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TUBB (tubulin beta class I)

Identity

Alias_namestubulin, beta polypeptide
tubulin, beta
tubulin, beta class I
Alias_symbol (synonym)OK/SW-cl.56
MGC16435
M40
Tubb5
Other aliasCDCBM6
CSCSC1
TUBB1
TUBB5
HGNC (Hugo) TUBB
LocusID (NCBI) 203068
Atlas_Id 43650
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 30720201 and ends at 30725426 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAFIP () / TUBB (6p21.33)MLLT6 (17q12) / TUBB (6p21.33)PLOD1 (1p36.22) / TUBB (6p21.33)
SP1 (12q13.13) / TUBB (6p21.33)TUBB (6p21.33) / ABCF1 (6p21.33)TUBB (6p21.33) / FAM149B1 (10q22.2)
TUBB (6p21.33) / SCD (10q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TUBB   20778
Cards
Entrez_Gene (NCBI)TUBB  203068  tubulin beta class I
AliasesCDCBM6; CSCSC1; M40; OK/SW-cl.56; 
TUBB1; TUBB5
GeneCards (Weizmann)TUBB
Ensembl hg19 (Hinxton)ENSG00000196230 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196230 [Gene_View]  ENSG00000196230 [Sequence]  chr6:30720201-30725426 [Contig_View]  TUBB [Vega]
ICGC DataPortalENSG00000196230
TCGA cBioPortalTUBB
AceView (NCBI)TUBB
Genatlas (Paris)TUBB
WikiGenes203068
SOURCE (Princeton)TUBB
Genetics Home Reference (NIH)TUBB
Genomic and cartography
GoldenPath hg38 (UCSC)TUBB  -     chr6:30720201-30725426 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUBB  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblTUBB - 6p21.33 [CytoView hg19]  TUBB - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBITUBB [Mapview hg19]  TUBB [Mapview hg38]
OMIM156610   191130   615771   
Gene and transcription
Genbank (Entrez)AB062393 AF070561 AF070593 AF070600 AF141349
RefSeq transcript (Entrez)NM_001293212 NM_001293213 NM_001293214 NM_001293215 NM_001293216 NM_178014
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_034142 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)TUBB
Cluster EST : UnigeneHs.636480 [ NCBI ]
CGAP (NCI)Hs.636480
Alternative Splicing GalleryENSG00000196230
Gene ExpressionTUBB [ NCBI-GEO ]   TUBB [ EBI - ARRAY_EXPRESS ]   TUBB [ SEEK ]   TUBB [ MEM ]
Gene Expression Viewer (FireBrowse)TUBB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)203068
GTEX Portal (Tissue expression)TUBB
Human Protein AtlasENSG00000196230-TUBB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07437   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07437  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07437
Splice isoforms : SwissVarP07437
PhosPhoSitePlusP07437
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)    TUBULIN_B_AUTOREG (PS00228)   
Domains : Interpro (EBI)Beta-tubulin_BS    Beta_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBB
DMDM Disease mutations203068
Blocks (Seattle)TUBB
PDB (SRS)3QNZ    3QO0   
PDB (PDBSum)3QNZ    3QO0   
PDB (IMB)3QNZ    3QO0   
PDB (RSDB)3QNZ    3QO0   
Structural Biology KnowledgeBase3QNZ    3QO0   
SCOP (Structural Classification of Proteins)3QNZ    3QO0   
CATH (Classification of proteins structures)3QNZ    3QO0   
SuperfamilyP07437
Human Protein Atlas [tissue]ENSG00000196230-TUBB [tissue]
Peptide AtlasP07437
IPIIPI01019113   IPI00908770   IPI01013012   IPI01025656   IPI01015236   IPI01018768   IPI00953417   IPI01014795   IPI01022236   IPI01020686   IPI01022164   IPI00647896   IPI00645452   
Protein Interaction databases
DIP (DOE-UCLA)P07437
IntAct (EBI)P07437
FunCoupENSG00000196230
BioGRIDTUBB
STRING (EMBL)TUBB
ZODIACTUBB
Ontologies - Pathways
QuickGOP07437
Ontology : AmiGOG2/M transition of mitotic cell cycle  GTPase activity  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  nucleus  nuclear envelope lumen  cytoplasm  cytoskeleton  microtubule  microtubule  microtubule-based process  cellular process  regulation of G2/M transition of mitotic cell cycle  protein domain specific binding  cytoskeleton-dependent intracellular transport  extracellular matrix  ubiquitin protein ligase binding  protein complex binding  GTPase activating protein binding  azurophil granule lumen  cytoplasmic ribonucleoprotein granule  natural killer cell mediated cytotoxicity  MHC class I protein binding  protein complex  neutrophil degranulation  cell body  membrane raft  spindle assembly  cell division  extracellular exosome  ciliary basal body-plasma membrane docking  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  GTPase activity  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  nucleus  nuclear envelope lumen  cytoplasm  cytoskeleton  microtubule  microtubule  microtubule-based process  cellular process  regulation of G2/M transition of mitotic cell cycle  protein domain specific binding  cytoskeleton-dependent intracellular transport  extracellular matrix  ubiquitin protein ligase binding  protein complex binding  GTPase activating protein binding  azurophil granule lumen  cytoplasmic ribonucleoprotein granule  natural killer cell mediated cytotoxicity  MHC class I protein binding  protein complex  neutrophil degranulation  cell body  membrane raft  spindle assembly  cell division  extracellular exosome  ciliary basal body-plasma membrane docking  
Pathways : KEGGGap junction   
NDEx NetworkTUBB
Atlas of Cancer Signalling NetworkTUBB
Wikipedia pathwaysTUBB
Orthology - Evolution
OrthoDB203068
GeneTree (enSembl)ENSG00000196230
Phylogenetic Trees/Animal Genes : TreeFamTUBB
HOVERGENP07437
HOGENOMP07437
Homologs : HomoloGeneTUBB
Homology/Alignments : Family Browser (UCSC)TUBB
Gene fusions - Rearrangements
Fusion : QuiverTUBB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBB
dbVarTUBB
ClinVarTUBB
1000_GenomesTUBB 
Exome Variant ServerTUBB
ExAC (Exome Aggregation Consortium)ENSG00000196230
GNOMAD BrowserENSG00000196230
Genetic variants : HAPMAP203068
Genomic Variants (DGV)TUBB [DGVbeta]
DECIPHERTUBB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUBB 
Mutations
ICGC Data PortalTUBB 
TCGA Data PortalTUBB 
Broad Tumor PortalTUBB
OASIS PortalTUBB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTUBB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUBB
DgiDB (Drug Gene Interaction Database)TUBB
DoCM (Curated mutations)TUBB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUBB (select a term)
intoGenTUBB
Cancer3DTUBB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM156610    191130    615771   
Orphanet2317   
DisGeNETTUBB
MedgenTUBB
Genetic Testing Registry TUBB
NextProtP07437 [Medical]
TSGene203068
GENETestsTUBB
Target ValidationTUBB
Huge Navigator TUBB [HugePedia]
snp3D : Map Gene to Disease203068
BioCentury BCIQTUBB
ClinGenTUBB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD203068
Chemical/Pharm GKB GenePA358
Clinical trialTUBB
Miscellaneous
canSAR (ICR)TUBB (select the gene name)
Probes
Litterature
PubMed233 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUBB
EVEXTUBB
GoPubMedTUBB
iHOPTUBB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:55:52 CEST 2018

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