Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TXN2 (thioredoxin 2)

Identity

Other namesMT-TRX
MTRX
TRX2
HGNC (Hugo) TXN2
LocusID (NCBI) 25828
Location 22q12.3
Location_base_pair Starts at 36863093 and ends at 36877687 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)TXN2   17772
Entrez_Gene (NCBI)TXN2  25828  thioredoxin 2
Cards
GeneCards (Weizmann)TXN2
Ensembl (Hinxton)ENSG00000100348 [Gene_View]  chr22:36863093-36877687 [Contig_View]  TXN2 [Vega]
AceView (NCBI)TXN2
Genatlas (Paris)TXN2
SOURCE (Stanford)NM_012473
Genomic and cartography
GoldenPath (UCSC)TXN2  -  22q12.3   chr22:36863093-36877687 -  22q12.3   [Description]    (hg19-Feb_2009)
EnsemblTXN2 - 22q12.3 [CytoView]
Mapping of homologs : NCBITXN2 [Mapview]
OMIM609063   
Gene and transcription
Genbank (Entrez)AF276920 AF480262 AK130187 AK301837 BC013726
RefSeq transcript (SRS)NM_012473
RefSeq transcript (Entrez)NM_012473
RefSeq genomic (SRS)AC_000154 NC_000022 NC_018933 NT_011520 NW_001838745 NW_004078112
RefSeq genomic (Entrez)AC_000154 NC_000022 NC_018933 NT_011520 NW_001838745 NW_004078112
Consensus coding sequences : CCDS (NCBI)TXN2
Cluster EST : UnigeneHs.211929 [ SRS ] Hs.211929 [ NCBI ]
CGAP (NCI)Hs.211929
Alternative Splicing : Fast-db (Paris)GSHG0020356
Alternative Splicing GalleryENSG00000100348
Gene ExpressionTXN2 [ NCBI-GEO ]   TXN2 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99757 (SRS) Q99757 (Uniprot)
NextProtQ99757
With graphics : InterProQ99757
Splice isoforms : SwissVarQ99757(Swissvar)
Domaine pattern : Prosite (SRS)THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (SRS)Thioredoxin    Thioredoxin-like_fold    Thioredoxin_CS    Thioredoxin_domain   
Domains : Interpro (EBI)Thioredoxin    Thioredoxin-like_fold    Thioredoxin_CS    Thioredoxin_domain   
Related proteins : CluSTrQ99757
Domain families : Pfam (SRS)Thioredoxin (PF00085)   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
DMDM25828
Blocks (Seattle)Q99757
PDB (SRS)1UVZ    1W4V    1W89   
PDB (PDBSum)1UVZ    1W4V    1W89   
PDB (IMB)1UVZ    1W4V    1W89   
PDB (RSDB)1UVZ    1W4V    1W89   
Human Protein AtlasENSG00000100348
HPRD07161
IPIIPI00017799   IPI00877683   
Protein Interaction databases
DIP (DOE-UCLA)Q99757
IntAct (EBI)Q99757
FunCoupENSG00000100348
REACTOMETXN2
Protein Interaction Database25828
BioGRIDTXN2
InParanoidQ99757
Interologous Interaction database Q99757
IntegromeDBTXN2
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)TXN2
SNP (GeneSNP Utah)TXN2
SNP : HGBaseTXN2
Genetic variants : HAPMAPTXN2
Somatic Mutations in Cancer : COSMICTXN2 
CONAN: Copy Number AnalysisTXN2 
Mutations and Diseases : HGMDTXN2
OMIM609063   
GENETests609063   
Disease Genetic AssociationTXN2
Huge Navigator TXN2 [HugePedia]  TXN2 [HugeCancerGEM]
Genomic VariantsTXN2  TXN2 [DGVbeta]
snp3D : Map Gene to Disease25828
General knowledge
Homologs : HomoloGeneTXN2
Homology/Alignments : Family Browser (UCSC)TXN2
Phylogenetic Trees/Animal Genes : TreeFamTXN2
Chemical/Protein Interactions : CTD25828
Chemical/Pharm GKB GenePA38245
Clinical trialTXN2
Cancer Resource (Charite)ENSG00000100348
Ontology : AmiGOresponse to hypoxia  nucleolus  mitochondrion  glycerol ether metabolic process  response to oxidative stress  response to nutrient  peptide-methionine (S)-S-oxide reductase activity  electron carrier activity  response to hormone stimulus  response to glucose stimulus  response to organic cyclic compound  protein disulfide oxidoreductase activity  electron transport chain  cellular response to nutrient levels  peptide-methionine (R)-S-oxide reductase activity  response to drug  cell redox homeostasis  response to axon injury  
Ontology : EGO-EBIresponse to hypoxia  nucleolus  mitochondrion  glycerol ether metabolic process  response to oxidative stress  response to nutrient  peptide-methionine (S)-S-oxide reductase activity  electron carrier activity  response to hormone stimulus  response to glucose stimulus  response to organic cyclic compound  protein disulfide oxidoreductase activity  electron transport chain  cellular response to nutrient levels  peptide-methionine (R)-S-oxide reductase activity  response to drug  cell redox homeostasis  response to axon injury  
Other databases
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
PubGeneTXN2
iHOPTXN2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:45:47 CEST 2013
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