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TYW1 (tRNA-yW synthesizing protein 1 homolog)

Identity

Alias (NCBI)RSAFD1
TYW1A
YPL207W
HGNC (Hugo) TYW1
HGNC Alias symbFLJ10900
MGC23001
MGC60291
YPL207W
TYW1A
HGNC Alias nametRNA-yW synthesizing protein 1 homolog A (S. cerevisiae)
HGNC Previous nameRSAFD1
HGNC Previous nameradical S-adenosyl methionine and flavodoxin domains 1
 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
LocusID (NCBI) 55253
Atlas_Id 54743
Location 7q11.21  [Link to chromosome band 7q11]
Location_base_pair Starts at 66996833 and ends at 67239514 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TYW1 (7q11.21) / C7orf50 (7p22.3)TYW1 (7q11.21) / HGSNAT (8p11.21)TYW1 (7q11.21) / RP11-366L20.2 ()
TYW1 (7q11.21) / RP11-571M6.15 ()TYW1 (7q11.21) / TMEM248 (7q11.21)TYW1 7q11.21 C7orf42
TYW1 7q11.21 RP11-366L20.2TYW1 7q11.21 RP11-571M6.15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TYW1   25598
Cards
Entrez_Gene (NCBI)TYW1    tRNA-yW synthesizing protein 1 homolog
AliasesRSAFD1; TYW1A; YPL207W
GeneCards (Weizmann)TYW1
Ensembl hg19 (Hinxton)ENSG00000198874 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198874 [Gene_View]  ENSG00000198874 [Sequence]  chr7:66996833-67239514 [Contig_View]  TYW1 [Vega]
ICGC DataPortalENSG00000198874
TCGA cBioPortalTYW1
AceView (NCBI)TYW1
Genatlas (Paris)TYW1
SOURCE (Princeton)TYW1
Genetics Home Reference (NIH)TYW1
Genomic and cartography
GoldenPath hg38 (UCSC)TYW1  -     chr7:66996833-67239514 +  7q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYW1  -     7q11.21   [Description]    (hg19-Feb_2009)
GoldenPathTYW1 - 7q11.21 [CytoView hg19]  TYW1 - 7q11.21 [CytoView hg38]
ImmunoBaseENSG00000198874
Genome Data Viewer NCBITYW1 [Mapview hg19]  
OMIM611243   
Gene and transcription
Genbank (Entrez)AK001762 AK022917 AK301330 BC015591 BC042156
RefSeq transcript (Entrez)NM_018264
Consensus coding sequences : CCDS (NCBI)TYW1
Gene ExpressionTYW1 [ NCBI-GEO ]   TYW1 [ EBI - ARRAY_EXPRESS ]   TYW1 [ SEEK ]   TYW1 [ MEM ]
Gene Expression Viewer (FireBrowse)TYW1 [ Firebrowse - Broad ]
GenevisibleExpression of TYW1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55253
GTEX Portal (Tissue expression)TYW1
Human Protein AtlasENSG00000198874-TYW1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NV66   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NV66  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NV66
Catalytic activity : Enzyme4.1.3.44 [ Enzyme-Expasy ]   4.1.3.444.1.3.44 [ IntEnz-EBI ]   4.1.3.44 [ BRENDA ]   4.1.3.44 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9NV66
Domaine pattern : Prosite (Expaxy)FLAVODOXIN_LIKE (PS50902)    RADICAL_SAM (PS51918)   
Domains : Interpro (EBI)Aldolase_TIM    Flavdoxin-like    Flavodoxin/NO_synth    Flavoprotein-like_sf    rSAM    tRNA_wybutosine-synth    tRNA_wybutosine-synthase   
Domain families : Pfam (Sanger)Flavodoxin_1 (PF00258)    Radical_SAM (PF04055)    Wyosine_form (PF08608)   
Domain families : Pfam (NCBI)pfam00258    pfam04055    pfam08608   
Conserved Domain (NCBI)TYW1
SuperfamilyQ9NV66
AlphaFold pdb e-kbQ9NV66   
Human Protein Atlas [tissue]ENSG00000198874-TYW1 [tissue]
HPRD07711
Protein Interaction databases
DIP (DOE-UCLA)Q9NV66
IntAct (EBI)Q9NV66
BioGRIDTYW1
STRING (EMBL)TYW1
ZODIACTYW1
Ontologies - Pathways
QuickGOQ9NV66
Ontology : AmiGOFMN binding  wybutosine biosynthetic process  metal ion binding  4 iron, 4 sulfur cluster binding  tRNA-4-demethylwyosine synthase activity  
Ontology : EGO-EBIFMN binding  wybutosine biosynthetic process  metal ion binding  4 iron, 4 sulfur cluster binding  tRNA-4-demethylwyosine synthase activity  
NDEx NetworkTYW1
Atlas of Cancer Signalling NetworkTYW1
Wikipedia pathwaysTYW1
Orthology - Evolution
OrthoDB55253
GeneTree (enSembl)ENSG00000198874
Phylogenetic Trees/Animal Genes : TreeFamTYW1
Homologs : HomoloGeneTYW1
Homology/Alignments : Family Browser (UCSC)TYW1
Gene fusions - Rearrangements
Fusion : MitelmanTYW1/HGSNAT [7q11.21/8p11.21]  
Fusion : MitelmanTYW1/TMEM248 [7q11.21/7q11.21]  
Fusion : QuiverTYW1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYW1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYW1
dbVarTYW1
ClinVarTYW1
MonarchTYW1
1000_GenomesTYW1 
Exome Variant ServerTYW1
GNOMAD BrowserENSG00000198874
Varsome BrowserTYW1
ACMGTYW1 variants
VarityQ9NV66
Genomic Variants (DGV)TYW1 [DGVbeta]
DECIPHERTYW1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYW1 
Mutations
ICGC Data PortalTYW1 
TCGA Data PortalTYW1 
Broad Tumor PortalTYW1
OASIS PortalTYW1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYW1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTYW1
Mutations and Diseases : HGMDTYW1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTYW1
DgiDB (Drug Gene Interaction Database)TYW1
DoCM (Curated mutations)TYW1
CIViC (Clinical Interpretations of Variants in Cancer)TYW1
Cancer3DTYW1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611243   
Orphanet
DisGeNETTYW1
MedgenTYW1
Genetic Testing Registry TYW1
NextProtQ9NV66 [Medical]
GENETestsTYW1
Target ValidationTYW1
Huge Navigator TYW1 [HugePedia]
ClinGenTYW1
Clinical trials, drugs, therapy
MyCancerGenomeTYW1
Protein Interactions : CTDTYW1
Pharm GKB GenePA134940167
PharosQ9NV66
Clinical trialTYW1
Miscellaneous
canSAR (ICR)TYW1
HarmonizomeTYW1
DataMed IndexTYW1
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTYW1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:36:59 CEST 2021

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