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TUBB (tubulin beta class I)

Identity

Alias (NCBI)CDCBM6
CSCSC1
M40
OK/SW-cl.56
TUBB1
TUBB5
HGNC (Hugo) TUBB
HGNC Alias symbOK/SW-cl.56
MGC16435
M40
Tubb5
HGNC Alias nameclass I beta-tubulin
 beta1-tubulin
HGNC Previous nametubulin, beta polypeptide
 tubulin, beta
 tubulin, beta class I
LocusID (NCBI) 203068
Atlas_Id 43650
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 30720352 and ends at 30725418 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAFIP () / TUBB (6p21.33)MLLT6 (17q12) / TUBB (6p21.33)PLOD1 (1p36.22) / TUBB (6p21.33)
SP1 (12q13.13) / TUBB (6p21.33)TUBB (6p21.33) / ABCF1 (6p21.33)TUBB (6p21.33) / FAM149B1 (10q22.2)
TUBB (6p21.33) / SCD (10q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TUBB   20778
Cards
Entrez_Gene (NCBI)TUBB    tubulin beta class I
AliasesCDCBM6; CSCSC1; M40; OK/SW-cl.56; 
TUBB1; TUBB5
GeneCards (Weizmann)TUBB
Ensembl hg19 (Hinxton)ENSG00000196230 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000196230 [Gene_View]  ENSG00000196230 [Sequence]  chr6:30720352-30725418 [Contig_View]  TUBB [Vega]
ICGC DataPortalENSG00000196230
TCGA cBioPortalTUBB
AceView (NCBI)TUBB
Genatlas (Paris)TUBB
SOURCE (Princeton)TUBB
Genetics Home Reference (NIH)TUBB
Genomic and cartography
GoldenPath hg38 (UCSC)TUBB  -     chr6:30720352-30725418 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUBB  -     6p21.33   [Description]    (hg19-Feb_2009)
GoldenPathTUBB - 6p21.33 [CytoView hg19]  TUBB - 6p21.33 [CytoView hg38]
ImmunoBaseENSG00000196230
Genome Data Viewer NCBITUBB [Mapview hg19]  
OMIM156610   191130   615771   
Gene and transcription
Genbank (Entrez)AB062393 AF070561 AF070593 AF070600 AF141349
RefSeq transcript (Entrez)NM_001293212 NM_001293213 NM_001293214 NM_001293215 NM_001293216 NM_178014
Consensus coding sequences : CCDS (NCBI)TUBB
Gene ExpressionTUBB [ NCBI-GEO ]   TUBB [ EBI - ARRAY_EXPRESS ]   TUBB [ SEEK ]   TUBB [ MEM ]
Gene Expression Viewer (FireBrowse)TUBB [ Firebrowse - Broad ]
GenevisibleExpression of TUBB in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)203068
GTEX Portal (Tissue expression)TUBB
Human Protein AtlasENSG00000196230-TUBB [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07437   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07437  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07437
PhosPhoSitePlusP07437
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)    TUBULIN_B_AUTOREG (PS00228)   
Domains : Interpro (EBI)Beta-tubulin_BS    Beta_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin/FtsZ_C_sf    Tubulin/FtsZ_GTPase_sf    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBB
PDB (RSDB)3QNZ    3QO0    5N5N    6I2I    6QUS    6QUY    6QVE    6QVJ   
PDB Europe3QNZ    3QO0    5N5N    6I2I    6QUS    6QUY    6QVE    6QVJ   
PDB (PDBSum)3QNZ    3QO0    5N5N    6I2I    6QUS    6QUY    6QVE    6QVJ   
PDB (IMB)3QNZ    3QO0    5N5N    6I2I    6QUS    6QUY    6QVE    6QVJ   
Structural Biology KnowledgeBase3QNZ    3QO0    5N5N    6I2I    6QUS    6QUY    6QVE    6QVJ   
SCOP (Structural Classification of Proteins)3QNZ    3QO0    5N5N    6I2I    6QUS    6QUY    6QVE    6QVJ   
CATH (Classification of proteins structures)3QNZ    3QO0    5N5N    6I2I    6QUS    6QUY    6QVE    6QVJ   
SuperfamilyP07437
AlphaFold pdb e-kbP07437   
Human Protein Atlas [tissue]ENSG00000196230-TUBB [tissue]
Protein Interaction databases
DIP (DOE-UCLA)P07437
IntAct (EBI)P07437
BioGRIDTUBB
STRING (EMBL)TUBB
ZODIACTUBB
Ontologies - Pathways
QuickGOP07437
