TXNDC5 (thioredoxin domain containing 5)

2007-12-01  

Identity

HGNC
LOCATION
6p24.3
LOCUSID
ALIAS
ENDOPDI,ERP46,HCC-2,HCC2,PDIA15,STRF8,UNQ364
FUSION GENES

Other Information

Locus ID:

NCBI: 81567
MIM: 616412
HGNC: 21073
Ensembl: ENSG00000239264

Variants:

dbSNP: 81567
ClinVar: 81567
TCGA: ENSG00000239264
COSMIC: TXNDC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239264ENST00000379757Q8NBS9
ENSG00000239264ENST00000473453Q8NBS9
ENSG00000239264ENST00000473453A0A024QZV0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198875852009Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins.75
129637162003EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor.40
178955232007Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study.30
198345352009Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.27
237135882013Hyperoxidized peroxiredoxin 2 interacts with the protein disulfide- isomerase ERp46.16
201577322010The influence of TXNDC5 gene on gastric cancer cell.15
255005402015The role of TXNDC5 in castration-resistant prostate cancer-involvement of androgen receptor signaling pathway.15
200745512010ERp46 binds to AdipoR1, but not AdipoR2, and modulates adiponectin signalling.14
233264102013Investigate pathogenic mechanism of TXNDC5 in rheumatoid arthritis.14
241009492013Investigating a pathogenic role for TXNDC5 in tumors.14

Citation

Dessen P

TXNDC5 (thioredoxin domain containing 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49897/txndc5