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UBA6 (ubiquitin like modifier activating enzyme 6)

Identity

Alias_namesUBE1L2
ubiquitin-activating enzyme E1-like 2
ubiquitin-like modifier activating enzyme 6
Alias_symbol (synonym)FLJ10808
Other aliasE1-L2
MOP-4
HGNC (Hugo) UBA6
LocusID (NCBI) 55236
Atlas_Id 75403
Location 4q13.2  [Link to chromosome band 4q13]
Location_base_pair Starts at 67615761 and ends at 67701171 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
UBA6 (4q13.2) / STAP1 (4q13.2)UBA6 (4q13.2) / UBA6 (4q13.2)UNC50 (2q11.2) / UBA6 (4q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBA6   25581
Cards
Entrez_Gene (NCBI)UBA6  55236  ubiquitin like modifier activating enzyme 6
AliasesE1-L2; MOP-4; UBE1L2
GeneCards (Weizmann)UBA6
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr4:67615761-67701171 [Contig_View]  UBA6 [Vega]
TCGA cBioPortalUBA6
AceView (NCBI)UBA6
Genatlas (Paris)UBA6
WikiGenes55236
SOURCE (Princeton)UBA6
Genetics Home Reference (NIH)UBA6
Genomic and cartography
GoldenPath hg38 (UCSC)UBA6  -     chr4:67615761-67701171 -  4q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBA6  -     4q13.2   [Description]    (hg19-Feb_2009)
EnsemblUBA6 - 4q13.2 [CytoView hg19]  UBA6 - 4q13.2 [CytoView hg38]
Mapping of homologs : NCBIUBA6 [Mapview hg19]  UBA6 [Mapview hg38]
OMIM611361   
Gene and transcription
Genbank (Entrez)AB014773 AK001670 AK027020 AK094164 AK094969
RefSeq transcript (Entrez)NM_018227
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBA6
Cluster EST : UnigeneHs.212774 [ NCBI ]
CGAP (NCI)Hs.212774
Gene ExpressionUBA6 [ NCBI-GEO ]   UBA6 [ EBI - ARRAY_EXPRESS ]   UBA6 [ SEEK ]   UBA6 [ MEM ]
Gene Expression Viewer (FireBrowse)UBA6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55236
GTEX Portal (Tissue expression)UBA6
Protein : pattern, domain, 3D structure
UniProt/SwissProtA0AVT1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtA0AVT1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProA0AVT1
Splice isoforms : SwissVarA0AVT1
PhosPhoSitePlusA0AVT1
Domains : Interpro (EBI)E1_4HB    E1_FCCH    NAD(P)-bd_dom    ThiF_NAD_FAD-bd    Ub-activating_enz_E1_C    UBA_E1_Cys    UBQ-activ_enz_E1    UBQ/SUMO-activ_enz_E1-like   
Domain families : Pfam (Sanger)E1_4HB (PF16191)    E1_FCCH (PF16190)    E1_UFD (PF09358)    ThiF (PF00899)    UBA_e1_thiolCys (PF10585)   
Domain families : Pfam (NCBI)pfam16191    pfam16190    pfam09358    pfam00899    pfam10585   
Domain families : Smart (EMBL)UBA_e1_C (SM00985)  
Conserved Domain (NCBI)UBA6
DMDM Disease mutations55236
Blocks (Seattle)UBA6
SuperfamilyA0AVT1
Peptide AtlasA0AVT1
HPRD13341
IPIIPI00023647   IPI00827491   IPI00828006   IPI00827864   IPI00967521   IPI00967786   
Protein Interaction databases
DIP (DOE-UCLA)A0AVT1
IntAct (EBI)A0AVT1
BioGRIDUBA6
STRING (EMBL)UBA6
ZODIACUBA6
Ontologies - Pathways
QuickGOA0AVT1
Ontology : AmiGOubiquitin activating enzyme activity  protein binding  ATP binding  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  learning  locomotory behavior  protein ubiquitination  protein ubiquitination  FAT10 activating enzyme activity  amygdala development  hippocampus development  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  dendritic spine development  
Ontology : EGO-EBIubiquitin activating enzyme activity  protein binding  ATP binding  cytoplasm  cytosol  ubiquitin-dependent protein catabolic process  learning  locomotory behavior  protein ubiquitination  protein ubiquitination  FAT10 activating enzyme activity  amygdala development  hippocampus development  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  dendritic spine development  
Pathways : KEGGUbiquitin mediated proteolysis   
NDEx NetworkUBA6
Atlas of Cancer Signalling NetworkUBA6
Wikipedia pathwaysUBA6
Orthology - Evolution
OrthoDB55236
Phylogenetic Trees/Animal Genes : TreeFamUBA6
HOVERGENA0AVT1
HOGENOMA0AVT1
Homologs : HomoloGeneUBA6
Homology/Alignments : Family Browser (UCSC)UBA6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBA6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBA6
dbVarUBA6
ClinVarUBA6
1000_GenomesUBA6 
Exome Variant ServerUBA6
ExAC (Exome Aggregation Consortium)UBA6 (select the gene name)
Genetic variants : HAPMAP55236
Genomic Variants (DGV)UBA6 [DGVbeta]
DECIPHERUBA6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBA6 
Mutations
ICGC Data PortalUBA6 
TCGA Data PortalUBA6 
Broad Tumor PortalUBA6
OASIS PortalUBA6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBA6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBA6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBA6
DgiDB (Drug Gene Interaction Database)UBA6
DoCM (Curated mutations)UBA6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBA6 (select a term)
intoGenUBA6
Cancer3DUBA6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611361   
Orphanet
MedgenUBA6
Genetic Testing Registry UBA6
NextProtA0AVT1 [Medical]
TSGene55236
GENETestsUBA6
Target ValidationUBA6
Huge Navigator UBA6 [HugePedia]
snp3D : Map Gene to Disease55236
BioCentury BCIQUBA6
ClinGenUBA6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55236
Chemical/Pharm GKB GenePA162407690
Clinical trialUBA6
Miscellaneous
canSAR (ICR)UBA6 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBA6
EVEXUBA6
GoPubMedUBA6
iHOPUBA6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:43:06 CEST 2017

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