TXNRD2 (thioredoxin reductase 2)

Identity

Other names	SELZ
	TR
	TR-BETA
	TR3
	TRXR2
HGNC	TXNRD2
Location	22q11.21
Location_base_pair	Starts at 18243040 and ends at 18309359 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TXNRD2   18155
Entrez_Gene	TXNRD2  10587  thioredoxin reductase 2
	Cards
GeneCards	TXNRD2
Ensembl	TXNRD2 [Search_View]   ENSG00000184470 [Gene_View]
Genatlas	TXNRD2
GeneLynx	TXNRD2
eGenome	TXNRD2
euGene	10587
	Genomic and cartography
GoldenPath	TXNRD2  -  22q11.21   chr22:18243040-18309359 -  22q11.21   [Description]    (hg18-March_2006)
Ensembl	TXNRD2 - 22q11.21 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TXNRD2
	Gene and transcription
Genbank	AB019694 [ ENTREZ ]
Genbank	AB019695 [ ENTREZ ]
Genbank	AB209724 [ ENTREZ ]
Genbank	AF044212 [ ENTREZ ]
Genbank	AF106697 [ ENTREZ ]
RefSeq	NM_006440 [ SRS ]    NM_006440 [ ENTREZ ]
RefSeq	AC_000065 [ SRS ]    AC_000065 [ ENTREZ ]
RefSeq	AC_000154 [ SRS ]    AC_000154 [ ENTREZ ]
RefSeq	NC_000022 [ SRS ]    NC_000022 [ ENTREZ ]
RefSeq	NT_011519 [ SRS ]    NT_011519 [ ENTREZ ]
RefSeq	NW_001838737 [ SRS ]    NW_001838737 [ ENTREZ ]
RefSeq	NW_927495 [ SRS ]    NW_927495 [ ENTREZ ]
AceView	TXNRD2 AceView - NCBI
Unigene	Hs.443430 [ SRS ]    Hs.443430 [ NCBI ]     HS443430 [ spliceNest ]
Fast-db	1400 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q17RE6 [ SRS]    Q17RE6 [ EXPASY ]     Q17RE6 [ INTERPRO ]     Q17RE6 [ UNIPROT ]
Prosite	PS00076 PYRIDINE_REDOX_1 [ SRS ]    PS00076 PYRIDINE_REDOX_1 [ Expasy ]
Interpro	IPR013027 FAD_pyr_nucl-diS_OxRdtase [ SRS ]    IPR013027 FAD_pyr_nucl-diS_OxRdtase [ EBI ]
Interpro	IPR000815 Hg_reductase [ SRS ]    IPR000815 Hg_reductase [ EBI ]
Interpro	IPR001100 Pyr_nuc-diS_OxRdtase [ SRS ]    IPR001100 Pyr_nuc-diS_OxRdtase [ EBI ]
Interpro	IPR004099 Pyr_nucl-diS_OxRdtase_dimer [ SRS ]    IPR004099 Pyr_nucl-diS_OxRdtase_dimer [ EBI ]
Interpro	IPR012999 Pyr_OxRdtase_I_AS [ SRS ]    IPR012999 Pyr_OxRdtase_I_AS [ EBI ]
Interpro	IPR001327 Pyr_OxRdtase_NAD_bd [ SRS ]    IPR001327 Pyr_OxRdtase_NAD_bd [ EBI ]
Interpro	IPR006338 Reduct_Se [ SRS ]    IPR006338 Reduct_Se [ EBI ]
CluSTr	Q17RE6
Pfam	PF00070 Pyr_redox [ SRS ]    PF00070 Pyr_redox [ Sanger ]    pfam00070 [ NCBI-CDD ]
Pfam	PF07992 Pyr_redox_2 [ SRS ]    PF07992 Pyr_redox_2 [ Sanger ]    pfam07992 [ NCBI-CDD ]
Pfam	PF02852 Pyr_redox_dim [ SRS ]    PF02852 Pyr_redox_dim [ Sanger ]    pfam02852 [ NCBI-CDD ]
Prodom	PD000139 FAD_pyr_redox[INRA-Toulouse]
Prodom	Q17RE6 Q17RE6_HUMAN [ Domain structure ]   Q17RE6 Q17RE6_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q17RE6
HPRD	05921
	Protein Interaction databases
DIP	Q17RE6
IntAct	Q17RE6
	Polymorphism : SNP, mutations, diseases
OMIM	606448    [ map ]
GENECLINICS	606448
SNP	TXNRD2 [dbSNP-NCBI]
SNP	NM_006440 [SNP-NCI]
SNP	TXNRD2 [GeneSNPs - Utah]  TXNRD2] [HGBASE - SRS]
HAPMAP	TXNRD2 [HAPMAP]
HGMD	TXNRD2
	General knowledge
Family Browser	TXNRD2 [UCSC Family Browser]
SOURCE	NM_006440
SMD	Hs.443430
SAGE	Hs.443430
GO	response to oxygen radical [Amigo]  response to oxygen radical
GO	thioredoxin-disulfide reductase activity [Amigo]  thioredoxin-disulfide reductase activity
GO	cytoplasm [Amigo]  cytoplasm
GO	mitochondrion [Amigo]  mitochondrion
GO	selenium binding [Amigo]  selenium binding
GO	electron carrier activity [Amigo]  electron carrier activity
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor [Amigo]  oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor
GO	cell redox homeostasis [Amigo]  cell redox homeostasis
GO	FAD binding [Amigo]  FAD binding
GO	NADP binding [Amigo]  NADP binding
GO	oxidation reduction [Amigo]  oxidation reduction
KEGG	Pyrimidine metabolism
PubGene	TXNRD2
TreeFam	TXNRD2
CTD	10587 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TXNRD2 Related clones (RZPD - Berlin)
	PubMed
PubMed	21 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Tue Oct 14 21:00:14 2008