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TUBB4B (tubulin beta 4B class IVb)

Identity

Alias_namesTUBB2C
tubulin
Alias_symbol (synonym)Beta2
Other aliasTUBB2
HGNC (Hugo) TUBB4B
LocusID (NCBI) 10383
Atlas_Id 52442
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 140135711 and ends at 140138159 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CDH5 (16q21) / TUBB4B (9q34.3)CTTNBP2NL (1p13.2) / TUBB4B (9q34.3)TUBB4B (9q34.3) / A2M (12p13.31)
TUBB4B (9q34.3) / ITPRIP (10q25.1)TUBB4B (9q34.3) / NELFB (9q34.3)TUBB4B (9q34.3) / PGAP2 (11p15.4)
TUBB4B (9q34.3) / TUBB4B (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)TUBB4B   20771
Cards
Entrez_Gene (NCBI)TUBB4B  10383  tubulin beta 4B class IVb
AliasesBeta2; TUBB2; TUBB2C
GeneCards (Weizmann)TUBB4B
Ensembl hg19 (Hinxton)ENSG00000188229 [Gene_View]  chr9:140135711-140138159 [Contig_View]  TUBB4B [Vega]
Ensembl hg38 (Hinxton)ENSG00000188229 [Gene_View]  chr9:140135711-140138159 [Contig_View]  TUBB4B [Vega]
ICGC DataPortalENSG00000188229
TCGA cBioPortalTUBB4B
AceView (NCBI)TUBB4B
Genatlas (Paris)TUBB4B
WikiGenes10383
SOURCE (Princeton)TUBB4B
Genetics Home Reference (NIH)TUBB4B
Genomic and cartography
GoldenPath hg19 (UCSC)TUBB4B  -     chr9:140135711-140138159 +  9q34.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TUBB4B  -     9q34.3   [Description]    (hg38-Dec_2013)
EnsemblTUBB4B - 9q34.3 [CytoView hg19]  TUBB4B - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBITUBB4B [Mapview hg19]  TUBB4B [Mapview hg38]
OMIM602660   
Gene and transcription
Genbank (Entrez)AF064849 AK000560 AK021414 AK026167 AK026594
RefSeq transcript (Entrez)NM_006088
RefSeq genomic (Entrez)NC_000009 NC_018920 NT_008470 NW_004929369
Consensus coding sequences : CCDS (NCBI)TUBB4B
Cluster EST : UnigeneHs.433615 [ NCBI ]
CGAP (NCI)Hs.433615
Alternative Splicing GalleryENSG00000188229
Gene ExpressionTUBB4B [ NCBI-GEO ]   TUBB4B [ EBI - ARRAY_EXPRESS ]   TUBB4B [ SEEK ]   TUBB4B [ MEM ]
Gene Expression Viewer (FireBrowse)TUBB4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10383
GTEX Portal (Tissue expression)TUBB4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtP68371   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP68371  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP68371
Splice isoforms : SwissVarP68371
PhosPhoSitePlusP68371
Domaine pattern : Prosite (Expaxy)TUBULIN (PS00227)    TUBULIN_B_AUTOREG (PS00228)   
Domains : Interpro (EBI)Beta-tubulin_BS    Beta_tubulin    Tub_FtsZ_C    Tubulin    Tubulin/FtsZ_2-layer-sand-dom    Tubulin_C    Tubulin_CS    Tubulin_FtsZ_GTPase   
Domain families : Pfam (Sanger)Tubulin (PF00091)    Tubulin_C (PF03953)   
Domain families : Pfam (NCBI)pfam00091    pfam03953   
Domain families : Smart (EMBL)Tubulin (SM00864)  Tubulin_C (SM00865)  
Conserved Domain (NCBI)TUBB4B
DMDM Disease mutations10383
Blocks (Seattle)TUBB4B
SuperfamilyP68371
Human Protein AtlasENSG00000188229
Peptide AtlasP68371
HPRD04043
IPIIPI00007752   IPI00956734   
Protein Interaction databases
DIP (DOE-UCLA)P68371
IntAct (EBI)P68371
FunCoupENSG00000188229
BioGRIDTUBB4B
STRING (EMBL)TUBB4B
ZODIACTUBB4B
Ontologies - Pathways
QuickGOP68371
Ontology : AmiGOG2/M transition of mitotic cell cycle  double-stranded RNA binding  GTPase activity  structural constituent of cytoskeleton  GTP binding  nucleus  cytosol  cytoskeleton  microtubule  movement of cell or subcellular component  microtubule-based process  metabolic process  natural killer cell mediated cytotoxicity  MHC class I protein binding  myelin sheath  unfolded protein binding  extracellular exosome  extracellular vesicle  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  double-stranded RNA binding  GTPase activity  structural constituent of cytoskeleton  GTP binding  nucleus  cytosol  cytoskeleton  microtubule  movement of cell or subcellular component  microtubule-based process  metabolic process  natural killer cell mediated cytotoxicity  MHC class I protein binding  myelin sheath  unfolded protein binding  extracellular exosome  extracellular vesicle  
Pathways : KEGGPhagosome    Gap junction    Pathogenic Escherichia coli infection   
NDEx NetworkTUBB4B
Atlas of Cancer Signalling NetworkTUBB4B
Wikipedia pathwaysTUBB4B
Orthology - Evolution
OrthoDB10383
GeneTree (enSembl)ENSG00000188229
Phylogenetic Trees/Animal Genes : TreeFamTUBB4B
HOVERGENP68371
HOGENOMP68371
Homologs : HomoloGeneTUBB4B
Homology/Alignments : Family Browser (UCSC)TUBB4B
Gene fusions - Rearrangements
Fusion : MitelmanTUBB4B/NELFB [9q34.3/9q34.3]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUBB4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUBB4B
dbVarTUBB4B
ClinVarTUBB4B
1000_GenomesTUBB4B 
Exome Variant ServerTUBB4B
ExAC (Exome Aggregation Consortium)TUBB4B (select the gene name)
Genetic variants : HAPMAP10383
Genomic Variants (DGV)TUBB4B [DGVbeta]
DECIPHER (Syndromes)9:140135711-140138159  ENSG00000188229
CONAN: Copy Number AnalysisTUBB4B 
Mutations
ICGC Data PortalTUBB4B 
TCGA Data PortalTUBB4B 
Broad Tumor PortalTUBB4B
OASIS PortalTUBB4B [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDTUBB4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUBB4B
DgiDB (Drug Gene Interaction Database)TUBB4B
DoCM (Curated mutations)TUBB4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUBB4B (select a term)
intoGenTUBB4B
Cancer3DTUBB4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602660   
Orphanet
MedgenTUBB4B
Genetic Testing Registry TUBB4B
NextProtP68371 [Medical]
TSGene10383
GENETestsTUBB4B
Huge Navigator TUBB4B [HugePedia]
snp3D : Map Gene to Disease10383
BioCentury BCIQTUBB4B
ClinGenTUBB4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10383
Chemical/Pharm GKB GenePA142670672
Clinical trialTUBB4B
Miscellaneous
canSAR (ICR)TUBB4B (select the gene name)
Probes
Litterature
PubMed108 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUBB4B
EVEXTUBB4B
GoPubMedTUBB4B
iHOPTUBB4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:32:48 CET 2017

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