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TXNDC12 (thioredoxin domain containing 12)

Identity

Alias (NCBI)AG1
AGR1
ERP16
ERP18
ERP19
PDIA16
TLP19
hAG-1
hTLP19
HGNC (Hugo) TXNDC12
HGNC Alias symbTLP19
ERP18
ERP19
hAG-1
AGR1
PDIA16
HGNC Alias nameendoplasmic reticulum thioredoxin superfamily member, 18 kDa
 anterior gradient homolog 1 (Xenopus laevis)
 protein disulfide isomerase family A, member 16
HGNC Previous namethioredoxin domain containing 12 (endoplasmic reticulum)
LocusID (NCBI) 51060
Atlas_Id 55702
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 52020132 and ends at 52055191 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LOC100188947 () / TXNDC12 (1p32.3)RAB3B (1p32.3) / TXNDC12 (1p32.3)TXNDC12 (1p32.3) / FAM107B (10p13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TXNDC12   24626
Cards
Entrez_Gene (NCBI)TXNDC12    thioredoxin domain containing 12
AliasesAG1; AGR1; ERP16; ERP18; 
ERP19; PDIA16; TLP19; hAG-1; hTLP19
GeneCards (Weizmann)TXNDC12
Ensembl hg19 (Hinxton)ENSG00000117862 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117862 [Gene_View]  ENSG00000117862 [Sequence]  chr1:52020132-52055191 [Contig_View]  TXNDC12 [Vega]
ICGC DataPortalENSG00000117862
TCGA cBioPortalTXNDC12
AceView (NCBI)TXNDC12
Genatlas (Paris)TXNDC12
SOURCE (Princeton)TXNDC12
Genetics Home Reference (NIH)TXNDC12
Genomic and cartography
GoldenPath hg38 (UCSC)TXNDC12  -     chr1:52020132-52055191 -  1p32.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNDC12  -     1p32.3   [Description]    (hg19-Feb_2009)
GoldenPathTXNDC12 - 1p32.3 [CytoView hg19]  TXNDC12 - 1p32.3 [CytoView hg38]
ImmunoBaseENSG00000117862
Genome Data Viewer NCBITXNDC12 [Mapview hg19]  
OMIM609448   
Gene and transcription
Genbank (Entrez)AF131758 AF543416 AK056169 AK075409 AY358982
RefSeq transcript (Entrez)NM_015913
Consensus coding sequences : CCDS (NCBI)TXNDC12
Gene ExpressionTXNDC12 [ NCBI-GEO ]   TXNDC12 [ EBI - ARRAY_EXPRESS ]   TXNDC12 [ SEEK ]   TXNDC12 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC12 [ Firebrowse - Broad ]
GenevisibleExpression of TXNDC12 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51060
GTEX Portal (Tissue expression)TXNDC12
Human Protein AtlasENSG00000117862-TXNDC12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95881   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95881  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95881
Catalytic activity : Enzyme1.8.4.2 [ Enzyme-Expasy ]   1.8.4.21.8.4.2 [ IntEnz-EBI ]   1.8.4.2 [ BRENDA ]   1.8.4.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO95881
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)ERp19    Thioredoxin-like_sf    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TXNDC12
PDB (RSDB)1SEN    2K8V   
PDB Europe1SEN    2K8V   
PDB (PDBSum)1SEN    2K8V   
PDB (IMB)1SEN    2K8V   
Structural Biology KnowledgeBase1SEN    2K8V   
SCOP (Structural Classification of Proteins)1SEN    2K8V   
CATH (Classification of proteins structures)1SEN    2K8V   
SuperfamilyO95881
AlphaFold pdb e-kbO95881   
Human Protein Atlas [tissue]ENSG00000117862-TXNDC12 [tissue]
HPRD11633
Protein Interaction databases
DIP (DOE-UCLA)O95881
IntAct (EBI)O95881
BioGRIDTXNDC12
STRING (EMBL)TXNDC12
ZODIACTXNDC12
Ontologies - Pathways
QuickGOO95881
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum lumen  protein-disulfide reductase activity  protein-disulfide reductase activity  protein-disulfide reductase (glutathione) activity  negative regulation of cell death  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum lumen  protein-disulfide reductase activity  protein-disulfide reductase activity  protein-disulfide reductase (glutathione) activity  negative regulation of cell death  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  
Pathways : KEGGGlutathione metabolism   
NDEx NetworkTXNDC12
Atlas of Cancer Signalling NetworkTXNDC12
Wikipedia pathwaysTXNDC12
Orthology - Evolution
OrthoDB51060
GeneTree (enSembl)ENSG00000117862
Phylogenetic Trees/Animal Genes : TreeFamTXNDC12
Homologs : HomoloGeneTXNDC12
Homology/Alignments : Family Browser (UCSC)TXNDC12
Gene fusions - Rearrangements
Fusion : QuiverTXNDC12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC12
dbVarTXNDC12
ClinVarTXNDC12
MonarchTXNDC12
1000_GenomesTXNDC12 
Exome Variant ServerTXNDC12
GNOMAD BrowserENSG00000117862
Varsome BrowserTXNDC12
ACMGTXNDC12 variants
VarityO95881
Genomic Variants (DGV)TXNDC12 [DGVbeta]
DECIPHERTXNDC12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNDC12 
Mutations
ICGC Data PortalTXNDC12 
TCGA Data PortalTXNDC12 
Broad Tumor PortalTXNDC12
OASIS PortalTXNDC12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTXNDC12
Mutations and Diseases : HGMDTXNDC12
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTXNDC12
DgiDB (Drug Gene Interaction Database)TXNDC12
DoCM (Curated mutations)TXNDC12
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC12
Cancer3DTXNDC12
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609448   
Orphanet
DisGeNETTXNDC12
MedgenTXNDC12
Genetic Testing Registry TXNDC12
NextProtO95881 [Medical]
GENETestsTXNDC12
Target ValidationTXNDC12
Huge Navigator TXNDC12 [HugePedia]
ClinGenTXNDC12
Clinical trials, drugs, therapy
MyCancerGenomeTXNDC12
Protein Interactions : CTDTXNDC12
Pharm GKB GenePA142670665
PharosO95881
Clinical trialTXNDC12
Miscellaneous
canSAR (ICR)TXNDC12
HarmonizomeTXNDC12
DataMed IndexTXNDC12
Probes
Litterature
PubMed45 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTXNDC12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:56 CEST 2021

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