TXNRD1 (thioredoxin reductase 1)

2007-02-01  

Identity

HGNC
LOCATION
12q23.3
LOCUSID
ALIAS
GRIM-12,TR,TR1,TRXR1,TXNR
FUSION GENES

Other Information

Locus ID:

NCBI: 7296
MIM: 601112
HGNC: 12437
Ensembl: ENSG00000198431

Variants:

dbSNP: 7296
ClinVar: 7296
TCGA: ENSG00000198431
COSMIC: TXNRD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198431ENST00000354940F8W809
ENSG00000198431ENST00000388854A0A087WSW9
ENSG00000198431ENST00000397736E2QRB9
ENSG00000198431ENST00000429002A0A087WSY9
ENSG00000198431ENST00000503506Q16881
ENSG00000198431ENST00000524698Q16881
ENSG00000198431ENST00000525566Q16881
ENSG00000198431ENST00000526266E9PLT3
ENSG00000198431ENST00000526390Q16881
ENSG00000198431ENST00000526580A0A0B4J225
ENSG00000198431ENST00000526691Q16881
ENSG00000198431ENST00000526950A0A182DWI3
ENSG00000198431ENST00000527335E9PKD3
ENSG00000198431ENST00000527688E9PIR7
ENSG00000198431ENST00000528079E9PJU2
ENSG00000198431ENST00000529546Q16881
ENSG00000198431ENST00000529751E9PRI8
ENSG00000198431ENST00000529784E9PQI3
ENSG00000198431ENST00000531689E9PKI4
ENSG00000198431ENST00000531691E9PIZ5

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Selenocompound metabolismKEGGko00450
Pyrimidine metabolismKEGGhsa00240
Selenocompound metabolismKEGGhsa00450
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Uptake and actions of bacterial toxinsREACTOMER-HSA-5339562
Uptake and function of diphtheria toxinREACTOMER-HSA-5336415
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781
Metabolism of nucleotidesREACTOMER-HSA-15869
Synthesis and interconversion of nucleotide di- and triphosphatesREACTOMER-HSA-499943
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested MeSeO2H into MeSeHREACTOMER-HSA-5263617
Metabolism of ingested H2SeO4 and H2SeO3 into H2SeREACTOMER-HSA-2408550

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA37091TXNGenePathwayassociated23913015
PA451898vitamin cChemicalPathwayassociated23913015

References

Pubmed IDYearTitleCitations
158795982005Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity.102
205843102010Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer.56
126686622003The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex.54
183826512008Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells.51
229772472012Glutathione and glutaredoxin act as a backup of human thioredoxin reductase 1 to reduce thioredoxin 1 preventing cell death by aurothioglucose.49
184833362008Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.41
184833362008Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.41
197667152009High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy.40
247782502014Thioredoxin-related protein of 14 kDa is an efficient L-cystine reductase and S-denitrosylase.40
164813282006Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase.38

Citation

Dessen P

TXNRD1 (thioredoxin reductase 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46587/txnrd1