Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TTK (TTK protein kinase)

Identity

Alias_symbol (synonym)MPS1
MPS1L1
CT96
MPH1
Other aliasESK
PYT
HGNC (Hugo) TTK
LocusID (NCBI) 7272
Atlas_Id 42725
Location 6q14.1  [Link to chromosome band 6q14]
Location_base_pair Starts at 80004605 and ends at 80042527 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TTK   12401
Cards
Entrez_Gene (NCBI)TTK  7272  TTK protein kinase
AliasesCT96; ESK; MPH1; MPS1; 
MPS1L1; PYT
GeneCards (Weizmann)TTK
Ensembl hg19 (Hinxton)ENSG00000112742 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112742 [Gene_View]  ENSG00000112742 [Sequence]  chr6:80004605-80042527 [Contig_View]  TTK [Vega]
ICGC DataPortalENSG00000112742
TCGA cBioPortalTTK
AceView (NCBI)TTK
Genatlas (Paris)TTK
WikiGenes7272
SOURCE (Princeton)TTK
Genetics Home Reference (NIH)TTK
Genomic and cartography
GoldenPath hg38 (UCSC)TTK  -     chr6:80004605-80042527 +  6q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTK  -     6q14.1   [Description]    (hg19-Feb_2009)
EnsemblTTK - 6q14.1 [CytoView hg19]  TTK - 6q14.1 [CytoView hg38]
Mapping of homologs : NCBITTK [Mapview hg19]  TTK [Mapview hg38]
OMIM604092   
Gene and transcription
Genbank (Entrez)AK095599 AK292460 AK315696 AU154042 AX775733
RefSeq transcript (Entrez)NM_001166691 NM_003318
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTK
Cluster EST : UnigeneHs.169840 [ NCBI ]
CGAP (NCI)Hs.169840
Alternative Splicing GalleryENSG00000112742
Gene ExpressionTTK [ NCBI-GEO ]   TTK [ EBI - ARRAY_EXPRESS ]   TTK [ SEEK ]   TTK [ MEM ]
Gene Expression Viewer (FireBrowse)TTK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7272
GTEX Portal (Tissue expression)TTK
Human Protein AtlasENSG00000112742-TTK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33981   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33981  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33981
Splice isoforms : SwissVarP33981
Catalytic activity : Enzyme2.7.12.1 [ Enzyme-Expasy ]   2.7.12.12.7.12.1 [ IntEnz-EBI ]   2.7.12.1 [ BRENDA ]   2.7.12.1 [ KEGG ]   
PhosPhoSitePlusP33981
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kin_Mps1_fam    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    TPR-like_helical_dom_sf   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)TTK
DMDM Disease mutations7272
Blocks (Seattle)TTK
PDB (SRS)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU    3W1F    3WYX    3WYY    3WZJ    3WZK    4B94    4BHZ    4BI0    4BI1    4BI2    4C4E    4C4F    4C4G    4C4H    4C4I    4C4J    4CV8    4CV9    4CVA    4D2S    4H7X    4H7Y    4JS8    4JT3    4O6L    4ZEG    5AP0    5AP1    5AP2    5AP3    5AP4    5AP5    5AP6    5AP7    5EH0    5EHL    5EHO    5EHY    5EI2    5EI6    5EI8    5LJJ    5MRB    5N7V    5N84    5N87    5N93    5N9S    5NA0    5NAD    5NTT    5O91    6B4W   
PDB (PDBSum)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU    3W1F    3WYX    3WYY    3WZJ    3WZK    4B94    4BHZ    4BI0    4BI1    4BI2    4C4E    4C4F    4C4G    4C4H    4C4I    4C4J    4CV8    4CV9    4CVA    4D2S    4H7X    4H7Y    4JS8    4JT3    4O6L    4ZEG    5AP0    5AP1    5AP2    5AP3    5AP4    5AP5    5AP6    5AP7    5EH0    5EHL    5EHO    5EHY    5EI2    5EI6    5EI8    5LJJ    5MRB    5N7V    5N84    5N87    5N93    5N9S    5NA0    5NAD    5NTT    5O91    6B4W   
PDB (IMB)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU    3W1F    3WYX    3WYY    3WZJ    3WZK    4B94    4BHZ    4BI0    4BI1    4BI2    4C4E    4C4F    4C4G    4C4H    4C4I    4C4J    4CV8    4CV9    4CVA    4D2S    4H7X    4H7Y    4JS8    4JT3    4O6L    4ZEG    5AP0    5AP1    5AP2    5AP3    5AP4    5AP5    5AP6    5AP7    5EH0    5EHL    5EHO    5EHY    5EI2    5EI6    5EI8    5LJJ    5MRB    5N7V    5N84    5N87    5N93    5N9S    5NA0    5NAD    5NTT    5O91    6B4W   
PDB (RSDB)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU    3W1F    3WYX    3WYY    3WZJ    3WZK    4B94    4BHZ    4BI0    4BI1    4BI2    4C4E    4C4F    4C4G    4C4H    4C4I    4C4J    4CV8    4CV9    4CVA    4D2S    4H7X    4H7Y    4JS8    4JT3    4O6L    4ZEG    5AP0    5AP1    5AP2    5AP3    5AP4    5AP5    5AP6    5AP7    5EH0    5EHL    5EHO    5EHY    5EI2    5EI6    5EI8    5LJJ    5MRB    5N7V    5N84    5N87    5N93    5N9S    5NA0    5NAD    5NTT    5O91    6B4W   
Structural Biology KnowledgeBase2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU    3W1F    3WYX    3WYY    3WZJ    3WZK    4B94    4BHZ    4BI0    4BI1    4BI2    4C4E    4C4F    4C4G    4C4H    4C4I    4C4J    4CV8    4CV9    4CVA    4D2S    4H7X    4H7Y    4JS8    4JT3    4O6L    4ZEG    5AP0    5AP1    5AP2    5AP3    5AP4    5AP5    5AP6    5AP7    5EH0    5EHL    5EHO    5EHY    5EI2    5EI6    5EI8    5LJJ    5MRB    5N7V    5N84    5N87    5N93    5N9S    5NA0    5NAD    5NTT    5O91    6B4W   
