Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TXNRD3 (thioredoxin reductase 3)

Identity

Alias_symbol (synonym)TR2
TRXR3
TGR
Other alias
HGNC (Hugo) TXNRD3
LocusID (NCBI) 114112
Atlas_Id 45542
Location 3q21.3  [Link to chromosome band 3q21]
Location_base_pair Starts at 126325895 and ends at 126373967 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DCBLD2 (3q12.1) / TXNRD3 (3q21.3)MICB (6p21.33) / TXNRD3 (3q21.3)TXNRD3 (3q21.3) / PODXL2 (3q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TXNRD3   20667
Cards
Entrez_Gene (NCBI)TXNRD3  114112  thioredoxin reductase 3
AliasesTGR; TR2; TRXR3
GeneCards (Weizmann)TXNRD3
Ensembl hg19 (Hinxton)ENSG00000197763 [Gene_View]  chr3:126325895-126373967 [Contig_View]  TXNRD3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000197763 [Gene_View]  chr3:126325895-126373967 [Contig_View]  TXNRD3 [Vega]
ICGC DataPortalENSG00000197763
TCGA cBioPortalTXNRD3
AceView (NCBI)TXNRD3
Genatlas (Paris)TXNRD3
WikiGenes114112
SOURCE (Princeton)TXNRD3
Genetics Home Reference (NIH)TXNRD3
Genomic and cartography
GoldenPath hg19 (UCSC)TXNRD3  -     chr3:126325895-126373967 -  3q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TXNRD3  -     3q21.3   [Description]    (hg38-Dec_2013)
EnsemblTXNRD3 - 3q21.3 [CytoView hg19]  TXNRD3 - 3q21.3 [CytoView hg38]
Mapping of homologs : NCBITXNRD3 [Mapview hg19]  TXNRD3 [Mapview hg38]
OMIM606235   
Gene and transcription
Genbank (Entrez)AF133519 AF171055 AK299502 BC030028 BC050032
RefSeq transcript (Entrez)NM_001173513 NM_052883
RefSeq genomic (Entrez)NC_000003 NC_018914 NT_005612 NW_004929311
Consensus coding sequences : CCDS (NCBI)TXNRD3
Cluster EST : UnigeneHs.477475 [ NCBI ]
CGAP (NCI)Hs.477475
Alternative Splicing GalleryENSG00000197763
Gene ExpressionTXNRD3 [ NCBI-GEO ]   TXNRD3 [ EBI - ARRAY_EXPRESS ]   TXNRD3 [ SEEK ]   TXNRD3 [ MEM ]
Gene Expression Viewer (FireBrowse)TXNRD3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)114112
GTEX Portal (Tissue expression)TXNRD3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86VQ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86VQ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86VQ6
Splice isoforms : SwissVarQ86VQ6
Catalytic activity : Enzyme1.8.1.9 [ Enzyme-Expasy ]   1.8.1.91.8.1.9 [ IntEnz-EBI ]   1.8.1.9 [ BRENDA ]   1.8.1.9 [ KEGG ]   
PhosPhoSitePlusQ86VQ6
Domaine pattern : Prosite (Expaxy)GLUTAREDOXIN_2 (PS51354)    PYRIDINE_REDOX_1 (PS00076)   
Domains : Interpro (EBI)FAD/NAD-binding_dom    FAD/NAD-linked_Rdtase_dimer    Glutaredoxin    Glutaredoxin_euk/vir    Pyr_nucl-diS_OxRdtase_dimer    Pyr_OxRdtase_I_AS    Thioredoxin-like_fold    Thioredoxin/glutathione_Rdtase   
Domain families : Pfam (Sanger)Glutaredoxin (PF00462)    Pyr_redox_2 (PF07992)    Pyr_redox_dim (PF02852)   
Domain families : Pfam (NCBI)pfam00462    pfam07992    pfam02852   
Conserved Domain (NCBI)TXNRD3
DMDM Disease mutations114112
Blocks (Seattle)TXNRD3
PDB (SRS)3H8Q   
PDB (PDBSum)3H8Q   
PDB (IMB)3H8Q   
PDB (RSDB)3H8Q   
Structural Biology KnowledgeBase3H8Q   
SCOP (Structural Classification of Proteins)3H8Q   
