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TUBA4A (tubulin alpha 4a)

Identity

Alias (NCBI)ALS22
H2-ALPHA
TUBA1
HGNC (Hugo) TUBA4A
HGNC Alias symbFLJ30169
H2-ALPHA
HGNC Previous nameTUBA1
HGNC Previous nametubulin, alpha 1 (testis specific)
 tubulin, alpha 1
LocusID (NCBI) 7277
Atlas_Id 42729
Location 2q35  [Link to chromosome band 2q35]
Location_base_pair Starts at 219249710 and ends at 219253918 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TM9SF4 (20q11.21) / TUBA4A (2q35)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TUBA4A   12407
Cards
Entrez_Gene (NCBI)TUBA4A    tubulin alpha 4a
AliasesALS22; H2-ALPHA; TUBA1
GeneCards (Weizmann)TUBA4A
Ensembl hg19 (Hinxton)ENSG00000127824 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000127824 [Gene_View]  ENSG00000127824 [Sequence]  chr2:219249710-219253918 [Contig_View]  TUBA4A [Vega]
ICGC DataPortalENSG00000127824
TCGA cBioPortalTUBA4A
AceView (NCBI)TUBA4A
Genatlas (Paris)TUBA4A
SOURCE (Princeton)TUBA4A
Genetics Home Reference (NIH)TUBA4A
Genomic and cartography
GoldenPath hg38 (UCSC)TUBA4A  -     chr2:219249710-219253918 -  2q35   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUBA4A  -     2q35   [Description]    (hg19-Feb_2009)
GoldenPathTUBA4A - 2q35 [CytoView hg19]  TUBA4A - 2q35 [CytoView hg38]
ImmunoBaseENSG00000127824
Genome Data Viewer NCBITUBA4A [Mapview hg19]  
OMIM191110   616208   
Gene and transcription
Genbank (Entrez)AK054731 AK299958 BC009238 BC018854 BP346611
RefSeq transcript (Entrez)NM_001278552 NM_006000
Consensus coding sequences : CCDS (NCBI)TUBA4A
Gene ExpressionTUBA4A [ NCBI-GEO ]   TUBA4A [ EBI - ARRAY_EXPRESS ]   TUBA4A [ SEEK ]   TUBA4A [ MEM ]
Gene Expression Viewer (FireBrowse)TUBA4A [ Firebrowse - Broad ]
GenevisibleExpression of TUBA4A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7277
GTEX Portal (Tissue expression)TUBA4A
Human Protein AtlasENSG00000127824-TUBA4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68366   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP68366  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68366
PhosPhoSitePlusP68366
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)   
Domains : Interpro (EBI)Alpha_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin/FtsZ_C_sf    Tubulin/FtsZ_GTPase_sf    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBA4A
SuperfamilyP68366
AlphaFold pdb e-kbP68366   
Human Protein Atlas [tissue]ENSG00000127824-TUBA4A [tissue]
HPRD01851
Protein Interaction databases
DIP (DOE-UCLA)P68366
IntAct (EBI)P68366
BioGRIDTUBA4A
STRING (EMBL)TUBA4A
ZODIACTUBA4A
Ontologies - Pathways
QuickGOP68366
Ontology : AmiGOG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  mitotic cell cycle  platelet degranulation  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  cytoplasm  cytosol  cytoskeleton  microtubule  microtubule  regulation of G2/M transition of mitotic cell cycle  microtubule cytoskeleton  protein kinase binding  extracellular exosome  ciliary basal body-plasma membrane docking  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  mitotic cell cycle  platelet degranulation  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  cytoplasm  cytosol  cytoskeleton  microtubule  microtubule  regulation of G2/M transition of mitotic cell cycle  microtubule cytoskeleton  protein kinase binding  extracellular exosome  ciliary basal body-plasma membrane docking  
Pathways : BIOCARTADownregulated of MTA-3 in ER-negative Breast Tumors [Genes]   
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBA4A
Atlas of Cancer Signalling NetworkTUBA4A
Wikipedia pathwaysTUBA4A
Orthology - Evolution
OrthoDB7277
GeneTree (enSembl)ENSG00000127824
Phylogenetic Trees/Animal Genes : TreeFamTUBA4A
Homologs : HomoloGeneTUBA4A
Homology/Alignments : Family Browser (UCSC)TUBA4A
Gene fusions - Rearrangements
Fusion : QuiverTUBA4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBA4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBA4A
dbVarTUBA4A
ClinVarTUBA4A
MonarchTUBA4A
1000_GenomesTUBA4A 
Exome Variant ServerTUBA4A
GNOMAD BrowserENSG00000127824
Varsome BrowserTUBA4A
ACMGTUBA4A variants
VarityP68366
Genomic Variants (DGV)TUBA4A [DGVbeta]
DECIPHERTUBA4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUBA4A 
Mutations
ICGC Data PortalTUBA4A 
TCGA Data PortalTUBA4A 
Broad Tumor PortalTUBA4A
OASIS PortalTUBA4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBA4A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTUBA4A
Mutations and Diseases : HGMDTUBA4A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTUBA4A
DgiDB (Drug Gene Interaction Database)TUBA4A
DoCM (Curated mutations)TUBA4A
CIViC (Clinical Interpretations of Variants in Cancer)TUBA4A
Cancer3DTUBA4A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191110    616208   
Orphanet
DisGeNETTUBA4A
MedgenTUBA4A
Genetic Testing Registry TUBA4A
NextProtP68366 [Medical]
GENETestsTUBA4A
Target ValidationTUBA4A
Huge Navigator TUBA4A [HugePedia]
ClinGenTUBA4A
Clinical trials, drugs, therapy
MyCancerGenomeTUBA4A
Protein Interactions : CTDTUBA4A
Pharm GKB GenePA162407391
PharosP68366
Clinical trialTUBA4A
Miscellaneous
canSAR (ICR)TUBA4A
HarmonizomeTUBA4A
DataMed IndexTUBA4A
Probes
Litterature
PubMed197 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTUBA4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:48 CEST 2021

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