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TUSC3 (tumor suppressor candidate 3)

Identity

Alias (NCBI)D8S1992
M33
MRT22
MRT7
MagT2
N33
OST3A
SLC58A2
HGNC (Hugo) TUSC3
HGNC Alias symbMGC13453
N33
OST3A
MRT7
MagT2
SLC58A2
HGNC Alias nameoligosaccharyltransferase 3 homolog A (S. cerevisiae)
 Magnesium uptake/transporter TUSC3
HGNC Previous nameMRT22
HGNC Previous namemental retardation, non-syndromic, autosomal recessive, 22
LocusID (NCBI) 7991
Atlas_Id 42732
Location 8p22  [Link to chromosome band 8p22]
Location_base_pair Starts at 15540087 and ends at 15766649 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ARHGEF7 (13q34) / TUSC3 (8p22)FAM160B2 (8p21.3) / TUSC3 (8p22)SCML4 (6q21) / TUSC3 (8p22)
SLC20A2 (8p11.21) / TUSC3 (8p22)TUSC3 (8p22) / LOXL2 (8p21.3)TUSC3 (8p22) / SORBS3 (8p21.3)
SCML4 6q21 / TUSC3 8p22SLC20A2 8p11.21 / TUSC3 8p22TUSC3 8p22 / LOXL2 8p21.3
TUSC3 8p22 / SORBS3 8p21.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TUSC3   30242
Cards
Entrez_Gene (NCBI)TUSC3    tumor suppressor candidate 3
AliasesD8S1992; M33; MRT22; MRT7; 
MagT2; N33; OST3A; SLC58A2
GeneCards (Weizmann)TUSC3
Ensembl hg19 (Hinxton)ENSG00000104723 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104723 [Gene_View]  ENSG00000104723 [Sequence]  chr8:15540087-15766649 [Contig_View]  TUSC3 [Vega]
ICGC DataPortalENSG00000104723
TCGA cBioPortalTUSC3
AceView (NCBI)TUSC3
Genatlas (Paris)TUSC3
SOURCE (Princeton)TUSC3
Genetics Home Reference (NIH)TUSC3
Genomic and cartography
GoldenPath hg38 (UCSC)TUSC3  -     chr8:15540087-15766649 +  8p22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUSC3  -     8p22   [Description]    (hg19-Feb_2009)
GoldenPathTUSC3 - 8p22 [CytoView hg19]  TUSC3 - 8p22 [CytoView hg38]
ImmunoBaseENSG00000104723
Genome Data Viewer NCBITUSC3 [Mapview hg19]  
OMIM601385   611093   
Gene and transcription
Genbank (Entrez)AF028729 AI366810 AK026149 AY530159 AY562998
RefSeq transcript (Entrez)NM_001356429 NM_006765 NM_178234
Consensus coding sequences : CCDS (NCBI)TUSC3
Gene ExpressionTUSC3 [ NCBI-GEO ]   TUSC3 [ EBI - ARRAY_EXPRESS ]   TUSC3 [ SEEK ]   TUSC3 [ MEM ]
Gene Expression Viewer (FireBrowse)TUSC3 [ Firebrowse - Broad ]
GenevisibleExpression of TUSC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7991
GTEX Portal (Tissue expression)TUSC3
Human Protein AtlasENSG00000104723-TUSC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13454   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13454  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13454
PhosPhoSitePlusQ13454
Domains : Interpro (EBI)OligosaccharylTrfase_OST3/OST6    Thioredoxin-like_sf   
Domain families : Pfam (Sanger)OST3_OST6 (PF04756)   
Domain families : Pfam (NCBI)pfam04756   
Conserved Domain (NCBI)TUSC3
PDB (RSDB)4M8G    4M90    4M91    4M92   
PDB Europe4M8G    4M90    4M91    4M92   
PDB (PDBSum)4M8G    4M90    4M91    4M92   
PDB (IMB)4M8G    4M90    4M91    4M92   
Structural Biology KnowledgeBase4M8G    4M90    4M91    4M92   
SCOP (Structural Classification of Proteins)4M8G    4M90    4M91    4M92   
CATH (Classification of proteins structures)4M8G    4M90    4M91    4M92   
SuperfamilyQ13454
AlphaFold pdb e-kbQ13454   
Human Protein Atlas [tissue]ENSG00000104723-TUSC3 [tissue]
HPRD03228
Protein Interaction databases
DIP (DOE-UCLA)Q13454
IntAct (EBI)Q13454
BioGRIDTUSC3
STRING (EMBL)TUSC3
ZODIACTUSC3
Ontologies - Pathways
QuickGOQ13454
Ontology : AmiGOmitochondrion  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  protein N-linked glycosylation  oligosaccharyltransferase complex  oligosaccharyltransferase complex  magnesium ion transmembrane transporter activity  magnesium ion transport  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  viral protein processing  cognition  transmembrane transport  magnesium ion transmembrane transport  
Ontology : EGO-EBImitochondrion  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  protein N-linked glycosylation  oligosaccharyltransferase complex  oligosaccharyltransferase complex  magnesium ion transmembrane transporter activity  magnesium ion transport  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  protein N-linked glycosylation via asparagine  viral protein processing  cognition  transmembrane transport  magnesium ion transmembrane transport  
Pathways : KEGGN-Glycan biosynthesis    Protein processing in endoplasmic reticulum   
NDEx NetworkTUSC3
Atlas of Cancer Signalling NetworkTUSC3
Wikipedia pathwaysTUSC3
Orthology - Evolution
OrthoDB7991
GeneTree (enSembl)ENSG00000104723
Phylogenetic Trees/Animal Genes : TreeFamTUSC3
Homologs : HomoloGeneTUSC3
Homology/Alignments : Family Browser (UCSC)TUSC3
Gene fusions - Rearrangements
Fusion : MitelmanSLC20A2/TUSC3 [8p11.21/8p22]  
Fusion : MitelmanTUSC3/LOXL2 [8p22/8p21.3]  
Fusion : MitelmanTUSC3/SORBS3 [8p22/8p21.3]  
Fusion : QuiverTUSC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUSC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TUSC3
dbVarTUSC3
ClinVarTUSC3
MonarchTUSC3
1000_GenomesTUSC3 
Exome Variant ServerTUSC3
GNOMAD BrowserENSG00000104723
Varsome BrowserTUSC3
ACMGTUSC3 variants
VarityQ13454
Genomic Variants (DGV)TUSC3 [DGVbeta]
DECIPHERTUSC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUSC3 
Mutations
ICGC Data PortalTUSC3 
TCGA Data PortalTUSC3 
Broad Tumor PortalTUSC3
OASIS PortalTUSC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUSC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTUSC3
Mutations and Diseases : HGMDTUSC3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTUSC3
DgiDB (Drug Gene Interaction Database)TUSC3
DoCM (Curated mutations)TUSC3
CIViC (Clinical Interpretations of Variants in Cancer)TUSC3
Cancer3DTUSC3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601385    611093   
Orphanet11804   
DisGeNETTUSC3
MedgenTUSC3
Genetic Testing Registry TUSC3
NextProtQ13454 [Medical]
GENETestsTUSC3
Target ValidationTUSC3
Huge Navigator TUSC3 [HugePedia]
ClinGenTUSC3
Clinical trials, drugs, therapy
MyCancerGenomeTUSC3
Protein Interactions : CTDTUSC3
Pharm GKB GenePA128394537
PharosQ13454
Clinical trialTUSC3
Miscellaneous
canSAR (ICR)TUSC3
HarmonizomeTUSC3
DataMed IndexTUSC3
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTUSC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:53 CEST 2021

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