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TTPA (alpha tocopherol transfer protein)

Identity

Alias (NCBI)ATTP
AVED
TTP1
alphaTTP
HGNC (Hugo) TTPA
HGNC Previous nameAVED
HGNC Previous nameataxia (Friedreich-like) with vitamin E deficiency
 tocopherol (alpha) transfer protein
LocusID (NCBI) 7274
Atlas_Id 50857
Location 8q12.3  [Link to chromosome band 8q12]
Location_base_pair Starts at 63059489 and ends at 63086053 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TTPA   12404
Cards
Entrez_Gene (NCBI)TTPA    alpha tocopherol transfer protein
AliasesATTP; AVED; TTP1; alphaTTP
GeneCards (Weizmann)TTPA
Ensembl hg19 (Hinxton)ENSG00000137561 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137561 [Gene_View]  ENSG00000137561 [Sequence]  chr8:63059489-63086053 [Contig_View]  TTPA [Vega]
ICGC DataPortalENSG00000137561
TCGA cBioPortalTTPA
AceView (NCBI)TTPA
Genatlas (Paris)TTPA
SOURCE (Princeton)TTPA
Genetics Home Reference (NIH)TTPA
Genomic and cartography
GoldenPath hg38 (UCSC)TTPA  -     chr8:63059489-63086053 -  8q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TTPA  -     8q12.3   [Description]    (hg19-Feb_2009)
GoldenPathTTPA - 8q12.3 [CytoView hg19]  TTPA - 8q12.3 [CytoView hg38]
ImmunoBaseENSG00000137561
Genome Data Viewer NCBITTPA [Mapview hg19]  
OMIM277460   600415   
Gene and transcription
Genbank (Entrez)BC041784 BC058000 D49488 U21938
RefSeq transcript (Entrez)NM_000370
Consensus coding sequences : CCDS (NCBI)TTPA
Gene ExpressionTTPA [ NCBI-GEO ]   TTPA [ EBI - ARRAY_EXPRESS ]   TTPA [ SEEK ]   TTPA [ MEM ]
Gene Expression Viewer (FireBrowse)TTPA [ Firebrowse - Broad ]
GenevisibleExpression of TTPA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7274
GTEX Portal (Tissue expression)TTPA
Human Protein AtlasENSG00000137561-TTPA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49638   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49638  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49638
PhosPhoSitePlusP49638
Domaine pattern : Prosite (Expaxy)CRAL_TRIO (PS50191)   
Domains : Interpro (EBI)CRAL-TRIO_dom    CRAL-TRIO_dom_sf    CRAL/TRIO_N_dom    CRAL/TRIO_N_dom_sf   
Domain families : Pfam (Sanger)CRAL_TRIO (PF00650)    CRAL_TRIO_N (PF03765)   
Domain families : Pfam (NCBI)pfam00650    pfam03765   
Domain families : Smart (EMBL)CRAL_TRIO_N (SM01100)  SEC14 (SM00516)  
Conserved Domain (NCBI)TTPA
PDB (RSDB)1OIP    1OIZ    1R5L    5MUE    5MUG   
PDB Europe1OIP    1OIZ    1R5L    5MUE    5MUG   
PDB (PDBSum)1OIP    1OIZ    1R5L    5MUE    5MUG   
PDB (IMB)1OIP    1OIZ    1R5L    5MUE    5MUG   
Structural Biology KnowledgeBase1OIP    1OIZ    1R5L    5MUE    5MUG   
SCOP (Structural Classification of Proteins)1OIP    1OIZ    1R5L    5MUE    5MUG   
CATH (Classification of proteins structures)1OIP    1OIZ    1R5L    5MUE    5MUG   
SuperfamilyP49638
AlphaFold pdb e-kbP49638   
Human Protein Atlas [tissue]ENSG00000137561-TTPA [tissue]
HPRD02685
Protein Interaction databases
DIP (DOE-UCLA)P49638
IntAct (EBI)P49638
BioGRIDTTPA
STRING (EMBL)TTPA
ZODIACTTPA
Ontologies - Pathways
QuickGOP49638
Ontology : AmiGOprotein binding  phosphatidylinositol-4,5-bisphosphate binding  late endosome  cytosol  lipid metabolic process  response to nutrient  vitamin E binding  vitamin E binding  response to pH  developmental process  vitamin E metabolic process  vitamin E metabolic process  phosphatidylinositol-3,4-bisphosphate binding  vitamin transport  vitamin transport  intracellular pH reduction  negative regulation of cell death  intermembrane lipid transfer  lipid transfer activity  phosphatidylinositol bisphosphate binding  
Ontology : EGO-EBIprotein binding  phosphatidylinositol-4,5-bisphosphate binding  late endosome  cytosol  lipid metabolic process  response to nutrient  vitamin E binding  vitamin E binding  response to pH  developmental process  vitamin E metabolic process  vitamin E metabolic process  phosphatidylinositol-3,4-bisphosphate binding  vitamin transport  vitamin transport  intracellular pH reduction  negative regulation of cell death  intermembrane lipid transfer  lipid transfer activity  phosphatidylinositol bisphosphate binding  
NDEx NetworkTTPA
Atlas of Cancer Signalling NetworkTTPA
Wikipedia pathwaysTTPA
Orthology - Evolution
OrthoDB7274
GeneTree (enSembl)ENSG00000137561
Phylogenetic Trees/Animal Genes : TreeFamTTPA
Homologs : HomoloGeneTTPA
Homology/Alignments : Family Browser (UCSC)TTPA
Gene fusions - Rearrangements
Fusion : QuiverTTPA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTTPA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TTPA
dbVarTTPA
ClinVarTTPA
MonarchTTPA
1000_GenomesTTPA 
Exome Variant ServerTTPA
GNOMAD BrowserENSG00000137561
Varsome BrowserTTPA
ACMGTTPA variants
VarityP49638
Genomic Variants (DGV)TTPA [DGVbeta]
DECIPHERTTPA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTTPA 
Mutations
ICGC Data PortalTTPA 
TCGA Data PortalTTPA 
Broad Tumor PortalTTPA
OASIS PortalTTPA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTTPA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTTPA
Mutations and Diseases : HGMDTTPA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTTPA
DgiDB (Drug Gene Interaction Database)TTPA
DoCM (Curated mutations)TTPA
CIViC (Clinical Interpretations of Variants in Cancer)TTPA
Cancer3DTTPA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM277460    600415   
Orphanet149   
DisGeNETTTPA
MedgenTTPA
Genetic Testing Registry TTPA
NextProtP49638 [Medical]
GENETestsTTPA
Target ValidationTTPA
Huge Navigator TTPA [HugePedia]
ClinGenTTPA
Clinical trials, drugs, therapy
MyCancerGenomeTTPA
Protein Interactions : CTDTTPA
Pharm GKB GenePA37068
PharosP49638
Clinical trialTTPA
Miscellaneous
canSAR (ICR)TTPA
HarmonizomeTTPA
DataMed IndexTTPA
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTTPA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:47 CEST 2021

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