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TTLL4 (tubulin tyrosine ligase like 4)

Identity

Alias_namestubulin tyrosine ligase-like family member 4
Alias_symbol (synonym)KIAA0173
Other alias-
HGNC (Hugo) TTLL4
LocusID (NCBI) 9654
Atlas_Id 75314
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218710845 and ends at 218755415 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TTLL4 (2q35) / MREG (2q35)TTLL4 (2q35) / RQCD1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TTLL4   28976
Cards
Entrez_Gene (NCBI)TTLL4  9654  tubulin tyrosine ligase like 4
Aliases
GeneCards (Weizmann)TTLL4
Ensembl hg19 (Hinxton)ENSG00000135912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135912 [Gene_View]  chr2:218710845-218755415 [Contig_View]  TTLL4 [Vega]
ICGC DataPortalENSG00000135912
TCGA cBioPortalTTLL4
AceView (NCBI)TTLL4
Genatlas (Paris)TTLL4
WikiGenes9654
SOURCE (Princeton)TTLL4
Genetics Home Reference (NIH)TTLL4
Genomic and cartography
GoldenPath hg38 (UCSC)TTLL4  -     chr2:218710845-218755415 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTLL4  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblTTLL4 - 2q35 [CytoView hg19]  TTLL4 - 2q35 [CytoView hg38]
Mapping of homologs : NCBITTLL4 [Mapview hg19]  TTLL4 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK091026 AK291770 AK296054 AK302728 AL833511
RefSeq transcript (Entrez)NM_014640
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTLL4
Cluster EST : UnigeneHs.471405 [ NCBI ]
CGAP (NCI)Hs.471405
Alternative Splicing GalleryENSG00000135912
Gene ExpressionTTLL4 [ NCBI-GEO ]   TTLL4 [ EBI - ARRAY_EXPRESS ]   TTLL4 [ SEEK ]   TTLL4 [ MEM ]
Gene Expression Viewer (FireBrowse)TTLL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9654
GTEX Portal (Tissue expression)TTLL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14679   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14679  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14679
Splice isoforms : SwissVarQ14679
Catalytic activity : Enzyme6.-.-.- [ Enzyme-Expasy ]   6.-.-.-6.-.-.- [ IntEnz-EBI ]   6.-.-.- [ BRENDA ]   6.-.-.- [ KEGG ]   
PhosPhoSitePlusQ14679
Domaine pattern : Prosite (Expaxy)TTL (PS51221)   
Domains : Interpro (EBI)TTL/TTLL_fam    TTLL-4   
Domain families : Pfam (Sanger)TTL (PF03133)   
Domain families : Pfam (NCBI)pfam03133   
Conserved Domain (NCBI)TTLL4
DMDM Disease mutations9654
Blocks (Seattle)TTLL4
SuperfamilyQ14679
Human Protein AtlasENSG00000135912
Peptide AtlasQ14679
HPRD15586
IPIIPI00005635   IPI00926829   IPI00927036   IPI00927276   IPI00924975   IPI00927757   IPI00927066   IPI00924715   IPI00925911   IPI00925179   IPI00924509   
Protein Interaction databases
DIP (DOE-UCLA)Q14679
IntAct (EBI)Q14679
FunCoupENSG00000135912
BioGRIDTTLL4
STRING (EMBL)TTLL4
ZODIACTTLL4
Ontologies - Pathways
QuickGOQ14679
Ontology : AmiGOATP binding  cytoplasm  microtubule  cilium  tubulin binding  protein polyglutamylation  peptidyl-glutamic acid modification  protein-glutamic acid ligase activity  
Ontology : EGO-EBIATP binding  cytoplasm  microtubule  cilium  tubulin binding  protein polyglutamylation  peptidyl-glutamic acid modification  protein-glutamic acid ligase activity  
NDEx NetworkTTLL4
Atlas of Cancer Signalling NetworkTTLL4
Wikipedia pathwaysTTLL4
Orthology - Evolution
OrthoDB9654
GeneTree (enSembl)ENSG00000135912
Phylogenetic Trees/Animal Genes : TreeFamTTLL4
HOVERGENQ14679
HOGENOMQ14679
Homologs : HomoloGeneTTLL4
Homology/Alignments : Family Browser (UCSC)TTLL4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTLL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTLL4
dbVarTTLL4
ClinVarTTLL4
1000_GenomesTTLL4 
Exome Variant ServerTTLL4
ExAC (Exome Aggregation Consortium)TTLL4 (select the gene name)
Genetic variants : HAPMAP9654
Genomic Variants (DGV)TTLL4 [DGVbeta]
DECIPHERTTLL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTLL4 
Mutations
ICGC Data PortalTTLL4 
TCGA Data PortalTTLL4 
Broad Tumor PortalTTLL4
OASIS PortalTTLL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTLL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTLL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTLL4
DgiDB (Drug Gene Interaction Database)TTLL4
DoCM (Curated mutations)TTLL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTLL4 (select a term)
intoGenTTLL4
Cancer3DTTLL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTTLL4
Genetic Testing Registry TTLL4
NextProtQ14679 [Medical]
TSGene9654
GENETestsTTLL4
Target ValidationTTLL4
Huge Navigator TTLL4 [HugePedia]
snp3D : Map Gene to Disease9654
BioCentury BCIQTTLL4
ClinGenTTLL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9654
Chemical/Pharm GKB GenePA134935712
Clinical trialTTLL4
Miscellaneous
canSAR (ICR)TTLL4 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTLL4
EVEXTTLL4
GoPubMedTTLL4
iHOPTTLL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:47:38 CEST 2017

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