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TUBB2A (tubulin beta 2A class IIa)

Identity

Alias_namesTUBB
TUBB2
tubulin, beta polypeptide
tubulin, beta 2
tubulin, beta 2A
Alias_symbol (synonym)dJ40E16.7
Other aliasCDCBM5
HGNC (Hugo) TUBB2A
LocusID (NCBI) 7280
Atlas_Id 46226
Location 6p25.2  [Link to chromosome band 6p25]
Location_base_pair Starts at 3153666 and ends at 3157549 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSNK1A1 (5q32) / TUBB2A (6p25.2)TUBB2A (6p25.2) / SLC22A23 (6p25.2)TUBB2A (6p25.2) / SRSF4 (1p35.3)
YY1 (14q32.2) / TUBB2A (6p25.2)TUBB2A 6p25.2 / SLC22A23 6p25.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TUBB2A/SLC22A23 (6p25)


External links

Nomenclature
HGNC (Hugo)TUBB2A   12412
Cards
Entrez_Gene (NCBI)TUBB2A  7280  tubulin beta 2A class IIa
AliasesCDCBM5; TUBB; TUBB2
GeneCards (Weizmann)TUBB2A
Ensembl hg19 (Hinxton)ENSG00000137267 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137267 [Gene_View]  ENSG00000137267 [Sequence]  chr6:3153666-3157549 [Contig_View]  TUBB2A [Vega]
ICGC DataPortalENSG00000137267
TCGA cBioPortalTUBB2A
AceView (NCBI)TUBB2A
Genatlas (Paris)TUBB2A
WikiGenes7280
SOURCE (Princeton)TUBB2A
Genetics Home Reference (NIH)TUBB2A
Genomic and cartography
GoldenPath hg38 (UCSC)TUBB2A  -     chr6:3153666-3157549 -  6p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUBB2A  -     6p25.2   [Description]    (hg19-Feb_2009)
EnsemblTUBB2A - 6p25.2 [CytoView hg19]  TUBB2A - 6p25.2 [CytoView hg38]
Mapping of homologs : NCBITUBB2A [Mapview hg19]  TUBB2A [Mapview hg38]
OMIM615101   615763   
Gene and transcription
Genbank (Entrez)AK308772 AK312621 AL038778 AY159127 BC001194
RefSeq transcript (Entrez)NM_001069 NM_001310315
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TUBB2A
Cluster EST : UnigeneHs.654543 [ NCBI ]
CGAP (NCI)Hs.654543
Alternative Splicing GalleryENSG00000137267
Gene ExpressionTUBB2A [ NCBI-GEO ]   TUBB2A [ EBI - ARRAY_EXPRESS ]   TUBB2A [ SEEK ]   TUBB2A [ MEM ]
Gene Expression Viewer (FireBrowse)TUBB2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7280
GTEX Portal (Tissue expression)TUBB2A
Human Protein AtlasENSG00000137267-TUBB2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13885   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13885  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13885
Splice isoforms : SwissVarQ13885
PhosPhoSitePlusQ13885
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)    TUBULIN_B_AUTOREG (PS00228)   
Domains : Interpro (EBI)Beta-tubulin_BS    Beta_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin/FtsZ_C_sf    Tubulin/FtsZ_GTPase_sf    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBB2A
DMDM Disease mutations7280
Blocks (Seattle)TUBB2A
SuperfamilyQ13885
Human Protein Atlas [tissue]ENSG00000137267-TUBB2A [tissue]
Peptide AtlasQ13885
HPRD01852
IPIIPI00013475   IPI00930715   IPI01015204   
Protein Interaction databases
DIP (DOE-UCLA)Q13885
IntAct (EBI)Q13885
FunCoupENSG00000137267
BioGRIDTUBB2A
STRING (EMBL)TUBB2A
ZODIACTUBB2A
Ontologies - Pathways
QuickGOQ13885
Ontology : AmiGOmicrotubule cytoskeleton organization  mitotic cell cycle  GTPase activity  structural constituent of cytoskeleton  protein binding  GTP binding  nucleus  cytoplasm  microtubule  microtubule  microtubule-based process  extracellular exosome  extracellular vesicle  
Ontology : EGO-EBImicrotubule cytoskeleton organization  mitotic cell cycle  GTPase activity  structural constituent of cytoskeleton  protein binding  GTP binding  nucleus  cytoplasm  microtubule  microtubule  microtubule-based process  extracellular exosome  extracellular vesicle  
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBB2A
Atlas of Cancer Signalling NetworkTUBB2A
Wikipedia pathwaysTUBB2A
Orthology - Evolution
OrthoDB7280
GeneTree (enSembl)ENSG00000137267
Phylogenetic Trees/Animal Genes : TreeFamTUBB2A
HOVERGENQ13885
HOGENOMQ13885
Homologs : HomoloGeneTUBB2A
Homology/Alignments : Family Browser (UCSC)TUBB2A
Gene fusions - Rearrangements
Fusion : MitelmanTUBB2A/SLC22A23 [6p25.2/6p25.2]  
Fusion PortalTUBB2A 6p25.2 SLC22A23 6p25.2 LUAD
Fusion : QuiverTUBB2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBB2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBB2A
dbVarTUBB2A
ClinVarTUBB2A
1000_GenomesTUBB2A 
Exome Variant ServerTUBB2A
ExAC (Exome Aggregation Consortium)ENSG00000137267
GNOMAD BrowserENSG00000137267
Varsome BrowserTUBB2A
Genetic variants : HAPMAP7280
Genomic Variants (DGV)TUBB2A [DGVbeta]
DECIPHERTUBB2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUBB2A 
Mutations
ICGC Data PortalTUBB2A 
TCGA Data PortalTUBB2A 
Broad Tumor PortalTUBB2A
OASIS PortalTUBB2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBB2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTUBB2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUBB2A
DgiDB (Drug Gene Interaction Database)TUBB2A
DoCM (Curated mutations)TUBB2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUBB2A (select a term)
intoGenTUBB2A
Cancer3DTUBB2A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615101    615763   
Orphanet
DisGeNETTUBB2A
MedgenTUBB2A
Genetic Testing Registry TUBB2A
NextProtQ13885 [Medical]
TSGene7280
GENETestsTUBB2A
Target ValidationTUBB2A
Huge Navigator TUBB2A [HugePedia]
snp3D : Map Gene to Disease7280
BioCentury BCIQTUBB2A
ClinGenTUBB2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7280
Chemical/Pharm GKB GenePA142670670
Clinical trialTUBB2A
Miscellaneous
canSAR (ICR)TUBB2A (select the gene name)
Probes
Litterature
PubMed146 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUBB2A
EVEXTUBB2A
GoPubMedTUBB2A
iHOPTUBB2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:47:30 CET 2018

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