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TXNRD1 (thioredoxin reductase 1)

Identity

Alias_symbol (synonym)TXNR
GRIM-12
Trxr1
Other aliasTR
TR1
TRXR1
HGNC (Hugo) TXNRD1
LocusID (NCBI) 7296
Atlas_Id 46587
Location 12q23.3  [Link to chromosome band 12q23]
Location_base_pair Starts at 104215779 and ends at 104350307 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CHST11 (12q23.3) / TXNRD1 (12q23.3)MAP7D1 (1p34.3) / TXNRD1 (12q23.3)SRSF11 (1p31.1) / TXNRD1 (12q23.3)
TXNRD1 (12q23.3) / ADGRD1 (12q24.33)TXNRD1 (12q23.3) / CHST11 (12q23.3)TXNRD1 (12q23.3) / HCFC2 (12q23.3)
TXNRD1 (12q23.3) / LCN2 (9q34.11)TXNRD1 (12q23.3) / NPM1 (5q35.1)TXNRD1 (12q23.3) / RNF185 (22q12.2)
TXNRD1 (12q23.3) / UIMC1 (5q35.2)TXNRD1 (12q23.3) / USP30 (12q24.11)TXNRD1 12q23.3 / HCFC2 12q23.3
TXNRD1 12q23.3 / USP30 12q24.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)TXNRD1   12437
Cards
Entrez_Gene (NCBI)TXNRD1  7296  thioredoxin reductase 1
AliasesGRIM-12; TR; TR1; TRXR1; 
TXNR
GeneCards (Weizmann)TXNRD1
Ensembl hg19 (Hinxton)ENSG00000198431 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198431 [Gene_View]  chr12:104215779-104350307 [Contig_View]  TXNRD1 [Vega]
ICGC DataPortalENSG00000198431
TCGA cBioPortalTXNRD1
AceView (NCBI)TXNRD1
Genatlas (Paris)TXNRD1
WikiGenes7296
SOURCE (Princeton)TXNRD1
Genetics Home Reference (NIH)TXNRD1
Genomic and cartography
GoldenPath hg38 (UCSC)TXNRD1  -     chr12:104215779-104350307 +  12q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TXNRD1  -     12q23.3   [Description]    (hg19-Feb_2009)
EnsemblTXNRD1 - 12q23.3 [CytoView hg19]  TXNRD1 - 12q23.3 [CytoView hg38]
Mapping of homologs : NCBITXNRD1 [Mapview hg19]  TXNRD1 [Mapview hg38]
OMIM601112   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001093771 NM_001261445 NM_001261446 NM_003330 NM_182729 NM_182742 NM_182743
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TXNRD1
Cluster EST : UnigeneHs.690011 [ NCBI ]
CGAP (NCI)Hs.690011
Alternative Splicing GalleryENSG00000198431
Gene ExpressionTXNRD1 [ NCBI-GEO ]   TXNRD1 [ EBI - ARRAY_EXPRESS ]   TXNRD1 [ SEEK ]   TXNRD1 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNRD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7296
GTEX Portal (Tissue expression)TXNRD1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16881   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16881  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16881
Splice isoforms : SwissVarQ16881
Catalytic activity : Enzyme1.8.1.9 [ Enzyme-Expasy ]   1.8.1.91.8.1.9 [ IntEnz-EBI ]   1.8.1.9 [ BRENDA ]   1.8.1.9 [ KEGG ]   
PhosPhoSitePlusQ16881
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_2 (PS51354)    PYRIDINE_REDOX_1 (PS00076)   
Domains : Interpro (EBI)FAD/NAD-binding_dom    FAD/NAD-linked_Rdtase_dimer    Glutaredoxin    Pyr_nucl-diS_OxRdtase_dimer    Pyr_OxRdtase_I_AS    Thioredoxin-like_fold    Thioredoxin/glutathione_Rdtase   
Domain families : Pfam (Sanger)Glutaredoxin (PF00462)    Pyr_redox_2 (PF07992)    Pyr_redox_dim (PF02852)   
Domain families : Pfam (NCBI)pfam00462    pfam07992    pfam02852   
Conserved Domain (NCBI)TXNRD1
DMDM Disease mutations7296
Blocks (Seattle)TXNRD1
PDB (SRS)1W1C    2CFY    2J3N    2ZZ0    2ZZB    2ZZC    3QFA    3QFB   
PDB (PDBSum)1W1C    2CFY    2J3N    2ZZ0    2ZZB    2ZZC    3QFA    3QFB   
PDB (IMB)1W1C    2CFY    2J3N    2ZZ0    2ZZB    2ZZC    3QFA    3QFB   
PDB (RSDB)1W1C    2CFY    2J3N    2ZZ0    2ZZB    2ZZC    3QFA    3QFB   
Structural Biology KnowledgeBase1W1C    2CFY    2J3N    2ZZ0    2ZZB    2ZZC    3QFA    3QFB   
SCOP (Structural Classification of Proteins)1W1C    2CFY    2J3N    2ZZ0    2ZZB    2ZZC    3QFA    3QFB   
CATH (Classification of proteins structures)1W1C    2CFY    2J3N    2ZZ0    2ZZB    2ZZC    3QFA    3QFB   
SuperfamilyQ16881
Human Protein AtlasENSG00000198431
Peptide AtlasQ16881
HPRD03068
