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TWF2 (twinfilin actin binding protein 2)

Identity

Alias_namesPTK9L
protein tyrosine kinase 9-like (A6-related protein)
PTK9L protein tyrosine kinase 9-like (A6-related protein)
twinfilin, actin-binding protein, homolog 2 (Drosophila)
Alias_symbol (synonym)A6RP
A6r
Other aliasMSTP011
HGNC (Hugo) TWF2
LocusID (NCBI) 11344
Atlas_Id 43439
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 52262626 and ends at 52273183 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
TWF2 (3p21.2) / FSTL4 (5q31.1)TWF2 3p21.2 / FSTL4 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TWF2   9621
Cards
Entrez_Gene (NCBI)TWF2  11344  twinfilin actin binding protein 2
AliasesA6RP; A6r; MSTP011; PTK9L
GeneCards (Weizmann)TWF2
Ensembl hg19 (Hinxton)ENSG00000247596 [Gene_View]  chr3:52262626-52273183 [Contig_View]  TWF2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000247596 [Gene_View]  chr3:52262626-52273183 [Contig_View]  TWF2 [Vega]
ICGC DataPortalENSG00000247596
TCGA cBioPortalTWF2
AceView (NCBI)TWF2
Genatlas (Paris)TWF2
WikiGenes11344
SOURCE (Princeton)TWF2
Genetics Home Reference (NIH)TWF2
Genomic and cartography
GoldenPath hg19 (UCSC)TWF2  -     chr3:52262626-52273183 -  3p21.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TWF2  -     3p21.2   [Description]    (hg38-Dec_2013)
EnsemblTWF2 - 3p21.2 [CytoView hg19]  TWF2 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBITWF2 [Mapview hg19]  TWF2 [Mapview hg38]
OMIM607433   
Gene and transcription
Genbank (Entrez)AF109365 AL136773 BC000327 BC003161 BC016452
RefSeq transcript (Entrez)NM_007284
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)TWF2
Cluster EST : UnigeneHs.436439 [ NCBI ]
CGAP (NCI)Hs.436439
Alternative Splicing GalleryENSG00000247596
Gene ExpressionTWF2 [ NCBI-GEO ]   TWF2 [ EBI - ARRAY_EXPRESS ]   TWF2 [ SEEK ]   TWF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TWF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11344
GTEX Portal (Tissue expression)TWF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IBS0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IBS0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IBS0
Splice isoforms : SwissVarQ6IBS0
PhosPhoSitePlusQ6IBS0
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom    Twinfilin   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
Conserved Domain (NCBI)TWF2
DMDM Disease mutations11344
Blocks (Seattle)TWF2
PDB (SRS)2VAC    2W0I   
PDB (PDBSum)2VAC    2W0I   
PDB (IMB)2VAC    2W0I   
PDB (RSDB)2VAC    2W0I   
Structural Biology KnowledgeBase2VAC    2W0I   
SCOP (Structural Classification of Proteins)2VAC    2W0I   
CATH (Classification of proteins structures)2VAC    2W0I   
SuperfamilyQ6IBS0
Human Protein AtlasENSG00000247596
Peptide AtlasQ6IBS0
HPRD08464
IPIIPI00550917   IPI00966182   
Protein Interaction databases
DIP (DOE-UCLA)Q6IBS0
IntAct (EBI)Q6IBS0
FunCoupENSG00000247596
BioGRIDTWF2
STRING (EMBL)TWF2
ZODIACTWF2
Ontologies - Pathways
QuickGOQ6IBS0
Ontology : AmiGOactin monomer binding  protein kinase C binding  protein binding  ATP binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytoskeleton  positive regulation of lamellipodium assembly  positive regulation of neuron projection development  myofibril  lamellipodium  cell projection organization  filopodium  growth cone  negative regulation of actin filament polymerization  stereocilium  regulation of microvillus length  regulation of actin cytoskeleton organization  sequestering of actin monomers  poly(A) RNA binding  positive regulation of axon extension  perinuclear region of cytoplasm  barbed-end actin filament capping  extracellular exosome  cellular response to retinoic acid  cellular response to growth factor stimulus  
Ontology : EGO-EBIactin monomer binding  protein kinase C binding  protein binding  ATP binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytoskeleton  positive regulation of lamellipodium assembly  positive regulation of neuron projection development  myofibril  lamellipodium  cell projection organization  filopodium  growth cone  negative regulation of actin filament polymerization  stereocilium  regulation of microvillus length  regulation of actin cytoskeleton organization  sequestering of actin monomers  poly(A) RNA binding  positive regulation of axon extension  perinuclear region of cytoplasm  barbed-end actin filament capping  extracellular exosome  cellular response to retinoic acid  cellular response to growth factor stimulus  
NDEx NetworkTWF2
Atlas of Cancer Signalling NetworkTWF2
Wikipedia pathwaysTWF2
Orthology - Evolution
OrthoDB11344
GeneTree (enSembl)ENSG00000247596
Phylogenetic Trees/Animal Genes : TreeFamTWF2
HOVERGENQ6IBS0
HOGENOMQ6IBS0
Homologs : HomoloGeneTWF2
Homology/Alignments : Family Browser (UCSC)TWF2
Gene fusions - Rearrangements
Fusion : MitelmanTWF2/FSTL4 [3p21.2/5q31.1]  
Fusion: TCGATWF2 3p21.2 FSTL4 5q31.1 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTWF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TWF2
dbVarTWF2
ClinVarTWF2
1000_GenomesTWF2 
Exome Variant ServerTWF2
ExAC (Exome Aggregation Consortium)TWF2 (select the gene name)
Genetic variants : HAPMAP11344
Genomic Variants (DGV)TWF2 [DGVbeta]
DECIPHER (Syndromes)3:52262626-52273183  ENSG00000247596
CONAN: Copy Number AnalysisTWF2 
Mutations
ICGC Data PortalTWF2 
TCGA Data PortalTWF2 
Broad Tumor PortalTWF2
OASIS PortalTWF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTWF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTWF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TWF2
DgiDB (Drug Gene Interaction Database)TWF2
DoCM (Curated mutations)TWF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TWF2 (select a term)
intoGenTWF2
Cancer3DTWF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607433   
Orphanet
MedgenTWF2
Genetic Testing Registry TWF2
NextProtQ6IBS0 [Medical]
TSGene11344
GENETestsTWF2
Huge Navigator TWF2 [HugePedia]
snp3D : Map Gene to Disease11344
BioCentury BCIQTWF2
ClinGenTWF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11344
Chemical/Pharm GKB GenePA162407429
Clinical trialTWF2
Miscellaneous
canSAR (ICR)TWF2 (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTWF2
EVEXTWF2
GoPubMedTWF2
iHOPTWF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:23:54 CEST 2017

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