Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TXNRD2 (thioredoxin reductase 2)

Identity

Alias_symbol (synonym)TR
TRXR2
TR3
Other aliasSELZ
TR-BETA
HGNC (Hugo) TXNRD2
LocusID (NCBI) 10587
Atlas_Id 42736
Location 22q11.21  [Link to chromosome band 22q11]
Location_base_pair Starts at 19881781 and ends at 19929515 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
AP2A1 (19q13.33) / TXNRD2 (22q11.21)MED15 (22q11.21) / TXNRD2 (22q11.21)TXNRD2 (22q11.21) / RHBDD1 (2q36.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TXNRD2   18155
LRG (Locus Reference Genomic)LRG_417
Cards
Entrez_Gene (NCBI)TXNRD2  10587  thioredoxin reductase 2
AliasesSELZ; TR; TR-BETA; TR3; 
TRXR2
GeneCards (Weizmann)TXNRD2
Ensembl hg19 (Hinxton)ENSG00000184470 [Gene_View]  chr22:19881781-19929515 [Contig_View]  TXNRD2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000184470 [Gene_View]  chr22:19881781-19929515 [Contig_View]  TXNRD2 [Vega]
ICGC DataPortalENSG00000184470
TCGA cBioPortalTXNRD2
AceView (NCBI)TXNRD2
Genatlas (Paris)TXNRD2
WikiGenes10587
SOURCE (Princeton)TXNRD2
Genetics Home Reference (NIH)TXNRD2
Genomic and cartography
GoldenPath hg19 (UCSC)TXNRD2  -     chr22:19881781-19929515 -  22q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TXNRD2  -     22q11.21   [Description]    (hg38-Dec_2013)
EnsemblTXNRD2 - 22q11.21 [CytoView hg19]  TXNRD2 - 22q11.21 [CytoView hg38]
Mapping of homologs : NCBITXNRD2 [Mapview hg19]  TXNRD2 [Mapview hg38]
OMIM606448   
Gene and transcription
Genbank (Entrez)AB019694 AB019695 AB209724 AF044212 AF106697
RefSeq transcript (Entrez)NM_001282512 NM_006440 NM_145747 NM_145748
RefSeq genomic (Entrez)NC_000022 NC_018933 NG_011835 NT_011520 NW_004929429
Consensus coding sequences : CCDS (NCBI)TXNRD2
Cluster EST : UnigeneHs.443430 [ NCBI ]
CGAP (NCI)Hs.443430
Alternative Splicing GalleryENSG00000184470
Gene ExpressionTXNRD2 [ NCBI-GEO ]   TXNRD2 [ EBI - ARRAY_EXPRESS ]   TXNRD2 [ SEEK ]   TXNRD2 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNRD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10587
GTEX Portal (Tissue expression)TXNRD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NNW7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NNW7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NNW7
Splice isoforms : SwissVarQ9NNW7
Catalytic activity : Enzyme1.8.1.9 [ Enzyme-Expasy ]   1.8.1.91.8.1.9 [ IntEnz-EBI ]   1.8.1.9 [ BRENDA ]   1.8.1.9 [ KEGG ]   
PhosPhoSitePlusQ9NNW7
Domaine pattern : Prosite (Expaxy)PYRIDINE_REDOX_1 (PS00076)   
Domains : Interpro (EBI)FAD/NAD-binding_dom    FAD/NAD-linked_Rdtase_dimer    Pyr_nucl-diS_OxRdtase_dimer    Pyr_OxRdtase_I_AS    Thioredoxin/glutathione_Rdtase   
Domain families : Pfam (Sanger)Pyr_redox_2 (PF07992)    Pyr_redox_dim (PF02852)   
Domain families : Pfam (NCBI)pfam07992    pfam02852   
Conserved Domain (NCBI)TXNRD2
DMDM Disease mutations10587
Blocks (Seattle)TXNRD2
PDB (SRS)1W1E   
PDB (PDBSum)1W1E   
PDB (IMB)1W1E   
PDB (RSDB)1W1E   
Structural Biology KnowledgeBase1W1E   
SCOP (Structural Classification of Proteins)1W1E   
CATH (Classification of proteins structures)1W1E   
SuperfamilyQ9NNW7
Human Protein AtlasENSG00000184470
Peptide AtlasQ9NNW7
HPRD05921
IPIIPI00220566   IPI01018202   IPI01021422   IPI00446645   IPI00157820   IPI01010380   IPI00883598   IPI00853011   IPI00853628   
Protein Interaction databases
DIP (DOE-UCLA)Q9NNW7
IntAct (EBI)Q9NNW7
FunCoupENSG00000184470
BioGRIDTXNRD2
STRING (EMBL)TXNRD2
ZODIACTXNRD2
Ontologies - Pathways
QuickGOQ9NNW7
Ontology : AmiGOresponse to reactive oxygen species  response to oxygen radical  thioredoxin-disulfide reductase activity  thioredoxin-disulfide reductase activity  protein binding  mitochondrion  mitochondrial matrix  cell redox homeostasis  flavin adenine dinucleotide binding  oxidation-reduction process  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  
Ontology : EGO-EBIresponse to reactive oxygen species  response to oxygen radical  thioredoxin-disulfide reductase activity  thioredoxin-disulfide reductase activity  protein binding  mitochondrion  mitochondrial matrix  cell redox homeostasis  flavin adenine dinucleotide binding  oxidation-reduction process  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  
Pathways : KEGGPyrimidine metabolism    Selenocompound metabolism   
NDEx NetworkTXNRD2
Atlas of Cancer Signalling NetworkTXNRD2
Wikipedia pathwaysTXNRD2
Orthology - Evolution
OrthoDB10587
GeneTree (enSembl)ENSG00000184470
Phylogenetic Trees/Animal Genes : TreeFamTXNRD2
HOVERGENQ9NNW7
HOGENOMQ9NNW7
Homologs : HomoloGeneTXNRD2
Homology/Alignments : Family Browser (UCSC)TXNRD2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNRD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNRD2
dbVarTXNRD2
ClinVarTXNRD2
1000_GenomesTXNRD2 
Exome Variant ServerTXNRD2
ExAC (Exome Aggregation Consortium)TXNRD2 (select the gene name)
Genetic variants : HAPMAP10587
Genomic Variants (DGV)TXNRD2 [DGVbeta]
DECIPHER (Syndromes)22:19881781-19929515  ENSG00000184470
CONAN: Copy Number AnalysisTXNRD2 
Mutations
ICGC Data PortalTXNRD2 
TCGA Data PortalTXNRD2 
Broad Tumor PortalTXNRD2
OASIS PortalTXNRD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNRD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXNRD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch TXNRD2
DgiDB (Drug Gene Interaction Database)TXNRD2
DoCM (Curated mutations)TXNRD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNRD2 (select a term)
intoGenTXNRD2
Cancer3DTXNRD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606448   
Orphanet635    3506   
MedgenTXNRD2
Genetic Testing Registry TXNRD2
NextProtQ9NNW7 [Medical]
TSGene10587
GENETestsTXNRD2
Huge Navigator TXNRD2 [HugePedia]
snp3D : Map Gene to Disease10587
BioCentury BCIQTXNRD2
ClinGenTXNRD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10587
Chemical/Pharm GKB GenePA38302
Clinical trialTXNRD2
Miscellaneous
canSAR (ICR)TXNRD2 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNRD2
EVEXTXNRD2
GoPubMedTXNRD2
iHOPTXNRD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:32:56 CET 2017

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