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TUBA1A (tubulin alpha 1a)

Identity

Other namesB-ALPHA-1
LIS3
TUBA3
HGNC (Hugo) TUBA1A
LocusID (NCBI) 7846
Atlas_Id 42730
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 49578578 and ends at 49583107 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PTPN13 (4q21.3) / TUBA1A (12q13.12)TUBA1A (12q13.12) / PTPN13 (4q21.3)TUBA1A (12q13.12) / SNRNP27 (2p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TUBA1A   20766
Cards
Entrez_Gene (NCBI)TUBA1A  7846  tubulin alpha 1a
AliasesB-ALPHA-1; LIS3; TUBA3
GeneCards (Weizmann)TUBA1A
Ensembl hg19 (Hinxton)ENSG00000167552 [Gene_View]  chr12:49578578-49583107 [Contig_View]  TUBA1A [Vega]
Ensembl hg38 (Hinxton)ENSG00000167552 [Gene_View]  chr12:49578578-49583107 [Contig_View]  TUBA1A [Vega]
ICGC DataPortalENSG00000167552
TCGA cBioPortalTUBA1A
AceView (NCBI)TUBA1A
Genatlas (Paris)TUBA1A
WikiGenes7846
SOURCE (Princeton)TUBA1A
Genomic and cartography
GoldenPath hg19 (UCSC)TUBA1A  -     chr12:49578578-49583107 -  12q13.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TUBA1A  -     12q13.12   [Description]    (hg38-Dec_2013)
EnsemblTUBA1A - 12q13.12 [CytoView hg19]  TUBA1A - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBITUBA1A [Mapview hg19]  TUBA1A [Mapview hg38]
OMIM602529   611603   
Gene and transcription
Genbank (Entrez)AF141347 AF141348 AK057842 AK289483 AK297775
RefSeq transcript (Entrez)NM_001270399 NM_001270400 NM_006009
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_008966 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)TUBA1A
Cluster EST : UnigeneHs.654422 [ NCBI ]
CGAP (NCI)Hs.654422
Alternative Splicing GalleryENSG00000167552
Gene ExpressionTUBA1A [ NCBI-GEO ]   TUBA1A [ EBI - ARRAY_EXPRESS ]   TUBA1A [ SEEK ]   TUBA1A [ MEM ]
Gene Expression Viewer (FireBrowse)TUBA1A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7846
GTEX Portal (Tissue expression)TUBA1A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ71U36 (Uniprot)
NextProtQ71U36  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ71U36
Splice isoforms : SwissVarQ71U36 (Swissvar)
PhosPhoSitePlusQ71U36
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)   
Domains : Interpro (EBI)Alpha_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
DMDM Disease mutations7846
Blocks (Seattle)TUBA1A
SuperfamilyQ71U36
Human Protein AtlasENSG00000167552
Peptide AtlasQ71U36
HPRD03959
IPIIPI00180675   IPI00909762   IPI00936821   IPI01022794   IPI01022358   IPI01022495   IPI01022069   IPI01022207   IPI01021634   IPI01021927   IPI01021331   IPI01021483   
Protein Interaction databases
DIP (DOE-UCLA)Q71U36
IntAct (EBI)Q71U36
FunCoupENSG00000167552
BioGRIDTUBA1A
STRING (EMBL)TUBA1A
ZODIACTUBA1A
Ontologies - Pathways
QuickGOQ71U36
Ontology : AmiGOG2/M transition of mitotic cell cycle  GTPase activity  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  nucleus  cytosol  microtubule  microtubule  cytoplasmic microtubule  microtubule-based process  metabolic process  protein domain specific binding  cytoskeleton-dependent intracellular transport  cytoplasmic ribonucleoprotein granule  myelin sheath  cell division  recycling endosome  extracellular exosome  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  GTPase activity  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  nucleus  cytosol  microtubule  microtubule  cytoplasmic microtubule  microtubule-based process  metabolic process  protein domain specific binding  cytoskeleton-dependent intracellular transport  cytoplasmic ribonucleoprotein granule  myelin sheath  cell division  recycling endosome  extracellular exosome  
Pathways : BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors [Genes]   
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBA1A
Atlas of Cancer Signalling NetworkTUBA1A
Wikipedia pathwaysTUBA1A
Orthology - Evolution
OrthoDB7846
GeneTree (enSembl)ENSG00000167552
Phylogenetic Trees/Animal Genes : TreeFamTUBA1A
Homologs : HomoloGeneTUBA1A
Homology/Alignments : Family Browser (UCSC)TUBA1A
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTUBA1A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBA1A
dbVarTUBA1A
ClinVarTUBA1A
1000_GenomesTUBA1A 
Exome Variant ServerTUBA1A
ExAC (Exome Aggregation Consortium)TUBA1A (select the gene name)
Genetic variants : HAPMAP7846
Genomic Variants (DGV)TUBA1A [DGVbeta]
Mutations
ICGC Data PortalTUBA1A 
TCGA Data PortalTUBA1A 
Broad Tumor PortalTUBA1A
OASIS PortalTUBA1A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBA1A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUBA1A
DgiDB (Drug Gene Interaction Database)TUBA1A
DoCM (Curated mutations)TUBA1A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUBA1A (select a term)
intoGenTUBA1A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:49578578-49583107  ENSG00000167552
CONAN: Copy Number AnalysisTUBA1A 
Mutations and Diseases : HGMDTUBA1A
OMIM602529    611603   
MedgenTUBA1A
Genetic Testing Registry TUBA1A
NextProtQ71U36 [Medical]
TSGene7846
GENETestsTUBA1A
Huge Navigator TUBA1A [HugePedia]
snp3D : Map Gene to Disease7846
BioCentury BCIQTUBA1A
ClinGenTUBA1A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7846
Chemical/Pharm GKB GenePA162407319
Clinical trialTUBA1A
Miscellaneous
canSAR (ICR)TUBA1A (select the gene name)
Probes
Litterature
PubMed196 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUBA1A
EVEXTUBA1A
GoPubMedTUBA1A
iHOPTUBA1A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:18:19 CEST 2016

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