Atlas of Genetics and Cytogenetics in Oncology and Haematology


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TYROBP (transmembrane immune signaling adaptor TYROBP)

Identity

Alias (NCBI)DAP12
KARAP
PLOSL
PLOSL1
HGNC (Hugo) TYROBP
HGNC Alias symbDAP12
PLO-SL
KARAP
HGNC Alias namekiller activating receptor associated protein
 DNAX-activation protein 12
 DNAX adaptor protein 12
HGNC Previous namePLOSL
HGNC Previous namepolycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
 TYRO protein tyrosine kinase binding protein
LocusID (NCBI) 7305
Atlas_Id 50904
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35904406 and ends at 35908295 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TYROBP   12449
LRG (Locus Reference Genomic)LRG_607
Cards
Entrez_Gene (NCBI)TYROBP    transmembrane immune signaling adaptor TYROBP
AliasesDAP12; KARAP; PLOSL; PLOSL1
GeneCards (Weizmann)TYROBP
Ensembl hg19 (Hinxton)ENSG00000011600 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011600 [Gene_View]  ENSG00000011600 [Sequence]  chr19:35904406-35908295 [Contig_View]  TYROBP [Vega]
ICGC DataPortalENSG00000011600
TCGA cBioPortalTYROBP
AceView (NCBI)TYROBP
Genatlas (Paris)TYROBP
SOURCE (Princeton)TYROBP
Genetics Home Reference (NIH)TYROBP
Genomic and cartography
GoldenPath hg38 (UCSC)TYROBP  -     chr19:35904406-35908295 -  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYROBP  -     19q13.12   [Description]    (hg19-Feb_2009)
GoldenPathTYROBP - 19q13.12 [CytoView hg19]  TYROBP - 19q13.12 [CytoView hg38]
ImmunoBaseENSG00000011600
Genome Data Viewer NCBITYROBP [Mapview hg19]  
OMIM221770   604142   
Gene and transcription
Genbank (Entrez)AF019562 AJ010098 AK290385 AY074782 BC011175
RefSeq transcript (Entrez)NM_001173514 NM_001173515 NM_003332 NM_198125
Consensus coding sequences : CCDS (NCBI)TYROBP
Gene ExpressionTYROBP [ NCBI-GEO ]   TYROBP [ EBI - ARRAY_EXPRESS ]   TYROBP [ SEEK ]   TYROBP [ MEM ]
Gene Expression Viewer (FireBrowse)TYROBP [ Firebrowse - Broad ]
GenevisibleExpression of TYROBP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7305
GTEX Portal (Tissue expression)TYROBP
Human Protein AtlasENSG00000011600-TYROBP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43914   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43914  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43914
PhosPhoSitePlusO43914
Domains : Interpro (EBI)Tyrobp   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)TYROBP
PDB (RSDB)2L34    2L35    4WO1    4WOL   
PDB Europe2L34    2L35    4WO1    4WOL   
PDB (PDBSum)2L34    2L35    4WO1    4WOL   
PDB (IMB)2L34    2L35    4WO1    4WOL   
Structural Biology KnowledgeBase2L34    2L35    4WO1    4WOL   
SCOP (Structural Classification of Proteins)2L34    2L35    4WO1    4WOL   
CATH (Classification of proteins structures)2L34    2L35    4WO1    4WOL   
SuperfamilyO43914
AlphaFold pdb e-kbO43914   
Human Protein Atlas [tissue]ENSG00000011600-TYROBP [tissue]
HPRD04996
Protein Interaction databases
DIP (DOE-UCLA)O43914
IntAct (EBI)O43914
BioGRIDTYROBP
STRING (EMBL)TYROBP
ZODIACTYROBP
Ontologies - Pathways
QuickGOO43914
Ontology : AmiGOstimulatory killer cell immunoglobulin-like receptor signaling pathway  stimulatory C-type lectin receptor signaling pathway  myeloid leukocyte activation  microglial cell activation involved in immune response  microglial cell activation involved in immune response  neutrophil activation involved in immune response  signaling receptor binding  signaling receptor binding  signaling receptor binding  signaling receptor binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cellular defense response  signal transduction  cell surface  cell surface  positive regulation of gene expression  integral component of membrane  actin cytoskeleton organization  osteoclast differentiation  secretory granule membrane  negative regulation of B cell proliferation  negative regulation of B cell proliferation  forebrain development  negative regulation of interleukin-10 production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell activation  negative regulation of transforming growth factor beta1 production  negative regulation of transforming growth factor beta1 production  positive regulation of superoxide anion generation  positive regulation of macrophage fusion  positive regulation of macrophage fusion  intracellular signal transduction  identical protein binding  protein homodimerization activity  apoptotic cell clearance  neutrophil degranulation  innate immune response  metal ion binding  response to axon injury  regulation of immune response  protein stabilization  protein stabilization  apoptotic signaling pathway  positive regulation of hippocampal neuron apoptotic process  negative regulation of long-term synaptic potentiation  positive regulation of neuron death  positive regulation of receptor localization to synapse  positive regulation of microglial cell mediated cytotoxicity  positive regulation of microglial cell mediated cytotoxicity  positive regulation of protein localization to cell surface  positive regulation of osteoclast development  
