Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TTC28 (tetratricopeptide repeat domain 28)

Identity

Alias_symbol (synonym)KIAA1043
Other aliasTPRBK
HGNC (Hugo) TTC28
LocusID (NCBI) 23331
Atlas_Id 54733
Location 22q12.1  [Link to chromosome band 22q12]
Location_base_pair Starts at 27978014 and ends at 28679865 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		EP300 (22q13.2) / TTC28 (22q12.1)EVA1A (2p12) / TTC28 (22q12.1)PDE4DIP (1q21.1) / TTC28 (22q12.1)
SLC16A7 (12q14.1) / TTC28 (22q12.1)SPATA16 (3q26.31) / TTC28 (22q12.1)TTC17 (11p12) / TTC28 (22q12.1)
TTC28 (22q12.1) / ATP5E (20q13.32)TTC28 (22q12.1) / CD99L2 (Xq28)TTC28 (22q12.1) / CHCHD3 (7q32.3)
TTC28 (22q12.1) / EP300 (22q13.2)TTC28 (22q12.1) / HS6ST2 (Xq26.2)TTC28 (22q12.1) / IGSF3 (1p13.1)
TTC28 (22q12.1) / ODF1 (8q22.3)TTC28 (22q12.1) / PITPNB (22q12.1)EP300 22q13.2 / TTC28 22q12.1
TTC28 22q12.1 / EP300 22q13.2TTC28 22q12.1 / ODF1 8q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)TTC28   29179
Cards
Entrez_Gene (NCBI)TTC28  23331  tetratricopeptide repeat domain 28
AliasesTPRBK
GeneCards (Weizmann)TTC28
Ensembl hg19 (Hinxton)ENSG00000100154 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100154 [Gene_View]  chr22:27978014-28679865 [Contig_View]  TTC28 [Vega]
ICGC DataPortalENSG00000100154
TCGA cBioPortalTTC28
AceView (NCBI)TTC28
Genatlas (Paris)TTC28
WikiGenes23331
SOURCE (Princeton)TTC28
Genetics Home Reference (NIH)TTC28
Genomic and cartography
GoldenPath hg38 (UCSC)TTC28  -     chr22:27978014-28679865 -  22q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTC28  -     22q12.1   [Description]    (hg19-Feb_2009)
EnsemblTTC28 - 22q12.1 [CytoView hg19]  TTC28 - 22q12.1 [CytoView hg38]
Mapping of homologs : NCBITTC28 [Mapview hg19]  TTC28 [Mapview hg38]
OMIM615098   
Gene and transcription
Genbank (Entrez)AB028966 AB665284 AK055553 AK092338 AL080174
RefSeq transcript (Entrez)NM_001145418 NM_015281
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTC28
Cluster EST : UnigeneHs.387856 [ NCBI ]
CGAP (NCI)Hs.387856
Alternative Splicing GalleryENSG00000100154
Gene ExpressionTTC28 [ NCBI-GEO ]   TTC28 [ EBI - ARRAY_EXPRESS ]   TTC28 [ SEEK ]   TTC28 [ MEM ]
Gene Expression Viewer (FireBrowse)TTC28 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23331
GTEX Portal (Tissue expression)TTC28
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96AY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96AY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96AY4
Splice isoforms : SwissVarQ96AY4
PhosPhoSitePlusQ96AY4
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)CHAT_dom    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat    TTC28   
Domain families : Pfam (Sanger)CHAT (PF12770)    TPR_7 (PF13176)    TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam12770    pfam13176    pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)TTC28
DMDM Disease mutations23331
Blocks (Seattle)TTC28
SuperfamilyQ96AY4
Human Protein AtlasENSG00000100154
Peptide AtlasQ96AY4
HPRD10020
IPIIPI00879193   IPI00879027   IPI00915468   
