Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TTL (tubulin tyrosine ligase)

Identity

Alias (NCBI)-
HGNC (Hugo) TTL
HGNC Alias symbMGC46235
LocusID (NCBI) 150465
Atlas_Id 55130
Location 2q14.1  [Link to chromosome band 2q14]
Location_base_pair Starts at 112482156 and ends at 112541739 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ETV6 (12p13.2) / TTL (2q13)TF (3q22.1) / TTL (2q13)TTL (2q13) / EIF6 (20q11.22)
TTL (2q13) / ETV6 (12p13.2)TTL (2q13) / GPC3 (Xq26.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TTL   21586
Cards
Entrez_Gene (NCBI)TTL    tubulin tyrosine ligase
Aliases
GeneCards (Weizmann)TTL
Ensembl hg19 (Hinxton)ENSG00000114999 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000114999 [Gene_View]  ENSG00000114999 [Sequence]  chr2:112482156-112541739 [Contig_View]  TTL [Vega]
ICGC DataPortalENSG00000114999
TCGA cBioPortalTTL
AceView (NCBI)TTL
Genatlas (Paris)TTL
SOURCE (Princeton)TTL
Genetics Home Reference (NIH)TTL
Genomic and cartography
GoldenPath hg38 (UCSC)TTL  -     chr2:112482156-112541739 +  2q14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTL  -     2q14.1   [Description]    (hg19-Feb_2009)
GoldenPathTTL - 2q14.1 [CytoView hg19]  TTL - 2q14.1 [CytoView hg38]
ImmunoBaseENSG00000114999
Genome Data Viewer NCBITTL [Mapview hg19]  
OMIM608291   
Gene and transcription
Genbank (Entrez)AA099055 AB071393 AK026673 AK126378 AK126549
RefSeq transcript (Entrez)NM_001371712 NM_153712
Consensus coding sequences : CCDS (NCBI)TTL
Gene ExpressionTTL [ NCBI-GEO ]   TTL [ EBI - ARRAY_EXPRESS ]   TTL [ SEEK ]   TTL [ MEM ]
Gene Expression Viewer (FireBrowse)TTL [ Firebrowse - Broad ]
GenevisibleExpression of TTL in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)150465
GTEX Portal (Tissue expression)TTL
Human Protein AtlasENSG00000114999-TTL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NG68   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NG68  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NG68
PhosPhoSitePlusQ8NG68
Domaine pattern : Prosite (Expaxy)TTL (PS51221)   
Domains : Interpro (EBI)TTL/TTLL_fam   
Domain families : Pfam (Sanger)TTL (PF03133)   
Domain families : Pfam (NCBI)pfam03133   
Conserved Domain (NCBI)TTL
SuperfamilyQ8NG68
AlphaFold pdb e-kbQ8NG68   
Human Protein Atlas [tissue]ENSG00000114999-TTL [tissue]
HPRD12206
Protein Interaction databases
DIP (DOE-UCLA)Q8NG68
IntAct (EBI)Q8NG68
BioGRIDTTL
STRING (EMBL)TTL
ZODIACTTL
Ontologies - Pathways
QuickGOQ8NG68
Ontology : AmiGOmicrotubule cytoskeleton organization  tubulin-tyrosine ligase activity  ATP binding  spindle microtubule  C-terminal protein-tyrosinylation  regulation of axon extension  positive regulation of mitotic cell cycle  regulation of metaphase plate congression  
Ontology : EGO-EBImicrotubule cytoskeleton organization  tubulin-tyrosine ligase activity  ATP binding  spindle microtubule  C-terminal protein-tyrosinylation  regulation of axon extension  positive regulation of mitotic cell cycle  regulation of metaphase plate congression  
NDEx NetworkTTL
Atlas of Cancer Signalling NetworkTTL
Wikipedia pathwaysTTL
Orthology - Evolution
OrthoDB150465
GeneTree (enSembl)ENSG00000114999
Phylogenetic Trees/Animal Genes : TreeFamTTL
Homologs : HomoloGeneTTL
Homology/Alignments : Family Browser (UCSC)TTL
Gene fusions - Rearrangements
Fusion : QuiverTTL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTL
dbVarTTL
ClinVarTTL
MonarchTTL
1000_GenomesTTL 
Exome Variant ServerTTL
GNOMAD BrowserENSG00000114999
Varsome BrowserTTL
ACMGTTL variants
VarityQ8NG68
Genomic Variants (DGV)TTL [DGVbeta]
DECIPHERTTL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTL 
Mutations
ICGC Data PortalTTL 
TCGA Data PortalTTL 
Broad Tumor PortalTTL
OASIS PortalTTL [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTL  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTL
Mutations and Diseases : HGMDTTL
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTL
DgiDB (Drug Gene Interaction Database)TTL
DoCM (Curated mutations)TTL
CIViC (Clinical Interpretations of Variants in Cancer)TTL
Cancer3DTTL
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608291   
Orphanet
DisGeNETTTL
MedgenTTL
Genetic Testing Registry TTL
NextProtQ8NG68 [Medical]
GENETestsTTL
Target ValidationTTL
Huge Navigator TTL [HugePedia]
ClinGenTTL
Clinical trials, drugs, therapy
MyCancerGenomeTTL
Protein Interactions : CTDTTL
Pharm GKB GenePA134934330
PharosQ8NG68
Clinical trialTTL
Miscellaneous
canSAR (ICR)TTL
HarmonizomeTTL
DataMed IndexTTL
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:36:45 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.