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TUBB2B (tubulin beta 2B class IIb)

Identity

Alias_namestubulin
Alias_symbol (synonym)MGC8685
DKFZp566F223
bA506K6.1
Other aliasCDCBM7
PMGYSA
HGNC (Hugo) TUBB2B
LocusID (NCBI) 347733
Atlas_Id 49846
Location 6p25.2  [Link to chromosome band 6p25]
Location_base_pair Starts at 3224261 and ends at 3227734 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NACA (12q13.3) / TUBB2B (6p25.2)TUBB2B (6p25.2) / DYRK2 (12q15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TUBB2B   30829
Cards
Entrez_Gene (NCBI)TUBB2B  347733  tubulin beta 2B class IIb
AliasesCDCBM7; PMGYSA; bA506K6.1
GeneCards (Weizmann)TUBB2B
Ensembl hg19 (Hinxton)ENSG00000137285 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137285 [Gene_View]  ENSG00000137285 [Sequence]  chr6:3224261-3227734 [Contig_View]  TUBB2B [Vega]
ICGC DataPortalENSG00000137285
TCGA cBioPortalTUBB2B
AceView (NCBI)TUBB2B
Genatlas (Paris)TUBB2B
WikiGenes347733
SOURCE (Princeton)TUBB2B
Genetics Home Reference (NIH)TUBB2B
Genomic and cartography
GoldenPath hg38 (UCSC)TUBB2B  -     chr6:3224261-3227734 -  6p25.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUBB2B  -     6p25.2   [Description]    (hg19-Feb_2009)
EnsemblTUBB2B - 6p25.2 [CytoView hg19]  TUBB2B - 6p25.2 [CytoView hg38]
Mapping of homologs : NCBITUBB2B [Mapview hg19]  TUBB2B [Mapview hg38]
OMIM610031   612850   
Gene and transcription
Genbank (Entrez)AF035316 AK289433 AK297568 AK308806 AL050056
RefSeq transcript (Entrez)NM_178012
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TUBB2B
Cluster EST : UnigeneHs.300701 [ NCBI ]
CGAP (NCI)Hs.300701
Alternative Splicing GalleryENSG00000137285
Gene ExpressionTUBB2B [ NCBI-GEO ]   TUBB2B [ EBI - ARRAY_EXPRESS ]   TUBB2B [ SEEK ]   TUBB2B [ MEM ]
Gene Expression Viewer (FireBrowse)TUBB2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)347733
GTEX Portal (Tissue expression)TUBB2B
Human Protein AtlasENSG00000137285-TUBB2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BVA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BVA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BVA1
Splice isoforms : SwissVarQ9BVA1
PhosPhoSitePlusQ9BVA1
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)    TUBULIN_B_AUTOREG (PS00228)   
Domains : Interpro (EBI)Beta-tubulin_BS    Beta_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin/FtsZ_C_sf    Tubulin/FtsZ_GTPase_sf    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBB2B
DMDM Disease mutations347733
Blocks (Seattle)TUBB2B
SuperfamilyQ9BVA1
Human Protein Atlas [tissue]ENSG00000137285-TUBB2B [tissue]
Peptide AtlasQ9BVA1
HPRD14707
IPIIPI00031370   IPI00827736   IPI01014387   
Protein Interaction databases
DIP (DOE-UCLA)Q9BVA1
IntAct (EBI)Q9BVA1
FunCoupENSG00000137285
BioGRIDTUBB2B
STRING (EMBL)TUBB2B
ZODIACTUBB2B
Ontologies - Pathways
QuickGOQ9BVA1
Ontology : AmiGOmicrotubule cytoskeleton organization  mitotic cell cycle  neuron migration  neuron migration  GTPase activity  structural constituent of cytoskeleton  protein binding  GTP binding  nucleus  cytoplasm  microtubule  microtubule  microtubule-based process  microtubule-based process  microtubule cytoskeleton  protein heterodimerization activity  modulation of chemical synaptic transmission  Schaffer collateral - CA1 synapse  positive regulation of axon guidance  
Ontology : EGO-EBImicrotubule cytoskeleton organization  mitotic cell cycle  neuron migration  neuron migration  GTPase activity  structural constituent of cytoskeleton  protein binding  GTP binding  nucleus  cytoplasm  microtubule  microtubule  microtubule-based process  microtubule-based process  microtubule cytoskeleton  protein heterodimerization activity  modulation of chemical synaptic transmission  Schaffer collateral - CA1 synapse  positive regulation of axon guidance  
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBB2B
Atlas of Cancer Signalling NetworkTUBB2B
Wikipedia pathwaysTUBB2B
Orthology - Evolution
OrthoDB347733
GeneTree (enSembl)ENSG00000137285
Phylogenetic Trees/Animal Genes : TreeFamTUBB2B
HOVERGENQ9BVA1
HOGENOMQ9BVA1
Homologs : HomoloGeneTUBB2B
Homology/Alignments : Family Browser (UCSC)TUBB2B
Gene fusions - Rearrangements
Fusion : QuiverTUBB2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBB2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBB2B
dbVarTUBB2B
ClinVarTUBB2B
1000_GenomesTUBB2B 
Exome Variant ServerTUBB2B
ExAC (Exome Aggregation Consortium)ENSG00000137285
GNOMAD BrowserENSG00000137285
Varsome BrowserTUBB2B
Genetic variants : HAPMAP347733
Genomic Variants (DGV)TUBB2B [DGVbeta]
DECIPHERTUBB2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUBB2B 
Mutations
ICGC Data PortalTUBB2B 
TCGA Data PortalTUBB2B 
Broad Tumor PortalTUBB2B
OASIS PortalTUBB2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUBB2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTUBB2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUBB2B
DgiDB (Drug Gene Interaction Database)TUBB2B
DoCM (Curated mutations)TUBB2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUBB2B (select a term)
intoGenTUBB2B
Cancer3DTUBB2B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610031    612850   
Orphanet21133    10586   
DisGeNETTUBB2B
MedgenTUBB2B
Genetic Testing Registry TUBB2B
NextProtQ9BVA1 [Medical]
TSGene347733
GENETestsTUBB2B
Target ValidationTUBB2B
Huge Navigator TUBB2B [HugePedia]
snp3D : Map Gene to Disease347733
BioCentury BCIQTUBB2B
ClinGenTUBB2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD347733
Chemical/Pharm GKB GenePA142670671
Clinical trialTUBB2B
Miscellaneous
canSAR (ICR)TUBB2B (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUBB2B
EVEXTUBB2B
GoPubMedTUBB2B
iHOPTUBB2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 6 11:47:31 CET 2018

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