC (Exome Aggregation Consortium)ENSG00000123607
GNOMAD BrowserENSG00000123607
Genetic variants : HAPMAP79809
Genomic Variants (DGV)TTC21B [DGVbeta]
DECIPHERTTC21B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTC21B 
Mutations
ICGC Data PortalTTC21B 
TCGA Data PortalTTC21B 
Broad Tumor PortalTTC21B
OASIS PortalTTC21B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC21B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTC21B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTC21B
DgiDB (Drug Gene Interaction Database)TTC21B
DoCM (Curated mutations)TTC21B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTC21B (select a term)
intoGenTTC21B
Cancer3DTTC21B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612014    613819    613820   
Orphanet283    12426   
DisGeNETTTC21B
MedgenTTC21B
Genetic Testing Registry TTC21B
NextProtQ7Z4L5 [Medical]
TSGene79809
GENETestsTTC21B
Target ValidationTTC21B
Huge Navigator TTC21B [HugePedia]
snp3D : Map Gene to Disease79809
BioCentury BCIQTTC21B
ClinGenTTC21B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79809
Chemical/Pharm GKB GenePA134882767
Clinical trialTTC21B
Miscellaneous
canSAR (ICR)TTC21B (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTC21B
EVEXTTC21B
GoPubMedTTC21B
iHOPTTC21B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:06:43 CET 2017

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