TUBA1B (tubulin alpha 1b)

2007-02-01  

Identity

HGNC
LOCATION
12q13.12
LOCUSID
ALIAS
K-ALPHA-1
FUSION GENES

Other Information

Locus ID:

NCBI: 10376
MIM: 602530
HGNC: 18809
Ensembl: ENSG00000123416

Variants:

dbSNP: 10376
ClinVar: 10376
TCGA: ENSG00000123416
COSMIC: TUBA1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123416ENST00000336023P68363
ENSG00000123416ENST00000547476F8VX09
ENSG00000123416ENST00000547765F8VU66
ENSG00000123416ENST00000549870F8VWV9
ENSG00000123416ENST00000550367F8VVB9
ENSG00000123416ENST00000552984F8VRK0

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
1000

Pathways

PathwaySourceExternal ID
ApoptosisKEGGko04210
Tight junctionKEGGko04530
Gap junctionKEGGko04540
Pathogenic Escherichia coli infectionKEGGko05130
ApoptosisKEGGhsa04210
Tight junctionKEGGhsa04530
Gap junctionKEGGhsa04540
Pathogenic Escherichia coli infectionKEGGhsa05130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183541702008De novo production of K-alpha1 tubulin-specific antibodies: role in chronic lung allograft rejection.86
194059532009Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation.38
120546442002Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells.22
181950042008alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease.22
203810702010Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia.22
248149812014Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels.17
187900942008cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins.16
232351602013ARHGAP21 protein, a new partner of α-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition.14
191744782009MeCP2 involvement in the regulation of neuronal alpha-tubulin production.13
192152292009Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast.12

Citation

Dessen P

TUBA1B (tubulin alpha 1b)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43596/tuba1b