TXNDC5 (thioredoxin domain containing 5)

2007-12-01  

Identity

HGNC
LOCATION
6p24.3
LOCUSID
ALIAS
ENDOPDI,ERP46,HCC-2,HCC2,PDIA15,STRF8,UNQ364
FUSION GENES

Other Information

Locus ID:

NCBI: 81567
MIM: 616412
HGNC: 21073
Ensembl: ENSG00000239264

Variants:

dbSNP: 81567
ClinVar: 81567
TCGA: ENSG00000239264
COSMIC: TXNDC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239264ENST00000379757Q8NBS9
ENSG00000239264ENST00000473453Q8NBS9
ENSG00000239264ENST00000473453A0A024QZV0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385487042024Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release.0
386290662024The role and mechanism of TXNDC5 in disease progression.0
385487042024Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release.0
386290662024The role and mechanism of TXNDC5 in disease progression.0
361064472023Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis.7
361064472023Identification of thioredoxin domain containing family members' expression pattern and prognostic value in diffuse gliomas via in silico analysis.7
346069822022Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p.4
359347052022The role and mechanism of TXNDC5 in diseases.7
360507162022The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications.5
346069822022Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p.4
359347052022The role and mechanism of TXNDC5 in diseases.7
360507162022The novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications.5
305223662020Maternal serum TXNDC5 levels and thiol/disulfide homeostasis in preeclamptic pregnancies.2
328481432020Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.43
305223662020Maternal serum TXNDC5 levels and thiol/disulfide homeostasis in preeclamptic pregnancies.2

Citation

Dessen P

TXNDC5 (thioredoxin domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49897/txndc5