TXNRD3 (thioredoxin reductase 3)

2007-02-01  

Identity

HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
TGR,TR2,TR2IT1,TRXR3,TXNRD3IT1,TXNRD3NB,TXNRD3NT1

Other Information

Locus ID:

NCBI: 114112
MIM: 606235
HGNC: 20667
Ensembl: ENSG00000197763

Variants:

dbSNP: 114112
ClinVar: 114112
TCGA: ENSG00000197763
COSMIC: TXNRD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197763ENST00000523403H0YBI6
ENSG00000197763ENST00000524230H0YBQ0

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Pyrimidine metabolismKEGGko00240
Selenocompound metabolismKEGGko00450
Pyrimidine metabolismKEGGhsa00240
Selenocompound metabolismKEGGhsa00450

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
200188452010CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes.25
226833722012The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium.13
292228422018Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms.1

Citation

Dessen P

TXNRD3 (thioredoxin reductase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45542/txnrd3