Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TTK (TTK protein kinase)

Identity

Other namesCT96
ESK
MPH1
MPS1
MPS1L1
PYT
HGNC (Hugo) TTK
LocusID (NCBI) 7272
Location 6q14.1
Location_base_pair Starts at 80714322 and ends at 80752244 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TTK   12401
Entrez_Gene (NCBI)TTK  7272  TTK protein kinase
Cards
GeneCards (Weizmann)TTK
Ensembl (Hinxton)ENSG00000112742 [Gene_View]  chr6:80714322-80752244 [Contig_View]  TTK [Vega]
AceView (NCBI)TTK
Genatlas (Paris)TTK
SOURCE (Stanford)NM_001166691 NM_003318
Genomic and cartography
GoldenPath (UCSC)TTK  -  6q14.1   chr6:80714322-80752244 +  6q14.1   [Description]    (hg19-Feb_2009)
EnsemblTTK - 6q14.1 [CytoView]
Mapping of homologs : NCBITTK [Mapview]
OMIM604092   
Gene and transcription
Genbank (Entrez)AK095599 AK292460 AK315696 AU154042 AX775733
RefSeq transcript (SRS)NM_001166691 NM_003318
RefSeq transcript (Entrez)NM_001166691 NM_003318
RefSeq genomic (SRS)AC_000138 NC_000006 NC_018917 NT_007299 NW_001838987 NW_004078027
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NT_007299 NW_001838987 NW_004078027
Consensus coding sequences : CCDS (NCBI)TTK
Cluster EST : UnigeneHs.169840 [ SRS ] Hs.169840 [ NCBI ]
CGAP (NCI)Hs.169840
Alternative Splicing : Fast-db (Paris)GSHG0025860
Alternative Splicing GalleryENSG00000112742
Gene ExpressionTTK [ NCBI-GEO ]   TTK [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33981 (SRS) P33981 (Uniprot)
NextProtP33981
With graphics : InterProP33981
Splice isoforms : SwissVarP33981(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS    TPR-like_helical   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS    TPR-like_helical   
Related proteins : CluSTrP33981
Domain families : Pfam (SRS)Pkinase (PF00069)   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM7272
Blocks (Seattle)P33981
PDB (SRS)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU   
PDB (PDBSum)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU   
PDB (IMB)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU   
PDB (RSDB)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU   
Human Protein AtlasENSG00000112742
HPRD04973
IPIIPI00151170   IPI00640529   IPI00967639   IPI00967234   IPI00964699   IPI00964482   
Protein Interaction databases
DIP (DOE-UCLA)P33981
IntAct (EBI)P33981
FunCoupENSG00000112742
REACTOMETTK
Protein Interaction Database7272
BioGRIDTTK
InParanoidP33981
Interologous Interaction database P33981
IntegromeDBTTK
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TTK
SNP (GeneSNP Utah)TTK
SNP : HGBaseTTK
Genetic variants : HAPMAPTTK
Somatic Mutations in Cancer : COSMICTTK 
CONAN: Copy Number AnalysisTTK 
Mutations and Diseases : HGMDTTK
OMIM604092   
GENETests604092   
Disease Genetic AssociationTTK
Huge Navigator TTK [HugePedia]  TTK [HugeCancerGEM]
Genomic VariantsTTK  TTK [DGVbeta]
snp3D : Map Gene to Disease7272
General knowledge
Homologs : HomoloGeneTTK
Homology/Alignments : Family Browser (UCSC)TTK
Phylogenetic Trees/Animal Genes : TreeFamTTK
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.1 [ Enzyme-SRS ]   2.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
Chemical/Protein Interactions : CTD7272
Chemical/Pharm GKB GenePA37066
Clinical trialTTK
Cancer Resource (Charite)ENSG00000112742
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  spindle  spindle organization  mitotic spindle organization  mitotic cell cycle spindle assembly checkpoint  positive regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  identical protein binding  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  ATP binding  spindle  spindle organization  mitotic spindle organization  mitotic cell cycle spindle assembly checkpoint  positive regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  identical protein binding  
Other databases
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
PubGeneTTK
iHOPTTK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:22:08 CEST 2013
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