SCOP (Structural Classification of Proteins)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU    3W1F    3WYX    3WYY    3WZJ    3WZK    4B94    4BHZ    4BI0    4BI1    4BI2    4C4E    4C4F    4C4G    4C4H    4C4I    4C4J    4CV8    4CV9    4CVA    4D2S    4H7X    4H7Y    4JS8    4JT3    4O6L    4ZEG    5AP0    5AP1    5AP2    5AP3    5AP4    5AP5    5AP6    5AP7    5EH0    5EHL    5EHO    5EHY    5EI2    5EI6    5EI8    5LJJ    5MRB    5N7V    5N84    5N87    5N93    5N9S    5NA0    5NAD    5NTT    5O91    6B4W   
CATH (Classification of proteins structures)2X9E    2ZMC    2ZMD    3CEK    3DBQ    3GFW    3H9F    3HMN    3HMO    3HMP    3VQU    3W1F    3WYX    3WYY    3WZJ    3WZK    4B94    4BHZ    4BI0    4BI1    4BI2    4C4E    4C4F    4C4G    4C4H    4C4I    4C4J    4CV8    4CV9    4CVA    4D2S    4H7X    4H7Y    4JS8    4JT3    4O6L    4ZEG    5AP0    5AP1    5AP2    5AP3    5AP4    5AP5    5AP6    5AP7    5EH0    5EHL    5EHO    5EHY    5EI2    5EI6    5EI8    5LJJ    5MRB    5N7V    5N84    5N87    5N93    5N9S    5NA0    5NAD    5NTT    5O91    6B4W   
SuperfamilyP33981
Human Protein Atlas [tissue]ENSG00000112742-TTK [tissue]
Peptide AtlasP33981
HPRD04973
IPIIPI00151170   IPI00640529   IPI00967639   IPI00967234   IPI00964699   IPI00964482   
Protein Interaction databases
DIP (DOE-UCLA)P33981
IntAct (EBI)P33981
FunCoupENSG00000112742
BioGRIDTTK
STRING (EMBL)TTK
ZODIACTTK
Ontologies - Pathways
QuickGOP33981
Ontology : AmiGOkinetochore  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  spindle  spindle organization  mitotic spindle organization  mitotic spindle assembly checkpoint  positive regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  membrane  female meiosis chromosome segregation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  meiotic spindle assembly checkpoint  protein localization to kinetochore  protein homodimerization activity  kinetochore binding  protein autophosphorylation  chromosome separation  protein localization to meiotic spindle midzone  
Ontology : EGO-EBIkinetochore  protein serine/threonine kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  cytoplasm  spindle  spindle organization  mitotic spindle organization  mitotic spindle assembly checkpoint  positive regulation of cell proliferation  positive regulation of pathway-restricted SMAD protein phosphorylation  membrane  female meiosis chromosome segregation  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  peptidyl-tyrosine phosphorylation  meiotic spindle assembly checkpoint  protein localization to kinetochore  protein homodimerization activity  kinetochore binding  protein autophosphorylation  chromosome separation  protein localization to meiotic spindle midzone  
Pathways : KEGGCell cycle   
NDEx NetworkTTK
Atlas of Cancer Signalling NetworkTTK
Wikipedia pathwaysTTK
Orthology - Evolution
OrthoDB7272
GeneTree (enSembl)ENSG00000112742
Phylogenetic Trees/Animal Genes : TreeFamTTK
HOVERGENP33981
HOGENOMP33981
Homologs : HomoloGeneTTK
Homology/Alignments : Family Browser (UCSC)TTK
Gene fusions - Rearrangements
Fusion : QuiverTTK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTK
dbVarTTK
ClinVarTTK
1000_GenomesTTK 
Exome Variant ServerTTK
ExAC (Exome Aggregation Consortium)ENSG00000112742
GNOMAD BrowserENSG00000112742
Varsome BrowserTTK
Genetic variants : HAPMAP7272
Genomic Variants (DGV)TTK [DGVbeta]
DECIPHERTTK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTK 
Mutations
ICGC Data PortalTTK 
TCGA Data PortalTTK 
Broad Tumor PortalTTK
OASIS PortalTTK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTK
DgiDB (Drug Gene Interaction Database)TTK
DoCM (Curated mutations)TTK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTK (select a term)
intoGenTTK
Cancer3DTTK(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604092   
Orphanet
DisGeNETTTK
MedgenTTK
Genetic Testing Registry TTK
NextProtP33981 [Medical]
TSGene7272
GENETestsTTK
Target ValidationTTK
Huge Navigator TTK [HugePedia]
snp3D : Map Gene to Disease7272
BioCentury BCIQTTK
ClinGenTTK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7272
Chemical/Pharm GKB GenePA37066
Clinical trialTTK
Miscellaneous
canSAR (ICR)TTK (select the gene name)
Probes
Litterature
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTK
EVEXTTK
GoPubMedTTK
iHOPTTK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:47:24 CET 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.