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TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific)

Identity

Alias (NCBI)PAPD2
RBM21
STARPAP
TENT1
TUTase
URLC6
HGNC (Hugo) TUT1
HGNC Alias symbFLJ22347
FLJ22267
FLJ21850
PAPD2
TUTase
TENT1
HGNC Alias nameRNA uridylyltransferase
 U6 TUTase
 TUTase 6
HGNC Previous nameRBM21
HGNC Previous nameRNA binding motif protein 21
LocusID (NCBI) 64852
Atlas_Id 55133
Location 11q12.3  [Link to chromosome band 11q12]
Location_base_pair Starts at 62575052 and ends at 62591523 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TUT1 (11q12.3) / BSCL2 (11q12.3)TUT1 (11q12.3) / SZT2 (1p34.2)TUT1 11q12.3 / BSCL2 11q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TUT1/BSCL2 (11q12)

External links

Nomenclature
HGNC (Hugo)TUT1   26184
Cards
Entrez_Gene (NCBI)TUT1    terminal uridylyl transferase 1, U6 snRNA-specific
AliasesPAPD2; RBM21; STARPAP; TENT1; 
TUTase; URLC6
GeneCards (Weizmann)TUT1
Ensembl hg19 (Hinxton)ENSG00000149016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149016 [Gene_View]  ENSG00000149016 [Sequence]  chr11:62575052-62591523 [Contig_View]  TUT1 [Vega]
ICGC DataPortalENSG00000149016
TCGA cBioPortalTUT1
AceView (NCBI)TUT1
Genatlas (Paris)TUT1
SOURCE (Princeton)TUT1
Genetics Home Reference (NIH)TUT1
Genomic and cartography
GoldenPath hg38 (UCSC)TUT1  -     chr11:62575052-62591523 -  11q12.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TUT1  -     11q12.3   [Description]    (hg19-Feb_2009)
GoldenPathTUT1 - 11q12.3 [CytoView hg19]  TUT1 - 11q12.3 [CytoView hg38]
ImmunoBaseENSG00000149016
genome Data Viewer NCBITUT1 [Mapview hg19]  
OMIM610641   
Gene and transcription
Genbank (Entrez)AB101208 AK025920 AK026000 AK292610 BC005013
RefSeq transcript (Entrez)NM_001367906 NM_022830
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TUT1
Alternative Splicing GalleryENSG00000149016
Gene ExpressionTUT1 [ NCBI-GEO ]   TUT1 [ EBI - ARRAY_EXPRESS ]   TUT1 [ SEEK ]   TUT1 [ MEM ]
Gene Expression Viewer (FireBrowse)TUT1 [ Firebrowse - Broad ]
GenevisibleExpression of TUT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64852
GTEX Portal (Tissue expression)TUT1
Human Protein AtlasENSG00000149016-TUT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H6E5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H6E5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H6E5
Splice isoforms : SwissVarQ9H6E5
PhosPhoSitePlusQ9H6E5
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    PAP_assoc    RBD_domain_sf    RRM_dom    Star-PAP    Star-PAP_RRM    Znf_C2H2_sf   
Domain families : Pfam (Sanger)PAP_assoc (PF03828)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam03828    pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)TUT1
Blocks (Seattle)TUT1
PDB (RSDB)2E5G    5WU1    5WU2    5WU3    5WU4    5WU5    5WU6   
PDB Europe2E5G    5WU1    5WU2    5WU3    5WU4    5WU5    5WU6   
PDB (PDBSum)2E5G    5WU1    5WU2    5WU3    5WU4    5WU5    5WU6   
PDB (IMB)2E5G    5WU1    5WU2    5WU3    5WU4    5WU5    5WU6   
Structural Biology KnowledgeBase2E5G    5WU1    5WU2    5WU3    5WU4    5WU5    5WU6   
SCOP (Structural Classification of Proteins)2E5G    5WU1    5WU2    5WU3    5WU4    5WU5    5WU6   
CATH (Classification of proteins structures)2E5G    5WU1    5WU2    5WU3    5WU4    5WU5    5WU6   
