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TTF2 (transcription termination factor 2)

Identity

Alias (NCBI)F2
HuF2
ZGRF6
HGNC (Hugo) TTF2
HGNC Alias symbHuF2
ZGRF6
HGNC Alias namezinc finger, GRF-type containing 6
 transcription release factor 2
HGNC Previous nametranscription termination factor, RNA polymerase II
LocusID (NCBI) 8458
Atlas_Id 55567
Location 1p13.1  [Link to chromosome band 1p13]
Location_base_pair Starts at 117060326 and ends at 117107453 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAN1A2 (1p12) / TTF2 (1p13.1)TTF2 (1p13.1) / BRD9 (5p15.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TTF2   12398
Cards
Entrez_Gene (NCBI)TTF2    transcription termination factor 2
AliasesF2; HuF2; ZGRF6
GeneCards (Weizmann)TTF2
Ensembl hg19 (Hinxton)ENSG00000116830 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116830 [Gene_View]  ENSG00000116830 [Sequence]  chr1:117060326-117107453 [Contig_View]  TTF2 [Vega]
ICGC DataPortalENSG00000116830
TCGA cBioPortalTTF2
AceView (NCBI)TTF2
Genatlas (Paris)TTF2
SOURCE (Princeton)TTF2
Genetics Home Reference (NIH)TTF2
Genomic and cartography
GoldenPath hg38 (UCSC)TTF2  -     chr1:117060326-117107453 +  1p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTF2  -     1p13.1   [Description]    (hg19-Feb_2009)
GoldenPathTTF2 - 1p13.1 [CytoView hg19]  TTF2 - 1p13.1 [CytoView hg38]
ImmunoBaseENSG00000116830
Genome Data Viewer NCBITTF2 [Mapview hg19]  
OMIM604718   
Gene and transcription
Genbank (Entrez)AB209845 AF073771 AF080255 AI991355 AK123765
RefSeq transcript (Entrez)NM_003594
Consensus coding sequences : CCDS (NCBI)TTF2
Gene ExpressionTTF2 [ NCBI-GEO ]   TTF2 [ EBI - ARRAY_EXPRESS ]   TTF2 [ SEEK ]   TTF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TTF2 [ Firebrowse - Broad ]
GenevisibleExpression of TTF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8458
GTEX Portal (Tissue expression)TTF2
Human Protein AtlasENSG00000116830-TTF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNY4
Catalytic activity : Enzyme3.6.4.- [ Enzyme-Expasy ]   3.6.4.-3.6.4.- [ IntEnz-EBI ]   3.6.4.- [ BRENDA ]   3.6.4.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9UNY4
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DNA/RNA_helicase_DEAH_CS    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    SNF2-like_sf    SNF2_N    Znf_GRF   
Domain families : Pfam (Sanger)Helicase_C (PF00271)    SNF2_N (PF00176)    zf-GRF (PF06839)   
Domain families : Pfam (NCBI)pfam00271    pfam00176    pfam06839   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)TTF2
SuperfamilyQ9UNY4
AlphaFold pdb e-kbQ9UNY4   
Human Protein Atlas [tissue]ENSG00000116830-TTF2 [tissue]
HPRD05280
Protein Interaction databases
DIP (DOE-UCLA)Q9UNY4
IntAct (EBI)Q9UNY4
BioGRIDTTF2
STRING (EMBL)TTF2
ZODIACTTF2
Ontologies - Pathways
QuickGOQ9UNY4
Ontology : AmiGODNA binding  helicase activity  protein binding  ATP binding  spliceosomal complex  cytosol  DNA-templated transcription, termination  termination of RNA polymerase II transcription  mRNA processing  transcription elongation factor complex  ATPase, acting on DNA  zinc ion binding  RNA splicing  hydrolase activity  nucleosome-dependent ATPase activity  
Ontology : EGO-EBIDNA binding  helicase activity  protein binding  ATP binding  spliceosomal complex  cytosol  DNA-templated transcription, termination  termination of RNA polymerase II transcription  mRNA processing  transcription elongation factor complex  ATPase, acting on DNA  zinc ion binding  RNA splicing  hydrolase activity  nucleosome-dependent ATPase activity  
Pathways : KEGGThyroid hormone synthesis   
NDEx NetworkTTF2
Atlas of Cancer Signalling NetworkTTF2
Wikipedia pathwaysTTF2
Orthology - Evolution
OrthoDB8458
GeneTree (enSembl)ENSG00000116830
Phylogenetic Trees/Animal Genes : TreeFamTTF2
Homologs : HomoloGeneTTF2
Homology/Alignments : Family Browser (UCSC)TTF2
Gene fusions - Rearrangements
Fusion : QuiverTTF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTF2
dbVarTTF2
ClinVarTTF2
MonarchTTF2
1000_GenomesTTF2 
Exome Variant ServerTTF2
GNOMAD BrowserENSG00000116830
Varsome BrowserTTF2
ACMGTTF2 variants
VarityQ9UNY4
Genomic Variants (DGV)TTF2 [DGVbeta]
DECIPHERTTF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTF2 
Mutations
ICGC Data PortalTTF2 
TCGA Data PortalTTF2 
Broad Tumor PortalTTF2
OASIS PortalTTF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTF2
Mutations and Diseases : HGMDTTF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTF2
DgiDB (Drug Gene Interaction Database)TTF2
DoCM (Curated mutations)TTF2
CIViC (Clinical Interpretations of Variants in Cancer)TTF2
Cancer3DTTF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604718   
Orphanet
DisGeNETTTF2
MedgenTTF2
Genetic Testing Registry TTF2
NextProtQ9UNY4 [Medical]
GENETestsTTF2
Target ValidationTTF2
Huge Navigator TTF2 [HugePedia]
ClinGenTTF2
Clinical trials, drugs, therapy
MyCancerGenomeTTF2
Protein Interactions : CTDTTF2
Pharm GKB GenePA37063
PharosQ9UNY4
Clinical trialTTF2
Miscellaneous
canSAR (ICR)TTF2
HarmonizomeTTF2
DataMed IndexTTF2
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:45 CEST 2021

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