Protein Interaction databases
DIP (DOE-UCLA)Q96AY4
IntAct (EBI)Q96AY4
FunCoupENSG00000100154
BioGRIDTTC28
STRING (EMBL)TTC28
ZODIACTTC28
Ontologies - Pathways
QuickGOQ96AY4
Ontology : AmiGOspindle pole  cytoplasm  centrosome  cell cycle  regulation of mitotic cell cycle  midbody  cell division  
Ontology : EGO-EBIspindle pole  cytoplasm  centrosome  cell cycle  regulation of mitotic cell cycle  midbody  cell division  
NDEx NetworkTTC28
Atlas of Cancer Signalling NetworkTTC28
Wikipedia pathwaysTTC28
Orthology - Evolution
OrthoDB23331
GeneTree (enSembl)ENSG00000100154
Phylogenetic Trees/Animal Genes : TreeFamTTC28
HOVERGENQ96AY4
HOGENOMQ96AY4
Homologs : HomoloGeneTTC28
Homology/Alignments : Family Browser (UCSC)TTC28
Gene fusions - Rearrangements
Fusion : MitelmanEP300/TTC28 [22q13.2/22q12.1]  [t(22;22)(q12;q13)]  
Fusion : MitelmanEVA1A/TTC28 [2p12/22q12.1]  [t(2;22)(p12;q12)]  
Fusion : MitelmanPDE4DIP/TTC28 [1q21.1/22q12.1]  [t(1;22)(q21;q12)]  
Fusion : MitelmanSLC16A7/TTC28 [12q14.1/22q12.1]  [t(12;22)(q14;q12)]  
Fusion : MitelmanSPATA16/TTC28 [3q26.31/22q12.1]  [t(3;22)(q26;q12)]  
Fusion : MitelmanTTC17/TTC28 [11p12/22q12.1]  [t(11;22)(p12;q12)]  
Fusion : MitelmanTTC28/CD99L2 [22q12.1/Xq28]  [t(X;22)(q28;q12)]  
Fusion : MitelmanTTC28/EP300 [22q12.1/22q13.2]  [t(22;22)(q12;q13)]  
Fusion : MitelmanTTC28/HS6ST2 [22q12.1/Xq26.2]  [t(X;22)(q26;q12)]  
Fusion : MitelmanTTC28/ODF1 [22q12.1/8q22.3]  [t(8;22)(q22;q12)]  
Fusion: TCGAEP300 22q13.2 TTC28 22q12.1 LUSC
Fusion: TCGATTC28 22q12.1 EP300 22q13.2 LUSC
Fusion: TCGATTC28 22q12.1 ODF1 8q22.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC28 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC28
dbVarTTC28
ClinVarTTC28
1000_GenomesTTC28 
Exome Variant ServerTTC28
ExAC (Exome Aggregation Consortium)TTC28 (select the gene name)
Genetic variants : HAPMAP23331
Genomic Variants (DGV)TTC28 [DGVbeta]
DECIPHERTTC28 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTC28 
Mutations
ICGC Data PortalTTC28 
TCGA Data PortalTTC28 
Broad Tumor PortalTTC28
OASIS PortalTTC28 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC28  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTC28
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTC28
DgiDB (Drug Gene Interaction Database)TTC28
DoCM (Curated mutations)TTC28 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTC28 (select a term)
intoGenTTC28
Cancer3DTTC28(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615098   
Orphanet
MedgenTTC28
Genetic Testing Registry TTC28
NextProtQ96AY4 [Medical]
TSGene23331
GENETestsTTC28
Target ValidationTTC28
Huge Navigator TTC28 [HugePedia]
snp3D : Map Gene to Disease23331
BioCentury BCIQTTC28
ClinGenTTC28
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23331
Chemical/Pharm GKB GenePA145147752
Clinical trialTTC28
Miscellaneous
canSAR (ICR)TTC28 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTC28
EVEXTTC28
GoPubMedTTC28
iHOPTTC28
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:36:40 CEST 2017
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