SuperfamilyQ9H6E5
Human Protein Atlas [tissue]ENSG00000149016-TUT1 [tissue]
Peptide AtlasQ9H6E5
HPRD15226
IPIIPI01012096   IPI00946813   IPI00946648   IPI00010212   
Protein Interaction databases
DIP (DOE-UCLA)Q9H6E5
IntAct (EBI)Q9H6E5
BioGRIDTUT1
STRING (EMBL)TUT1
ZODIACTUT1
Ontologies - Pathways
QuickGOQ9H6E5
Ontology : AmiGORNA binding  mRNA 3'-UTR binding  polynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  mRNA cleavage and polyadenylation specificity factor complex  mRNA polyadenylation  mRNA polyadenylation  mRNA polyadenylation  mRNA processing  snRNA processing  nuclear speck  nucleotidyltransferase activity  U6 snRNA binding  enzyme binding  U6 snRNA 3'-end processing  metal ion binding  RNA uridylyltransferase activity  histone mRNA catabolic process  pre-mRNA cleavage required for polyadenylation  
Ontology : EGO-EBIRNA binding  mRNA 3'-UTR binding  polynucleotide adenylyltransferase activity  polynucleotide adenylyltransferase activity  protein binding  ATP binding  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  mRNA cleavage and polyadenylation specificity factor complex  mRNA polyadenylation  mRNA polyadenylation  mRNA polyadenylation  mRNA processing  snRNA processing  nuclear speck  nucleotidyltransferase activity  U6 snRNA binding  enzyme binding  U6 snRNA 3'-end processing  metal ion binding  RNA uridylyltransferase activity  histone mRNA catabolic process  pre-mRNA cleavage required for polyadenylation  
NDEx NetworkTUT1
Atlas of Cancer Signalling NetworkTUT1
Wikipedia pathwaysTUT1
Orthology - Evolution
OrthoDB64852
GeneTree (enSembl)ENSG00000149016
Phylogenetic Trees/Animal Genes : TreeFamTUT1
HOGENOMQ9H6E5
Homologs : HomoloGeneTUT1
Homology/Alignments : Family Browser (UCSC)TUT1
Gene fusions - Rearrangements
Fusion : MitelmanTUT1/BSCL2 [11q12.3/11q12.3]  
Fusion PortalTUT1 11q12.3 BSCL2 11q12.3 BRCA
Fusion : QuiverTUT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTUT1 [hg38]
dbVarTUT1
ClinVarTUT1
MonarchTUT1
1000_GenomesTUT1 
Exome Variant ServerTUT1
GNOMAD BrowserENSG00000149016
Varsome BrowserTUT1
Genomic Variants (DGV)TUT1 [DGVbeta]
DECIPHERTUT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTUT1 
Mutations
ICGC Data PortalTUT1 
TCGA Data PortalTUT1 
Broad Tumor PortalTUT1
OASIS PortalTUT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTUT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTUT1
Mutations and Diseases : HGMDTUT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TUT1
DgiDB (Drug Gene Interaction Database)TUT1
DoCM (Curated mutations)TUT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TUT1 (select a term)
intoGenTUT1
Cancer3DTUT1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610641   
Orphanet
DisGeNETTUT1
MedgenTUT1
Genetic Testing Registry TUT1
NextProtQ9H6E5 [Medical]
GENETestsTUT1
Target ValidationTUT1
Huge Navigator TUT1 [HugePedia]
ClinGenTUT1
Clinical trials, drugs, therapy
MyCancerGenomeTUT1
Protein Interactions : CTD
Pharm GKB GenePA162407405
PharosQ9H6E5
Clinical trialTUT1
Miscellaneous
canSAR (ICR)TUT1 (select the gene name)
HarmonizomeTUT1
DataMed IndexTUT1
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTUT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jan 1 18:42:56 CET 2021
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