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TTC5 (tetratricopeptide repeat domain 5)

Identity

Alias (NCBI)NEDCAFD
Strap
HGNC (Hugo) TTC5
HGNC Alias symbStrap
LocusID (NCBI) 91875
Atlas_Id 50198
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 20286227 and ends at 20305951 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TTC5   19274
Cards
Entrez_Gene (NCBI)TTC5    tetratricopeptide repeat domain 5
AliasesNEDCAFD; Strap
GeneCards (Weizmann)TTC5
Ensembl hg19 (Hinxton)ENSG00000136319 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000136319 [Gene_View]  ENSG00000136319 [Sequence]  chr14:20286227-20305951 [Contig_View]  TTC5 [Vega]
ICGC DataPortalENSG00000136319
TCGA cBioPortalTTC5
AceView (NCBI)TTC5
Genatlas (Paris)TTC5
SOURCE (Princeton)TTC5
Genetics Home Reference (NIH)TTC5
Genomic and cartography
GoldenPath hg38 (UCSC)TTC5  -     chr14:20286227-20305951 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTC5  -     14q11.2   [Description]    (hg19-Feb_2009)
GoldenPathTTC5 - 14q11.2 [CytoView hg19]  TTC5 - 14q11.2 [CytoView hg38]
ImmunoBaseENSG00000136319
Genome Data Viewer NCBITTC5 [Mapview hg19]  
OMIM619014   619244   
Gene and transcription
Genbank (Entrez)AK074553 BC008647 BC030822 BC053538 BM998414
RefSeq transcript (Entrez)NM_138376
Consensus coding sequences : CCDS (NCBI)TTC5
Gene ExpressionTTC5 [ NCBI-GEO ]   TTC5 [ EBI - ARRAY_EXPRESS ]   TTC5 [ SEEK ]   TTC5 [ MEM ]
Gene Expression Viewer (FireBrowse)TTC5 [ Firebrowse - Broad ]
GenevisibleExpression of TTC5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)91875
GTEX Portal (Tissue expression)TTC5
Human Protein AtlasENSG00000136319-TTC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N0Z6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N0Z6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N0Z6
PhosPhoSitePlusQ8N0Z6
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat    TTC5_OB    TTC5_OB_sf   
Domain families : Pfam (Sanger)TTC5_OB (PF16669)   
Domain families : Pfam (NCBI)pfam16669   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)TTC5
PDB (RSDB)2XVS    6T59   
PDB Europe2XVS    6T59   
PDB (PDBSum)2XVS    6T59   
PDB (IMB)2XVS    6T59   
Structural Biology KnowledgeBase2XVS    6T59   
SCOP (Structural Classification of Proteins)2XVS    6T59   
CATH (Classification of proteins structures)2XVS    6T59   
SuperfamilyQ8N0Z6
AlphaFold pdb e-kbQ8N0Z6   
Human Protein Atlas [tissue]ENSG00000136319-TTC5 [tissue]
HPRD15584
Protein Interaction databases
DIP (DOE-UCLA)Q8N0Z6
IntAct (EBI)Q8N0Z6
BioGRIDTTC5
STRING (EMBL)TTC5
ZODIACTTC5
Ontologies - Pathways
QuickGOQ8N0Z6
Ontology : AmiGODNA binding  chromatin binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  positive regulation of transcription by RNA polymerase II  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIDNA binding  chromatin binding  protein binding  nucleoplasm  nucleoplasm  cytoplasm  DNA repair  positive regulation of transcription by RNA polymerase II  regulation of signal transduction by p53 class mediator  
NDEx NetworkTTC5
Atlas of Cancer Signalling NetworkTTC5
Wikipedia pathwaysTTC5
Orthology - Evolution
OrthoDB91875
GeneTree (enSembl)ENSG00000136319
Phylogenetic Trees/Animal Genes : TreeFamTTC5
Homologs : HomoloGeneTTC5
Homology/Alignments : Family Browser (UCSC)TTC5
Gene fusions - Rearrangements
Fusion : QuiverTTC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC5
dbVarTTC5
ClinVarTTC5
MonarchTTC5
1000_GenomesTTC5 
Exome Variant ServerTTC5
GNOMAD BrowserENSG00000136319
Varsome BrowserTTC5
ACMGTTC5 variants
VarityQ8N0Z6
Genomic Variants (DGV)TTC5 [DGVbeta]
DECIPHERTTC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTC5 
Mutations
ICGC Data PortalTTC5 
TCGA Data PortalTTC5 
Broad Tumor PortalTTC5
OASIS PortalTTC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTC5
Mutations and Diseases : HGMDTTC5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTC5
DgiDB (Drug Gene Interaction Database)TTC5
DoCM (Curated mutations)TTC5
CIViC (Clinical Interpretations of Variants in Cancer)TTC5
Cancer3DTTC5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619014    619244   
Orphanet
DisGeNETTTC5
MedgenTTC5
Genetic Testing Registry TTC5
NextProtQ8N0Z6 [Medical]
GENETestsTTC5
Target ValidationTTC5
Huge Navigator TTC5 [HugePedia]
ClinGenTTC5
Clinical trials, drugs, therapy
MyCancerGenomeTTC5
Protein Interactions : CTDTTC5
Pharm GKB GenePA134919164
PharosQ8N0Z6
Clinical trialTTC5
Miscellaneous
canSAR (ICR)TTC5
HarmonizomeTTC5
DataMed IndexTTC5
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:44 CEST 2021

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