Atlas of Genetics and Cytogenetics in Oncology and Haematology


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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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TXK (TXK tyrosine kinase)

Identity

Other namesBTKL
PSCTK5
PTK4
RLK
TKL
HGNC (Hugo) TXK
LocusID (NCBI) 7294
Location 4p12
Location_base_pair Starts at 48068410 and ends at 48136273 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TXK   12434
Cards
Entrez_Gene (NCBI)TXK  7294  TXK tyrosine kinase
GeneCards (Weizmann)TXK
Ensembl hg19 (Hinxton)ENSG00000074966 [Gene_View]  chr4:48068410-48136273 [Contig_View]  TXK [Vega]
Ensembl hg38 (Hinxton)ENSG00000074966 [Gene_View]  chr4:48068410-48136273 [Contig_View]  TXK [Vega]
ICGC DataPortalENSG00000074966
cBioPortalTXK
AceView (NCBI)TXK
Genatlas (Paris)TXK
WikiGenes7294
SOURCE (Princeton)TXK
Genomic and cartography
GoldenPath hg19 (UCSC)TXK  -     chr4:48068410-48136273 -  4p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TXK  -     4p12   [Description]    (hg38-Dec_2013)
EnsemblTXK - 4p12 [CytoView hg19]  TXK - 4p12 [CytoView hg38]
Mapping of homologs : NCBITXK [Mapview hg19]  TXK [Mapview hg38]
OMIM600058   
Gene and transcription
Genbank (Entrez)AK300141 AK307055 BC017829 BC166632 DB103575
RefSeq transcript (Entrez)NM_003328
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006238 NW_004929317
Consensus coding sequences : CCDS (NCBI)TXK
Cluster EST : UnigeneHs.479669 [ NCBI ]
CGAP (NCI)Hs.479669
Alternative Splicing : Fast-db (Paris)GSHG0023239
Alternative Splicing GalleryENSG00000074966
Gene ExpressionTXK [ NCBI-GEO ]     TXK [ SEEK ]   TXK [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42681 (Uniprot)
NextProtP42681  [Medical]
With graphics : InterProP42681
Splice isoforms : SwissVarP42681 (Swissvar)
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Related proteins : CluSTrP42681
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
DMDM Disease mutations7294
Blocks (Seattle)P42681
PDB (SRS)2DM0   
PDB (PDBSum)2DM0   
PDB (IMB)2DM0   
PDB (RSDB)2DM0   
Human Protein AtlasENSG00000074966
Peptide AtlasP42681
HPRD02505
IPIIPI00000879   IPI00967614   IPI00967315   IPI00967008   IPI00967623   
Protein Interaction databases
DIP (DOE-UCLA)P42681
IntAct (EBI)P42681
FunCoupENSG00000074966
BioGRIDTXK
IntegromeDBTXK
STRING (EMBL)TXK
Ontologies - Pathways
QuickGOP42681
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II regulatory region DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  cytokine production  NK T cell differentiation  adaptive immune response  adaptive immune response  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of phospholipase C activity  T cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  interferon-gamma production  interleukin-4 production  positive regulation of interferon-gamma production  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II regulatory region DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  cytokine production  NK T cell differentiation  adaptive immune response  adaptive immune response  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  nucleus  cytoplasm  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of phospholipase C activity  T cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  interferon-gamma production  interleukin-4 production  positive regulation of interferon-gamma production  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  T cell receptor signaling pathway  T cell receptor signaling pathway  B cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Pathways : KEGGLeukocyte transendothelial migration   
Protein Interaction DatabaseTXK
DoCM (Curated mutations)TXK
Wikipedia pathwaysTXK
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerTXK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXK
dbVarTXK
ClinVarTXK
1000_GenomesTXK 
Exome Variant ServerTXK
SNP (GeneSNP Utah)TXK
SNP : HGBaseTXK
Genetic variants : HAPMAPTXK
Genomic Variants (DGV)TXK [DGVbeta]
Mutations
ICGC Data PortalENSG00000074966 
Somatic Mutations in Cancer : COSMICTXK 
CONAN: Copy Number AnalysisTXK 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:48068410-48136273
Mutations and Diseases : HGMDTXK
OMIM600058   
MedgenTXK
NextProtP42681 [Medical]
GENETestsTXK
Disease Genetic AssociationTXK
Huge Navigator TXK [HugePedia]  TXK [HugeCancerGEM]
snp3D : Map Gene to Disease7294
DGIdb (Drug Gene Interaction db)TXK
General knowledge
Homologs : HomoloGeneTXK
Homology/Alignments : Family Browser (UCSC)TXK
Phylogenetic Trees/Animal Genes : TreeFamTXK
Chemical/Protein Interactions : CTD7294
Chemical/Pharm GKB GenePA37090
Clinical trialTXK
Cancer Resource (Charite)ENSG00000074966
Other databases
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
CoreMineTXK
GoPubMedTXK
iHOPTXK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 17:45:23 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.