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TWSG1 (twisted gastrulation BMP signaling modulator 1)

Identity

Alias (NCBI)TSG
HGNC (Hugo) TWSG1
HGNC Alias symbTSG
HGNC Previous nametwisted gastrulation homolog 1 (Drosophila)
LocusID (NCBI) 57045
Atlas_Id 54739
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 9334773 and ends at 9402420 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
RALBP1 (18p11.22) / TWSG1 (18p11.22)RBM17 (10p15.1) / TWSG1 (18p11.22)SERINC3 (20q13.12) / TWSG1 (18p11.22)
TWSG1 (18p11.22) / PIK3C3 (18q12.3)RALBP1 18p11.22 / TWSG1 18p11.22RBM17 10p15.1 / TWSG1 18p11.22
SERINC3 20q13.12 / TWSG1 18p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TWSG1   12429
Cards
Entrez_Gene (NCBI)TWSG1    twisted gastrulation BMP signaling modulator 1
AliasesTSG
GeneCards (Weizmann)TWSG1
Ensembl hg19 (Hinxton)ENSG00000128791 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128791 [Gene_View]  ENSG00000128791 [Sequence]  chr18:9334773-9402420 [Contig_View]  TWSG1 [Vega]
ICGC DataPortalENSG00000128791
TCGA cBioPortalTWSG1
AceView (NCBI)TWSG1
Genatlas (Paris)TWSG1
SOURCE (Princeton)TWSG1
Genetics Home Reference (NIH)TWSG1
Genomic and cartography
GoldenPath hg38 (UCSC)TWSG1  -     chr18:9334773-9402420 +  18p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TWSG1  -     18p11.22   [Description]    (hg19-Feb_2009)
GoldenPathTWSG1 - 18p11.22 [CytoView hg19]  TWSG1 - 18p11.22 [CytoView hg38]
ImmunoBaseENSG00000128791
Genome Data Viewer NCBITWSG1 [Mapview hg19]  
OMIM605049   
Gene and transcription
Genbank (Entrez)AF196834 AF294628 AI742025 AJ297391 AK027629
RefSeq transcript (Entrez)NM_020648
Consensus coding sequences : CCDS (NCBI)TWSG1
Gene ExpressionTWSG1 [ NCBI-GEO ]   TWSG1 [ EBI - ARRAY_EXPRESS ]   TWSG1 [ SEEK ]   TWSG1 [ MEM ]
Gene Expression Viewer (FireBrowse)TWSG1 [ Firebrowse - Broad ]
GenevisibleExpression of TWSG1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57045
GTEX Portal (Tissue expression)TWSG1
Human Protein AtlasENSG00000128791-TWSG1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZX9
PhosPhoSitePlusQ9GZX9
Domains : Interpro (EBI)Tsg   
Domain families : Pfam (Sanger)Tsg (PF04668)   
Domain families : Pfam (NCBI)pfam04668   
Conserved Domain (NCBI)TWSG1
SuperfamilyQ9GZX9
AlphaFold pdb e-kbQ9GZX9   
Human Protein Atlas [tissue]ENSG00000128791-TWSG1 [tissue]
HPRD05443
Protein Interaction databases
DIP (DOE-UCLA)Q9GZX9
IntAct (EBI)Q9GZX9
BioGRIDTWSG1
STRING (EMBL)TWSG1
ZODIACTWSG1
Ontologies - Pathways
QuickGOQ9GZX9
Ontology : AmiGOossification  mesoderm formation  negative regulation of cytokine production  protein binding  extracellular space  transforming growth factor beta receptor signaling pathway  salivary gland morphogenesis  positive regulation of pathway-restricted SMAD protein phosphorylation  hemopoiesis  cell differentiation  BMP signaling pathway  regulation of BMP signaling pathway  positive regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  forebrain development  camera-type eye development  negative regulation of osteoblast differentiation  transforming growth factor beta binding  negative regulation of CD4-positive, alpha-beta T cell activation  negative regulation of CD4-positive, alpha-beta T cell proliferation  
Ontology : EGO-EBIossification  mesoderm formation  negative regulation of cytokine production  protein binding  extracellular space  transforming growth factor beta receptor signaling pathway  salivary gland morphogenesis  positive regulation of pathway-restricted SMAD protein phosphorylation  hemopoiesis  cell differentiation  BMP signaling pathway  regulation of BMP signaling pathway  positive regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  forebrain development  camera-type eye development  negative regulation of osteoblast differentiation  transforming growth factor beta binding  negative regulation of CD4-positive, alpha-beta T cell activation  negative regulation of CD4-positive, alpha-beta T cell proliferation  
NDEx NetworkTWSG1
Atlas of Cancer Signalling NetworkTWSG1
Wikipedia pathwaysTWSG1
Orthology - Evolution
OrthoDB57045
GeneTree (enSembl)ENSG00000128791
Phylogenetic Trees/Animal Genes : TreeFamTWSG1
Homologs : HomoloGeneTWSG1
Homology/Alignments : Family Browser (UCSC)TWSG1
Gene fusions - Rearrangements
Fusion : MitelmanRALBP1/TWSG1 [18p11.22/18p11.22]  
Fusion : MitelmanRBM17/TWSG1 [10p15.1/18p11.22]  
Fusion : MitelmanSERINC3/TWSG1 [20q13.12/18p11.22]  
Fusion : MitelmanTWSG1/PIK3C3 [18p11.22/18q12.3]  
Fusion : QuiverTWSG1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTWSG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TWSG1
dbVarTWSG1
ClinVarTWSG1
MonarchTWSG1
1000_GenomesTWSG1 
Exome Variant ServerTWSG1
GNOMAD BrowserENSG00000128791
Varsome BrowserTWSG1
ACMGTWSG1 variants
VarityQ9GZX9
Genomic Variants (DGV)TWSG1 [DGVbeta]
DECIPHERTWSG1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTWSG1 
Mutations
ICGC Data PortalTWSG1 
TCGA Data PortalTWSG1 
Broad Tumor PortalTWSG1
OASIS PortalTWSG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTWSG1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTWSG1
Mutations and Diseases : HGMDTWSG1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTWSG1
DgiDB (Drug Gene Interaction Database)TWSG1
DoCM (Curated mutations)TWSG1
CIViC (Clinical Interpretations of Variants in Cancer)TWSG1
Cancer3DTWSG1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605049   
Orphanet
DisGeNETTWSG1
MedgenTWSG1
Genetic Testing Registry TWSG1
NextProtQ9GZX9 [Medical]
GENETestsTWSG1
Target ValidationTWSG1
Huge Navigator TWSG1 [HugePedia]
ClinGenTWSG1
Clinical trials, drugs, therapy
MyCancerGenomeTWSG1
Protein Interactions : CTDTWSG1
Pharm GKB GenePA37089
PharosQ9GZX9
Clinical trialTWSG1
Miscellaneous
canSAR (ICR)TWSG1
HarmonizomeTWSG1
DataMed IndexTWSG1
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTWSG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:55 CEST 2021

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