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TXNDC5 (thioredoxin domain containing 5)

Identity

Alias_namesmember 15
Alias_symbol (synonym)MGC3178
FLJ21353
FLJ90810
EndoPDI
Hcc-2
ERp46
PDIA15
HGNC (Hugo) TXNDC5
LocusID (NCBI) 81567
Atlas_Id 49897
Location 6p24.3  [Link to chromosome band 6p24]
Location_base_pair Starts at 7881483 and ends at 7910310 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CFL1 (11q13.1) / TXNDC5 (6p24.3)ELN (7q11.23) / TXNDC5 (6p24.3)FBXL18 (7p22.1) / TXNDC5 (6p24.3)
LPCAT2 (16q12.2) / TXNDC5 (6p24.3)NCOA3 (20q13.12) / TXNDC5 (6p24.3)RANBP9 (6p23) / TXNDC5 (6p24.3)
SGTA (19p13.3) / TXNDC5 (6p24.3)TXNDC5 (6p24.3) / BLOC1S5 (6p24.3)TXNDC5 (6p24.3) / BMP6 (6p24.3)
TXNDC5 (6p24.3) / H19 (11p15.5)TXNDC5 (6p24.3) / PXK (3p14.3)TXNDC5 (6p24.3) / TXNDC5 (6p24.3)
RANBP9 6p23 / TXNDC5 6p24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TXNDC5   21073
Cards
Entrez_Gene (NCBI)TXNDC5  81567  thioredoxin domain containing 5
AliasesENDOPDI; ERP46; HCC-2; HCC2; 
PDIA15; STRF8; UNQ364
GeneCards (Weizmann)TXNDC5
Ensembl hg19 (Hinxton)ENSG00000239264 [Gene_View]  chr6:7881483-7910310 [Contig_View]  TXNDC5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000239264 [Gene_View]  chr6:7881483-7910310 [Contig_View]  TXNDC5 [Vega]
ICGC DataPortalENSG00000239264
TCGA cBioPortalTXNDC5
AceView (NCBI)TXNDC5
Genatlas (Paris)TXNDC5
WikiGenes81567
SOURCE (Princeton)TXNDC5
Genetics Home Reference (NIH)TXNDC5
Genomic and cartography
GoldenPath hg19 (UCSC)TXNDC5  -     chr6:7881483-7910310 -  6p24.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TXNDC5  -     6p24.3   [Description]    (hg38-Dec_2013)
EnsemblTXNDC5 - 6p24.3 [CytoView hg19]  TXNDC5 - 6p24.3 [CytoView hg38]
Mapping of homologs : NCBITXNDC5 [Mapview hg19]  TXNDC5 [Mapview hg38]
OMIM616412   
Gene and transcription
Genbank (Entrez)AJ440721 AK025006 AK075291 AK098089 AK315598
RefSeq transcript (Entrez)NM_001145549 NM_022085 NM_030810
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_007592 NW_004929326
Consensus coding sequences : CCDS (NCBI)TXNDC5
Cluster EST : UnigeneHs.150837 [ NCBI ]
CGAP (NCI)Hs.150837
Alternative Splicing GalleryENSG00000239264
Gene ExpressionTXNDC5 [ NCBI-GEO ]   TXNDC5 [ EBI - ARRAY_EXPRESS ]   TXNDC5 [ SEEK ]   TXNDC5 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)81567
GTEX Portal (Tissue expression)TXNDC5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8NBS9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8NBS9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8NBS9
Splice isoforms : SwissVarQ8NBS9
PhosPhoSitePlusQ8NBS9
Domaine pattern : Prosite (Expaxy)ER_TARGET (PS00014)    THIOREDOXIN_1 (PS00194)    THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)Disulphide_isomerase    Thioredoxin-like_fold    Thioredoxin_CS    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXNDC5
DMDM Disease mutations81567
Blocks (Seattle)TXNDC5
PDB (SRS)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
PDB (PDBSum)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
PDB (IMB)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
PDB (RSDB)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
Structural Biology KnowledgeBase2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
SCOP (Structural Classification of Proteins)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
CATH (Classification of proteins structures)2DIZ    3UJ1    3UVT    3WGD    3WGE    3WGX   
SuperfamilyQ8NBS9
Human Protein AtlasENSG00000239264
Peptide AtlasQ8NBS9
HPRD18249
Protein Interaction databases
DIP (DOE-UCLA)Q8NBS9
IntAct (EBI)Q8NBS9
FunCoupENSG00000239264
BioGRIDTXNDC5
STRING (EMBL)TXNDC5
ZODIACTXNDC5
Ontologies - Pathways
QuickGOQ8NBS9
Ontology : AmiGOprotein disulfide isomerase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  metabolic process  response to endoplasmic reticulum stress  negative regulation of apoptotic process  lysosomal lumen  apoptotic cell clearance  cell redox homeostasis  extracellular exosome  
Ontology : EGO-EBIprotein disulfide isomerase activity  protein binding  endoplasmic reticulum  endoplasmic reticulum lumen  protein folding  metabolic process  response to endoplasmic reticulum stress  negative regulation of apoptotic process  lysosomal lumen  apoptotic cell clearance  cell redox homeostasis  extracellular exosome  
Pathways : KEGGProtein processing in endoplasmic reticulum   
NDEx NetworkTXNDC5
Atlas of Cancer Signalling NetworkTXNDC5
Wikipedia pathwaysTXNDC5
Orthology - Evolution
OrthoDB81567
GeneTree (enSembl)ENSG00000239264
Phylogenetic Trees/Animal Genes : TreeFamTXNDC5
HOVERGENQ8NBS9
HOGENOMQ8NBS9
Homologs : HomoloGeneTXNDC5
Homology/Alignments : Family Browser (UCSC)TXNDC5
Gene fusions - Rearrangements
Fusion : MitelmanRANBP9/TXNDC5 [6p23/6p24.3]  [t(6;6)(p23;p24)]  
Fusion: TCGARANBP9 6p23 TXNDC5 6p24.3 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC5
dbVarTXNDC5
ClinVarTXNDC5
1000_GenomesTXNDC5 
Exome Variant ServerTXNDC5
ExAC (Exome Aggregation Consortium)TXNDC5 (select the gene name)
Genetic variants : HAPMAP81567
Genomic Variants (DGV)TXNDC5 [DGVbeta]
DECIPHER (Syndromes)6:7881483-7910310  ENSG00000239264
CONAN: Copy Number AnalysisTXNDC5 
Mutations
ICGC Data PortalTXNDC5 
TCGA Data PortalTXNDC5 
Broad Tumor PortalTXNDC5
OASIS PortalTXNDC5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXNDC5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TXNDC5
DgiDB (Drug Gene Interaction Database)TXNDC5
DoCM (Curated mutations)TXNDC5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC5 (select a term)
intoGenTXNDC5
Cancer3DTXNDC5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616412   
Orphanet
MedgenTXNDC5
Genetic Testing Registry TXNDC5
NextProtQ8NBS9 [Medical]
TSGene81567
GENETestsTXNDC5
Huge Navigator TXNDC5 [HugePedia]
snp3D : Map Gene to Disease81567
BioCentury BCIQTXNDC5
ClinGenTXNDC5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD81567
Chemical/Pharm GKB GenePA134992492
Clinical trialTXNDC5
Miscellaneous
canSAR (ICR)TXNDC5 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNDC5
EVEXTXNDC5
GoPubMedTXNDC5
iHOPTXNDC5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:54:57 CET 2016

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