TTI1 (TELO2 interacting protein 1)

2014-11-01  

Identity

HGNC
LOCATION
20q11.23
LOCUSID
ALIAS
KIAA0406,smg-10
FUSION GENES

Other Information

Locus ID:

NCBI: 9675
MIM: 614425
HGNC: 29029
Ensembl: ENSG00000101407

Variants:

dbSNP: 9675
ClinVar: 9675
TCGA: ENSG00000101407
COSMIC: TTI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101407ENST00000373447O43156
ENSG00000101407ENST00000373448O43156
ENSG00000101407ENST00000449821O43156
ENSG00000101407ENST00000620381A0A087WT32

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
mTOR signaling pathwayKEGGhsa04150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208106502010A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.87
204272872010Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.86
246571682014Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.44
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12

Citation

Dessen P

TTI1 (TELO2 interacting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75305/tti1