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TTF2 (transcription termination factor 2)

Identity

Alias_namestranscription termination factor, RNA polymerase II
Alias_symbol (synonym)HuF2
ZGRF6
Other alias
HGNC (Hugo) TTF2
LocusID (NCBI) 8458
Atlas_Id 55567
Location 1p13.1  [Link to chromosome band 1p13]
Location_base_pair Starts at 117060327 and ends at 117102869 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAN1A2 (1p12) / TTF2 (1p13.1)TTF2 (1p13.1) / BRD9 (5p15.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]

Solid Tumors TT_t0101p12p13ID103505


External links

Nomenclature
HGNC (Hugo)TTF2   12398
Cards
Entrez_Gene (NCBI)TTF2  8458  transcription termination factor 2
AliasesHuF2; ZGRF6
GeneCards (Weizmann)TTF2
Ensembl hg19 (Hinxton)ENSG00000116830 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116830 [Gene_View]  ENSG00000116830 [Sequence]  chr1:117060327-117102869 [Contig_View]  TTF2 [Vega]
ICGC DataPortalENSG00000116830
TCGA cBioPortalTTF2
AceView (NCBI)TTF2
Genatlas (Paris)TTF2
WikiGenes8458
SOURCE (Princeton)TTF2
Genetics Home Reference (NIH)TTF2
Genomic and cartography
GoldenPath hg38 (UCSC)TTF2  -     chr1:117060327-117102869 +  1p13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTF2  -     1p13.1   [Description]    (hg19-Feb_2009)
GoldenPathTTF2 - 1p13.1 [CytoView hg19]  TTF2 - 1p13.1 [CytoView hg38]
ImmunoBaseENSG00000116830
Mapping of homologs : NCBITTF2 [Mapview hg19]  TTF2 [Mapview hg38]
OMIM604718   
Gene and transcription
Genbank (Entrez)AB209845 AF073771 AF080255 AI991355 AK123765
RefSeq transcript (Entrez)NM_003594
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTF2
Cluster EST : UnigeneHs.486818 [ NCBI ]
CGAP (NCI)Hs.486818
Alternative Splicing GalleryENSG00000116830
Gene ExpressionTTF2 [ NCBI-GEO ]   TTF2 [ EBI - ARRAY_EXPRESS ]   TTF2 [ SEEK ]   TTF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TTF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8458
GTEX Portal (Tissue expression)TTF2
Human Protein AtlasENSG00000116830-TTF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UNY4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UNY4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UNY4
Splice isoforms : SwissVarQ9UNY4
PhosPhoSitePlusQ9UNY4
Domaine pattern : Prosite (Expaxy)DEAH_ATP_HELICASE (PS00690)    HELICASE_ATP_BIND_1 (PS51192)    HELICASE_CTER (PS51194)   
Domains : Interpro (EBI)DNA/RNA_helicase_DEAH_CS    Helicase_ATP-bd    Helicase_C    P-loop_NTPase    SNF2-like_sf    SNF2_N    Znf_GRF   
Domain families : Pfam (Sanger)Helicase_C (PF00271)    SNF2_N (PF00176)    zf-GRF (PF06839)   
Domain families : Pfam (NCBI)pfam00271    pfam00176    pfam06839   
Domain families : Smart (EMBL)DEXDc (SM00487)  HELICc (SM00490)  
Conserved Domain (NCBI)TTF2
DMDM Disease mutations8458
Blocks (Seattle)TTF2
SuperfamilyQ9UNY4
Human Protein Atlas [tissue]ENSG00000116830-TTF2 [tissue]
Peptide AtlasQ9UNY4
HPRD05280
IPIIPI00290812   IPI00640904   IPI00555864   IPI00645509   
Protein Interaction databases
DIP (DOE-UCLA)Q9UNY4
IntAct (EBI)Q9UNY4
FunCoupENSG00000116830
BioGRIDTTF2
STRING (EMBL)TTF2
ZODIACTTF2
Ontologies - Pathways
QuickGOQ9UNY4
Ontology : AmiGODNA binding  helicase activity  protein binding  ATP binding  spliceosomal complex  cytosol  DNA-templated transcription, termination  termination of RNA polymerase II transcription  mRNA processing  transcription elongation factor complex  DNA-dependent ATPase activity  zinc ion binding  RNA splicing  
Ontology : EGO-EBIDNA binding  helicase activity  protein binding  ATP binding  spliceosomal complex  cytosol  DNA-templated transcription, termination  termination of RNA polymerase II transcription  mRNA processing  transcription elongation factor complex  DNA-dependent ATPase activity  zinc ion binding  RNA splicing  
Pathways : KEGGThyroid hormone synthesis   
NDEx NetworkTTF2
Atlas of Cancer Signalling NetworkTTF2
Wikipedia pathwaysTTF2
Orthology - Evolution
OrthoDB8458
GeneTree (enSembl)ENSG00000116830
Phylogenetic Trees/Animal Genes : TreeFamTTF2
HOGENOMQ9UNY4
Homologs : HomoloGeneTTF2
Homology/Alignments : Family Browser (UCSC)TTF2
Gene fusions - Rearrangements
Fusion : QuiverTTF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTF2
dbVarTTF2
ClinVarTTF2
1000_GenomesTTF2 
Exome Variant ServerTTF2
ExAC (Exome Aggregation Consortium)ENSG00000116830
GNOMAD BrowserENSG00000116830
Varsome BrowserTTF2
Genetic variants : HAPMAP8458
Genomic Variants (DGV)TTF2 [DGVbeta]
DECIPHERTTF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTF2 
Mutations
ICGC Data PortalTTF2 
TCGA Data PortalTTF2 
Broad Tumor PortalTTF2
OASIS PortalTTF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTF2
Mutations and Diseases : HGMDTTF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTF2
DgiDB (Drug Gene Interaction Database)TTF2
DoCM (Curated mutations)TTF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTF2 (select a term)
intoGenTTF2
Cancer3DTTF2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604718   
Orphanet
DisGeNETTTF2
MedgenTTF2
Genetic Testing Registry TTF2
NextProtQ9UNY4 [Medical]
TSGene8458
GENETestsTTF2
Target ValidationTTF2
Huge Navigator TTF2 [HugePedia]
snp3D : Map Gene to Disease8458
BioCentury BCIQTTF2
ClinGenTTF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8458
Chemical/Pharm GKB GenePA37063
Clinical trialTTF2
Miscellaneous
canSAR (ICR)TTF2 (select the gene name)
DataMed IndexTTF2
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTF2
EVEXTTF2
GoPubMedTTF2
iHOPTTF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 26 18:33:50 CEST 2019

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