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TYW5 (tRNA-yW synthesizing protein 5)

Identity

Alias (NCBI)C2orf60
hTYW5
HGNC (Hugo) TYW5
HGNC Alias symbFLJ37953
HGNC Previous nameC2orf60
HGNC Previous namechromosome 2 open reading frame 60
LocusID (NCBI) 129450
Atlas_Id 75398
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 199928913 and ends at 199955491 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)TYW5   26754
Cards
Entrez_Gene (NCBI)TYW5    tRNA-yW synthesizing protein 5
AliasesC2orf60; hTYW5
GeneCards (Weizmann)TYW5
Ensembl hg19 (Hinxton)ENSG00000162971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162971 [Gene_View]  ENSG00000162971 [Sequence]  chr2:199928913-199955491 [Contig_View]  TYW5 [Vega]
ICGC DataPortalENSG00000162971
TCGA cBioPortalTYW5
AceView (NCBI)TYW5
Genatlas (Paris)TYW5
SOURCE (Princeton)TYW5
Genetics Home Reference (NIH)TYW5
Genomic and cartography
GoldenPath hg38 (UCSC)TYW5  -     chr2:199928913-199955491 -  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYW5  -     2q33.1   [Description]    (hg19-Feb_2009)
GoldenPathTYW5 - 2q33.1 [CytoView hg19]  TYW5 - 2q33.1 [CytoView hg38]
ImmunoBaseENSG00000162971
Genome Data Viewer NCBITYW5 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AK095272 AK293064 AK298977 BC025758 BC063502
RefSeq transcript (Entrez)NM_001039693 NM_152382
Consensus coding sequences : CCDS (NCBI)TYW5
Gene ExpressionTYW5 [ NCBI-GEO ]   TYW5 [ EBI - ARRAY_EXPRESS ]   TYW5 [ SEEK ]   TYW5 [ MEM ]
Gene Expression Viewer (FireBrowse)TYW5 [ Firebrowse - Broad ]
GenevisibleExpression of TYW5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129450
GTEX Portal (Tissue expression)TYW5
Human Protein AtlasENSG00000162971-TYW5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA2RUC4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA2RUC4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA2RUC4
Catalytic activity : Enzyme1.14.11.42 [ Enzyme-Expasy ]   1.14.11.421.14.11.42 [ IntEnz-EBI ]   1.14.11.42 [ BRENDA ]   1.14.11.42 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusA2RUC4
Domaine pattern : Prosite (Expaxy)JMJC (PS51184)   
Domains : Interpro (EBI)Cupin_8    JmjC_dom    TYW5   
Domain families : Pfam (Sanger)Cupin_8 (PF13621)   
Domain families : Pfam (NCBI)pfam13621   
Domain families : Smart (EMBL)JmjC (SM00558)  
Conserved Domain (NCBI)TYW5
PDB (RSDB)3AL5    3AL6   
PDB Europe3AL5    3AL6   
PDB (PDBSum)3AL5    3AL6   
PDB (IMB)3AL5    3AL6   
Structural Biology KnowledgeBase3AL5    3AL6   
SCOP (Structural Classification of Proteins)3AL5    3AL6   
CATH (Classification of proteins structures)3AL5    3AL6   
SuperfamilyA2RUC4
AlphaFold pdb e-kbA2RUC4   
Human Protein Atlas [tissue]ENSG00000162971-TYW5 [tissue]
HPRD08232
Protein Interaction databases
DIP (DOE-UCLA)A2RUC4
IntAct (EBI)A2RUC4
BioGRIDTYW5
STRING (EMBL)TYW5
ZODIACTYW5
Ontologies - Pathways
QuickGOA2RUC4
Ontology : AmiGOtRNA binding  tRNA binding  iron ion binding  cytoplasm  tRNA modification  2-oxoglutarate-dependent dioxygenase activity  2-oxoglutarate-dependent dioxygenase activity  wybutosine biosynthetic process  wybutosine biosynthetic process  protein homodimerization activity  tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity  
Ontology : EGO-EBItRNA binding  tRNA binding  iron ion binding  cytoplasm  tRNA modification  2-oxoglutarate-dependent dioxygenase activity  2-oxoglutarate-dependent dioxygenase activity  wybutosine biosynthetic process  wybutosine biosynthetic process  protein homodimerization activity  tRNAPhe (7-(3-amino-3-carboxypropyl)wyosine37-C2)-hydroxylase activity  
NDEx NetworkTYW5
Atlas of Cancer Signalling NetworkTYW5
Wikipedia pathwaysTYW5
Orthology - Evolution
OrthoDB129450
GeneTree (enSembl)ENSG00000162971
Phylogenetic Trees/Animal Genes : TreeFamTYW5
Homologs : HomoloGeneTYW5
Homology/Alignments : Family Browser (UCSC)TYW5
Gene fusions - Rearrangements
Fusion : QuiverTYW5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYW5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYW5
dbVarTYW5
ClinVarTYW5
MonarchTYW5
1000_GenomesTYW5 
Exome Variant ServerTYW5
GNOMAD BrowserENSG00000162971
Varsome BrowserTYW5
ACMGTYW5 variants
VarityA2RUC4
Genomic Variants (DGV)TYW5 [DGVbeta]
DECIPHERTYW5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYW5 
Mutations
ICGC Data PortalTYW5 
TCGA Data PortalTYW5 
Broad Tumor PortalTYW5
OASIS PortalTYW5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYW5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTYW5
Mutations and Diseases : HGMDTYW5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaTYW5
DgiDB (Drug Gene Interaction Database)TYW5
DoCM (Curated mutations)TYW5
CIViC (Clinical Interpretations of Variants in Cancer)TYW5
Cancer3DTYW5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTYW5
MedgenTYW5
Genetic Testing Registry TYW5
NextProtA2RUC4 [Medical]
GENETestsTYW5
Target ValidationTYW5
Huge Navigator TYW5 [HugePedia]
ClinGenTYW5
Clinical trials, drugs, therapy
MyCancerGenomeTYW5
Protein Interactions : CTDTYW5
Pharm GKB GenePA162379298
PharosA2RUC4
Clinical trialTYW5
Miscellaneous
canSAR (ICR)TYW5
HarmonizomeTYW5
DataMed IndexTYW5
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXTYW5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 16:27:39 CEST 2021

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