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TTLL8 (tubulin tyrosine ligase like 8)

Identity

Alias_namestubulin tyrosine ligase-like family member 8
Other alias-
HGNC (Hugo) TTLL8
LocusID (NCBI) 164714
Atlas_Id 78988
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50018575 and ends at 50058227 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TTLL8   34000
Cards
Entrez_Gene (NCBI)TTLL8  164714  tubulin tyrosine ligase like 8
Aliases
GeneCards (Weizmann)TTLL8
Ensembl hg19 (Hinxton)ENSG00000138892 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138892 [Gene_View]  chr22:50018575-50058227 [Contig_View]  TTLL8 [Vega]
ICGC DataPortalENSG00000138892
TCGA cBioPortalTTLL8
AceView (NCBI)TTLL8
Genatlas (Paris)TTLL8
WikiGenes164714
SOURCE (Princeton)TTLL8
Genetics Home Reference (NIH)TTLL8
Genomic and cartography
GoldenPath hg38 (UCSC)TTLL8  -     chr22:50018575-50058227 -  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTLL8  -     22q13.33   [Description]    (hg19-Feb_2009)
EnsemblTTLL8 - 22q13.33 [CytoView hg19]  TTLL8 - 22q13.33 [CytoView hg38]
Mapping of homologs : NCBITTLL8 [Mapview hg19]  TTLL8 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI026623
RefSeq transcript (Entrez)NM_001080447 NM_001350317
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TTLL8
Cluster EST : UnigeneHs.526713 [ NCBI ]
CGAP (NCI)Hs.526713
Alternative Splicing GalleryENSG00000138892
Gene ExpressionTTLL8 [ NCBI-GEO ]   TTLL8 [ EBI - ARRAY_EXPRESS ]   TTLL8 [ SEEK ]   TTLL8 [ MEM ]
Gene Expression Viewer (FireBrowse)TTLL8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)164714
GTEX Portal (Tissue expression)TTLL8
Human Protein AtlasENSG00000138892-TTLL8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA6PVC2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA6PVC2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA6PVC2
Splice isoforms : SwissVarA6PVC2
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
PhosPhoSitePlusA6PVC2
Domaine pattern : Prosite (Expaxy)TTL (PS51221)   
Domains : Interpro (EBI)TTL/TTLL_fam   
Domain families : Pfam (Sanger)TTL (PF03133)   
Domain families : Pfam (NCBI)pfam03133   
Conserved Domain (NCBI)TTLL8
DMDM Disease mutations164714
Blocks (Seattle)TTLL8
SuperfamilyA6PVC2
Human Protein Atlas [tissue]ENSG00000138892-TTLL8 [tissue]
Peptide AtlasA6PVC2
IPIIPI00852793   IPI00094972   
Protein Interaction databases
DIP (DOE-UCLA)A6PVC2
IntAct (EBI)A6PVC2
FunCoupENSG00000138892
BioGRIDTTLL8
STRING (EMBL)TTLL8
ZODIACTTLL8
Ontologies - Pathways
QuickGOA6PVC2
Ontology : AmiGOATP binding  cytosol  microtubule  cilium  axoneme  microtubule cytoskeleton  protein polyglycylation  protein polyglycylation  protein-glycine ligase activity  protein-glycine ligase activity  protein-glycine ligase activity, initiating  
Ontology : EGO-EBIATP binding  cytosol  microtubule  cilium  axoneme  microtubule cytoskeleton  protein polyglycylation  protein polyglycylation  protein-glycine ligase activity  protein-glycine ligase activity  protein-glycine ligase activity, initiating  
NDEx NetworkTTLL8
Atlas of Cancer Signalling NetworkTTLL8
Wikipedia p`thwys8/A>TTLL8
Orthology - Evolution
OrthoDB164714
GeneTree (enSembl)ENSG00000138892
Phylogenetic Trees/Animal Genes : TreeFamTTLL8
HOVERGENA6PVC2
HOGENOMA6PVC2
Homologs : HomoloGeneTTLL8
Homology/Alignments : Family Browser (UCSC)TTLL8
Gene fusions - Rearrangements
Tumor Fusion PortalTTLL8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTLL8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTLL8
dbVarTTLL8
ClinVarTTLL8
1000_GenomesTTLL8 
Exome Variant ServerTTLL8
ExAC (Exome Aggregation Consortium)ENSG00000138892
GNOMAD BrowserENSG00000138892
Genetic variants : HAPMAP164714
Genomic Variants (DGV)TTLL8 [DGVbeta]
DECIPHERTTLL8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTLL8 
Mutations
ICGC Data PortalTTLL8 
TCGA Data PortalTTLL8 
Broad Tumor PortalTTLL8
OASIS PortalTTLL8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTLL8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTTLL8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TTLL8
DgiDB (Drug Gene Interaction Database)TTLL8
DoCM (Curated mutations)TTLL8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TTLL8 (select a term)
intoGenTTLL8
Cancer3DTTLL8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTTLL8
MedgenTTLL8
Genetic Testing Registry TTLL8
NextProtA6PVC2 [Medical]
TSGene164714
GENETestsTTLL8
Target ValidationTTLL8
Huge Navigator TTLL8 [HugePedia]
snp3D : Map Gene to Disease164714
BioCentury BCIQTTLL8
ClinGenTTLL8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD164714
Chemical/Pharm GKB GenePA162407295
Clinical trialTTLL8
Miscellaneous
canSAR (ICR)TTLL8 (select the gene name)
Probes
Litterature
PubMed1 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTTLL8
EVEXTTLL8
GoPubMedTTLL8
iHOPTTLL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:44:29 CET 2017

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