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TTLL3 (tubulin tyrosine ligase like 3)

Identity

Alias (NCBI)HOTTL
HGNC (Hugo) TTLL3
HGNC Alias symbDKFZP434B103
HOTTL
HGNC Previous nametubulin tyrosine ligase-like family member 3
LocusID (NCBI) 26140
Atlas_Id 54736
Location 3p25.3  [Link to chromosome band 3p25]
Location_base_pair Starts at 9810262 and ends at 9836365 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANP32B (9q22.33) / TTLL3 (3p25.3)ARPC4 (3p25.3) / TTLL3 (3p25.3)TTLL3 (3p25.3) / MTMR14 (3p25.3)
ZC3H4 (19q13.32) / TTLL3 (3p25.3)ZC3H4 19q13.32 / TTLL3 3p25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TTLL3   24483
Cards
Entrez_Gene (NCBI)TTLL3    tubulin tyrosine ligase like 3
AliasesHOTTL
GeneCards (Weizmann)TTLL3
Ensembl hg19 (Hinxton)ENSG00000214021 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000214021 [Gene_View]  ENSG00000214021 [Sequence]  chr3:9810262-9836365 [Contig_View]  TTLL3 [Vega]
ICGC DataPortalENSG00000214021
TCGA cBioPortalTTLL3
AceView (NCBI)TTLL3
Genatlas (Paris)TTLL3
SOURCE (Princeton)TTLL3
Genetics Home Reference (NIH)TTLL3
Genomic and cartography
GoldenPath hg38 (UCSC)TTLL3  -     chr3:9810262-9836365 +  3p25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTLL3  -     3p25.3   [Description]    (hg19-Feb_2009)
GoldenPathTTLL3 - 3p25.3 [CytoView hg19]  TTLL3 - 3p25.3 [CytoView hg38]
ImmunoBaseENSG00000214021
Genome Data Viewer NCBITTLL3 [Mapview hg19]  
OMIM619195   
Gene and transcription
Genbank (Entrez)AA742169 AF078842 AK023960 AK097236 AK125875
RefSeq transcript (Entrez)NM_001025930 NM_001366051 NM_001387446 NM_001387447 NM_001387448 NM_001387449 NM_001387450 NM_001387451 NM_001387452 NM_001387453 NM_001387454 NM_001387455 NM_001387456 NM_001387457 NM_001387458 NM_001387459 NM_001387460 NM_001387461 NM_001387462 NM_001387463 NM_001387464 NM_001387465 NM_001387466 NM_001387467 NM_015644
Consensus coding sequences : CCDS (NCBI)TTLL3
Gene ExpressionTTLL3 [ NCBI-GEO ]   TTLL3 [ EBI - ARRAY_EXPRESS ]   TTLL3 [ SEEK ]   TTLL3 [ MEM ]
Gene Expression Viewer (FireBrowse)TTLL3 [ Firebrowse - Broad ]
GenevisibleExpression of TTLL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26140
GTEX Portal (Tissue expression)TTLL3
Human Protein AtlasENSG00000214021-TTLL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4R7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4R7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4R7
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y4R7
Domaine pattern : Prosite (Expaxy)TTL (PS51221)   
Domains : Interpro (EBI)TTL/TTLL_fam    TTLL3   
Domain families : Pfam (Sanger)TTL (PF03133)   
Domain families : Pfam (NCBI)pfam03133   
Conserved Domain (NCBI)TTLL3
SuperfamilyQ9Y4R7
AlphaFold pdb e-kbQ9Y4R7   
Human Protein Atlas [tissue]ENSG00000214021-TTLL3 [tissue]
HPRD15585
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4R7
IntAct (EBI)Q9Y4R7
BioGRIDTTLL3
STRING (EMBL)TTLL3
ZODIACTTLL3
Ontologies - Pathways
QuickGOQ9Y4R7
Ontology : AmiGOATP binding  cytosol  microtubule  cilium  axoneme  microtubule cytoskeleton  protein polyglycylation  protein polyglycylation  axoneme assembly  cilium assembly  protein-glycine ligase activity  protein-glycine ligase activity, initiating  
Ontology : EGO-EBIATP binding  cytosol  microtubule  cilium  axoneme  microtubule cytoskeleton  protein polyglycylation  protein polyglycylation  axoneme assembly  cilium assembly  protein-glycine ligase activity  protein-glycine ligase activity, initiating  
NDEx NetworkTTLL3
Atlas of Cancer Signalling NetworkTTLL3
Wikipedia pathwaysTTLL3
Orthology - Evolution
OrthoDB26140
GeneTree (enSembl)ENSG00000214021
Phylogenetic Trees/Animal Genes : TreeFamTTLL3
Homologs : HomoloGeneTTLL3
Homology/Alignments : Family Browser (UCSC)TTLL3
Gene fusions - Rearrangements
Fusion : MitelmanTTLL3/MTMR14 [3p25.3/3p25.3]  
Fusion : MitelmanZC3H4/TTLL3 [19q13.32/3p25.3]  
Fusion : QuiverTTLL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTLL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTLL3
dbVarTTLL3
ClinVarTTLL3
MonarchTTLL3
1000_GenomesTTLL3 
Exome Variant ServerTTLL3
GNOMAD BrowserENSG00000214021
Varsome BrowserTTLL3
ACMGTTLL3 variants
VarityQ9Y4R7
Genomic Variants (DGV)TTLL3 [DGVbeta]
DECIPHERTTLL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTLL3 
Mutations
ICGC Data PortalTTLL3 
TCGA Data PortalTTLL3 
Broad Tumor PortalTTLL3
OASIS PortalTTLL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTLL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTLL3
Mutations and Diseases : HGMDTTLL3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTLL3
DgiDB (Drug Gene Interaction Database)TTLL3
DoCM (Curated mutations)TTLL3
CIViC (Clinical Interpretations of Variants in Cancer)TTLL3
Cancer3DTTLL3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619195   
Orphanet
DisGeNETTTLL3
MedgenTTLL3
Genetic Testing Registry TTLL3
NextProtQ9Y4R7 [Medical]
GENETestsTTLL3
Target ValidationTTLL3
Huge Navigator TTLL3 [HugePedia]
ClinGenTTLL3
Clinical trials, drugs, therapy
MyCancerGenomeTTLL3
Protein Interactions : CTDTTLL3
Pharm GKB GenePA134942870
PharosQ9Y4R7
Clinical trialTTLL3
Miscellaneous
canSAR (ICR)TTLL3
HarmonizomeTTLL3
DataMed IndexTTLL3
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTLL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:46 CEST 2021

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