IPIIPI00983068   IPI00871867   IPI00783641   IPI00847482   IPI00554786   IPI00885213   IPI00984188   IPI00983539   IPI00981495   IPI00985249   IPI00984681   IPI00982356   IPI00977771   IPI00979993   IPI00983604   IPI00979268   IPI00981644   IPI00977989   
Protein Interaction databases
DIP (DOE-UCLA)Q16881
IntAct (EBI)Q16881
FunCoupENSG00000198431
BioGRIDTXNRD1
STRING (EMBL)TXNRD1
ZODIACTXNRD1
Ontologies - Pathways
QuickGOQ16881
Ontology : AmiGOresponse to reactive oxygen species  response to oxygen radical  fibrillar center  selenium compound metabolic process  thioredoxin-disulfide reductase activity  thioredoxin-disulfide reductase activity  protein binding  nucleoplasm  mitochondrion  cytosol  signal transduction  electron carrier activity  protein disulfide oxidoreductase activity  nucleobase-containing small molecule interconversion  cell redox homeostasis  flavin adenine dinucleotide binding  oxidation-reduction process  extracellular exosome  methylselenol reductase activity  methylseleninic acid reductase activity  cellular oxidant detoxification  
Ontology : EGO-EBIresponse to reactive oxygen species  response to oxygen radical  fibrillar center  selenium compound metabolic process  thioredoxin-disulfide reductase activity  thioredoxin-disulfide reductase activity  protein binding  nucleoplasm  mitochondrion  cytosol  signal transduction  electron carrier activity  protein disulfide oxidoreductase activity  nucleobase-containing small molecule interconversion  cell redox homeostasis  flavin adenine dinucleotide binding  oxidation-reduction process  extracellular exosome  methylselenol reductase activity  methylseleninic acid reductase activity  cellular oxidant detoxification  
Pathways : KEGGPyrimidine metabolism    Selenocompound metabolism   
NDEx NetworkTXNRD1
Atlas of Cancer Signalling NetworkTXNRD1
Wikipedia pathwaysTXNRD1
Orthology - Evolution
OrthoDB7296
GeneTree (enSembl)ENSG00000198431
Phylogenetic Trees/Animal Genes : TreeFamTXNRD1
HOVERGENQ16881
HOGENOMQ16881
Homologs : HomoloGeneTXNRD1
Homology/Alignments : Family Browser (UCSC)TXNRD1
Gene fusions - Rearrangements
Fusion : MitelmanTXNRD1/GPR133 [12q23.3/]  
Fusion : MitelmanTXNRD1/HCFC2 [12q23.3/12q23.3]  [t(12;12)(q23;q23)]  
Fusion : MitelmanTXNRD1/USP30 [12q23.3/12q24.11]  [t(12;12)(q23;q24)]  
Fusion: TCGATXNRD1 12q23.3 HCFC2 12q23.3 LUSC
Fusion: TCGATXNRD1 12q23.3 USP30 12q24.11 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNRD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNRD1
dbVarTXNRD1
ClinVarTXNRD1
1000_GenomesTXNRD1 
Exome Variant ServerTXNRD1
ExAC (Exome Aggregation Consortium)TXNRD1 (select the gene name)
Genetic variants : HAPMAP7296
Genomic Variants (DGV)TXNRD1 [DGVbeta]
DECIPHERTXNRD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTXNRD1 
Mutations
ICGC Data PortalTXNRD1 
TCGA Data PortalTXNRD1 
Broad Tumor PortalTXNRD1
OASIS PortalTXNRD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNRD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXNRD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TXNRD1
DgiDB (Drug Gene Interaction Database)TXNRD1
DoCM (Curated mutations)TXNRD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNRD1 (select a term)
intoGenTXNRD1
Cancer3DTXNRD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601112   
Orphanet
MedgenTXNRD1
Genetic Testing Registry TXNRD1
NextProtQ16881 [Medical]
TSGene7296
GENETestsTXNRD1
Huge Navigator TXNRD1 [HugePedia]
snp3D : Map Gene to Disease7296
BioCentury BCIQTXNRD1
ClinGenTXNRD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7296
Chemical/Pharm GKB GenePA37093
Clinical trialTXNRD1
Miscellaneous
canSAR (ICR)TXNRD1 (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNRD1
EVEXTXNRD1
GoPubMedTXNRD1
iHOPTXNRD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:42:53 CEST 2017

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