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TYW1 (tRNA-yW synthesizing protein 1 homolog)

Identity

Alias_namesRSAFD1
radical S-adenosyl methionine and flavodoxin domains 1
tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
Alias_symbol (synonym)FLJ10900
MGC23001
MGC60291
YPL207W
TYW1A
Other alias
HGNC (Hugo) TYW1
LocusID (NCBI) 55253
Atlas_Id 54743
Location 7q11.21  [Link to chromosome band 7q11]
Location_base_pair Starts at 66996805 and ends at 67239520 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TYW1 (7q11.21) / C7orf50 (7p22.3)TYW1 (7q11.21) / HGSNAT (8p11.21)TYW1 (7q11.21) / RP11-366L20.2 ()
TYW1 (7q11.21) / RP11-571M6.15 ()TYW1 (7q11.21) / TMEM248 (7q11.21)TYW1 7q11.21 C7orf42
TYW1 7q11.21 RP11-366L20.2TYW1 7q11.21 RP11-571M6.15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TYW1   25598
Cards
Entrez_Gene (NCBI)TYW1  55253  tRNA-yW synthesizing protein 1 homolog
AliasesRSAFD1; TYW1A; YPL207W
GeneCards (Weizmann)TYW1
Ensembl hg19 (Hinxton)ENSG00000198874 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198874 [Gene_View]  chr7:66996805-67239520 [Contig_View]  TYW1 [Vega]
ICGC DataPortalENSG00000198874
TCGA cBioPortalTYW1
AceView (NCBI)TYW1
Genatlas (Paris)TYW1
WikiGenes55253
SOURCE (Princeton)TYW1
Genetics Home Reference (NIH)TYW1
Genomic and cartography
GoldenPath hg38 (UCSC)TYW1  -     chr7:66996805-67239520 +  7q11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYW1  -     7q11.21   [Description]    (hg19-Feb_2009)
EnsemblTYW1 - 7q11.21 [CytoView hg19]  TYW1 - 7q11.21 [CytoView hg38]
Mapping of homologs : NCBITYW1 [Mapview hg19]  TYW1 [Mapview hg38]
OMIM611243   
Gene and transcription
Genbank (Entrez)AK001762 AK022917 AK301330 BC015591 BC042156
RefSeq transcript (Entrez)NM_018264
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TYW1
Cluster EST : UnigeneHs.520917 [ NCBI ]
CGAP (NCI)Hs.520917
Alternative Splicing GalleryENSG00000198874
Gene ExpressionTYW1 [ NCBI-GEO ]   TYW1 [ EBI - ARRAY_EXPRESS ]   TYW1 [ SEEK ]   TYW1 [ MEM ]
Gene Expression Viewer (FireBrowse)TYW1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55253
GTEX Portal (Tissue expression)TYW1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NV66   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NV66  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NV66
Splice isoforms : SwissVarQ9NV66
Catalytic activity : Enzyme4.1.3.44 [ Enzyme-Expasy ]   4.1.3.444.1.3.44 [ IntEnz-EBI ]   4.1.3.44 [ BRENDA ]   4.1.3.44 [ KEGG ]   
PhosPhoSitePlusQ9NV66
Domaine pattern : Prosite (Expaxy)FLAVODOXIN_LIKE (PS50902)   
Domains : Interpro (EBI)Aldolase_TIM    Flavdoxin-like    Flavodoxin/NO_synth    Flavoprotein-like_dom    rSAM    tRNA_wybutosine-synth   
Domain families : Pfam (Sanger)Flavodoxin_1 (PF00258)    Radical_SAM (PF04055)    Wyosine_form (PF08608)   
Domain families : Pfam (NCBI)pfam00258    pfam04055    pfam08608   
Conserved Domain (NCBI)TYW1
DMDM Disease mutations55253
Blocks (Seattle)TYW1
SuperfamilyQ9NV66
Human Protein AtlasENSG00000198874
Peptide AtlasQ9NV66
HPRD07711
IPIIPI00182304   IPI00844116   IPI00969408   IPI01020691   IPI00956508   IPI00927855   IPI00910541   IPI00924829   IPI00926811   
Protein Interaction databases
DIP (DOE-UCLA)Q9NV66
IntAct (EBI)Q9NV66
FunCoupENSG00000198874
BioGRIDTYW1
STRING (EMBL)TYW1
ZODIACTYW1
Ontologies - Pathways
QuickGOQ9NV66
Ontology : AmiGOtRNA processing  FMN binding  lyase activity  metal ion binding  4 iron, 4 sulfur cluster binding  oxidation-reduction process  
Ontology : EGO-EBItRNA processing  FMN binding  lyase activity  metal ion binding  4 iron, 4 sulfur cluster binding  oxidation-reduction process  
NDEx NetworkTYW1
Atlas of Cancer Signalling NetworkTYW1
Wikipedia pathwaysTYW1
Orthology - Evolution
OrthoDB55253
GeneTree (enSembl)ENSG00000198874
Phylogenetic Trees/Animal Genes : TreeFamTYW1
HOVERGENQ9NV66
HOGENOMQ9NV66
Homologs : HomoloGeneTYW1
Homology/Alignments : Family Browser (UCSC)TYW1
Gene fusions - Rearrangements
Fusion : MitelmanTYW1/HGSNAT [7q11.21/8p11.21]  
Fusion : MitelmanTYW1/TMEM248 [7q11.21/7q11.21]  [t(7;7)(q11;q11)]  
Fusion: TCGATYW1 7q11.21 C7orf42 BRCA LUAD
Fusion: TCGATYW1 7q11.21 RP11-366L20.2 LUAD
Fusion: TCGATYW1 7q11.21 RP11-571M6.15 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYW1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYW1
dbVarTYW1
ClinVarTYW1
1000_GenomesTYW1 
Exome Variant ServerTYW1
ExAC (Exome Aggregation Consortium)TYW1 (select the gene name)
Genetic variants : HAPMAP55253
Genomic Variants (DGV)TYW1 [DGVbeta]
DECIPHERTYW1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYW1 
Mutations
ICGC Data PortalTYW1 
TCGA Data PortalTYW1 
Broad Tumor PortalTYW1
OASIS PortalTYW1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYW1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTYW1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TYW1
DgiDB (Drug Gene Interaction Database)TYW1
DoCM (Curated mutations)TYW1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TYW1 (select a term)
intoGenTYW1
Cancer3DTYW1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611243   
Orphanet
MedgenTYW1
Genetic Testing Registry TYW1
NextProtQ9NV66 [Medical]
TSGene55253
GENETestsTYW1
Target ValidationTYW1
Huge Navigator TYW1 [HugePedia]
snp3D : Map Gene to Disease55253
BioCentury BCIQTYW1
ClinGenTYW1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55253
Chemical/Pharm GKB GenePA134940167
Clinical trialTYW1
Miscellaneous
canSAR (ICR)TYW1 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTYW1
EVEXTYW1
GoPubMedTYW1
iHOPTYW1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:36:58 CEST 2017

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