TXNDC2 (thioredoxin domain containing 2)

2016-10-01  

Identity

HGNC
TXNDC2
LOCATION
18p11.22
LOCUSID
84203
ALIAS
SPTRX,SPTRX1

Other Information

Locus ID:

NCBI: 84203
MIM: 617790
HGNC: 16470
Ensembl: ENSG00000168454

Variants:

dbSNP: 84203
ClinVar: 84203
TCGA: ENSG00000168454
COSMIC: TXNDC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168454ENST00000306084Q86VQ3
ENSG00000168454ENST00000306084A0A140VJY8
ENSG00000168454ENST00000357775Q86VQ3
ENSG00000168454ENST00000536353F5H6S7
ENSG00000168454ENST00000584255J3QSG5
ENSG00000168454ENST00000611534Q86VQ3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
117372682001Sptrx-2, a fusion protein composed of one thioredoxin and three tandemly repeated NDP-kinase domains is expressed in human testis germ cells.20
213754722011Is serum thioredoxin-1 a useful clinical marker for malignant pleural mesothelioma?5
123878702002Human spermatid-specific thioredoxin-1 (Sptrx-1) is a two-domain protein with oxidizing activity.3

Citation

Dessen P

TXNDC2 (thioredoxin domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56412/txndc2