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TXK (TXK tyrosine kinase)

Identity

Alias_namesPTK4
PTK4 protein tyrosine kinase 4
Alias_symbol (synonym)TKL
PSCTK5
BTKL
RLK
HGNC (Hugo) TXK
LocusID (NCBI) 7294
Atlas_Id 42734
Location 4p12  [Link to chromosome band 4p12]
Location_base_pair Starts at 48068410 and ends at 48136273 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MYLK (3q21.1) / TXK (4p12)PKN2 (1p22.2) / TXK (4p12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TXK   12434
Cards
Entrez_Gene (NCBI)TXK  7294  TXK tyrosine kinase
AliasesBTKL; PSCTK5; PTK4; RLK; 
TKL
GeneCards (Weizmann)TXK
Ensembl hg19 (Hinxton)ENSG00000074966 [Gene_View]  chr4:48068410-48136273 [Contig_View]  TXK [Vega]
Ensembl hg38 (Hinxton)ENSG00000074966 [Gene_View]  chr4:48068410-48136273 [Contig_View]  TXK [Vega]
ICGC DataPortalENSG00000074966
TCGA cBioPortalTXK
AceView (NCBI)TXK
Genatlas (Paris)TXK
WikiGenes7294
SOURCE (Princeton)TXK
Genetics Home Reference (NIH)TXK
Genomic and cartography
GoldenPath hg19 (UCSC)TXK  -     chr4:48068410-48136273 -  4p12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TXK  -     4p12   [Description]    (hg38-Dec_2013)
EnsemblTXK - 4p12 [CytoView hg19]  TXK - 4p12 [CytoView hg38]
Mapping of homologs : NCBITXK [Mapview hg19]  TXK [Mapview hg38]
OMIM600058   
Gene and transcription
Genbank (Entrez)AK300141 AK307055 BC017829 BC166632 DB103575
RefSeq transcript (Entrez)NM_003328
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_006238 NW_004929317
Consensus coding sequences : CCDS (NCBI)TXK
Cluster EST : UnigeneHs.479669 [ NCBI ]
CGAP (NCI)Hs.479669
Alternative Splicing GalleryENSG00000074966
Gene ExpressionTXK [ NCBI-GEO ]   TXK [ EBI - ARRAY_EXPRESS ]   TXK [ SEEK ]   TXK [ MEM ]
Gene Expression Viewer (FireBrowse)TXK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7294
GTEX Portal (Tissue expression)TXK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42681   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42681  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42681
Splice isoforms : SwissVarP42681
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP42681
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)TXK
DMDM Disease mutations7294
Blocks (Seattle)TXK
PDB (SRS)2DM0   
PDB (PDBSum)2DM0   
PDB (IMB)2DM0   
PDB (RSDB)2DM0   
Structural Biology KnowledgeBase2DM0   
SCOP (Structural Classification of Proteins)2DM0   
CATH (Classification of proteins structures)2DM0   
SuperfamilyP42681
Human Protein AtlasENSG00000074966
Peptide AtlasP42681
HPRD02505
IPIIPI00000879   IPI00967614   IPI00967315   IPI00967008   IPI00967623   
Protein Interaction databases
DIP (DOE-UCLA)P42681
IntAct (EBI)P42681
FunCoupENSG00000074966
BioGRIDTXK
STRING (EMBL)TXK
ZODIACTXK
Ontologies - Pathways
QuickGOP42681
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II regulatory region DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  cytokine production  adaptive immune response  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of phospholipase C activity  integrin-mediated signaling pathway  regulation of platelet activation  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of interferon-gamma production  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  tissue regeneration  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  T cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II regulatory region DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  cytokine production  adaptive immune response  non-membrane spanning protein tyrosine kinase activity  receptor binding  protein binding  ATP binding  nucleus  cytoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  protein phosphorylation  transmembrane receptor protein tyrosine kinase signaling pathway  activation of phospholipase C activity  integrin-mediated signaling pathway  regulation of platelet activation  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  positive regulation of interferon-gamma production  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  tissue regeneration  positive regulation of transcription from RNA polymerase II promoter  protein autophosphorylation  T cell receptor signaling pathway  positive regulation of interferon-gamma-mediated signaling pathway  
Pathways : KEGGLeukocyte transendothelial migration   
NDEx NetworkTXK
Atlas of Cancer Signalling NetworkTXK
Wikipedia pathwaysTXK
Orthology - Evolution
OrthoDB7294
GeneTree (enSembl)ENSG00000074966
Phylogenetic Trees/Animal Genes : TreeFamTXK
HOVERGENP42681
HOGENOMP42681
Homologs : HomoloGeneTXK
Homology/Alignments : Family Browser (UCSC)TXK
Gene fusions - Rearrangements
Fusion : MitelmanMYLK/TXK [3q21.1/4p12]  [t(3;4)(q21;p12)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXK
dbVarTXK
ClinVarTXK
1000_GenomesTXK 
Exome Variant ServerTXK
ExAC (Exome Aggregation Consortium)TXK (select the gene name)
Genetic variants : HAPMAP7294
Genomic Variants (DGV)TXK [DGVbeta]
DECIPHER (Syndromes)4:48068410-48136273  ENSG00000074966
CONAN: Copy Number AnalysisTXK 
Mutations
ICGC Data PortalTXK 
TCGA Data PortalTXK 
Broad Tumor PortalTXK
OASIS PortalTXK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TXK
DgiDB (Drug Gene Interaction Database)TXK
DoCM (Curated mutations)TXK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXK (select a term)
intoGenTXK
Cancer3DTXK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600058   
Orphanet
MedgenTXK
Genetic Testing Registry TXK
NextProtP42681 [Medical]
TSGene7294
GENETestsTXK
Huge Navigator TXK [HugePedia]
snp3D : Map Gene to Disease7294
BioCentury BCIQTXK
ClinGenTXK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7294
Chemical/Pharm GKB GenePA37090
Clinical trialTXK
Miscellaneous
canSAR (ICR)TXK (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXK
EVEXTXK
GoPubMedTXK
iHOPTXK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:54:55 CET 2016

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