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TTF1 (transcription termination factor 1)

Identity

Alias (NCBI)TTF-1
TTF-I
HGNC (Hugo) TTF1
HGNC Previous nametranscription termination factor, RNA polymerase I
LocusID (NCBI) 7270
Atlas_Id 46184
Location 9q34.13  [Link to chromosome band 9q34]
Location_base_pair Starts at 132375549 and ends at 132406840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SETX (9q34.13) / TTF1 (9q34.13)TTF1 (9q34.13) / TOM1L2 (17p11.2)TTF1 (9q34.13) / TTF1 (9q34.13)
SETX 9q34.13 / TTF1 9q34.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p13;q13) ETV6/BAZ2A


External links

 

Nomenclature
HGNC (Hugo)TTF1   12397
Cards
Entrez_Gene (NCBI)TTF1    transcription termination factor 1
AliasesTTF-1; TTF-I
GeneCards (Weizmann)TTF1
Ensembl hg19 (Hinxton)ENSG00000125482 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125482 [Gene_View]  ENSG00000125482 [Sequence]  chr9:132375549-132406840 [Contig_View]  TTF1 [Vega]
ICGC DataPortalENSG00000125482
TCGA cBioPortalTTF1
AceView (NCBI)TTF1
Genatlas (Paris)TTF1
SOURCE (Princeton)TTF1
Genetics Home Reference (NIH)TTF1
Genomic and cartography
GoldenPath hg38 (UCSC)TTF1  -     chr9:132375549-132406840 -  9q34.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTF1  -     9q34.13   [Description]    (hg19-Feb_2009)
GoldenPathTTF1 - 9q34.13 [CytoView hg19]  TTF1 - 9q34.13 [CytoView hg38]
ImmunoBaseENSG00000125482
Genome Data Viewer NCBITTF1 [Mapview hg19]  
OMIM600777   
Gene and transcription
Genbank (Entrez)AK225119 AK302902 BC050734 BC062692 BC104639
RefSeq transcript (Entrez)NM_001205296 NM_007344
Consensus coding sequences : CCDS (NCBI)TTF1
Gene ExpressionTTF1 [ NCBI-GEO ]   TTF1 [ EBI - ARRAY_EXPRESS ]   TTF1 [ SEEK ]   TTF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TTF1 [ Firebrowse - Broad ]
GenevisibleExpression of TTF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7270
GTEX Portal (Tissue expression)TTF1
Human Protein AtlasENSG00000125482-TTF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15361   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15361  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15361
PhosPhoSitePlusQ15361
Domaine pattern : Prosite (Expaxy)MYB_LIKE (PS50090)   
Domains : Interpro (EBI)Myb-like_dom    SANT/Myb   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)SANT (SM00717)  
Conserved Domain (NCBI)TTF1
SuperfamilyQ15361
AlphaFold pdb e-kbQ15361   
Human Protein Atlas [tissue]ENSG00000125482-TTF1 [tissue]
HPRD02866
Protein Interaction databases
DIP (DOE-UCLA)Q15361
IntAct (EBI)Q15361
BioGRIDTTF1
STRING (EMBL)TTF1
ZODIACTTF1
Ontologies - Pathways
QuickGOQ15361
Ontology : AmiGODNA binding  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytosol  plasma membrane  DNA-templated transcription, termination  termination of RNA polymerase I transcription  termination of RNA polymerase I transcription  negative regulation of DNA replication  cellular protein metabolic process  
Ontology : EGO-EBIDNA binding  chromatin binding  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleolus  nucleolus  cytosol  plasma membrane  DNA-templated transcription, termination  termination of RNA polymerase I transcription  termination of RNA polymerase I transcription  negative regulation of DNA replication  cellular protein metabolic process  
Pathways : KEGGThyroid hormone synthesis   
NDEx NetworkTTF1
Atlas of Cancer Signalling NetworkTTF1
Wikipedia pathwaysTTF1
Orthology - Evolution
OrthoDB7270
GeneTree (enSembl)ENSG00000125482
Phylogenetic Trees/Animal Genes : TreeFamTTF1
Homologs : HomoloGeneTTF1
Homology/Alignments : Family Browser (UCSC)TTF1
Gene fusions - Rearrangements
Fusion : MitelmanSETX/TTF1 [9q34.13/9q34.13]  
Fusion : QuiverTTF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTF1
dbVarTTF1
ClinVarTTF1
MonarchTTF1
1000_GenomesTTF1 
Exome Variant ServerTTF1
GNOMAD BrowserENSG00000125482
Varsome BrowserTTF1
ACMGTTF1 variants
VarityQ15361
Genomic Variants (DGV)TTF1 [DGVbeta]
DECIPHERTTF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTF1 
Mutations
ICGC Data PortalTTF1 
TCGA Data PortalTTF1 
Broad Tumor PortalTTF1
OASIS PortalTTF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTF1
Mutations and Diseases : HGMDTTF1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTF1
DgiDB (Drug Gene Interaction Database)TTF1
DoCM (Curated mutations)TTF1
CIViC (Clinical Interpretations of Variants in Cancer)TTF1
Cancer3DTTF1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600777   
Orphanet
DisGeNETTTF1
MedgenTTF1
Genetic Testing Registry TTF1
NextProtQ15361 [Medical]
GENETestsTTF1
Target ValidationTTF1
Huge Navigator TTF1 [HugePedia]
ClinGenTTF1
Clinical trials, drugs, therapy
MyCancerGenomeTTF1
Protein Interactions : CTDTTF1
Pharm GKB GenePA37062
PharosQ15361
Clinical trialTTF1
Miscellaneous
canSAR (ICR)TTF1
HarmonizomeTTF1
DataMed IndexTTF1
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:45 CEST 2021

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