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UBA1 (ubiquitin-like modifier activating enzyme 1)

Identity

Other namesA1S9
A1S9T
A1ST
AMCX1
GXP1
POC20
SMAX2
UBA1A
UBE1
UBE1X
HGNC (Hugo) UBA1
LocusID (NCBI) 7317
Location Xp11.23
Location_base_pair Starts at 47053201 and ends at 47074527 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)UBA1   12469
Cards
Entrez_Gene (NCBI)UBA1  7317  ubiquitin-like modifier activating enzyme 1
GeneCards (Weizmann)UBA1
Ensembl (Hinxton)ENSG00000130985 [Gene_View]  chrX:47053201-47074527 [Contig_View]  UBA1 [Vega]
AceView (NCBI)UBA1
Genatlas (Paris)UBA1
WikiGenes7317
SOURCE (Princeton)NM_003334 NM_153280
Genomic and cartography
GoldenPath (UCSC)UBA1  -  Xp11.23   chrX:47053201-47074527 +  Xp11.23   [Description]    (hg19-Feb_2009)
EnsemblUBA1 - Xp11.23 [CytoView]
Mapping of homologs : NCBIUBA1 [Mapview]
OMIM301830   314370   
Gene and transcription
Genbank (Entrez)AF258566 AK097343 AK131341 AK293161 AK296866
RefSeq transcript (Entrez)NM_003334 NM_153280
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_009161 NT_079573 NW_001842362 NW_004166866 NW_004929439
Consensus coding sequences : CCDS (NCBI)UBA1
Cluster EST : UnigeneHs.533273 [ NCBI ]
CGAP (NCI)Hs.533273
Alternative Splicing : Fast-db (Paris)GSHG0031491
Alternative Splicing GalleryENSG00000130985
Gene ExpressionUBA1 [ NCBI-GEO ]     UBA1 [ SEEK ]   UBA1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22314 (Uniprot)
NextProtP22314  [Medical]
With graphics : InterProP22314
Splice isoforms : SwissVarP22314 (Swissvar)
Domaine pattern : Prosite (Expaxy)UBIQUITIN_ACTIVAT_1 (PS00536)    UBIQUITIN_ACTIVAT_2 (PS00865)   
Domains : Interpro (EBI)Molybdenum_cofac_synth_MoeB    NAD(P)-bd_dom    ThiF_NAD_FAD-bd    Ub-activating_enz_e1_C    Ub-like_act_enz_cat_cys_dom    UBact_repeat    Ubiquitin-activating_enzyme    UBQ-activ_enz_E1    UBQ-activ_enz_E1_AS    UBQ/SUMO-activ_enz_E1-like   
Related proteins : CluSTrP22314
Domain families : Pfam (Sanger)ThiF (PF00899)    UBA_e1_C (PF09358)    UBA_e1_thiolCys (PF10585)    UBACT (PF02134)   
Domain families : Pfam (NCBI)pfam00899    pfam09358    pfam10585    pfam02134   
Domain families : Smart (EMBL)UBA_e1_C (SM00985)  
DMDM Disease mutations7317
Blocks (Seattle)P22314
Human Protein AtlasENSG00000130985
Peptide AtlasP22314
HPRD02440
IPIIPI00645078   IPI00908755   IPI00383182   IPI00026119   IPI00644183   IPI00647463   IPI00646990   IPI00641319   IPI00552452   
Protein Interaction databases
DIP (DOE-UCLA)P22314
IntAct (EBI)P22314
FunCoupENSG00000130985
BioGRIDUBA1
InParanoidP22314
Interologous Interaction database P22314
IntegromeDBUBA1
STRING (EMBL)UBA1
Ontologies - Pathways
Ontology : AmiGOprotein binding  ATP binding  cell death  small protein activating enzyme activity  protein ubiquitination  ligase activity  
Ontology : EGO-EBIprotein binding  ATP binding  cell death  small protein activating enzyme activity  protein ubiquitination  ligase activity  
Pathways : KEGGUbiquitin mediated proteolysis    Parkinson's disease   
REACTOMEUBA1
Protein Interaction DatabaseUBA1
Wikipedia pathwaysUBA1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)UBA1
SNP (GeneSNP Utah)UBA1
SNP : HGBaseUBA1
Genetic variants : HAPMAPUBA1
1000_GenomesUBA1 
ICGC programENSG00000130985 
Somatic Mutations in Cancer : COSMICUBA1 
CONAN: Copy Number AnalysisUBA1 
Mutations and Diseases : HGMDUBA1
OMIM301830    314370   
GENETestsUBA1
Disease Genetic AssociationUBA1
Huge Navigator UBA1 [HugePedia]  UBA1 [HugeCancerGEM]
Genomic VariantsUBA1  UBA1 [DGVbeta]
Exome VariantUBA1
dbVarUBA1
ClinVarUBA1
snp3D : Map Gene to Disease7317
General knowledge
Homologs : HomoloGeneUBA1
Homology/Alignments : Family Browser (UCSC)UBA1
Phylogenetic Trees/Animal Genes : TreeFamUBA1
Chemical/Protein Interactions : CTD7317
Chemical/Pharm GKB GenePA37119
Clinical trialUBA1
Cancer Resource (Charite)ENSG00000130985
Other databases
Probes
Litterature
PubMed93 Pubmed reference(s) in Entrez
CoreMineUBA1
iHOPUBA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:09:01 CEST 2014

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