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TUSC2 (tumor suppressor candidate 2)

Identity

Alias_namesPDAP2
PDGFA associated protein 2
Alias_symbol (synonym)FUS1
PAP
C3orf11
Other alias
HGNC (Hugo) TUSC2
LocusID (NCBI) 11334
Atlas_Id 42731
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 50362340 and ends at 50365669 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TUSC2   17034
Cards
Entrez_Gene (NCBI)TUSC2  11334  tumor suppressor candidate 2
AliasesC3orf11; FUS1; PAP; PDAP2
GeneCards (Weizmann)TUSC2
Ensembl hg19 (Hinxton)ENSG00000114383 [Gene_View]  chr3:50362340-50365669 [Contig_View]  TUSC2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000114383 [Gene_View]  chr3:50362340-50365669 [Contig_View]  TUSC2 [Vega]
ICGC DataPortalENSG00000114383
TCGA cBioPortalTUSC2
AceView (NCBI)TUSC2
Genatlas (Paris)TUSC2
WikiGenes11334
SOURCE (Princeton)TUSC2
Genetics Home Reference (NIH)TUSC2
Genomic and cartography
GoldenPath hg19 (UCSC)TUSC2  -     chr3:50362340-50365669 -  3p21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TUSC2  -     3p21.31   [Description]    (hg38-Dec_2013)
EnsemblTUSC2 - 3p21.31 [CytoView hg19]  TUSC2 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBITUSC2 [Mapview hg19]  TUSC2 [Mapview hg38]
OMIM607052   
Gene and transcription
Genbank (Entrez)AF055479 AK124058 AK311998 BC023976 CA392689
RefSeq transcript (Entrez)NM_007275
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TUSC2
Cluster EST : UnigeneHs.517981 [ NCBI ]
CGAP (NCI)Hs.517981
Alternative Splicing GalleryENSG00000114383
Gene ExpressionTUSC2 [ NCBI-GEO ]   TUSC2 [ EBI - ARRAY_EXPRESS ]   TUSC2 [ SEEK ]   TUSC2 [ MEM ]
Gene Expression Viewer (FireBrowse)TUSC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11334
GTEX Portal (Tissue expression)TUSC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75896   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75896  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75896
Splice isoforms : SwissVarO75896
PhosPhoSitePlusO75896
Domains : Interpro (EBI)FUS1   
Domain families : Pfam (Sanger)TUSC2 (PF15000)   
Domain families : Pfam (NCBI)pfam15000   
Conserved Domain (NCBI)TUSC2
DMDM Disease mutations11334
Blocks (Seattle)TUSC2
SuperfamilyO75896
Human Protein AtlasENSG00000114383
Peptide AtlasO75896
HPRD06134
IPIIPI00027248   IPI00927820   IPI00927129   
Protein Interaction databases
DIP (DOE-UCLA)O75896
IntAct (EBI)O75896
FunCoupENSG00000114383
BioGRIDTUSC2
STRING (EMBL)TUSC2
ZODIACTUSC2
Ontologies - Pathways
QuickGOO75896
Ontology : AmiGOnatural killer cell differentiation  protein binding  mitochondrion  phagocytosis  inflammatory response  cell cycle  cell-cell signaling  cell proliferation  interleukin-15 production  negative regulation of interleukin-17 production  positive regulation of interleukin-10 production  cell maturation  regulation of mitochondrial membrane potential  response to defense-related host reactive oxygen species production  neutrophil mediated killing of gram-negative bacterium  chemokine (C-C motif) ligand 5 production  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBInatural killer cell differentiation  protein binding  mitochondrion  phagocytosis  inflammatory response  cell cycle  cell-cell signaling  cell proliferation  interleukin-15 production  negative regulation of interleukin-17 production  positive regulation of interleukin-10 production  cell maturation  regulation of mitochondrial membrane potential  response to defense-related host reactive oxygen species production  neutrophil mediated killing of gram-negative bacterium  chemokine (C-C motif) ligand 5 production  regulation of reactive oxygen species metabolic process  
NDEx NetworkTUSC2
Atlas of Cancer Signalling NetworkTUSC2
Wikipedia pathwaysTUSC2
Orthology - Evolution
OrthoDB11334
GeneTree (enSembl)ENSG00000114383
Phylogenetic Trees/Animal Genes : TreeFamTUSC2
HOVERGENO75896
HOGENOMO75896
Homologs : HomoloGeneTUSC2
Homology/Alignments : Family Browser (UCSC)TUSC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUSC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUSC2
dbVarTUSC2
ClinVarTUSC2
1000_GenomesTUSC2 
Exome Variant ServerTUSC2
ExAC (Exome Aggregation Consortium)TUSC2 (select the gene name)
Genetic variants : HAPMAP11334
Genomic Variants (DGV)TUSC2 [DGVbeta]
DECIPHER (Syndromes)3:50362340-50365669  ENSG00000114383
CONAN: Copy Number AnalysisTUSC2 
Mutations
ICGC Data PortalTUSC2 
TCGA Data PortalTUSC2 
Broad Tumor PortalTUSC2
OASIS PortalTUSC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUSC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTUSC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUSC2
DgiDB (Drug Gene Interaction Database)TUSC2
DoCM (Curated mutations)TUSC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUSC2 (select a term)
intoGenTUSC2
Cancer3DTUSC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607052   
Orphanet
MedgenTUSC2
Genetic Testing Registry TUSC2
NextProtO75896 [Medical]
TSGene11334
GENETestsTUSC2
Huge Navigator TUSC2 [HugePedia]
snp3D : Map Gene to Disease11334
BioCentury BCIQTUSC2
ClinGenTUSC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11334
Chemical/Pharm GKB GenePA134968273
Clinical trialTUSC2
Miscellaneous
canSAR (ICR)TUSC2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTUSC2
EVEXTUSC2
GoPubMedTUSC2
iHOPTUSC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:32:50 CET 2017

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