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TXNDC2 (thioredoxin domain containing 2)

Identity

Alias_namesthioredoxin domain containing 2 (spermatozoa)
Alias_symbol (synonym)SPTRX1
Other aliasSPTRX
HGNC (Hugo) TXNDC2
LocusID (NCBI) 84203
Atlas_Id 56412
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 9885726 and ends at 9888159 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TXNDC2   16470
Cards
Entrez_Gene (NCBI)TXNDC2  84203  thioredoxin domain containing 2
AliasesSPTRX; SPTRX1
GeneCards (Weizmann)TXNDC2
Ensembl hg19 (Hinxton)ENSG00000168454 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168454 [Gene_View]  chr18:9885726-9888159 [Contig_View]  TXNDC2 [Vega]
ICGC DataPortalENSG00000168454
TCGA cBioPortalTXNDC2
AceView (NCBI)TXNDC2
Genatlas (Paris)TXNDC2
WikiGenes84203
SOURCE (Princeton)TXNDC2
Genetics Home Reference (NIH)TXNDC2
Genomic and cartography
GoldenPath hg38 (UCSC)TXNDC2  -     chr18:9885726-9888159 +  18p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNDC2  -     18p11.22   [Description]    (hg19-Feb_2009)
EnsemblTXNDC2 - 18p11.22 [CytoView hg19]  TXNDC2 - 18p11.22 [CytoView hg38]
Mapping of homologs : NCBITXNDC2 [Mapview hg19]  TXNDC2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF080095 AK097656 AK303045 AL136742 BC050132
RefSeq transcript (Entrez)NM_001098529 NM_032243
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TXNDC2
Cluster EST : UnigeneHs.98712 [ NCBI ]
CGAP (NCI)Hs.98712
Alternative Splicing GalleryENSG00000168454
Gene ExpressionTXNDC2 [ NCBI-GEO ]   TXNDC2 [ EBI - ARRAY_EXPRESS ]   TXNDC2 [ SEEK ]   TXNDC2 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84203
GTEX Portal (Tissue expression)TXNDC2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VQ3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VQ3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VQ3
Splice isoforms : SwissVarQ86VQ3
PhosPhoSitePlusQ86VQ3
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Thioredoxin    Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXNDC2
DMDM Disease mutations84203
Blocks (Seattle)TXNDC2
SuperfamilyQ86VQ3
Human Protein AtlasENSG00000168454
Peptide AtlasQ86VQ3
HPRD11654
IPIIPI00410323   IPI00479021   IPI00910041   IPI01015881   
Protein Interaction databases
DIP (DOE-UCLA)Q86VQ3
IntAct (EBI)Q86VQ3
FunCoupENSG00000168454
BioGRIDTXNDC2
STRING (EMBL)TXNDC2
ZODIACTXNDC2
Ontologies - Pathways
QuickGOQ86VQ3
Ontology : AmiGOouter dense fiber  thioredoxin-disulfide reductase activity  thioredoxin-disulfide reductase activity  cytoplasm  cytoplasm  glycerol ether metabolic process  multicellular organism development  spermatogenesis  protein disulfide oxidoreductase activity  oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor  cell differentiation  cellular response to oxidative stress  cell redox homeostasis  cell redox homeostasis  protein-disulfide reductase activity  oxidation-reduction process  cellular oxidant detoxification  
Ontology : EGO-EBIouter dense fiber  thioredoxin-disulfide reductase activity  thioredoxin-disulfide reductase activity  cytoplasm  cytoplasm  glycerol ether metabolic process  multicellular organism development  spermatogenesis  protein disulfide oxidoreductase activity  oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor  cell differentiation  cellular response to oxidative stress  cell redox homeostasis  cell redox homeostasis  protein-disulfide reductase activity  oxidation-reduction process  cellular oxidant detoxification  
NDEx NetworkTXNDC2
Atlas of Cancer Signalling NetworkTXNDC2
Wikipedia pathwaysTXNDC2
Orthology - Evolution
OrthoDB84203
GeneTree (enSembl)ENSG00000168454
Phylogenetic Trees/Animal Genes : TreeFamTXNDC2
HOVERGENQ86VQ3
HOGENOMQ86VQ3
Homologs : HomoloGeneTXNDC2
Homology/Alignments : Family Browser (UCSC)TXNDC2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC2
dbVarTXNDC2
ClinVarTXNDC2
1000_GenomesTXNDC2 
Exome Variant ServerTXNDC2
ExAC (Exome Aggregation Consortium)TXNDC2 (select the gene name)
Genetic variants : HAPMAP84203
Genomic Variants (DGV)TXNDC2 [DGVbeta]
DECIPHERTXNDC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNDC2 
Mutations
ICGC Data PortalTXNDC2 
TCGA Data PortalTXNDC2 
Broad Tumor PortalTXNDC2
OASIS PortalTXNDC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXNDC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TXNDC2
DgiDB (Drug Gene Interaction Database)TXNDC2
DoCM (Curated mutations)TXNDC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC2 (select a term)
intoGenTXNDC2
Cancer3DTXNDC2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTXNDC2
Genetic Testing Registry TXNDC2
NextProtQ86VQ3 [Medical]
TSGene84203
GENETestsTXNDC2
Target ValidationTXNDC2
Huge Navigator TXNDC2 [HugePedia]
snp3D : Map Gene to Disease84203
BioCentury BCIQTXNDC2
ClinGenTXNDC2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84203
Chemical/Pharm GKB GenePA38147
Clinical trialTXNDC2
Miscellaneous
canSAR (ICR)TXNDC2 (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNDC2
EVEXTXNDC2
GoPubMedTXNDC2
iHOPTXNDC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:18:04 CEST 2017

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