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TYROBP (TYRO protein tyrosine kinase binding protein)

Identity

Alias_namesPLOSL
Alias_symbol (synonym)DAP12
PLO-SL
KARAP
Other alias
HGNC (Hugo) TYROBP
LocusID (NCBI) 7305
Atlas_Id 50904
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35904401 and ends at 35908309 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TYROBP   12449
LRG (Locus Reference Genomic)LRG_607
Cards
Entrez_Gene (NCBI)TYROBP  7305  TYRO protein tyrosine kinase binding protein
AliasesDAP12; KARAP; PLOSL
GeneCards (Weizmann)TYROBP
Ensembl hg19 (Hinxton)ENSG00000011600 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011600 [Gene_View]  chr19:35904401-35908309 [Contig_View]  TYROBP [Vega]
ICGC DataPortalENSG00000011600
TCGA cBioPortalTYROBP
AceView (NCBI)TYROBP
Genatlas (Paris)TYROBP
WikiGenes7305
SOURCE (Princeton)TYROBP
Genetics Home Reference (NIH)TYROBP
Genomic and cartography
GoldenPath hg38 (UCSC)TYROBP  -     chr19:35904401-35908309 -  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYROBP  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblTYROBP - 19q13.12 [CytoView hg19]  TYROBP - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBITYROBP [Mapview hg19]  TYROBP [Mapview hg38]
OMIM221770   604142   
Gene and transcription
Genbank (Entrez)AF019562 AJ010098 AK290385 AY074782 BC011175
RefSeq transcript (Entrez)NM_001173514 NM_001173515 NM_003332 NM_198125
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TYROBP
Cluster EST : UnigeneHs.515369 [ NCBI ]
CGAP (NCI)Hs.515369
Alternative Splicing GalleryENSG00000011600
Gene ExpressionTYROBP [ NCBI-GEO ]   TYROBP [ EBI - ARRAY_EXPRESS ]   TYROBP [ SEEK ]   TYROBP [ MEM ]
Gene Expression Viewer (FireBrowse)TYROBP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7305
GTEX Portal (Tissue expression)TYROBP
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43914   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43914  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43914
Splice isoforms : SwissVarO43914
PhosPhoSitePlusO43914
Domains : Interpro (EBI)Tyrobp   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TYROBP
DMDM Disease mutations7305
Blocks (Seattle)TYROBP
PDB (SRS)2L34    2L35    4WO1    4WOL   
PDB (PDBSum)2L34    2L35    4WO1    4WOL   
PDB (IMB)2L34    2L35    4WO1    4WOL   
PDB (RSDB)2L34    2L35    4WO1    4WOL   
Structural Biology KnowledgeBase2L34    2L35    4WO1    4WOL   
SCOP (Structural Classification of Proteins)2L34    2L35    4WO1    4WOL   
CATH (Classification of proteins structures)2L34    2L35    4WO1    4WOL   
SuperfamilyO43914
Human Protein AtlasENSG00000011600
Peptide AtlasO43914
HPRD04996
IPIIPI00015144   IPI00384633   IPI00956488   IPI00956573   
Protein Interaction databases
DIP (DOE-UCLA)O43914
IntAct (EBI)O43914
FunCoupENSG00000011600
BioGRIDTYROBP
STRING (EMBL)TYROBP
ZODIACTYROBP
Ontologies - Pathways
QuickGOO43914
Ontology : AmiGOmacrophage activation involved in immune response  signal transducer activity, downstream of receptor  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cellular defense response  signal transduction  integrin-mediated signaling pathway  cell surface  secretory granule membrane  intracellular signal transduction  identical protein binding  neutrophil degranulation  innate immune response  regulation of immune response  regulation of osteoclast development  
Ontology : EGO-EBImacrophage activation involved in immune response  signal transducer activity, downstream of receptor  receptor binding  protein binding  plasma membrane  integral component of plasma membrane  cellular defense response  signal transduction  integrin-mediated signaling pathway  cell surface  secretory granule membrane  intracellular signal transduction  identical protein binding  neutrophil degranulation  innate immune response  regulation of immune response  regulation of osteoclast development  
Pathways : KEGGOsteoclast differentiation    Natural killer cell mediated cytotoxicity   
NDEx NetworkTYROBP
Atlas of Cancer Signalling NetworkTYROBP
Wikipedia pathwaysTYROBP
Orthology - Evolution
OrthoDB7305
GeneTree (enSembl)ENSG00000011600
Phylogenetic Trees/Animal Genes : TreeFamTYROBP
HOVERGENO43914
HOGENOMO43914
Homologs : HomoloGeneTYROBP
Homology/Alignments : Family Browser (UCSC)TYROBP
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYROBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYROBP
dbVarTYROBP
ClinVarTYROBP
1000_GenomesTYROBP 
Exome Variant ServerTYROBP
ExAC (Exome Aggregation Consortium)TYROBP (select the gene name)
Genetic variants : HAPMAP7305
Genomic Variants (DGV)TYROBP [DGVbeta]
DECIPHERTYROBP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYROBP 
Mutations
ICGC Data PortalTYROBP 
TCGA Data PortalTYROBP 
Broad Tumor PortalTYROBP
OASIS PortalTYROBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYROBP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTYROBP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TYROBP
DgiDB (Drug Gene Interaction Database)TYROBP
DoCM (Curated mutations)TYROBP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TYROBP (select a term)
intoGenTYROBP
Cancer3DTYROBP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM221770    604142   
Orphanet2523   
MedgenTYROBP
Genetic Testing Registry TYROBP
NextProtO43914 [Medical]
TSGene7305
GENETestsTYROBP
Target ValidationTYROBP
Huge Navigator TYROBP [HugePedia]
snp3D : Map Gene to Disease7305
BioCentury BCIQTYROBP
ClinGenTYROBP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7305
Chemical/Pharm GKB GenePA37100
Clinical trialTYROBP
Miscellaneous
canSAR (ICR)TYROBP (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTYROBP
EVEXTYROBP
GoPubMedTYROBP
iHOPTYROBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:36:58 CEST 2017

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