Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TXK (TXK tyrosine kinase)

Identity

Other namesBTKL
PSCTK5
PTK4
RLK
TKL
HGNC (Hugo) TXK
LocusID (NCBI) 7294
Location 4p12
Location_base_pair Starts at 48068410 and ends at 48136273 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)TXK   12434
Cards
Entrez_Gene (NCBI)TXK  7294  TXK tyrosine kinase
GeneCards (Weizmann)TXK
Ensembl (Hinxton)ENSG00000074966 [Gene_View]  chr4:48068410-48136273 [Contig_View]  TXK [Vega]
ICGC DataPortalENSG00000074966
cBioPortalTXK
AceView (NCBI)TXK
Genatlas (Paris)TXK
WikiGenes7294
SOURCE (Princeton)NM_003328
Genomic and cartography
GoldenPath (UCSC)TXK  -  4p12   chr4:48068410-48136273 -  4p12   [Description]    (hg19-Feb_2009)
EnsemblTXK - 4p12 [CytoView]
Mapping of homologs : NCBITXK [Mapview]
OMIM600058   
Gene and transcription
Genbank (Entrez)AK300141 AK307055 BC017829 BC166632 DB103575
RefSeq transcript (Entrez)NM_003328
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NT_006238 NW_001838903 NW_004929317
Consensus coding sequences : CCDS (NCBI)TXK
Cluster EST : UnigeneHs.479669 [ NCBI ]
CGAP (NCI)Hs.479669
Alternative Splicing : Fast-db (Paris)GSHG0023239
Alternative Splicing GalleryENSG00000074966
Gene ExpressionTXK [ NCBI-GEO ]     TXK [ SEEK ]   TXK [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42681 (Uniprot)
NextProtP42681  [Medical]
With graphics : InterProP42681
Splice isoforms : SwissVarP42681 (Swissvar)
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser-Thr/Tyr_kinase_cat_dom [organisation]   SH2 [organisation]   SH3_domain [organisation]   Tyr_kinase_AS [organisation]   Tyr_kinase_cat_dom [organisation]  
Related proteins : CluSTrP42681
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
DMDM Disease mutations7294
Blocks (Seattle)P42681
PDB (SRS)2DM0   
PDB (PDBSum)2DM0   
PDB (IMB)2DM0   
PDB (RSDB)2DM0   
Human Protein AtlasENSG00000074966 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP42681
HPRD02505
IPIIPI00000879   IPI00967614   IPI00967315   IPI00967008   IPI00967623   
Protein Interaction databases
DIP (DOE-UCLA)P42681
IntAct (EBI)P42681
FunCoupENSG00000074966
BioGRIDTXK
InParanoidP42681
Interologous Interaction database P42681
IntegromeDBTXK
STRING (EMBL)TXK
Ontologies - Pathways
Ontology : AmiGORNA polymerase II regulatory region DNA binding  cytokine production  NK T cell differentiation  adaptive immune response  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  activation of phospholipase C activity  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  interferon-gamma production  interleukin-4 production  positive regulation of interferon-gamma production  protein autophosphorylation  T cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Ontology : EGO-EBIRNA polymerase II regulatory region DNA binding  cytokine production  NK T cell differentiation  adaptive immune response  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  transcription, DNA-templated  regulation of transcription from RNA polymerase II promoter  protein phosphorylation  activation of phospholipase C activity  peptidyl-tyrosine phosphorylation  peptidyl-tyrosine phosphorylation  interferon-gamma production  interleukin-4 production  positive regulation of interferon-gamma production  protein autophosphorylation  T cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Pathways : KEGGLeukocyte transendothelial migration   
Protein Interaction DatabaseTXK
Wikipedia pathwaysTXK
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TXK
snp3D : Map Gene to Disease7294
SNP (GeneSNP Utah)TXK
SNP : HGBaseTXK
Genetic variants : HAPMAPTXK
Exome VariantTXK
1000_GenomesTXK 
ICGC programENSG00000074966 
Somatic Mutations in Cancer : COSMICTXK 
CONAN: Copy Number AnalysisTXK 
Mutations and Diseases : HGMDTXK
Mutations and Diseases : intOGenTXK
Genomic VariantsTXK  TXK [DGVbeta]
dbVarTXK
ClinVarTXK
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM600058   
MedgenTXK
GENETestsTXK
Disease Genetic AssociationTXK
Huge Navigator TXK [HugePedia]  TXK [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneTXK
Homology/Alignments : Family Browser (UCSC)TXK
Phylogenetic Trees/Animal Genes : TreeFamTXK
Chemical/Protein Interactions : CTD7294
Chemical/Pharm GKB GenePA37090
Clinical trialTXK
Cancer Resource (Charite)ENSG00000074966
Other databases
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
CoreMineTXK
iHOPTXK
OncoSearchTXK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 17:09:10 CEST 2014

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.