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TTC7B (tetratricopeptide repeat domain 7B)

Identity

Alias (NCBI)TTC7L1
c14_5685
HGNC (Hugo) TTC7B
HGNC Previous nameTTC7L1
HGNC Previous nametetratricopeptide repeat domain 7 like 1
LocusID (NCBI) 145567
Atlas_Id 75300
Location 14q32.11  [Link to chromosome band 14q32]
Location_base_pair Starts at 90540588 and ends at 90816417 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDAH2 (6p21.33) / TTC7B (14q32.11)TTC7B (14q32.11) / NT5E (6q14.3)TTC7B (14q32.11) / PPP2R5C (14q32.31)
TTC7B (14q32.11) / RPS6KA5 (14q32.11)TTC7B (14q32.11) / TTC7B (14q32.11)TTC7B RPS6KA5
TTC7B PPP2R5C

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;14)(q23;q32) TTC7B/SYNE2
t(14;14)(q23;q32) TTC7B/SYNE2


External links

 

Nomenclature
HGNC (Hugo)TTC7B   19858
Cards
Entrez_Gene (NCBI)TTC7B    tetratricopeptide repeat domain 7B
AliasesTTC7L1; c14_5685
GeneCards (Weizmann)TTC7B
Ensembl hg19 (Hinxton)ENSG00000165914 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165914 [Gene_View]  ENSG00000165914 [Sequence]  chr14:90540588-90816417 [Contig_View]  TTC7B [Vega]
ICGC DataPortalENSG00000165914
TCGA cBioPortalTTC7B
AceView (NCBI)TTC7B
Genatlas (Paris)TTC7B
SOURCE (Princeton)TTC7B
Genetics Home Reference (NIH)TTC7B
Genomic and cartography
GoldenPath hg38 (UCSC)TTC7B  -     chr14:90540588-90816417 -  14q32.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTC7B  -     14q32.11   [Description]    (hg19-Feb_2009)
GoldenPathTTC7B - 14q32.11 [CytoView hg19]  TTC7B - 14q32.11 [CytoView hg38]
ImmunoBaseENSG00000165914
Genome Data Viewer NCBITTC7B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK126571 AL832848 AW081996 BC035865 BC048270
RefSeq transcript (Entrez)NM_001010854 NM_001320421
Consensus coding sequences : CCDS (NCBI)TTC7B
Gene ExpressionTTC7B [ NCBI-GEO ]   TTC7B [ EBI - ARRAY_EXPRESS ]   TTC7B [ SEEK ]   TTC7B [ MEM ]
Gene Expression Viewer (FireBrowse)TTC7B [ Firebrowse - Broad ]
GenevisibleExpression of TTC7B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)145567
GTEX Portal (Tissue expression)TTC7B
Human Protein AtlasENSG00000165914-TTC7B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86TV6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86TV6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86TV6
PhosPhoSitePlusQ86TV6
Domaine pattern : Prosite (Expaxy)TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)TPR-contain_dom    TPR-like_helical_dom_sf    TPR_repeat   
Domain families : Pfam (Sanger)TPR_8 (PF13181)   
Domain families : Pfam (NCBI)pfam13181   
Domain families : Smart (EMBL)TPR (SM00028)  
Conserved Domain (NCBI)TTC7B
PDB (RSDB)5DSE    6BQ1   
PDB Europe5DSE    6BQ1   
PDB (PDBSum)5DSE    6BQ1   
PDB (IMB)5DSE    6BQ1   
Structural Biology KnowledgeBase5DSE    6BQ1   
SCOP (Structural Classification of Proteins)5DSE    6BQ1   
CATH (Classification of proteins structures)5DSE    6BQ1   
SuperfamilyQ86TV6
AlphaFold pdb e-kbQ86TV6   
Human Protein Atlas [tissue]ENSG00000165914-TTC7B [tissue]
HPRD18503
Protein Interaction databases
DIP (DOE-UCLA)Q86TV6
IntAct (EBI)Q86TV6
BioGRIDTTC7B
STRING (EMBL)TTC7B
ZODIACTTC7B
Ontologies - Pathways
QuickGOQ86TV6
Ontology : AmiGOprotein binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol phosphate biosynthetic process  phosphatidylinositol phosphate biosynthetic process  protein localization to plasma membrane  protein localization to plasma membrane  
Ontology : EGO-EBIprotein binding  cytosol  plasma membrane  plasma membrane  phosphatidylinositol phosphate biosynthetic process  phosphatidylinositol phosphate biosynthetic process  protein localization to plasma membrane  protein localization to plasma membrane  
NDEx NetworkTTC7B
Atlas of Cancer Signalling NetworkTTC7B
Wikipedia pathwaysTTC7B
Orthology - Evolution
OrthoDB145567
GeneTree (enSembl)ENSG00000165914
Phylogenetic Trees/Animal Genes : TreeFamTTC7B
Homologs : HomoloGeneTTC7B
Homology/Alignments : Family Browser (UCSC)TTC7B
Gene fusions - Rearrangements
Fusion : QuiverTTC7B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTC7B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTC7B
dbVarTTC7B
ClinVarTTC7B
MonarchTTC7B
1000_GenomesTTC7B 
Exome Variant ServerTTC7B
GNOMAD BrowserENSG00000165914
Varsome BrowserTTC7B
ACMGTTC7B variants
VarityQ86TV6
Genomic Variants (DGV)TTC7B [DGVbeta]
DECIPHERTTC7B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTC7B 
Mutations
ICGC Data PortalTTC7B 
TCGA Data PortalTTC7B 
Broad Tumor PortalTTC7B
OASIS PortalTTC7B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTC7B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTC7B
Mutations and Diseases : HGMDTTC7B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTC7B
DgiDB (Drug Gene Interaction Database)TTC7B
DoCM (Curated mutations)TTC7B
CIViC (Clinical Interpretations of Variants in Cancer)TTC7B
Cancer3DTTC7B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTTC7B
MedgenTTC7B
Genetic Testing Registry TTC7B
NextProtQ86TV6 [Medical]
GENETestsTTC7B
Target ValidationTTC7B
Huge Navigator TTC7B [HugePedia]
ClinGenTTC7B
Clinical trials, drugs, therapy
MyCancerGenomeTTC7B
Protein Interactions : CTDTTC7B
Pharm GKB GenePA134947112
PharosQ86TV6
Clinical trialTTC7B
Miscellaneous
canSAR (ICR)TTC7B
HarmonizomeTTC7B
DataMed IndexTTC7B
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTC7B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:27:21 CEST 2021

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