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TXNDC8 (thioredoxin domain containing 8)

Identity

Alias_namesthioredoxin domain containing 8 (spermatozoa)
Alias_symbol (synonym)bA427L11.2
TRX6
SPTRX-3
Other alias
HGNC (Hugo) TXNDC8
LocusID (NCBI) 255220
Atlas_Id 53656
Location 9q31.3  [Link to chromosome band 9q31]
Location_base_pair Starts at 110303587 and ends at 110337884 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TXNDC8   31454
Cards
Entrez_Gene (NCBI)TXNDC8  255220  thioredoxin domain containing 8
AliasesSPTRX-3; TRX6; bA427L11.2
GeneCards (Weizmann)TXNDC8
Ensembl hg19 (Hinxton)ENSG00000204193 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204193 [Gene_View]  chr9:110303587-110337884 [Contig_View]  TXNDC8 [Vega]
ICGC DataPortalENSG00000204193
TCGA cBioPortalTXNDC8
AceView (NCBI)TXNDC8
Genatlas (Paris)TXNDC8
WikiGenes255220
SOURCE (Princeton)TXNDC8
Genetics Home Reference (NIH)TXNDC8
Genomic and cartography
GoldenPath hg38 (UCSC)TXNDC8  -     chr9:110303587-110337884 -  9q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNDC8  -     9q31.3   [Description]    (hg19-Feb_2009)
EnsemblTXNDC8 - 9q31.3 [CytoView hg19]  TXNDC8 - 9q31.3 [CytoView hg38]
Mapping of homologs : NCBITXNDC8 [Mapview hg19]  TXNDC8 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF305830 BC035743 BC130549 BC130551 BC144461
RefSeq transcript (Entrez)NM_001003936 NM_001286946 NM_001286947
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TXNDC8
Cluster EST : UnigeneHs.147064 [ NCBI ]
CGAP (NCI)Hs.147064
Alternative Splicing GalleryENSG00000204193
Gene ExpressionTXNDC8 [ NCBI-GEO ]   TXNDC8 [ EBI - ARRAY_EXPRESS ]   TXNDC8 [ SEEK ]   TXNDC8 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNDC8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)255220
GTEX Portal (Tissue expression)TXNDC8
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6A555   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6A555  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6A555
Splice isoforms : SwissVarQ6A555
PhosPhoSitePlusQ6A555
Domains : Interpro (EBI)Thioredoxin    Thioredoxin-like_fold    Thioredoxin_domain   
Domain families : Pfam (Sanger)Thioredoxin (PF00085)   
Domain families : Pfam (NCBI)pfam00085   
Conserved Domain (NCBI)TXNDC8
DMDM Disease mutations255220
Blocks (Seattle)TXNDC8
SuperfamilyQ6A555
Human Protein AtlasENSG00000204193
Peptide AtlasQ6A555
HPRD18251
IPIIPI00607678   IPI00160585   IPI00514086   IPI00922489   
Protein Interaction databases
DIP (DOE-UCLA)Q6A555
IntAct (EBI)Q6A555
FunCoupENSG00000204193
BioGRIDTXNDC8
STRING (EMBL)TXNDC8
ZODIACTXNDC8
Ontologies - Pathways
QuickGOQ6A555
Ontology : AmiGOacrosomal vesicle  acrosome assembly  thioredoxin-disulfide reductase activity  cytoplasm  Golgi apparatus  glycerol ether metabolic process  multicellular organism development  spermatogenesis  protein disulfide oxidoreductase activity  oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor  cellular response to oxidative stress  sperm flagellum  cell redox homeostasis  protein-disulfide reductase activity  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  
Ontology : EGO-EBIacrosomal vesicle  acrosome assembly  thioredoxin-disulfide reductase activity  cytoplasm  Golgi apparatus  glycerol ether metabolic process  multicellular organism development  spermatogenesis  protein disulfide oxidoreductase activity  oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor  cellular response to oxidative stress  sperm flagellum  cell redox homeostasis  protein-disulfide reductase activity  oxidation-reduction process  extracellular exosome  cellular oxidant detoxification  
NDEx NetworkTXNDC8
Atlas of Cancer Signalling NetworkTXNDC8
Wikipedia pathwaysTXNDC8
Orthology - Evolution
OrthoDB255220
GeneTree (enSembl)ENSG00000204193
Phylogenetic Trees/Animal Genes : TreeFamTXNDC8
HOVERGENQ6A555
HOGENOMQ6A555
Homologs : HomoloGeneTXNDC8
Homology/Alignments : Family Browser (UCSC)TXNDC8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNDC8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNDC8
dbVarTXNDC8
ClinVarTXNDC8
1000_GenomesTXNDC8 
Exome Variant ServerTXNDC8
ExAC (Exome Aggregation Consortium)TXNDC8 (select the gene name)
Genetic variants : HAPMAP255220
Genomic Variants (DGV)TXNDC8 [DGVbeta]
DECIPHERTXNDC8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNDC8 
Mutations
ICGC Data PortalTXNDC8 
TCGA Data PortalTXNDC8 
Broad Tumor PortalTXNDC8
OASIS PortalTXNDC8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNDC8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXNDC8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TXNDC8
DgiDB (Drug Gene Interaction Database)TXNDC8
DoCM (Curated mutations)TXNDC8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNDC8 (select a term)
intoGenTXNDC8
Cancer3DTXNDC8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenTXNDC8
Genetic Testing Registry TXNDC8
NextProtQ6A555 [Medical]
TSGene255220
GENETestsTXNDC8
Target ValidationTXNDC8
Huge Navigator TXNDC8 [HugePedia]
snp3D : Map Gene to Disease255220
BioCentury BCIQTXNDC8
ClinGenTXNDC8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD255220
Chemical/Pharm GKB GenePA134935003
Clinical trialTXNDC8
Miscellaneous
canSAR (ICR)TXNDC8 (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNDC8
EVEXTXNDC8
GoPubMedTXNDC8
iHOPTXNDC8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:36:55 CEST 2017

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