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TTF1 (transcription termination factor 1)

Identity

Alias_namestranscription termination factor
Other aliasTTF-1
TTF-I
HGNC (Hugo) TTF1
LocusID (NCBI) 7270
Atlas_Id 46184
Location 9q34.13  [Link to chromosome band 9q34]
Location_base_pair Starts at 132375549 and ends at 132406851 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SETX (9q34.13) / TTF1 (9q34.13)TTF1 (9q34.13) / TOM1L2 (17p11.2)TTF1 (9q34.13) / TTF1 (9q34.13)
SETX 9q34.13 / TTF1 9q34.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p13;q13) ETV6/BAZ2A


External links

Nomenclature
HGNC (Hugo)TTF1   12397
Cards
Entrez_Gene (NCBI)TTF1  7270  transcription termination factor 1
AliasesTTF-1; TTF-I
GeneCards (Weizmann)TTF1
Ensembl hg19 (Hinxton)ENSG00000125482 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125482 [Gene_View]  chr9:132375549-132406851 [Contig_View]  TTF1 [Vega]
ICGC DataPortalENSG00000125482
TCGA cBioPortalTTF1
AceView (NCBI)TTF1
Genatlas (Paris)TTF1
WikiGenes7270
SOURCE (Princeton)TTF1
Genetics Home Reference (NIH)TTF1
Genomic and cartography
GoldenPath hg38 (UCSC)TTF1  -     chr9:132375549-132406851 -  9q34.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTF1  -     9q34.13   [Description]    (hg19-Feb_2009)
EnsemblTTF1 - 9q34.13 [CytoView hg19]  TTF1 - 9q34.13 [CytoView hg38]
Mapping of homologs : NCBITTF1 [Mapview hg19]  TTF1 [Mapview hg38]
OMIM600777   
Gene and transcription
Genbank (Entrez)AK225119 AK302902 BC050734 BC062692 BC104639
RefSeq transcript (Entrez)NM_001205296 NM_007344
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTF1
Cluster EST : UnigeneHs.732733 [ NCBI ]
CGAP (NCI)Hs.732733
Alternative Splicing GalleryENSG00000125482
Gene ExpressionTTF1 [ NCBI-GEO ]   TTF1 [ EBI - ARRAY_EXPRESS ]   TTF1 [ SEEK ]   TTF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TTF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7270
GTEX Portal (Tissue expression)TTF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15361   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15361  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15361
Splice isoforms : SwissVarQ15361
PhosPhoSitePlusQ15361
Domaine pattern : Prosite (Expaxy)MYB_LIKE (PS50090)   
Domains : Interpro (EBI)Homeobox-like    Myb-like_dom    SANT/Myb   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)SANT (SM00717)  
Conserved Domain (NCBI)TTF1
DMDM Disease mutations7270
Blocks (Seattle)TTF1
SuperfamilyQ15361
Human Protein AtlasENSG00000125482
Peptide AtlasQ15361
HPRD02866
IPIIPI00385712   IPI00856089   IPI01009207   
Protein Interaction databases
DIP (DOE-UCLA)Q15361
IntAct (EBI)Q15361
FunCoupENSG00000125482
BioGRIDTTF1
STRING (EMBL)TTF1
ZODIACTTF1
Ontologies - Pathways
QuickGOQ15361
Ontology : AmiGORNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II transcription factor recruiting  chromatin binding  nucleus  nucleus  nucleus  nucleoplasm  nucleolus  cytosol  plasma membrane  chromatin remodeling  DNA-templated transcription, termination  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  negative regulation of DNA replication  cell differentiation  sequence-specific DNA binding  transcription regulatory region DNA binding  cellular protein metabolic process  
Ontology : EGO-EBIRNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, RNA polymerase II transcription factor recruiting  chromatin binding  nucleus  nucleus  nucleus  nucleoplasm  nucleolus  cytosol  plasma membrane  chromatin remodeling  DNA-templated transcription, termination  regulation of transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  negative regulation of DNA replication  cell differentiation  sequence-specific DNA binding  transcription regulatory region DNA binding  cellular protein metabolic process  
Pathways : KEGGThyroid hormone synthesis   
NDEx NetworkTTF1
Atlas of Cancer Signalling NetworkTTF1
Wikipedia pathwaysTTF1
Orthology - Evolution
OrthoDB7270
GeneTree (enSembl)ENSG00000125482
Phylogenetic Trees/Animal Genes : TreeFamTTF1
HOVERGENQ15361
HOGENOMQ15361
Homologs : HomoloGeneTTF1
Homology/Alignments : Family Browser (UCSC)TTF1
Gene fusions - Rearrangements
Fusion : MitelmanSETX/TTF1 [9q34.13/9q34.13]  [t(9;9)(q34;q34)]  
Fusion: TCGASETX 9q34.13 TTF1 9q34.13 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTF1
dbVarTTF1
ClinVarTTF1
1000_GenomesTTF1 
Exome Variant ServerTTF1
ExAC (Exome Aggregation Consortium)TTF1 (select the gene name)
Genetic variants : HAPMAP7270
Genomic Variants (DGV)TTF1 [DGVbeta]
DECIPHERTTF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTF1 
Mutations
ICGC Data PortalTTF1 
TCGA Data PortalTTF1 
Broad Tumor PortalTTF1
OASIS PortalTTF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTF1
DgiDB (Drug Gene Interaction Database)TTF1
DoCM (Curated mutations)TTF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTF1 (select a term)
intoGenTTF1
Cancer3DTTF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600777   
Orphanet
MedgenTTF1
Genetic Testing Registry TTF1
NextProtQ15361 [Medical]
TSGene7270
GENETestsTTF1
Target ValidationTTF1
Huge Navigator TTF1 [HugePedia]
snp3D : Map Gene to Disease7270
BioCentury BCIQTTF1
ClinGenTTF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7270
Chemical/Pharm GKB GenePA37062
Clinical trialTTF1
Miscellaneous
canSAR (ICR)TTF1 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTF1
EVEXTTF1
GoPubMedTTF1
iHOPTTF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:17:56 CEST 2017

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