CATH (Classification of proteins structures)3H8Q   
SuperfamilyQ86VQ6
Human Protein AtlasENSG00000197763
Peptide AtlasQ86VQ6
IPIIPI00908781   IPI00981128   IPI00978136   IPI00974099   
Protein Interaction databases
DIP (DOE-UCLA)Q86VQ6
IntAct (EBI)Q86VQ6
FunCoupENSG00000197763
BioGRIDTXNRD3
STRING (EMBL)TXNRD3
ZODIACTXNRD3
Ontologies - Pathways
QuickGOQ86VQ6
Ontology : AmiGOthioredoxin-disulfide reductase activity  nucleus  endoplasmic reticulum  multicellular organism development  spermatogenesis  electron carrier activity  protein disulfide oxidoreductase activity  cell differentiation  cell redox homeostasis  flavin adenine dinucleotide binding  oxidation-reduction process  cellular oxidant detoxification  cellular oxidant detoxification  
Ontology : EGO-EBIthioredoxin-disulfide reductase activity  nucleus  endoplasmic reticulum  multicellular organism development  spermatogenesis  electron carrier activity  protein disulfide oxidoreductase activity  cell differentiation  cell redox homeostasis  flavin adenine dinucleotide binding  oxidation-reduction process  cellular oxidant detoxification  cellular oxidant detoxification  
Pathways : KEGGPyrimidine metabolism    Selenocompound metabolism   
NDEx NetworkTXNRD3
Atlas of Cancer Signalling NetworkTXNRD3
Wikipedia pathwaysTXNRD3
Orthology - Evolution
OrthoDB114112
GeneTree (enSembl)ENSG00000197763
Phylogenetic Trees/Animal Genes : TreeFamTXNRD3
HOVERGENQ86VQ6
HOGENOMQ86VQ6
Homologs : HomoloGeneTXNRD3
Homology/Alignments : Family Browser (UCSC)TXNRD3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTXNRD3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TXNRD3
dbVarTXNRD3
ClinVarTXNRD3
1000_GenomesTXNRD3 
Exome Variant ServerTXNRD3
ExAC (Exome Aggregation Consortium)TXNRD3 (select the gene name)
Genetic variants : HAPMAP114112
Genomic Variants (DGV)TXNRD3 [DGVbeta]
DECIPHER (Syndromes)3:126325895-126373967  ENSG00000197763
CONAN: Copy Number AnalysisTXNRD3 
Mutations
ICGC Data PortalTXNRD3 
TCGA Data PortalTXNRD3 
Broad Tumor PortalTXNRD3
OASIS PortalTXNRD3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTXNRD3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTXNRD3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TXNRD3
DgiDB (Drug Gene Interaction Database)TXNRD3
DoCM (Curated mutations)TXNRD3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TXNRD3 (select a term)
intoGenTXNRD3
Cancer3DTXNRD3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606235   
Orphanet
MedgenTXNRD3
Genetic Testing Registry TXNRD3
NextProtQ86VQ6 [Medical]
TSGene114112
GENETestsTXNRD3
Huge Navigator TXNRD3 [HugePedia]
snp3D : Map Gene to Disease114112
BioCentury BCIQTXNRD3
ClinGenTXNRD3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD114112
Chemical/Pharm GKB GenePA134920642
Clinical trialTXNRD3
Miscellaneous
canSAR (ICR)TXNRD3 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTXNRD3
EVEXTXNRD3
GoPubMedTXNRD3
iHOPTXNRD3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:32:56 CET 2017

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