Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TXN2 (thioredoxin 2)

Identity

Alias_symbol (synonym)MT-TRX
Other aliasCOXPD29
MTRX
TRX2
HGNC (Hugo) TXN2
LocusID (NCBI) 25828
Atlas_Id 52545
Location 22q12.3  [Link to chromosome band 22q12]
Location_base_pair Starts at 36863093 and ends at 36877687 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ENOX2 (Xq26.1) / TXN2 (22q12.3)FOXRED2 (22q12.3) / TXN2 (22q12.3)MYH9 (22q12.3) / TXN2 (22q12.3)
TXN2 (22q12.3) / DIAPH3 (13q21.2)TXN2 (22q12.3) / TXN2 (22q12.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TXN2   17772
Cards
Entrez_Gene (NCBI)TXN2  25828  thioredoxin 2
AliasesCOXPD29; MT-TRX; MTRX; TRX2
GeneCards (Weizmann)TXN2
Ensembl hg19 (Hinxton)ENSG00000100348 [Gene_View]  chr22:36863093-36877687 [Contig_View]  TXN2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000100348 [Gene_View]  chr22:36863093-36877687 [Contig_View]  TXN2 [Vega]
ICGC DataPortalENSG00000100348
TCGA cBioPortalTXN2
AceView (NCBI)TXN2
Genatlas (Paris)TXN2
WikiGenes25828
SOURCE (Princeton)TXN2
Genetics Home Reference (NIH)TXN2
Genomic and cartography
GoldenPath hg19 (UCSC)TXN2  -     chr22:36863093-36877687 -  22q12.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TXN2  -     22q12.3   [Description]    (hg38-Dec_2013)
EnsemblTXN2 - 22q12.3 [CytoView hg19]  TXN2 - 22q12.3 [CytoView hg38]
Mapping of homologs : NCBITXN2 [Mapview hg19]  TXN2 [Mapview hg38]
OMIM609063   
Gene and transcription
Genbank (Entrez)AF276920 AF480262 AK123361 AK130187 AK301837
RefSeq transcript (Entrez)NM_012473
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_046718 NT_011520 NW_004929430
Consensus coding sequences : CCDS (NCBI)TXN2
Cluster EST : UnigeneHs.211929 [ NCBI ]
CGAP (NCI)Hs.211929
Alternative Splicing GalleryENSG00000100348
Gene ExpressionTXN2 [ NCBI-GEO ]   TXN2 [ EBI - ARRAY_EXPRESS ]   TXN2 [ SEEK ]   TXN2 [ MEM ]
Gene Expression Viewer (FireBrowse)TXN2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25828
GTEX Portal (Tissue expression)TXN2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99757   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99757  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99757
Splice isoforms : SwissVarQ99757
PhosPhoSitePlusQ99757
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin    Thioredoxin-like_fold    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXN2
DMDM Disease mutations25828
Blocks (Seattle)TXN2
PDB (SRS)1UVZ    1W4V    1W89   
PDB (PDBSum)1UVZ    1W4V    1W89   
PDB (IMB)1UVZ    1W4V    1W89   
PDB (RSDB)1UVZ    1W4V    1W89   
Structural Biology KnowledgeBase1UVZ    1W4V    1W89   
SCOP (Structural Classification of Proteins)1UVZ    1W4V    1W89   
CATH (Classification of proteins structures)1UVZ    1W4V    1W89   
SuperfamilyQ99757
Human Protein AtlasENSG00000100348
Peptide AtlasQ99757
HPRD07161
IPIIPI00017799   IPI00877683   
Protein Interaction databases
DIP (DOE-UCLA)Q99757
IntAct (EBI)Q99757
FunCoupENSG00000100348
BioGRIDTXN2
STRING (EMBL)TXN2
ZODIACTXN2
Ontologies - Pathways
QuickGOQ99757
Ontology : AmiGOsulfate assimilation  response to reactive oxygen species  response to hypoxia  protein binding  nucleolus  mitochondrion  mitochondrial matrix  protein folding  glycerol ether metabolic process  response to nutrient  peptide-methionine (S)-S-oxide reductase activity  response to hormone  response to glucose  response to organic cyclic compound  protein disulfide oxidoreductase activity  oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor  dendrite  cellular response to nutrient levels  protein complex binding  peptide-methionine (R)-S-oxide reductase activity  cellular response to oxidative stress  response to drug  neuronal cell body  cell redox homeostasis  response to axon injury  oxidation-reduction process  
Ontology : EGO-EBIsulfate assimilation  response to reactive oxygen species  response to hypoxia  protein binding  nucleolus  mitochondrion  mitochondrial matrix  protein folding  glycerol ether metabolic process  response to nutrient  peptide-methionine (S)-S-oxide reductase activity  response to hormone  response to glucose  response to organic cyclic compound  protein disulfide oxidoreductase activity  oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor  dendrite  cellular response to nutrient levels  protein complex binding  peptide-methionine (R)-S-oxide reductase activity  cellular response to oxidative stress  response to drug  neuronal cell body  cell redox homeostasis  response to axon injury  oxidation-reduction process  
NDEx NetworkTXN2
Atlas of Cancer Signalling NetworkTXN2
Wikipedia pathwaysTXN2
Orthology - Evolution
OrthoDB25828
GeneTree (enSembl)ENSG00000100348
Phylogenetic Trees/Animal Genes : TreeFamTXN2
HOVERGENQ99757
HOGENOMQ99757
Homologs : HomoloGeneTXN2
Homology/Alignments : Family Browser (UCSC)TXN2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXN2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXN2
dbVarTXN2
ClinVarTXN2
1000_GenomesTXN2 
Exome Variant ServerTXN2
ExAC (Exome Aggregation Consortium)TXN2 (select the gene name)
Genetic variants : HAPMAP25828
Genomic Variants (DGV)TXN2 [DGVbeta]
DECIPHER (Syndromes)22:36863093-36877687  ENSG00000100348
CONAN: Copy Number AnalysisTXN2 
Mutations
ICGC Data PortalTXN2 
TCGA Data PortalTXN2 
Broad Tumor PortalTXN2
OASIS PortalTXN2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXN2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXN2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TXN2
DgiDB (Drug Gene Interaction Database)TXN2
DoCM (Curated mutations)TXN2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXN2 (select a term)
intoGenTXN2
Cancer3DTXN2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609063   
Orphanet
MedgenTXN2
Genetic Testing Registry TXN2
NextProtQ99757 [Medical]
TSGene25828
GENETestsTXN2
Huge Navigator TXN2 [HugePedia]
snp3D : Map Gene to Disease25828
BioCentury BCIQTXN2
ClinGenTXN2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD25828
Chemical/Pharm GKB GenePA38245
Clinical trialTXN2
Miscellaneous
canSAR (ICR)TXN2 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXN2
EVEXTXN2
GoPubMedTXN2
iHOPTXN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:23:55 CEST 2017

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.