TYRO3 (TYRO3 protein tyrosine kinase)

Identity

Other names	BYK
	Brt
	Dtk
	RSE
	Sky
	Tif
HGNC	TYRO3
Location	15q15.1-q21.1
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	TYRO3   12446
Entrez_Gene	TYRO3  7301  TYRO3 protein tyrosine kinase
	Cards
GeneCards	TYRO3
Ensembl	TYRO3 [Search_View]   ENSG00000092445 [Gene_View]
Genatlas	TYRO3
GeneLynx	TYRO3
eGenome	TYRO3
euGene	7301
	Genomic and cartography
GoldenPath	TYRO3  -     chr15:39638524-39658818 +  15q15.1   [Description]    (hg18-March_2006)
Ensembl	TYRO3 - 15q15.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TYRO3
	Gene and transcription
Genbank	AB209431 [ ENTREZ ]
Genbank	AK022124 [ ENTREZ ]
Genbank	BC029925 [ ENTREZ ]
Genbank	BC034960 [ ENTREZ ]
Genbank	BC049368 [ ENTREZ ]
RefSeq	NM_006293 [ SRS ]    NM_006293 [ ENTREZ ]
RefSeq	AC_000058 [ SRS ]    AC_000058 [ ENTREZ ]
RefSeq	AC_000147 [ SRS ]    AC_000147 [ ENTREZ ]
RefSeq	NC_000015 [ SRS ]    NC_000015 [ ENTREZ ]
RefSeq	NT_010194 [ SRS ]    NT_010194 [ ENTREZ ]
RefSeq	NW_001838214 [ SRS ]    NW_001838214 [ ENTREZ ]
RefSeq	NW_925840 [ SRS ]    NW_925840 [ ENTREZ ]
AceView	TYRO3 AceView - NCBI
Unigene	Hs.381282 [ SRS ]    Hs.381282 [ NCBI ]     HS381282 [ spliceNest ]
Fast-db	2650 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q06418 [ SRS]    Q06418 [ EXPASY ]     Q06418 [ INTERPRO ]     Q06418 [ UNIPROT ]
Prosite	PS50853 FN3 [ SRS ]    PS50853 FN3 [ Expasy ]
Prosite	PS50835 IG_LIKE [ SRS ]    PS50835 IG_LIKE [ Expasy ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00109 PROTEIN_KINASE_TYR [ SRS ]    PS00109 PROTEIN_KINASE_TYR [ Expasy ]
Interpro	IPR008957 Fibronectin_typ-III-like_fold [ SRS ]    IPR008957 Fibronectin_typ-III-like_fold [ EBI ]
Interpro	IPR003961 FN_III [ SRS ]    IPR003961 FN_III [ EBI ]
Interpro	IPR013151 Ig [ SRS ]    IPR013151 Ig [ EBI ]
Interpro	IPR007110 Ig-like [ SRS ]    IPR007110 Ig-like [ EBI ]
Interpro	IPR013783 Ig-like_fold [ SRS ]    IPR013783 Ig-like_fold [ EBI ]
Interpro	IPR003599 Ig_sub [ SRS ]    IPR003599 Ig_sub [ EBI ]
Interpro	IPR003598 Ig_sub2 [ SRS ]    IPR003598 Ig_sub2 [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR001245 Tyr_pkinase [ SRS ]    IPR001245 Tyr_pkinase [ EBI ]
Interpro	IPR008266 Tyr_pkinase_AS [ SRS ]    IPR008266 Tyr_pkinase_AS [ EBI ]
CluSTr	Q06418
Pfam	PF00041 fn3 [ SRS ]    PF00041 fn3 [ Sanger ]    pfam00041 [ NCBI-CDD ]
Pfam	PF00047 ig [ SRS ]    PF00047 ig [ Sanger ]    pfam00047 [ NCBI-CDD ]
Pfam	PF07714 Pkinase_Tyr [ SRS ]    PF07714 Pkinase_Tyr [ Sanger ]    pfam07714 [ NCBI-CDD ]
Smart	SM00060 FN3 [EMBL]
Smart	SM00409 IG [EMBL]
Smart	SM00408 IGc2 [EMBL]
Smart	SM00219 TyrKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	Q06418 TYRO3_HUMAN [ Domain structure ]   Q06418 TYRO3_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q06418
PDB	1RHF [ SRS ]    1RHF [ PdbSum ],   1RHF [ IMB ]   1RHF [ RSDB ]
HPRD	02641
	Protein Interaction databases
DIP	Q06418
IntAct	Q06418
	Polymorphism : SNP, mutations, diseases
OMIM	600341    [ map ]
GENECLINICS	600341
SNP	TYRO3 [dbSNP-NCBI]
SNP	NM_006293 [SNP-NCI]
SNP	TYRO3 [GeneSNPs - Utah]  TYRO3] [HGBASE - SRS]
HAPMAP	TYRO3 [HAPMAP]
COSMIC	TYRO3 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	TYRO3
	General knowledge
Family Browser	TYRO3 [UCSC Family Browser]
SOURCE	NM_006293
SMD	Hs.381282
SAGE	Hs.381282
Enzyme	2.7.10.1 [ Enzyme-Expasy ]   2.7.10.1 [ Enzyme-SRS ]   2.7.10.1 [ IntEnz-EBI ]   2.7.10.1 [ BRENDA ]   2.7.10.1 [ KEGG ]   2.7.10.1 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	transmembrane receptor protein tyrosine kinase activity [Amigo]  transmembrane receptor protein tyrosine kinase activity
GO	receptor signaling protein tyrosine kinase activity [Amigo]  receptor signaling protein tyrosine kinase activity
GO	receptor activity [Amigo]  receptor activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	integral to plasma membrane [Amigo]  integral to plasma membrane
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	cell adhesion [Amigo]  cell adhesion
GO	signal transduction [Amigo]  signal transduction
GO	membrane [Amigo]  membrane
GO	transferase activity [Amigo]  transferase activity
PubGene	TYRO3
TreeFam	TYRO3
CTD	7301 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TYRO3 Related clones (RZPD - Berlin)
	PubMed
PubMed	20 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:37:05 2008