Ontology : AmiGOG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  mitotic cell cycle  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  nucleus  nuclear envelope lumen  cytoplasm  cytoplasm  cytosol  cytoskeleton  microtubule  microtubule  microtubule  microtubule-based process  cellular process  regulation of G2/M transition of mitotic cell cycle  protein domain specific binding  cytoskeleton-dependent intracellular transport  ubiquitin protein ligase binding  GTPase activating protein binding  protein-containing complex  azurophil granule lumen  cytoplasmic ribonucleoprotein granule  natural killer cell mediated cytotoxicity  MHC class I protein binding  neutrophil degranulation  cell body  protein-containing complex binding  membrane raft  regulation of synapse organization  spindle assembly  cell division  extracellular exosome  ciliary basal body-plasma membrane docking  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  microtubule cytoskeleton organization  mitotic cell cycle  structural molecule activity  structural constituent of cytoskeleton  protein binding  GTP binding  extracellular region  nucleus  nuclear envelope lumen  cytoplasm  cytoplasm  cytosol  cytoskeleton  microtubule  microtubule  microtubule  microtubule-based process  cellular process  regulation of G2/M transition of mitotic cell cycle  protein domain specific binding  cytoskeleton-dependent intracellular transport  ubiquitin protein ligase binding  GTPase activating protein binding  protein-containing complex  azurophil granule lumen  cytoplasmic ribonucleoprotein granule  natural killer cell mediated cytotoxicity  MHC class I protein binding  neutrophil degranulation  cell body  protein-containing complex binding  membrane raft  regulation of synapse organization  spindle assembly  cell division  extracellular exosome  ciliary basal body-plasma membrane docking  
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBB
Atlas of Cancer Signalling NetworkTUBB
Wikipedia pathwaysTUBB
Orthology - Evolution
OrthoDB203068
GeneTree (enSembl)ENSG00000196230
Phylogenetic Trees/Animal Genes : TreeFamTUBB
Homologs : HomoloGeneTUBB
Homology/Alignments : Family Browser (UCSC)TUBB
Gene fusions - Rearrangements
Fusion : QuiverTUBB
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBB
dbVarTUBB
ClinVarTUBB
MonarchTUBB
1000_GenomesTUBB 
Exome Variant ServerTUBB
GNOMAD BrowserENSG00000196230
Varsome BrowserTUBB
ACMGTUBB variants
VarityP07437
Genomic Variants (DGV)TUBB [DGVbeta]
DECIPHERTUBB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUBB 
Mutations
ICGC Data PortalTUBB 
TCGA Data PortalTUBB 
Broad Tumor PortalTUBB
OASIS PortalTUBB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBB  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTUBB
Mutations and Diseases : HGMDTUBB
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTUBB
DgiDB (Drug Gene Interaction Database)TUBB
DoCM (Curated mutations)TUBB
CIViC (Clinical Interpretations of Variants in Cancer)TUBB
Cancer3DTUBB
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM156610    191130    615771   
Orphanet2317   
DisGeNETTUBB
MedgenTUBB
Genetic Testing Registry TUBB
NextProtP07437 [Medical]
GENETestsTUBB
Target ValidationTUBB
Huge Navigator TUBB [HugePedia]
ClinGenTUBB
Clinical trials, drugs, therapy
MyCancerGenomeTUBB
Protein Interactions : CTDTUBB
Pharm GKB GenePA358
PharosP07437
Clinical trialTUBB
Miscellaneous
canSAR (ICR)TUBB
HarmonizomeTUBB
DataMed IndexTUBB
Probes
Litterature
PubMed336 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTUBB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:36:49 CEST 2021

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