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TWSG1 (twisted gastrulation BMP signaling modulator 1)

Identity

Alias_namestwisted gastrulation homolog 1 (Drosophila)
Alias_symbol (synonym)TSG
Other alias
HGNC (Hugo) TWSG1
LocusID (NCBI) 57045
Atlas_Id 54739
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 9334765 and ends at 9402418 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RALBP1 (18p11.22) / TWSG1 (18p11.22)RBM17 (10p15.1) / TWSG1 (18p11.22)SERINC3 (20q13.12) / TWSG1 (18p11.22)
TWSG1 (18p11.22) / PIK3C3 (18q12.3)RALBP1 18p11.22 / TWSG1 18p11.22RBM17 10p15.1 / TWSG1 18p11.22
SERINC3 20q13.12 / TWSG1 18p11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TWSG1   12429
Cards
Entrez_Gene (NCBI)TWSG1  57045  twisted gastrulation BMP signaling modulator 1
AliasesTSG
GeneCards (Weizmann)TWSG1
Ensembl hg19 (Hinxton)ENSG00000128791 [Gene_View]  chr18:9334765-9402418 [Contig_View]  TWSG1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000128791 [Gene_View]  chr18:9334765-9402418 [Contig_View]  TWSG1 [Vega]
ICGC DataPortalENSG00000128791
TCGA cBioPortalTWSG1
AceView (NCBI)TWSG1
Genatlas (Paris)TWSG1
WikiGenes57045
SOURCE (Princeton)TWSG1
Genetics Home Reference (NIH)TWSG1
Genomic and cartography
GoldenPath hg19 (UCSC)TWSG1  -     chr18:9334765-9402418 +  18p11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TWSG1  -     18p11.22   [Description]    (hg38-Dec_2013)
EnsemblTWSG1 - 18p11.22 [CytoView hg19]  TWSG1 - 18p11.22 [CytoView hg38]
Mapping of homologs : NCBITWSG1 [Mapview hg19]  TWSG1 [Mapview hg38]
OMIM605049   
Gene and transcription
Genbank (Entrez)AF196834 AF294628 AI742025 AJ297391 AK027629
RefSeq transcript (Entrez)NM_020648
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010859 NW_004929409
Consensus coding sequences : CCDS (NCBI)TWSG1
Cluster EST : UnigeneHs.514685 [ NCBI ]
CGAP (NCI)Hs.514685
Alternative Splicing GalleryENSG00000128791
Gene ExpressionTWSG1 [ NCBI-GEO ]   TWSG1 [ EBI - ARRAY_EXPRESS ]   TWSG1 [ SEEK ]   TWSG1 [ MEM ]
Gene Expression Viewer (FireBrowse)TWSG1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57045
GTEX Portal (Tissue expression)TWSG1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9GZX9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9GZX9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9GZX9
Splice isoforms : SwissVarQ9GZX9
PhosPhoSitePlusQ9GZX9
Domains : Interpro (EBI)Tsg   
Domain families : Pfam (Sanger)Tsg (PF04668)   
Domain families : Pfam (NCBI)pfam04668   
Conserved Domain (NCBI)TWSG1
DMDM Disease mutations57045
Blocks (Seattle)TWSG1
SuperfamilyQ9GZX9
Human Protein AtlasENSG00000128791
Peptide AtlasQ9GZX9
HPRD05443
IPIIPI00410487   IPI00830092   
Protein Interaction databases
DIP (DOE-UCLA)Q9GZX9
IntAct (EBI)Q9GZX9
FunCoupENSG00000128791
BioGRIDTWSG1
STRING (EMBL)TWSG1
ZODIACTWSG1
Ontologies - Pathways
QuickGOQ9GZX9
Ontology : AmiGOossification  mesoderm formation  protein binding  extracellular space  salivary gland morphogenesis  hemopoiesis  cell differentiation  BMP signaling pathway  positive regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  forebrain development  camera-type eye development  negative regulation of osteoblast differentiation  extracellular exosome  
Ontology : EGO-EBIossification  mesoderm formation  protein binding  extracellular space  salivary gland morphogenesis  hemopoiesis  cell differentiation  BMP signaling pathway  positive regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  forebrain development  camera-type eye development  negative regulation of osteoblast differentiation  extracellular exosome  
NDEx NetworkTWSG1
Atlas of Cancer Signalling NetworkTWSG1
Wikipedia pathwaysTWSG1
Orthology - Evolution
OrthoDB57045
GeneTree (enSembl)ENSG00000128791
Phylogenetic Trees/Animal Genes : TreeFamTWSG1
HOVERGENQ9GZX9
HOGENOMQ9GZX9
Homologs : HomoloGeneTWSG1
Homology/Alignments : Family Browser (UCSC)TWSG1
Gene fusions - Rearrangements
Fusion : MitelmanRALBP1/TWSG1 [18p11.22/18p11.22]  [t(18;18)(p11;p11)]  
Fusion : MitelmanRBM17/TWSG1 [10p15.1/18p11.22]  [t(10;18)(p15;p11)]  
Fusion : MitelmanSERINC3/TWSG1 [20q13.12/18p11.22]  [t(18;20)(p11;q13)]  
Fusion : MitelmanTWSG1/PIK3C3 [18p11.22/18q12.3]  [t(18;18)(p11;q12)]  
Fusion: TCGARALBP1 18p11.22 TWSG1 18p11.22 BRCA
Fusion: TCGARBM17 10p15.1 TWSG1 18p11.22 LUAD
Fusion: TCGASERINC3 20q13.12 TWSG1 18p11.22 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTWSG1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TWSG1
dbVarTWSG1
ClinVarTWSG1
1000_GenomesTWSG1 
Exome Variant ServerTWSG1
ExAC (Exome Aggregation Consortium)TWSG1 (select the gene name)
Genetic variants : HAPMAP57045
Genomic Variants (DGV)TWSG1 [DGVbeta]
DECIPHER (Syndromes)18:9334765-9402418  ENSG00000128791
CONAN: Copy Number AnalysisTWSG1 
Mutations
ICGC Data PortalTWSG1 
TCGA Data PortalTWSG1 
Broad Tumor PortalTWSG1
OASIS PortalTWSG1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTWSG1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTWSG1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TWSG1
DgiDB (Drug Gene Interaction Database)TWSG1
DoCM (Curated mutations)TWSG1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TWSG1 (select a term)
intoGenTWSG1
Cancer3DTWSG1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605049   
Orphanet
MedgenTWSG1
Genetic Testing Registry TWSG1
NextProtQ9GZX9 [Medical]
TSGene57045
GENETestsTWSG1
Huge Navigator TWSG1 [HugePedia]
snp3D : Map Gene to Disease57045
BioCentury BCIQTWSG1
ClinGenTWSG1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57045
Chemical/Pharm GKB GenePA37089
Clinical trialTWSG1
Miscellaneous
canSAR (ICR)TWSG1 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTWSG1
EVEXTWSG1
GoPubMedTWSG1
iHOPTWSG1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:23:54 CEST 2017

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