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TXK (TXK tyrosine kinase)

Identity

Alias (NCBI)BTKL
PSCTK5
PTK4
RLK
TKL
HGNC (Hugo) TXK
HGNC Alias symbTKL
PSCTK5
BTKL
RLK
HGNC Previous namePTK4
HGNC Previous namePTK4 protein tyrosine kinase 4
LocusID (NCBI) 7294
Atlas_Id 42734
Location 4p12  [Link to chromosome band 4p12]
Location_base_pair Starts at 48066393 and ends at 48134250 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MYLK (3q21.1) / TXK (4p12)PKN2 (1p22.2) / TXK (4p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TXK   12434
Cards
Entrez_Gene (NCBI)TXK    TXK tyrosine kinase
AliasesBTKL; PSCTK5; PTK4; RLK; 
TKL
GeneCards (Weizmann)TXK
Ensembl hg19 (Hinxton)ENSG00000074966 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000074966 [Gene_View]  ENSG00000074966 [Sequence]  chr4:48066393-48134250 [Contig_View]  TXK [Vega]
ICGC DataPortalENSG00000074966
TCGA cBioPortalTXK
AceView (NCBI)TXK
Genatlas (Paris)TXK
SOURCE (Princeton)TXK
Genetics Home Reference (NIH)TXK
Genomic and cartography
GoldenPath hg38 (UCSC)TXK  -     chr4:48066393-48134250 -  4p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXK  -     4p12   [Description]    (hg19-Feb_2009)
GoldenPathTXK - 4p12 [CytoView hg19]  TXK - 4p12 [CytoView hg38]
ImmunoBaseENSG00000074966
Genome Data Viewer NCBITXK [Mapview hg19]  
OMIM600058   
Gene and transcription
Genbank (Entrez)AK300141 AK307055 BC017829 DB103575 L27071
RefSeq transcript (Entrez)NM_003328
Consensus coding sequences : CCDS (NCBI)TXK
Gene ExpressionTXK [ NCBI-GEO ]   TXK [ EBI - ARRAY_EXPRESS ]   TXK [ SEEK ]   TXK [ MEM ]
Gene Expression Viewer (FireBrowse)TXK [ Firebrowse - Broad ]
GenevisibleExpression of TXK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7294
GTEX Portal (Tissue expression)TXK
Human Protein AtlasENSG00000074966-TXK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42681   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42681  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42681
PhosPhoSitePlusP42681
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    Txk_SH2    TXK_SH3    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)PK_Tyr_Ser-Thr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)TXK
PDB (RSDB)2DM0   
PDB Europe2DM0   
PDB (PDBSum)2DM0   
PDB (IMB)2DM0   
Structural Biology KnowledgeBase2DM0   
SCOP (Structural Classification of Proteins)2DM0   
CATH (Classification of proteins structures)2DM0   
SuperfamilyP42681
AlphaFold pdb e-kbP42681   
Human Protein Atlas [tissue]ENSG00000074966-TXK [tissue]
HPRD02505
Protein Interaction databases
DIP (DOE-UCLA)P42681
IntAct (EBI)P42681
BioGRIDTXK
STRING (EMBL)TXK
ZODIACTXK
Ontologies - Pathways
QuickGOP42681
Ontology : AmiGOpositive regulation of cytokine production  adaptive immune response  adaptive immune response  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  protein phosphorylation  activation of phospholipase C activity  integrin-mediated signaling pathway  regulation of gene expression  regulation of platelet activation  positive regulation of interferon-gamma production  peptidyl-tyrosine autophosphorylation  tissue regeneration  positive regulation of transcription by RNA polymerase II  protein autophosphorylation  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Ontology : EGO-EBIpositive regulation of cytokine production  adaptive immune response  adaptive immune response  protein tyrosine kinase activity  transmembrane receptor protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  plasma membrane  protein phosphorylation  activation of phospholipase C activity  integrin-mediated signaling pathway  regulation of gene expression  regulation of platelet activation  positive regulation of interferon-gamma production  peptidyl-tyrosine autophosphorylation  tissue regeneration  positive regulation of transcription by RNA polymerase II  protein autophosphorylation  T cell receptor signaling pathway  T cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Pathways : KEGGLeukocyte transendothelial migration   
NDEx NetworkTXK
Atlas of Cancer Signalling NetworkTXK
Wikipedia pathwaysTXK
Orthology - Evolution
OrthoDB7294
GeneTree (enSembl)ENSG00000074966
Phylogenetic Trees/Animal Genes : TreeFamTXK
Homologs : HomoloGeneTXK
Homology/Alignments : Family Browser (UCSC)TXK
Gene fusions - Rearrangements
Fusion : MitelmanMYLK/TXK [3q21.1/4p12]  
Fusion : QuiverTXK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXK
dbVarTXK
ClinVarTXK
MonarchTXK
1000_GenomesTXK 
Exome Variant ServerTXK
GNOMAD BrowserENSG00000074966
Varsome BrowserTXK
ACMGTXK variants
VarityP42681
Genomic Variants (DGV)TXK [DGVbeta]
DECIPHERTXK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXK 
Mutations
ICGC Data PortalTXK 
TCGA Data PortalTXK 
Broad Tumor PortalTXK
OASIS PortalTXK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTXK
Mutations and Diseases : HGMDTXK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTXK
DgiDB (Drug Gene Interaction Database)TXK
DoCM (Curated mutations)TXK
CIViC (Clinical Interpretations of Variants in Cancer)TXK
Cancer3DTXK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600058   
Orphanet
DisGeNETTXK
MedgenTXK
Genetic Testing Registry TXK
NextProtP42681 [Medical]
GENETestsTXK
Target ValidationTXK
Huge Navigator TXK [HugePedia]
ClinGenTXK
Clinical trials, drugs, therapy
MyCancerGenomeTXK
Protein Interactions : CTDTXK
Pharm GKB GenePA37090
PharosP42681
Clinical trialTXK
Miscellaneous
canSAR (ICR)TXK
HarmonizomeTXK
DataMed IndexTXK
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTXK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:55 CEST 2021

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