Ontology : EGO-EBIstimulatory killer cell immunoglobulin-like receptor signaling pathway  stimulatory C-type lectin receptor signaling pathway  myeloid leukocyte activation  microglial cell activation involved in immune response  microglial cell activation involved in immune response  neutrophil activation involved in immune response  signaling receptor binding  signaling receptor binding  signaling receptor binding  signaling receptor binding  protein binding  plasma membrane  plasma membrane  integral component of plasma membrane  cellular defense response  signal transduction  cell surface  cell surface  positive regulation of gene expression  integral component of membrane  actin cytoskeleton organization  osteoclast differentiation  secretory granule membrane  negative regulation of B cell proliferation  negative regulation of B cell proliferation  forebrain development  negative regulation of interleukin-10 production  positive regulation of interleukin-1 beta production  positive regulation of interleukin-6 production  positive regulation of tumor necrosis factor production  positive regulation of natural killer cell activation  negative regulation of transforming growth factor beta1 production  negative regulation of transforming growth factor beta1 production  positive regulation of superoxide anion generation  positive regulation of macrophage fusion  positive regulation of macrophage fusion  intracellular signal transduction  identical protein binding  protein homodimerization activity  apoptotic cell clearance  neutrophil degranulation  innate immune response  metal ion binding  response to axon injury  regulation of immune response  protein stabilization  protein stabilization  apoptotic signaling pathway  positive regulation of hippocampal neuron apoptotic process  negative regulation of long-term synaptic potentiation  positive regulation of neuron death  positive regulation of receptor localization to synapse  positive regulation of microglial cell mediated cytotoxicity  positive regulation of microglial cell mediated cytotoxicity  positive regulation of protein localization to cell surface  positive regulation of osteoclast development  
Pathways : KEGGOsteoclast differentiation    Natural killer cell mediated cytotoxicity   
NDEx NetworkTYROBP
Atlas of Cancer Signalling NetworkTYROBP
Wikipedia pathwaysTYROBP
Orthology - Evolution
OrthoDB7305
GeneTree (enSembl)ENSG00000011600
Phylogenetic Trees/Animal Genes : TreeFamTYROBP
Homologs : HomoloGeneTYROBP
Homology/Alignments : Family Browser (UCSC)TYROBP
Gene fusions - Rearrangements
Fusion : QuiverTYROBP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYROBP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYROBP
dbVarTYROBP
ClinVarTYROBP
MonarchTYROBP
1000_GenomesTYROBP 
Exome Variant ServerTYROBP
GNOMAD BrowserENSG00000011600
Varsome BrowserTYROBP
ACMGTYROBP variants
VarityO43914
Genomic Variants (DGV)TYROBP [DGVbeta]
DECIPHERTYROBP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYROBP 
Mutations
ICGC Data PortalTYROBP 
TCGA Data PortalTYROBP 
Broad Tumor PortalTYROBP
OASIS PortalTYROBP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYROBP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTYROBP
Mutations and Diseases : HGMDTYROBP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTYROBP
DgiDB (Drug Gene Interaction Database)TYROBP
DoCM (Curated mutations)TYROBP
CIViC (Clinical Interpretations of Variants in Cancer)TYROBP
Cancer3DTYROBP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM221770    604142   
Orphanet2523   
DisGeNETTYROBP
MedgenTYROBP
Genetic Testing Registry TYROBP
NextProtO43914 [Medical]
GENETestsTYROBP
Target ValidationTYROBP
Huge Navigator TYROBP [HugePedia]
ClinGenTYROBP
Clinical trials, drugs, therapy
MyCancerGenomeTYROBP
Protein Interactions : CTDTYROBP
Pharm GKB GenePA37100
PharosO43914
Clinical trialTYROBP
Miscellaneous
canSAR (ICR)TYROBP
HarmonizomeTYROBP
DataMed IndexTYROBP
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTYROBP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:36:59 CEST 2021

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