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TYW5 (tRNA-yW synthesizing protein 5)

Identity

Alias_namesC2orf60
chromosome 2 open reading frame 60
Alias_symbol (synonym)FLJ37953
Other aliashTYW5
HGNC (Hugo) TYW5
LocusID (NCBI) 129450
Atlas_Id 75398
Location 2q33.1  [Link to chromosome band 2q33]
Location_base_pair Starts at 199928911 and ends at 199955736 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)TYW5   26754
Cards
Entrez_Gene (NCBI)TYW5  129450  tRNA-yW synthesizing protein 5
AliasesC2orf60; hTYW5
GeneCards (Weizmann)TYW5
Ensembl hg19 (Hinxton)ENSG00000162971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000162971 [Gene_View]  chr2:199928911-199955736 [Contig_View]  TYW5 [Vega]
ICGC DataPortalENSG00000162971
TCGA cBioPortalTYW5
AceView (NCBI)TYW5
Genatlas (Paris)TYW5
WikiGenes129450
SOURCE (Princeton)TYW5
Genetics Home Reference (NIH)TYW5
Genomic and cartography
GoldenPath hg38 (UCSC)TYW5  -     chr2:199928911-199955736 -  2q33.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TYW5  -     2q33.1   [Description]    (hg19-Feb_2009)
EnsemblTYW5 - 2q33.1 [CytoView hg19]  TYW5 - 2q33.1 [CytoView hg38]
Mapping of homologs : NCBITYW5 [Mapview hg19]  TYW5 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK095272 AK293064 AK298977 BC025758 BC063502
RefSeq transcript (Entrez)NM_001039693 NM_152382
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TYW5
Cluster EST : UnigeneHs.204619 [ NCBI ]
CGAP (NCI)Hs.204619
Alternative Splicing GalleryENSG00000162971
Gene ExpressionTYW5 [ NCBI-GEO ]   TYW5 [ EBI - ARRAY_EXPRESS ]   TYW5 [ SEEK ]   TYW5 [ MEM ]
Gene Expression Viewer (FireBrowse)TYW5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)129450
GTEX Portal (Tissue expression)TYW5
Human Protein AtlasENSG00000162971-TYW5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtA2RUC4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA2RUC4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA2RUC4
Splice isoforms : SwissVarA2RUC4
Catalytic activity : Enzyme1.14.11.42 [ Enzyme-Expasy ]   1.14.11.421.14.11.42 [ IntEnz-EBI ]   1.14.11.42 [ BRENDA ]   1.14.11.42 [ KEGG ]   
PhosPhoSitePlusA2RUC4
Domaine pattern : Prosite (Expaxy)JMJC (PS51184)   
Domains : Interpro (EBI)JmjC_dom    TYW5   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)JmjC (SM00558)  
Conserved Domain (NCBI)TYW5
DMDM Disease mutations129450
Blocks (Seattle)TYW5
PDB (SRS)3AL5    3AL6   
PDB (PDBSum)3AL5    3AL6   
PDB (IMB)3AL5    3AL6   
PDB (RSDB)3AL5    3AL6   
Structural Biology KnowledgeBase3AL5    3AL6   
SCOP (Structural Classification of Proteins)3AL5    3AL6   
CATH (Classification of proteins structures)3AL5    3AL6   
SuperfamilyA2RUC4
Human Protein Atlas [tissue]ENSG00000162971-TYW5 [tissue]
Peptide AtlasA2RUC4
HPRD08232
IPIIPI00181373   IPI00872995   IPI00877043   
Protein Interaction databases
DIP (DOE-UCLA)A2RUC4
IntAct (EBI)A2RUC4
FunCoupENSG00000162971
BioGRIDTYW5
STRING (EMBL)TYW5
ZODIACTYW5
Ontologies - Pathways
QuickGOA2RUC4
Ontology : AmiGOtRNA binding  iron ion binding  cytoplasm  tRNA modification  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  wybutosine biosynthetic process  protein homodimerization activity  oxidation-reduction process  
Ontology : EGO-EBItRNA binding  iron ion binding  cytoplasm  tRNA modification  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors  wybutosine biosynthetic process  protein homodimerization activity  oxidation-reduction process  
NDEx NetworkTYW5
Atlas of Cancer Signalling NetworkTYW5
Wikipedia pathwaysTYW5
Orthology - Evolution
OrthoDB129450
GeneTree (enSembl)ENSG00000162971
Phylogenetic Trees/Animal Genes : TreeFamTYW5
HOVERGENA2RUC4
HOGENOMA2RUC4
Homologs : HomoloGeneTYW5
Homology/Alignments : Family Browser (UCSC)TYW5
Gene fusions - Rearrangements
Tumor Fusion PortalTYW5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTYW5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TYW5
dbVarTYW5
ClinVarTYW5
1000_GenomesTYW5 
Exome Variant ServerTYW5
ExAC (Exome Aggregation Consortium)ENSG00000162971
GNOMAD BrowserENSG00000162971
Genetic variants : HAPMAP129450
Genomic Variants (DGV)TYW5 [DGVbeta]
DECIPHERTYW5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTYW5 
Mutations
ICGC Data PortalTYW5 
TCGA Data PortalTYW5 
Broad Tumor PortalTYW5
OASIS PortalTYW5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTYW5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTYW5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TYW5
DgiDB (Drug Gene Interaction Database)TYW5
DoCM (Curated mutations)TYW5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TYW5 (select a term)
intoGenTYW5
Cancer3DTYW5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETTYW5
MedgenTYW5
Genetic Testing Registry TYW5
NextProtA2RUC4 [Medical]
TSGene129450
GENETestsTYW5
Target ValidationTYW5
Huge Navigator TYW5 [HugePedia]
snp3D : Map Gene to Disease129450
BioCentury BCIQTYW5
ClinGenTYW5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD129450
Chemical/Pharm GKB GenePA162379298
Clinical trialTYW5
Miscellaneous
canSAR (ICR)TYW5 (select the gene name)
Probes
Litterature
PubMed8 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTYW5
EVEXTYW5
GoPubMedTYW5
iHOPTYW5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:06:46 CET 2017

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