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U2AF2 (U2 small nuclear RNA auxiliary factor 2)

Identity

Alias_namesU2 (RNU2) small nuclear RNA auxiliary factor 2
Alias_symbol (synonym)U2AF65
Other alias
HGNC (Hugo) U2AF2
LocusID (NCBI) 11338
Atlas_Id 55838
Location 19q13.42  [Link to chromosome band 19q13]
Location_base_pair Starts at 55654050 and ends at 55674716 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AKT2 (19q13.2) / U2AF2 (19q13.42)DYNLT3 (Xp11.4) / U2AF2 (19q13.42)EPN1 (19q13.42) / U2AF2 (19q13.42)
MALAT1 (11q13.1) / U2AF2 (19q13.42)U2AF2 (19q13.42) / ECSCR (5q31.2)U2AF2 (19q13.42) / F11R (1q23.3)
U2AF2 (19q13.42) / KCNK1 (1q42.2)U2AF2 (19q13.42) / NLRP9 (19q13.42)U2AF2 (19q13.42) / RERE (1p36.23)
U2AF2 (19q13.42) / U2AF2 (19q13.42)U2AF2 (19q13.42) / ZFP36L2 (2p21)U2AF2 (19q13.42) / ZNF524 (19q13.42)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)U2AF2   23156
LRG (Locus Reference Genomic)LRG_623
Cards
Entrez_Gene (NCBI)U2AF2  11338  U2 small nuclear RNA auxiliary factor 2
AliasesU2AF65
GeneCards (Weizmann)U2AF2
Ensembl hg19 (Hinxton)ENSG00000063244 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000063244 [Gene_View]  chr19:55654050-55674716 [Contig_View]  U2AF2 [Vega]
ICGC DataPortalENSG00000063244
TCGA cBioPortalU2AF2
AceView (NCBI)U2AF2
Genatlas (Paris)U2AF2
WikiGenes11338
SOURCE (Princeton)U2AF2
Genetics Home Reference (NIH)U2AF2
Genomic and cartography
GoldenPath hg38 (UCSC)U2AF2  -     chr19:55654050-55674716 +  19q13.42   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)U2AF2  -     19q13.42   [Description]    (hg19-Feb_2009)
EnsemblU2AF2 - 19q13.42 [CytoView hg19]  U2AF2 - 19q13.42 [CytoView hg38]
Mapping of homologs : NCBIU2AF2 [Mapview hg19]  U2AF2 [Mapview hg38]
OMIM191318   
Gene and transcription
Genbank (Entrez)AB451261 AB451387 AK311672 BC008740 BC030574
RefSeq transcript (Entrez)NM_001012478 NM_007279
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)U2AF2
Cluster EST : UnigeneHs.528007 [ NCBI ]
CGAP (NCI)Hs.528007
Alternative Splicing GalleryENSG00000063244
Gene ExpressionU2AF2 [ NCBI-GEO ]   U2AF2 [ EBI - ARRAY_EXPRESS ]   U2AF2 [ SEEK ]   U2AF2 [ MEM ]
Gene Expression Viewer (FireBrowse)U2AF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11338
GTEX Portal (Tissue expression)U2AF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26368   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26368  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26368
Splice isoforms : SwissVarP26368
PhosPhoSitePlusP26368
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait    RRM_dom    U2AF_lg   
Domain families : Pfam (Sanger)RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
Conserved Domain (NCBI)U2AF2
DMDM Disease mutations11338
Blocks (Seattle)U2AF2
PDB (SRS)1JMT    1O0P    1OPI    1U2F    2G4B    2HZC    2M0G    2U2F    2YH0    2YH1    3VAF    3VAG    3VAH    3VAI    3VAJ    3VAK    3VAL    3VAM    4FXW    4TU7    4TU8    4TU9    5EV1    5EV2    5EV3    5EV4   
PDB (PDBSum)1JMT    1O0P    1OPI    1U2F    2G4B    2HZC    2M0G    2U2F    2YH0    2YH1    3VAF    3VAG    3VAH    3VAI    3VAJ    3VAK    3VAL    3VAM    4FXW    4TU7    4TU8    4TU9    5EV1    5EV2    5EV3    5EV4   
PDB (IMB)1JMT    1O0P    1OPI    1U2F    2G4B    2HZC    2M0G    2U2F    2YH0    2YH1    3VAF    3VAG    3VAH    3VAI    3VAJ    3VAK    3VAL    3VAM    4FXW    4TU7    4TU8    4TU9    5EV1    5EV2    5EV3    5EV4   
PDB (RSDB)1JMT    1O0P    1OPI    1U2F    2G4B    2HZC    2M0G    2U2F    2YH0    2YH1    3VAF    3VAG    3VAH    3VAI    3VAJ    3VAK    3VAL    3VAM    4FXW    4TU7    4TU8    4TU9    5EV1    5EV2    5EV3    5EV4   
Structural Biology KnowledgeBase1JMT    1O0P    1OPI    1U2F    2G4B    2HZC    2M0G    2U2F    2YH0    2YH1    3VAF    3VAG    3VAH    3VAI    3VAJ    3VAK    3VAL    3VAM    4FXW    4TU7    4TU8    4TU9    5EV1    5EV2    5EV3    5EV4   
