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TTLL4 (tubulin tyrosine ligase like 4)

Identity

Alias (NCBI)-
HGNC (Hugo) TTLL4
HGNC Alias symbKIAA0173
HGNC Previous nametubulin tyrosine ligase-like family member 4
LocusID (NCBI) 9654
Atlas_Id 75314
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 218710835 and ends at 218755415 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TTLL4 (2q35) / MREG (2q35)TTLL4 (2q35) / RQCD1 (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TTLL4   28976
Cards
Entrez_Gene (NCBI)TTLL4    tubulin tyrosine ligase like 4
Aliases
GeneCards (Weizmann)TTLL4
Ensembl hg19 (Hinxton)ENSG00000135912 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000135912 [Gene_View]  ENSG00000135912 [Sequence]  chr2:218710835-218755415 [Contig_View]  TTLL4 [Vega]
ICGC DataPortalENSG00000135912
TCGA cBioPortalTTLL4
AceView (NCBI)TTLL4
Genatlas (Paris)TTLL4
SOURCE (Princeton)TTLL4
Genetics Home Reference (NIH)TTLL4
Genomic and cartography
GoldenPath hg38 (UCSC)TTLL4  -     chr2:218710835-218755415 +  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTLL4  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathTTLL4 - 2q35 [CytoView hg19]  TTLL4 - 2q35 [CytoView hg38]
ImmunoBaseENSG00000135912
Genome Data Viewer NCBITTLL4 [Mapview hg19]  
OMIM618738   
Gene and transcription
Genbank (Entrez)AK091026 AK291770 AK296054 AK302728 AL833511
RefSeq transcript (Entrez)NM_014640
Consensus coding sequences : CCDS (NCBI)TTLL4
Gene ExpressionTTLL4 [ NCBI-GEO ]   TTLL4 [ EBI - ARRAY_EXPRESS ]   TTLL4 [ SEEK ]   TTLL4 [ MEM ]
Gene Expression Viewer (FireBrowse)TTLL4 [ Firebrowse - Broad ]
GenevisibleExpression of TTLL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9654
GTEX Portal (Tissue expression)TTLL4
Human Protein AtlasENSG00000135912-TTLL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14679   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14679  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14679
PhosPhoSitePlusQ14679
Domaine pattern : Prosite (Expaxy)TTL (PS51221)   
Domains : Interpro (EBI)ATP_grasp_subdomain_1    TTL/TTLL_fam    TTLL-4   
Domain families : Pfam (Sanger)TTL (PF03133)   
Domain families : Pfam (NCBI)pfam03133   
Conserved Domain (NCBI)TTLL4
PDB (RSDB)5T6X   
PDB Europe5T6X   
PDB (PDBSum)5T6X   
PDB (IMB)5T6X   
Structural Biology KnowledgeBase5T6X   
SCOP (Structural Classification of Proteins)5T6X   
CATH (Classification of proteins structures)5T6X   
SuperfamilyQ14679
AlphaFold pdb e-kbQ14679   
Human Protein Atlas [tissue]ENSG00000135912-TTLL4 [tissue]
HPRD15586
Protein Interaction databases
DIP (DOE-UCLA)Q14679
IntAct (EBI)Q14679
BioGRIDTTLL4
STRING (EMBL)TTLL4
ZODIACTTLL4
Ontologies - Pathways
QuickGOQ14679
Ontology : AmiGOmicrotubule cytoskeleton organization  ATP binding  cytosol  microtubule  cilium  tubulin binding  tubulin binding  protein polyglutamylation  protein polyglutamylation  protein polyglutamylation  peptidyl-glutamic acid modification  ciliary basal body  protein-glutamic acid ligase activity  tubulin-glutamic acid ligase activity  9+0 non-motile cilium  regulation of blastocyst development  
Ontology : EGO-EBImicrotubule cytoskeleton organization  ATP binding  cytosol  microtubule  cilium  tubulin binding  tubulin binding  protein polyglutamylation  protein polyglutamylation  protein polyglutamylation  peptidyl-glutamic acid modification  ciliary basal body  protein-glutamic acid ligase activity  tubulin-glutamic acid ligase activity  9+0 non-motile cilium  regulation of blastocyst development  
NDEx NetworkTTLL4
Atlas of Cancer Signalling NetworkTTLL4
Wikipedia pathwaysTTLL4
Orthology - Evolution
OrthoDB9654
GeneTree (enSembl)ENSG00000135912
Phylogenetic Trees/Animal Genes : TreeFamTTLL4
Homologs : HomoloGeneTTLL4
Homology/Alignments : Family Browser (UCSC)TTLL4
Gene fusions - Rearrangements
Fusion : QuiverTTLL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTLL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTLL4
dbVarTTLL4
ClinVarTTLL4
MonarchTTLL4
1000_GenomesTTLL4 
Exome Variant ServerTTLL4
GNOMAD BrowserENSG00000135912
Varsome BrowserTTLL4
ACMGTTLL4 variants
VarityQ14679
Genomic Variants (DGV)TTLL4 [DGVbeta]
DECIPHERTTLL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTLL4 
Mutations
ICGC Data PortalTTLL4 
TCGA Data PortalTTLL4 
Broad Tumor PortalTTLL4
OASIS PortalTTLL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTLL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTLL4
Mutations and Diseases : HGMDTTLL4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTLL4
DgiDB (Drug Gene Interaction Database)TTLL4
DoCM (Curated mutations)TTLL4
CIViC (Clinical Interpretations of Variants in Cancer)TTLL4
Cancer3DTTLL4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM618738   
Orphanet
DisGeNETTTLL4
MedgenTTLL4
Genetic Testing Registry TTLL4
NextProtQ14679 [Medical]
GENETestsTTLL4
Target ValidationTTLL4
Huge Navigator TTLL4 [HugePedia]
ClinGenTTLL4
Clinical trials, drugs, therapy
MyCancerGenomeTTLL4
Protein Interactions : CTDTTLL4
Pharm GKB GenePA134935712
PharosQ14679
Clinical trialTTLL4
Miscellaneous
canSAR (ICR)TTLL4
HarmonizomeTTLL4
DataMed IndexTTLL4
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTLL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:27:23 CEST 2021

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