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TXNDC2 (thioredoxin domain containing 2)

Identity

Alias (NCBI)SPTRX
SPTRX1
HGNC (Hugo) TXNDC2
HGNC Alias symbSPTRX1
HGNC Alias namesperm-specific thioredoxin 1
HGNC Previous namethioredoxin domain containing 2 (spermatozoa)
LocusID (NCBI) 84203
Atlas_Id 56412
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 9885973 and ends at 9889275 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TXNDC2   16470
Cards
Entrez_Gene (NCBI)TXNDC2    thioredoxin domain containing 2
AliasesSPTRX; SPTRX1
GeneCards (Weizmann)TXNDC2
Ensembl hg19 (Hinxton)ENSG00000168454 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168454 [Gene_View]  ENSG00000168454 [Sequence]  chr18:9885973-9889275 [Contig_View]  TXNDC2 [Vega]
ICGC DataPortalENSG00000168454
TCGA cBioPortalTXNDC2
AceView (NCBI)TXNDC2
Genatlas (Paris)TXNDC2
SOURCE (Princeton)TXNDC2
Genetics Home Reference (NIH)TXNDC2
Genomic and cartography
GoldenPath hg38 (UCSC)TXNDC2  -     chr18:9885973-9889275 +  18p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNDC2  -     18p11.22   [Description]    (hg19-Feb_2009)
GoldenPathTXNDC2 - 18p11.22 [CytoView hg19]  TXNDC2 - 18p11.22 [CytoView hg38]
ImmunoBaseENSG00000168454
Genome Data Viewer NCBITXNDC2 [Mapview hg19]  
OMIM617790   
Gene and transcription
Genbank (Entrez)AF080095 AK097656 AK303045 AL136742 BC050132
RefSeq transcript (Entrez)NM_001098529 NM_032243
Consensus coding sequences : CCDS (NCBI)TXNDC2
Gene ExpressionTXNDC2 [ NCBI-GEO ]   TXNDC2 [ EBI - ARRAY_EXPRESS ]   TXNDC2 [ SEEK ]   TXNDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC2 [ Firebrowse - Broad ]
GenevisibleExpression of TXNDC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84203
GTEX Portal (Tissue expression)TXNDC2
Human Protein AtlasENSG00000168454-TXNDC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VQ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VQ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VQ3
PhosPhoSitePlusQ86VQ3
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin-like_sf    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXNDC2
SuperfamilyQ86VQ3
AlphaFold pdb e-kbQ86VQ3   
Human Protein Atlas [tissue]ENSG00000168454-TXNDC2 [tissue]
HPRD11654
Protein Interaction databases
DIP (DOE-UCLA)Q86VQ3
IntAct (EBI)Q86VQ3
BioGRIDTXNDC2
STRING (EMBL)TXNDC2
ZODIACTXNDC2
Ontologies - Pathways
QuickGOQ86VQ3
Ontology : AmiGOthioredoxin-disulfide reductase activity  protein binding  cytoplasm  multicellular organism development  spermatogenesis  cell differentiation  cell redox homeostasis  cellular oxidant detoxification  
Ontology : EGO-EBIthioredoxin-disulfide reductase activity  protein binding  cytoplasm  multicellular organism development  spermatogenesis  cell differentiation  cell redox homeostasis  cellular oxidant detoxification  
NDEx NetworkTXNDC2
Atlas of Cancer Signalling NetworkTXNDC2
Wikipedia pathwaysTXNDC2
Orthology - Evolution
OrthoDB84203
GeneTree (enSembl)ENSG00000168454
Phylogenetic Trees/Animal Genes : TreeFamTXNDC2
Homologs : HomoloGeneTXNDC2
Homology/Alignments : Family Browser (UCSC)TXNDC2
Gene fusions - Rearrangements
Fusion : QuiverTXNDC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC2
dbVarTXNDC2
ClinVarTXNDC2
MonarchTXNDC2
1000_GenomesTXNDC2 
Exome Variant ServerTXNDC2
GNOMAD BrowserENSG00000168454
Varsome BrowserTXNDC2
ACMGTXNDC2 variants
VarityQ86VQ3
Genomic Variants (DGV)TXNDC2 [DGVbeta]
DECIPHERTXNDC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNDC2 
Mutations
ICGC Data PortalTXNDC2 
TCGA Data PortalTXNDC2 
Broad Tumor PortalTXNDC2
OASIS PortalTXNDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTXNDC2
Mutations and Diseases : HGMDTXNDC2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTXNDC2
DgiDB (Drug Gene Interaction Database)TXNDC2
DoCM (Curated mutations)TXNDC2
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC2
Cancer3DTXNDC2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617790   
Orphanet
DisGeNETTXNDC2
MedgenTXNDC2
Genetic Testing Registry TXNDC2
NextProtQ86VQ3 [Medical]
GENETestsTXNDC2
Target ValidationTXNDC2
Huge Navigator TXNDC2 [HugePedia]
ClinGenTXNDC2
Clinical trials, drugs, therapy
MyCancerGenomeTXNDC2
Protein Interactions : CTDTXNDC2
Pharm GKB GenePA38147
PharosQ86VQ3
Clinical trialTXNDC2
Miscellaneous
canSAR (ICR)TXNDC2
HarmonizomeTXNDC2
DataMed IndexTXNDC2
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTXNDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:57 CEST 2021

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