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TUBA1B (tubulin alpha 1b)

Identity

Alias_namesalpha
ubiquitous
Alias_symbol (synonym)K-ALPHA-1
Other alias
HGNC (Hugo) TUBA1B
LocusID (NCBI) 10376
Atlas_Id 43596
Location 12q13.12  [Link to chromosome band 12q13]
Location_base_pair Starts at 49127784 and ends at 49131521 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FTL (19q13.33) / TUBA1B (12q13.12)KIF1B (1p36.22) / TUBA1B (12q13.12)NPTXR (22q13.1) / TUBA1B (12q13.12)
PTPN18 (2q21.1) / TUBA1B (12q13.12)SNRPN (15q11.2) / TUBA1B (12q13.12)TMEM246 (9q31.1) / TUBA1B (12q13.12)
TUBA1B (12q13.12) / CNOT7 (8p22)TUBA1B (12q13.12) / F8A3 (Xq28)TUBA1B (12q13.12) / GRM4 (6p21.31)
TUBA1B (12q13.12) / PFKM (12q13.11)TUBA1B (12q13.12) / RNU5F-1 (1q41)TUBA1B (12q13.12) / ZSCAN29 (15q15.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TUBA1B   18809
Cards
Entrez_Gene (NCBI)TUBA1B  10376  tubulin alpha 1b
AliasesK-ALPHA-1
GeneCards (Weizmann)TUBA1B
Ensembl hg19 (Hinxton)ENSG00000123416 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123416 [Gene_View]  chr12:49127784-49131521 [Contig_View]  TUBA1B [Vega]
ICGC DataPortalENSG00000123416
TCGA cBioPortalTUBA1B
AceView (NCBI)TUBA1B
Genatlas (Paris)TUBA1B
WikiGenes10376
SOURCE (Princeton)TUBA1B
Genetics Home Reference (NIH)TUBA1B
Genomic and cartography
GoldenPath hg38 (UCSC)TUBA1B  -     chr12:49127784-49131521 -  12q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUBA1B  -     12q13.12   [Description]    (hg19-Feb_2009)
EnsemblTUBA1B - 12q13.12 [CytoView hg19]  TUBA1B - 12q13.12 [CytoView hg38]
Mapping of homologs : NCBITUBA1B [Mapview hg19]  TUBA1B [Mapview hg38]
OMIM602530   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_006082
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TUBA1B
Cluster EST : UnigeneHs.524390 [ NCBI ]
CGAP (NCI)Hs.524390
Alternative Splicing GalleryENSG00000123416
Gene ExpressionTUBA1B [ NCBI-GEO ]   TUBA1B [ EBI - ARRAY_EXPRESS ]   TUBA1B [ SEEK ]   TUBA1B [ MEM ]
Gene Expression Viewer (FireBrowse)TUBA1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10376
GTEX Portal (Tissue expression)TUBA1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68363   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP68363  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68363
Splice isoforms : SwissVarP68363
PhosPhoSitePlusP68363
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)   
Domains : Interpro (EBI)Alpha_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBA1B
DMDM Disease mutations10376
Blocks (Seattle)TUBA1B
PDB (SRS)2E4H    5IJ0    5IJ9   
PDB (PDBSum)2E4H    5IJ0    5IJ9   
PDB (IMB)2E4H    5IJ0    5IJ9   
PDB (RSDB)2E4H    5IJ0    5IJ9   
Structural Biology KnowledgeBase2E4H    5IJ0    5IJ9   
SCOP (Structural Classification of Proteins)2E4H    5IJ0    5IJ9   
CATH (Classification of proteins structures)2E4H    5IJ0    5IJ9   
SuperfamilyP68363
Human Protein AtlasENSG00000123416
Peptide AtlasP68363
HPRD03960
IPIIPI00930688   IPI01018889   IPI00793930   IPI01020802   IPI01021735   IPI01021600   IPI01021407   IPI01021237   IPI01022238   
Protein Interaction databases
DIP (DOE-UCLA)P68363
IntAct (EBI)P68363
FunCoupENSG00000123416
BioGRIDTUBA1B
STRING (EMBL)TUBA1B
ZODIACTUBA1B
Ontologies - Pathways
QuickGOP68363
Ontology : AmiGOmicrotubule cytoskeleton organization  double-stranded RNA binding  GTPase activity  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  microtubule  microtubule  cytoplasmic microtubule  microtubule-based process  microtubule cytoskeleton  cytoskeleton-dependent intracellular transport  ubiquitin protein ligase binding  myelin sheath  membrane raft  cell division  extracellular exosome  cellular response to interleukin-4  
Ontology : EGO-EBImicrotubule cytoskeleton organization  double-stranded RNA binding  GTPase activity  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  microtubule  microtubule  cytoplasmic microtubule  microtubule-based process  microtubule cytoskeleton  cytoskeleton-dependent intracellular transport  ubiquitin protein ligase binding  myelin sheath  membrane raft  cell division  extracellular exosome  cellular response to interleukin-4  
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBA1B
Atlas of Cancer Signalling NetworkTUBA1B
Wikipedia pathwaysTUBA1B
Orthology - Evolution
OrthoDB10376
GeneTree (enSembl)ENSG00000123416
Phylogenetic Trees/Animal Genes : TreeFamTUBA1B
HOVERGENP68363
HOGENOMP68363
Homologs : HomoloGeneTUBA1B
Homology/Alignments : Family Browser (UCSC)TUBA1B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBA1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBA1B
dbVarTUBA1B
ClinVarTUBA1B
1000_GenomesTUBA1B 
Exome Variant ServerTUBA1B
ExAC (Exome Aggregation Consortium)TUBA1B (select the gene name)
Genetic variants : HAPMAP10376
Genomic Variants (DGV)TUBA1B [DGVbeta]
DECIPHERTUBA1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUBA1B 
Mutations
ICGC Data PortalTUBA1B 
TCGA Data PortalTUBA1B 
Broad Tumor PortalTUBA1B
OASIS PortalTUBA1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBA1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTUBA1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUBA1B
DgiDB (Drug Gene Interaction Database)TUBA1B
DoCM (Curated mutations)TUBA1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUBA1B (select a term)
intoGenTUBA1B
Cancer3DTUBA1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602530   
Orphanet
MedgenTUBA1B
Genetic Testing Registry TUBA1B
NextProtP68363 [Medical]
TSGene10376
GENETestsTUBA1B
Target ValidationTUBA1B
Huge Navigator TUBA1B [HugePedia]
snp3D : Map Gene to Disease10376
BioCentury BCIQTUBA1B
ClinGenTUBA1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10376
Chemical/Pharm GKB GenePA162407332
Clinical trialTUBA1B
Miscellaneous
canSAR (ICR)TUBA1B (select the gene name)
Probes
Litterature
PubMed133 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUBA1B
EVEXTUBA1B
GoPubMedTUBA1B
iHOPTUBA1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:01:18 CEST 2017

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