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TXNDC11 (thioredoxin domain containing 11)

Identity

Alias_symbol (synonym)EFP1
Other alias
HGNC (Hugo) TXNDC11
LocusID (NCBI) 51061
Atlas_Id 54741
Location 16p13.13  [Link to chromosome band 16p13]
Location_base_pair Starts at 11679080 and ends at 11742878 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLEC16A (16p13.13) / TXNDC11 (16p13.13)TXNDC11 (16p13.13) / GSPT1 (16p13.13)TXNDC11 (16p13.13) / RSL1D1 (16p13.13)
TXNDC11 (16p13.13) / RUVBL1 (3q21.3)TXNDC11 (16p13.13) / ZC3H7A (16p13.13)CLEC16A 16p13.13 / TXNDC11 16p13.13
TXNDC11 16p13.13 / GSPT1 16p13.13TXNDC11 16p13.13 / ZC3H7A 16p13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)TXNDC11   28030
Cards
Entrez_Gene (NCBI)TXNDC11  51061  thioredoxin domain containing 11
AliasesEFP1
GeneCards (Weizmann)TXNDC11
Ensembl hg19 (Hinxton)ENSG00000153066 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000153066 [Gene_View]  chr16:11679080-11742878 [Contig_View]  TXNDC11 [Vega]
ICGC DataPortalENSG00000153066
TCGA cBioPortalTXNDC11
AceView (NCBI)TXNDC11
Genatlas (Paris)TXNDC11
WikiGenes51061
SOURCE (Princeton)TXNDC11
Genetics Home Reference (NIH)TXNDC11
Genomic and cartography
GoldenPath hg38 (UCSC)TXNDC11  -     chr16:11679080-11742878 -  16p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNDC11  -     16p13.13   [Description]    (hg19-Feb_2009)
EnsemblTXNDC11 - 16p13.13 [CytoView hg19]  TXNDC11 - 16p13.13 [CytoView hg38]
Mapping of homologs : NCBITXNDC11 [Mapview hg19]  TXNDC11 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF131780 AK027464 AK027646 AK074534 AK297094
RefSeq transcript (Entrez)NM_001303447 NM_001324022 NM_001324024 NM_001324025 NM_015914
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TXNDC11
Cluster EST : UnigeneHs.313847 [ NCBI ]
CGAP (NCI)Hs.313847
Alternative Splicing GalleryENSG00000153066
Gene ExpressionTXNDC11 [ NCBI-GEO ]   TXNDC11 [ EBI - ARRAY_EXPRESS ]   TXNDC11 [ SEEK ]   TXNDC11 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51061
GTEX Portal (Tissue expression)TXNDC11
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6PKC3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6PKC3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6PKC3
Splice isoforms : SwissVarQ6PKC3
PhosPhoSitePlusQ6PKC3
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXNDC11
DMDM Disease mutations51061
Blocks (Seattle)TXNDC11
SuperfamilyQ6PKC3
Human Protein AtlasENSG00000153066
Peptide AtlasQ6PKC3
HPRD07125
IPIIPI00478749   IPI00074799   IPI00384063   IPI00953456   
Protein Interaction databases
DIP (DOE-UCLA)Q6PKC3
IntAct (EBI)Q6PKC3
FunCoupENSG00000153066
BioGRIDTXNDC11
STRING (EMBL)TXNDC11
ZODIACTXNDC11
Ontologies - Pathways
QuickGOQ6PKC3
Ontology : AmiGOprotein disulfide isomerase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  protein folding  integral component of membrane  response to endoplasmic reticulum stress  cell redox homeostasis  
Ontology : EGO-EBIprotein disulfide isomerase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum membrane  protein folding  integral component of membrane  response to endoplasmic reticulum stress  cell redox homeostasis  
NDEx NetworkTXNDC11
Atlas of Cancer Signalling NetworkTXNDC11
Wikipedia pathwaysTXNDC11
Orthology - Evolution
OrthoDB51061
GeneTree (enSembl)ENSG00000153066
Phylogenetic Trees/Animal Genes : TreeFamTXNDC11
HOVERGENQ6PKC3
HOGENOMQ6PKC3
Homologs : HomoloGeneTXNDC11
Homology/Alignments : Family Browser (UCSC)TXNDC11
Gene fusions - Rearrangements
Fusion : MitelmanCLEC16A/TXNDC11 [16p13.13/16p13.13]  [t(16;16)(p13;p13)]  
Fusion : MitelmanTXNDC11/GSPT1 [16p13.13/16p13.13]  [t(16;16)(p13;p13)]  
Fusion : MitelmanTXNDC11/RUVBL1 [16p13.13/3q21.3]  [t(3;16)(q21;p13)]  
Fusion : MitelmanTXNDC11/ZC3H7A [16p13.13/16p13.13]  [t(16;16)(p13;p13)]  
Fusion: TCGACLEC16A 16p13.13 TXNDC11 16p13.13 GBM
Fusion: TCGATXNDC11 16p13.13 GSPT1 16p13.13 OV
Fusion: TCGATXNDC11 16p13.13 ZC3H7A 16p13.13 BRCA
Fusion Cancer (Beijing)TXNDC11 [16p13.13]  -  RSL1D1 [16p13.13]  [FUSC000419]  [FUSC000419]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC11
dbVarTXNDC11
ClinVarTXNDC11
1000_GenomesTXNDC11 
Exome Variant ServerTXNDC11
ExAC (Exome Aggregation Consortium)TXNDC11 (select the gene name)
Genetic variants : HAPMAP51061
Genomic Variants (DGV)TXNDC11 [DGVbeta]
DECIPHERTXNDC11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNDC11 
Mutations
ICGC Data PortalTXNDC11 
TCGA Data PortalTXNDC11 
Broad Tumor PortalTXNDC11
OASIS PortalTXNDC11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXNDC11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TXNDC11
DgiDB (Drug Gene Interaction Database)TXNDC11
DoCM (Curated mutations)TXNDC11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC11 (select a term)
intoGenTXNDC11
Cancer3DTXNDC11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTXNDC11
Genetic Testing Registry TXNDC11
NextProtQ6PKC3 [Medical]
TSGene51061
GENETestsTXNDC11
Target ValidationTXNDC11
Huge Navigator TXNDC11 [HugePedia]
snp3D : Map Gene to Disease51061
BioCentury BCIQTXNDC11
ClinGenTXNDC11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51061
Chemical/Pharm GKB GenePA134915251
Clinical trialTXNDC11
Miscellaneous
canSAR (ICR)TXNDC11 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNDC11
EVEXTXNDC11
GoPubMedTXNDC11
iHOPTXNDC11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:18:03 CEST 2017

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