TUBB2B (tubulin beta 2B class IIb)

2007-12-01 Affiliation

Identity

HGNC

TUBB2B

LOCATION

6p25.2

LOCUSID

347733

ALIAS

CDCBM7,PMGYSA,bA506K6.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 347733
MIM: 612850
HGNC: 30829
Ensembl: ENSG00000137285

Variants:

dbSNP: 347733
ClinVar: 347733
TCGA: ENSG00000137285
COSMIC: TUBB2B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137285	ENST00000259818	Q9BVA1
ENSG00000137285	ENST00000259818	A0A384MEE3

Expression (GTEx)

100

150

200

250

300

350

400

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gap junction	KEGG	ko04540
Pathogenic Escherichia coli infection	KEGG	ko05130
Gap junction	KEGG	hsa04540
Pathogenic Escherichia coli infection	KEGG	hsa05130
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	REACTOME	R-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriC	REACTOME	R-HSA-389957
Formation of tubulin folding intermediates by CCT/TriC	REACTOME	R-HSA-389960
Post-chaperonin tubulin folding pathway	REACTOME	R-HSA-389977

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19165527	2009	Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.	56
23361065	2013	Overlapping cortical malformations and mutations in TUBB2B and TUBA1A.	42
19034380	2009	Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis.	36
27306797	2016	Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length.	16
18613117	2008	Beta-tubulin isotype classes II and V expression patterns in nonsmall cell lung carcinomas.	15
24392928	2014	Brain malformations and mutations in α- and β-tubulin genes: a review of the literature and description of two new cases.	8
19996274	2009	Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics.	7
26331477	2015	Everolimus Stabilizes Podocyte Microtubules via Enhancing TUBB2B and DCDC2 Expression.	4
30621030	2019	Over-Expression of βII-Tubulin and Especially Its Localization in Cell Nuclei Correlates with Poorer Outcomes in Colorectal Cancer.	1
12533264	2002	Microtubule-associated parameters as predictive markers of docetaxel activity in advanced breast cancer patients: results of a pilot study.	0

Citation

Dessen P

TUBB2B (tubulin beta 2B class IIb)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49846/tubb2b