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TXNDC5 (thioredoxin domain containing 5)

Identity

Alias (NCBI)ENDOPDI
ERP46
HCC-2
HCC2
PDIA15
STRF8
UNQ364
HGNC (Hugo) TXNDC5
HGNC Alias symbMGC3178
FLJ21353
FLJ90810
EndoPDI
Hcc-2
ERp46
PDIA15
HGNC Alias nameprotein disulfide isomerase family A, member 15
LocusID (NCBI) 81567
Atlas_Id 49897
Location 6p24.3  [Link to chromosome band 6p24]
Location_base_pair Starts at 7881519 and ends at 7910788 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CFL1 (11q13.1) / TXNDC5 (6p24.3)ELN (7q11.23) / TXNDC5 (6p24.3)FBXL18 (7p22.1) / TXNDC5 (6p24.3)
LPCAT2 (16q12.2) / TXNDC5 (6p24.3)NCOA3 (20q13.12) / TXNDC5 (6p24.3)RANBP9 (6p23) / TXNDC5 (6p24.3)
SGTA (19p13.3) / TXNDC5 (6p24.3)TXNDC5 (6p24.3) / BLOC1S5 (6p24.3)TXNDC5 (6p24.3) / BMP6 (6p24.3)
TXNDC5 (6p24.3) / H19 (11p15.5)TXNDC5 (6p24.3) / PXK (3p14.3)TXNDC5 (6p24.3) / TXNDC5 (6p24.3)
RANBP9 6p23 / TXNDC5 6p24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TXNDC5   21073
Cards
Entrez_Gene (NCBI)TXNDC5    thioredoxin domain containing 5
AliasesENDOPDI; ERP46; HCC-2; HCC2; 
PDIA15; STRF8; UNQ364
GeneCards (Weizmann)TXNDC5
Ensembl hg19 (Hinxton)ENSG00000239264 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000239264 [Gene_View]  ENSG00000239264 [Sequence]  chr6:7881519-7910788 [Contig_View]  TXNDC5 [Vega]
ICGC DataPortalENSG00000239264
TCGA cBioPortalTXNDC5
AceView (NCBI)TXNDC5
Genatlas (Paris)TXNDC5
SOURCE (Princeton)TXNDC5
Genetics Home Reference (NIH)TXNDC5
Genomic and cartography
GoldenPath hg38 (UCSC)TXNDC5  -     chr6:7881519-7910788 -  6p24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNDC5  -     6p24.3   [Description]    (hg19-Feb_2009)
GoldenPathTXNDC5 - 6p24.3 [CytoView hg19]  TXNDC5 - 6p24.3 [CytoView hg38]
ImmunoBaseENSG00000239264
Genome Data Viewer NCBITXNDC5 [Mapview hg19]  
OMIM616412   
Gene and transcription
Genbank (Entrez)AJ440721 AK025006 AK075291 AK098089 AK315598
RefSeq transcript (Entrez)NM_001145549 NM_022085 NM_030810
Consensus coding sequences : CCDS (NCBI)TXNDC5
Gene ExpressionTXNDC5 [ NCBI-GEO ]   TXNDC5 [ EBI - ARRAY_EXPRESS ]   TXNDC5 [ SEEK ]   TXNDC5 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC5 [ Firebrowse - Broad ]
GenevisibleExpression of TXNDC5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81567
GTEX Portal (Tissue expression)TXNDC5
Human Protein AtlasENSG00000239264-TXNDC5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NBS9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NBS9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NBS9
PhosPhoSitePlusQ8NBS9
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Disulphide_isomerase    Thioredoxin-like_sf    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXNDC5
PDB (RSDB)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
PDB Europe2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
PDB (PDBSum)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
PDB (IMB)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
Structural Biology KnowledgeBase2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
SCOP (Structural Classification of Proteins)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
CATH (Classification of proteins structures)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
SuperfamilyQ8NBS9
AlphaFold pdb e-kbQ8NBS9   
Human Protein Atlas [tissue]ENSG00000239264-TXNDC5 [tissue]
HPRD18249
Protein Interaction databases
DIP (DOE-UCLA)Q8NBS9
IntAct (EBI)Q8NBS9
BioGRIDTXNDC5
STRING (EMBL)TXNDC5
ZODIACTXNDC5
Ontologies - Pathways
QuickGOQ8NBS9
Ontology : AmiGOprotein disulfide isomerase activity  protein binding  extracellular region  endoplasmic reticulum  endoplasmic reticulum lumen  post-Golgi vesicle-mediated transport  azurophil granule lumen  negative regulation of apoptotic process  lysosomal lumen  apoptotic cell clearance  neutrophil degranulation  extracellular exosome  
Ontology : EGO-EBIprotein disulfide isomerase activity  protein binding  extracellular region  endoplasmic reticulum  endoplasmic reticulum lumen  post-Golgi vesicle-mediated transport  azurophil granule lumen  negative regulation of apoptotic process  lysosomal lumen  apoptotic cell clearance  neutrophil degranulation  extracellular exosome  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkTXNDC5
Atlas of Cancer Signalling NetworkTXNDC5
Wikipedia pathwaysTXNDC5
Orthology - Evolution
OrthoDB81567
GeneTree (enSembl)ENSG00000239264
Phylogenetic Trees/Animal Genes : TreeFamTXNDC5
Homologs : HomoloGeneTXNDC5
Homology/Alignments : Family Browser (UCSC)TXNDC5
Gene fusions - Rearrangements
Fusion : MitelmanRANBP9/TXNDC5 [6p23/6p24.3]  
Fusion : QuiverTXNDC5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC5
dbVarTXNDC5
ClinVarTXNDC5
MonarchTXNDC5
1000_GenomesTXNDC5 
Exome Variant ServerTXNDC5
GNOMAD BrowserENSG00000239264
Varsome BrowserTXNDC5
ACMGTXNDC5 variants
VarityQ8NBS9
Genomic Variants (DGV)TXNDC5 [DGVbeta]
DECIPHERTXNDC5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNDC5 
Mutations
ICGC Data PortalTXNDC5 
TCGA Data PortalTXNDC5 
Broad Tumor PortalTXNDC5
OASIS PortalTXNDC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTXNDC5
Mutations and Diseases : HGMDTXNDC5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTXNDC5
DgiDB (Drug Gene Interaction Database)TXNDC5
DoCM (Curated mutations)TXNDC5
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC5
Cancer3DTXNDC5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616412   
Orphanet
DisGeNETTXNDC5
MedgenTXNDC5
Genetic Testing Registry TXNDC5
NextProtQ8NBS9 [Medical]
GENETestsTXNDC5
Target ValidationTXNDC5
Huge Navigator TXNDC5 [HugePedia]
ClinGenTXNDC5
Clinical trials, drugs, therapy
MyCancerGenomeTXNDC5
Protein Interactions : CTDTXNDC5
Pharm GKB GenePA134992492
PharosQ8NBS9
Clinical trialTXNDC5
Miscellaneous
canSAR (ICR)TXNDC5
HarmonizomeTXNDC5
DataMed IndexTXNDC5
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTXNDC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:36:57 CEST 2021

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