Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TTC3 (tetratricopeptide repeat domain 3)

Identity

Alias_symbol (synonym)TPRD
TPRDI
DCRR1
TPRDII
TPRDIII
RNF105
Other alias
HGNC (Hugo) TTC3
LocusID (NCBI) 7267
Atlas_Id 75282
Location 21q22.13  [Link to chromosome band 21q22]
Location_base_pair Starts at 38445571 and ends at 38575408 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCDC71 (3p21.31) / TTC3 (21q22.13)CENPP (9q22.31) / TTC3 (21q22.13)DYRK1A (21q22.13) / TTC3 (21q22.13)
SMARCB1 (22q11.23) / TTC3 (21q22.13)TTC3 (21q22.13) / BRWD1 (21q22.2)TTC3 (21q22.13) / TTC3 (21q22.13)
TTC3 (21q22.13) / UBR5 (8q22.3)WHSC1L1 (8p11.23) / TTC3 (21q22.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TTC3   12393
Cards
Entrez_Gene (NCBI)TTC3  7267  tetratricopeptide repeat domain 3
AliasesDCRR1; RNF105; TPRDIII
GeneCards (Weizmann)TTC3
Ensembl hg19 (Hinxton)ENSG00000182670 [Gene_View]  chr21:38445571-38575408 [Contig_View]  TTC3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000182670 [Gene_View]  chr21:38445571-38575408 [Contig_View]  TTC3 [Vega]
ICGC DataPortalENSG00000182670
TCGA cBioPortalTTC3
AceView (NCBI)TTC3
Genatlas (Paris)TTC3
WikiGenes7267
SOURCE (Princeton)TTC3
Genetics Home Reference (NIH)TTC3
Genomic and cartography
GoldenPath hg19 (UCSC)TTC3  -     chr21:38445571-38575408 +  21q22.13   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TTC3  -     21q22.13   [Description]    (hg38-Dec_2013)
EnsemblTTC3 - 21q22.13 [CytoView hg19]  TTC3 - 21q22.13 [CytoView hg38]
Mapping of homologs : NCBITTC3 [Mapview hg19]  TTC3 [Mapview hg38]
OMIM602259   
Gene and transcription
Genbank (Entrez)AJ001866 AK125473 AK126194 AK126418 AK291992
RefSeq transcript (Entrez)NM_001001894 NM_003316
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)TTC3
Cluster EST : UnigeneHs.368214 [ NCBI ]
CGAP (NCI)Hs.368214
Alternative Splicing GalleryENSG00000182670
Gene ExpressionTTC3 [ NCBI-GEO ]   TTC3 [ EBI - ARRAY_EXPRESS ]   TTC3 [ SEEK ]   TTC3 [ MEM ]
Gene Expression Viewer (FireBrowse)TTC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7267
GTEX Portal (Tissue expression)TTC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP53804   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP53804  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP53804
Splice isoforms : SwissVarP53804
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusP53804
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom    TPR_1    TPR_repeat    Znf_RING    Znf_RING/FYVE/PHD   
Domain families : Pfam (Sanger)TPR_1 (PF00515)    zf-RING_2 (PF13639)   
Domain families : Pfam (NCBI)pfam00515    pfam13639   
Domain families : Smart (EMBL)RING (SM00184)  TPR (SM00028)  
Conserved Domain (NCBI)TTC3
DMDM Disease mutations7267
Blocks (Seattle)TTC3
SuperfamilyP53804
Human Protein AtlasENSG00000182670
Peptide AtlasP53804
HPRD03773
IPIIPI00023977   IPI00215848   IPI00215849   IPI00922045   IPI00790123   IPI00793407   IPI00791903   IPI00794467   IPI00792735   IPI00795884   IPI00794134   
Protein Interaction databases
DIP (DOE-UCLA)P53804
IntAct (EBI)P53804
FunCoupENSG00000182670
BioGRIDTTC3
STRING (EMBL)TTC3
ZODIACTTC3
Ontologies - Pathways
QuickGOP53804
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  mitochondrion  vacuole  ubiquitin-dependent protein catabolic process  zinc ion binding  negative regulation of cell morphogenesis involved in differentiation  ligase activity  negative regulation of neuron differentiation  protein K48-linked ubiquitination  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  nucleus  nucleoplasm  mitochondrion  vacuole  ubiquitin-dependent protein catabolic process  zinc ion binding  negative regulation of cell morphogenesis involved in differentiation  ligase activity  negative regulation of neuron differentiation  protein K48-linked ubiquitination  
NDEx NetworkTTC3
Atlas of Cancer Signalling NetworkTTC3
Wikipedia pathwaysTTC3
Orthology - Evolution
OrthoDB7267
GeneTree (enSembl)ENSG00000182670
Phylogenetic Trees/Animal Genes : TreeFamTTC3
HOVERGENP53804
HOGENOMP53804
Homologs : HomoloGeneTTC3
Homology/Alignments : Family Browser (UCSC)TTC3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC3
dbVarTTC3
ClinVarTTC3
1000_GenomesTTC3 
Exome Variant ServerTTC3
ExAC (Exome Aggregation Consortium)TTC3 (select the gene name)
Genetic variants : HAPMAP7267
Genomic Variants (DGV)TTC3 [DGVbeta]
DECIPHER (Syndromes)21:38445571-38575408  ENSG00000182670
CONAN: Copy Number AnalysisTTC3 
Mutations
ICGC Data PortalTTC3 
TCGA Data PortalTTC3 
Broad Tumor PortalTTC3
OASIS PortalTTC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTC3
DgiDB (Drug Gene Interaction Database)TTC3
DoCM (Curated mutations)TTC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTC3 (select a term)
intoGenTTC3
Cancer3DTTC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602259   
Orphanet
MedgenTTC3
Genetic Testing Registry TTC3
NextProtP53804 [Medical]
TSGene7267
GENETestsTTC3
Huge Navigator TTC3 [HugePedia]
snp3D : Map Gene to Disease7267
BioCentury BCIQTTC3
ClinGenTTC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7267
Chemical/Pharm GKB GenePA37058
Clinical trialTTC3
Miscellaneous
canSAR (ICR)TTC3 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTC3
EVEXTTC3
GoPubMedTTC3
iHOPTTC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:50:08 CET 2017

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