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TUBA4A (tubulin alpha 4a)

Identity

Alias_namesTUBA1
tubulin, alpha 1 (testis specific)
tubulin, alpha 1
Alias_symbol (synonym)FLJ30169
H2-ALPHA
Other aliasALS22
HGNC (Hugo) TUBA4A
LocusID (NCBI) 7277
Atlas_Id 42729
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219249711 and ends at 219254608 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TM9SF4 (20q11.21) / TUBA4A (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TUBA4A   12407
Cards
Entrez_Gene (NCBI)TUBA4A  7277  tubulin alpha 4a
AliasesALS22; H2-ALPHA; TUBA1
GeneCards (Weizmann)TUBA4A
Ensembl hg19 (Hinxton)ENSG00000127824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127824 [Gene_View]  chr2:219249711-219254608 [Contig_View]  TUBA4A [Vega]
ICGC DataPortalENSG00000127824
TCGA cBioPortalTUBA4A
AceView (NCBI)TUBA4A
Genatlas (Paris)TUBA4A
WikiGenes7277
SOURCE (Princeton)TUBA4A
Genetics Home Reference (NIH)TUBA4A
Genomic and cartography
GoldenPath hg38 (UCSC)TUBA4A  -     chr2:219249711-219254608 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUBA4A  -     2q35   [Description]    (hg19-Feb_2009)
EnsemblTUBA4A - 2q35 [CytoView hg19]  TUBA4A - 2q35 [CytoView hg38]
Mapping of homologs : NCBITUBA4A [Mapview hg19]  TUBA4A [Mapview hg38]
OMIM191110   616208   
Gene and transcription
Genbank (Entrez)AK054731 AK299958 BC009238 BC018854 BP346611
RefSeq transcript (Entrez)NM_001278552 NM_006000
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TUBA4A
Cluster EST : UnigeneHs.75318 [ NCBI ]
CGAP (NCI)Hs.75318
Alternative Splicing GalleryENSG00000127824
Gene ExpressionTUBA4A [ NCBI-GEO ]   TUBA4A [ EBI - ARRAY_EXPRESS ]   TUBA4A [ SEEK ]   TUBA4A [ MEM ]
Gene Expression Viewer (FireBrowse)TUBA4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7277
GTEX Portal (Tissue expression)TUBA4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68366   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP68366  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68366
Splice isoforms : SwissVarP68366
PhosPhoSitePlusP68366
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)   
Domains : Interpro (EBI)Alpha_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBA4A
DMDM Disease mutations7277
Blocks (Seattle)TUBA4A
SuperfamilyP68366
Human Protein AtlasENSG00000127824
Peptide AtlasP68366
HPRD01851
IPIIPI00792677   
Protein Interaction databases
DIP (DOE-UCLA)P68366
IntAct (EBI)P68366
FunCoupENSG00000127824
BioGRIDTUBA4A
STRING (EMBL)TUBA4A
ZODIACTUBA4A
Ontologies - Pathways
QuickGOP68366
Ontology : AmiGOG2/M transition of mitotic cell cycle  platelet degranulation  GTPase activity  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  cytosol  microtubule  cytoskeleton organization  microtubule-based process  microtubule cytoskeleton  enzyme binding  extracellular exosome  ciliary basal body docking  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  platelet degranulation  GTPase activity  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  cytosol  microtubule  cytoskeleton organization  microtubule-based process  microtubule cytoskeleton  enzyme binding  extracellular exosome  ciliary basal body docking  
Pathways : BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors [Genes]   
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBA4A
Atlas of Cancer Signalling NetworkTUBA4A
Wikipedia pathwaysTUBA4A
Orthology - Evolution
OrthoDB7277
GeneTree (enSembl)ENSG00000127824
Phylogenetic Trees/Animal Genes : TreeFamTUBA4A
HOVERGENP68366
HOGENOMP68366
Homologs : HomoloGeneTUBA4A
Homology/Alignments : Family Browser (UCSC)TUBA4A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBA4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBA4A
dbVarTUBA4A
ClinVarTUBA4A
1000_GenomesTUBA4A 
Exome Variant ServerTUBA4A
ExAC (Exome Aggregation Consortium)TUBA4A (select the gene name)
Genetic variants : HAPMAP7277
Genomic Variants (DGV)TUBA4A [DGVbeta]
DECIPHERTUBA4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUBA4A 
Mutations
ICGC Data PortalTUBA4A 
TCGA Data PortalTUBA4A 
Broad Tumor PortalTUBA4A
OASIS PortalTUBA4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBA4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTUBA4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUBA4A
DgiDB (Drug Gene Interaction Database)TUBA4A
DoCM (Curated mutations)TUBA4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUBA4A (select a term)
intoGenTUBA4A
Cancer3DTUBA4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191110    616208   
Orphanet
MedgenTUBA4A
Genetic Testing Registry TUBA4A
NextProtP68366 [Medical]
TSGene7277
GENETestsTUBA4A
Target ValidationTUBA4A
Huge Navigator TUBA4A [HugePedia]
snp3D : Map Gene to Disease7277
BioCentury BCIQTUBA4A
ClinGenTUBA4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7277
Chemical/Pharm GKB GenePA162407391
Clinical trialTUBA4A
Miscellaneous
canSAR (ICR)TUBA4A (select the gene name)
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUBA4A
EVEXTUBA4A
GoPubMedTUBA4A
iHOPTUBA4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 13:01:19 CEST 2017

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