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TWF2 (twinfilin actin binding protein 2)

Identity

Alias (NCBI)A6RP
A6r
MSTP011
PTK9L
HGNC (Hugo) TWF2
HGNC Alias symbA6RP
A6r
HGNC Previous namePTK9L
HGNC Previous nameprotein tyrosine kinase 9-like (A6-related protein)
 PTK9L protein tyrosine kinase 9-like (A6-related protein)
 twinfilin, actin-binding protein, homolog 2 (Drosophila)
LocusID (NCBI) 11344
Atlas_Id 43439
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 52228612 and ends at 52239158 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TWF2 (3p21.2) / FSTL4 (5q31.1)TWF2 3p21.2 / FSTL4 5q31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TWF2   9621
Cards
Entrez_Gene (NCBI)TWF2    twinfilin actin binding protein 2
AliasesA6RP; A6r; MSTP011; PTK9L
GeneCards (Weizmann)TWF2
Ensembl hg19 (Hinxton)ENSG00000247596 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000247596 [Gene_View]  ENSG00000247596 [Sequence]  chr3:52228612-52239158 [Contig_View]  TWF2 [Vega]
ICGC DataPortalENSG00000247596
TCGA cBioPortalTWF2
AceView (NCBI)TWF2
Genatlas (Paris)TWF2
SOURCE (Princeton)TWF2
Genetics Home Reference (NIH)TWF2
Genomic and cartography
GoldenPath hg38 (UCSC)TWF2  -     chr3:52228612-52239158 -  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TWF2  -     3p21.2   [Description]    (hg19-Feb_2009)
GoldenPathTWF2 - 3p21.2 [CytoView hg19]  TWF2 - 3p21.2 [CytoView hg38]
ImmunoBaseENSG00000247596
Genome Data Viewer NCBITWF2 [Mapview hg19]  
OMIM607433   
Gene and transcription
Genbank (Entrez)AF109365 AL136773 BC000327 BC003161 BC016452
RefSeq transcript (Entrez)NM_007284
Consensus coding sequences : CCDS (NCBI)TWF2
Gene ExpressionTWF2 [ NCBI-GEO ]   TWF2 [ EBI - ARRAY_EXPRESS ]   TWF2 [ SEEK ]   TWF2 [ MEM ]
Gene Expression Viewer (FireBrowse)TWF2 [ Firebrowse - Broad ]
GenevisibleExpression of TWF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11344
GTEX Portal (Tissue expression)TWF2
Human Protein AtlasENSG00000247596-TWF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IBS0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IBS0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IBS0
PhosPhoSitePlusQ6IBS0
Domaine pattern : Prosite (Expaxy)ADF_H (PS51263)   
Domains : Interpro (EBI)ADF-H    ADF-H/Gelsolin-like_dom_sf    Twinfilin   
Domain families : Pfam (Sanger)Cofilin_ADF (PF00241)   
Domain families : Pfam (NCBI)pfam00241   
Domain families : Smart (EMBL)ADF (SM00102)  
Conserved Domain (NCBI)TWF2
PDB (RSDB)2VAC    2W0I   
PDB Europe2VAC    2W0I   
PDB (PDBSum)2VAC    2W0I   
PDB (IMB)2VAC    2W0I   
Structural Biology KnowledgeBase2VAC    2W0I   
SCOP (Structural Classification of Proteins)2VAC    2W0I   
CATH (Classification of proteins structures)2VAC    2W0I   
SuperfamilyQ6IBS0
AlphaFold pdb e-kbQ6IBS0   
Human Protein Atlas [tissue]ENSG00000247596-TWF2 [tissue]
HPRD08464
Protein Interaction databases
DIP (DOE-UCLA)Q6IBS0
IntAct (EBI)Q6IBS0
BioGRIDTWF2
STRING (EMBL)TWF2
ZODIACTWF2
Ontologies - Pathways
QuickGOQ6IBS0
Ontology : AmiGORNA binding  actin monomer binding  actin monomer binding  protein kinase C binding  protein binding  ATP binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytoplasm  cytoplasm  actin filament  regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  positive regulation of neuron projection development  positive regulation of neuron projection development  myofibril  myofibril  lamellipodium  cell projection organization  actin filament depolymerization  filopodium  growth cone  negative regulation of actin filament polymerization  stereocilium  regulation of microvillus length  regulation of actin cytoskeleton organization  sequestering of actin monomers  sequestering of actin monomers  cadherin binding  positive regulation of axon extension  perinuclear region of cytoplasm  actin filament binding  barbed-end actin filament capping  barbed-end actin filament capping  extracellular exosome  cellular response to retinoic acid  cellular response to growth factor stimulus  
Ontology : EGO-EBIRNA binding  actin monomer binding  actin monomer binding  protein kinase C binding  protein binding  ATP binding  phosphatidylinositol-4,5-bisphosphate binding  cytoplasm  cytoplasm  cytoplasm  actin filament  regulation of lamellipodium assembly  positive regulation of lamellipodium assembly  positive regulation of neuron projection development  positive regulation of neuron projection development  myofibril  myofibril  lamellipodium  cell projection organization  actin filament depolymerization  filopodium  growth cone  negative regulation of actin filament polymerization  stereocilium  regulation of microvillus length  regulation of actin cytoskeleton organization  sequestering of actin monomers  sequestering of actin monomers  cadherin binding  positive regulation of axon extension  perinuclear region of cytoplasm  actin filament binding  barbed-end actin filament capping  barbed-end actin filament capping  extracellular exosome  cellular response to retinoic acid  cellular response to growth factor stimulus  
NDEx NetworkTWF2
Atlas of Cancer Signalling NetworkTWF2
Wikipedia pathwaysTWF2
Orthology - Evolution
OrthoDB11344
GeneTree (enSembl)ENSG00000247596
Phylogenetic Trees/Animal Genes : TreeFamTWF2
Homologs : HomoloGeneTWF2
Homology/Alignments : Family Browser (UCSC)TWF2
Gene fusions - Rearrangements
Fusion : MitelmanTWF2/FSTL4 [3p21.2/5q31.1]  
Fusion : QuiverTWF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTWF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TWF2
dbVarTWF2
ClinVarTWF2
MonarchTWF2
1000_GenomesTWF2 
Exome Variant ServerTWF2
GNOMAD BrowserENSG00000247596
Varsome BrowserTWF2
ACMGTWF2 variants
VarityQ6IBS0
Genomic Variants (DGV)TWF2 [DGVbeta]
DECIPHERTWF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTWF2 
Mutations
ICGC Data PortalTWF2 
TCGA Data PortalTWF2 
Broad Tumor PortalTWF2
OASIS PortalTWF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTWF2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTWF2
Mutations and Diseases : HGMDTWF2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTWF2
DgiDB (Drug Gene Interaction Database)TWF2
DoCM (Curated mutations)TWF2
CIViC (Clinical Interpretations of Variants in Cancer)TWF2
Cancer3DTWF2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607433   
Orphanet
DisGeNETTWF2
MedgenTWF2
Genetic Testing Registry TWF2
NextProtQ6IBS0 [Medical]
GENETestsTWF2
Target ValidationTWF2
Huge Navigator TWF2 [HugePedia]
ClinGenTWF2
Clinical trials, drugs, therapy
MyCancerGenomeTWF2
Protein Interactions : CTDTWF2
Pharm GKB GenePA162407429
PharosQ6IBS0
Clinical trialTWF2
Miscellaneous
canSAR (ICR)TWF2
HarmonizomeTWF2
DataMed IndexTWF2
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTWF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:36:54 CEST 2021

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