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TTLL3 (tubulin tyrosine ligase like 3)

Identity

Alias_namestubulin tyrosine ligase-like family member 3
Alias_symbol (synonym)DKFZP434B103
HOTTL
Other alias
HGNC (Hugo) TTLL3
LocusID (NCBI) 26140
Atlas_Id 54736
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 9851644 and ends at 9878040 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANP32B (9q22.33) / TTLL3 (3p25.3)ARPC4 (3p25.3) / TTLL3 (3p25.3)TTLL3 (3p25.3) / MTMR14 (3p25.3)
ZC3H4 (19q13.32) / TTLL3 (3p25.3)ZC3H4 19q13.32 / TTLL3 3p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)TTLL3   24483
Cards
Entrez_Gene (NCBI)TTLL3  26140  tubulin tyrosine ligase like 3
AliasesHOTTL
GeneCards (Weizmann)TTLL3
Ensembl hg19 (Hinxton)ENSG00000214021 [Gene_View]  chr3:9851644-9878040 [Contig_View]  TTLL3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000214021 [Gene_View]  chr3:9851644-9878040 [Contig_View]  TTLL3 [Vega]
ICGC DataPortalENSG00000214021
TCGA cBioPortalTTLL3
AceView (NCBI)TTLL3
Genatlas (Paris)TTLL3
WikiGenes26140
SOURCE (Princeton)TTLL3
Genetics Home Reference (NIH)TTLL3
Genomic and cartography
GoldenPath hg19 (UCSC)TTLL3  -     chr3:9851644-9878040 +  3p25.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TTLL3  -     3p25.3   [Description]    (hg38-Dec_2013)
EnsemblTTLL3 - 3p25.3 [CytoView hg19]  TTLL3 - 3p25.3 [CytoView hg38]
Mapping of homologs : NCBITTLL3 [Mapview hg19]  TTLL3 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA742169 AF078842 AK023960 AK097236 AK125875
RefSeq transcript (Entrez)NM_001025930 NM_015644
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TTLL3
Cluster EST : UnigeneHs.726435 [ NCBI ]
CGAP (NCI)Hs.726435
Alternative Splicing GalleryENSG00000214021
Gene ExpressionTTLL3 [ NCBI-GEO ]   TTLL3 [ EBI - ARRAY_EXPRESS ]   TTLL3 [ SEEK ]   TTLL3 [ MEM ]
Gene Expression Viewer (FireBrowse)TTLL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26140
GTEX Portal (Tissue expression)TTLL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4R7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4R7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4R7
Splice isoforms : SwissVarQ9Y4R7
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusQ9Y4R7
Domaine pattern : Prosite (Expaxy)TTL (PS51221)   
Domains : Interpro (EBI)TTL/TTLL_fam   
Domain families : Pfam (Sanger)TTL (PF03133)   
Domain families : Pfam (NCBI)pfam03133   
Conserved Domain (NCBI)TTLL3
DMDM Disease mutations26140
Blocks (Seattle)TTLL3
SuperfamilyQ9Y4R7
Human Protein AtlasENSG00000214021
Peptide AtlasQ9Y4R7
HPRD15585
IPIIPI00642191   IPI00887371   IPI01018637   IPI00925089   IPI00910545   IPI00444047   IPI00789856   IPI00852991   IPI00852914   IPI00853121   IPI00853056   IPI00852698   IPI00924458   IPI00925249   IPI00924461   IPI00926732   IPI00926487   IPI00927139   IPI00925933   IPI00925696   IPI00795382   IPI00926113   IPI01012714   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4R7
IntAct (EBI)Q9Y4R7
FunCoupENSG00000214021
BioGRIDTTLL3
STRING (EMBL)TTLL3
ZODIACTTLL3
Ontologies - Pathways
QuickGOQ9Y4R7
Ontology : AmiGOATP binding  cytoplasm  microtubule  cilium  axoneme  microtubule cytoskeleton  protein polyglycylation  axoneme assembly  cilium assembly  protein-glycine ligase activity  protein-glycine ligase activity, initiating  
Ontology : EGO-EBIATP binding  cytoplasm  microtubule  cilium  axoneme  microtubule cytoskeleton  protein polyglycylation  axoneme assembly  cilium assembly  protein-glycine ligase activity  protein-glycine ligase activity, initiating  
NDEx NetworkTTLL3
Atlas of Cancer Signalling NetworkTTLL3
Wikipedia pathwaysTTLL3
Orthology - Evolution
OrthoDB26140
GeneTree (enSembl)ENSG00000214021
Phylogenetic Trees/Animal Genes : TreeFamTTLL3
HOVERGENQ9Y4R7
HOGENOMQ9Y4R7
Homologs : HomoloGeneTTLL3
Homology/Alignments : Family Browser (UCSC)TTLL3
Gene fusions - Rearrangements
Fusion : MitelmanTTLL3/MTMR14 [3p25.3/3p25.3]  
Fusion : MitelmanZC3H4/TTLL3 [19q13.32/3p25.3]  [t(3;19)(p25;q13)]  
Fusion: TCGAZC3H4 19q13.32 TTLL3 3p25.3 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTLL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTLL3
dbVarTTLL3
ClinVarTTLL3
1000_GenomesTTLL3 
Exome Variant ServerTTLL3
ExAC (Exome Aggregation Consortium)TTLL3 (select the gene name)
Genetic variants : HAPMAP26140
Genomic Variants (DGV)TTLL3 [DGVbeta]
DECIPHER (Syndromes)3:9851644-9878040  ENSG00000214021
CONAN: Copy Number AnalysisTTLL3 
Mutations
ICGC Data PortalTTLL3 
TCGA Data PortalTTLL3 
Broad Tumor PortalTTLL3
OASIS PortalTTLL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTLL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTLL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTLL3
DgiDB (Drug Gene Interaction Database)TTLL3
DoCM (Curated mutations)TTLL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTLL3 (select a term)
intoGenTTLL3
Cancer3DTTLL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTTLL3
Genetic Testing Registry TTLL3
NextProtQ9Y4R7 [Medical]
TSGene26140
GENETestsTTLL3
Huge Navigator TTLL3 [HugePedia]
snp3D : Map Gene to Disease26140
BioCentury BCIQTTLL3
ClinGenTTLL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26140
Chemical/Pharm GKB GenePA134942870
Clinical trialTTLL3
Miscellaneous
canSAR (ICR)TTLL3 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTLL3
EVEXTTLL3
GoPubMedTTLL3
iHOPTTLL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:32:44 CET 2017

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