SCOP (Structural Classification of Proteins)1JMT    1O0P    1OPI    1U2F    2G4B    2HZC    2M0G    2U2F    2YH0    2YH1    3VAF    3VAG    3VAH    3VAI    3VAJ    3VAK    3VAL    3VAM    4FXW    4TU7    4TU8    4TU9    5EV1    5EV2    5EV3    5EV4   
CATH (Classification of proteins structures)1JMT    1O0P    1OPI    1U2F    2G4B    2HZC    2M0G    2U2F    2YH0    2YH1    3VAF    3VAG    3VAH    3VAI    3VAJ    3VAK    3VAL    3VAM    4FXW    4TU7    4TU8    4TU9    5EV1    5EV2    5EV3    5EV4   
SuperfamilyP26368
Human Protein AtlasENSG00000063244
Peptide AtlasP26368
HPRD01872
IPIIPI00031556   IPI00830039   
Protein Interaction databases
DIP (DOE-UCLA)P26368
IntAct (EBI)P26368
FunCoupENSG00000063244
BioGRIDU2AF2
STRING (EMBL)U2AF2
ZODIACU2AF2
Ontologies - Pathways
QuickGOP26368
Ontology : AmiGOcommitment complex  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  RNA binding  protein binding  nucleus  nucleoplasm  spliceosomal complex  termination of RNA polymerase II transcription  mRNA processing  RNA export from nucleus  mRNA export from nucleus  poly-pyrimidine tract binding  nuclear speck  enzyme binding  pre-mRNA 3'-splice site binding  mRNA 3'-end processing  negative regulation of protein ubiquitination  negative regulation of protein ubiquitination  positive regulation of RNA splicing  negative regulation of mRNA splicing, via spliceosome  C2H2 zinc finger domain binding  U2-type prespliceosome  U2AF  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  
Ontology : EGO-EBIcommitment complex  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  mRNA splicing, via spliceosome  Prp19 complex  RNA binding  protein binding  nucleus  nucleoplasm  spliceosomal complex  termination of RNA polymerase II transcription  mRNA processing  RNA export from nucleus  mRNA export from nucleus  poly-pyrimidine tract binding  nuclear speck  enzyme binding  pre-mRNA 3'-splice site binding  mRNA 3'-end processing  negative regulation of protein ubiquitination  negative regulation of protein ubiquitination  positive regulation of RNA splicing  negative regulation of mRNA splicing, via spliceosome  C2H2 zinc finger domain binding  U2-type prespliceosome  U2AF  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  
Pathways : KEGGSpliceosome   
NDEx NetworkU2AF2
Atlas of Cancer Signalling NetworkU2AF2
Wikipedia pathwaysU2AF2
Orthology - Evolution
OrthoDB11338
GeneTree (enSembl)ENSG00000063244
Phylogenetic Trees/Animal Genes : TreeFamU2AF2
HOVERGENP26368
HOGENOMP26368
Homologs : HomoloGeneU2AF2
Homology/Alignments : Family Browser (UCSC)U2AF2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerU2AF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)U2AF2
dbVarU2AF2
ClinVarU2AF2
1000_GenomesU2AF2 
Exome Variant ServerU2AF2
ExAC (Exome Aggregation Consortium)U2AF2 (select the gene name)
Genetic variants : HAPMAP11338
Genomic Variants (DGV)U2AF2 [DGVbeta]
DECIPHERU2AF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisU2AF2 
Mutations
ICGC Data PortalU2AF2 
TCGA Data PortalU2AF2 
Broad Tumor PortalU2AF2
OASIS PortalU2AF2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICU2AF2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDU2AF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch U2AF2
DgiDB (Drug Gene Interaction Database)U2AF2
DoCM (Curated mutations)U2AF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)U2AF2 (select a term)
intoGenU2AF2
Cancer3DU2AF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191318   
Orphanet
MedgenU2AF2
Genetic Testing Registry U2AF2
NextProtP26368 [Medical]
TSGene11338
GENETestsU2AF2
Target ValidationU2AF2
Huge Navigator U2AF2 [HugePedia]
snp3D : Map Gene to Disease11338
BioCentury BCIQU2AF2
ClinGenU2AF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11338
Chemical/Pharm GKB GenePA134908683
Clinical trialU2AF2
Miscellaneous
canSAR (ICR)U2AF2 (select the gene name)
Probes
Litterature
PubMed133 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineU2AF2
EVEXU2AF2
GoPubMedU2AF2
iHOPU2AF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:36:58 CEST 2017

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