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UBA7 (ubiquitin like modifier activating enzyme 7)

Identity

Alias_namesUBE1L
ubiquitin-activating enzyme E1-like
ubiquitin-like modifier activating enzyme 7
Alias_symbol (synonym)D8
UBE2
UBA1B
Other alias
HGNC (Hugo) UBA7
LocusID (NCBI) 7318
Atlas_Id 42745
Location 3p21.31  [Link to chromosome band 3p21]
Location_base_pair Starts at 49805205 and ends at 49813958 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
UBA7 (3p21.31) / UBA7 (3p21.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBA7   12471
Cards
Entrez_Gene (NCBI)UBA7  7318  ubiquitin like modifier activating enzyme 7
AliasesD8; UBA1B; UBE1L; UBE2
GeneCards (Weizmann)UBA7
Ensembl hg19 (Hinxton)ENSG00000182179 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182179 [Gene_View]  chr3:49805205-49813958 [Contig_View]  UBA7 [Vega]
ICGC DataPortalENSG00000182179
TCGA cBioPortalUBA7
AceView (NCBI)UBA7
Genatlas (Paris)UBA7
WikiGenes7318
SOURCE (Princeton)UBA7
Genetics Home Reference (NIH)UBA7
Genomic and cartography
GoldenPath hg38 (UCSC)UBA7  -     chr3:49805205-49813958 -  3p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBA7  -     3p21.31   [Description]    (hg19-Feb_2009)
EnsemblUBA7 - 3p21.31 [CytoView hg19]  UBA7 - 3p21.31 [CytoView hg38]
Mapping of homologs : NCBIUBA7 [Mapview hg19]  UBA7 [Mapview hg38]
OMIM191325   
Gene and transcription
Genbank (Entrez)BC006378 BM152341 BT007026 CA425139 DQ893307
RefSeq transcript (Entrez)NM_003335
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBA7
Cluster EST : UnigeneHs.16695 [ NCBI ]
CGAP (NCI)Hs.16695
Alternative Splicing GalleryENSG00000182179
Gene ExpressionUBA7 [ NCBI-GEO ]   UBA7 [ EBI - ARRAY_EXPRESS ]   UBA7 [ SEEK ]   UBA7 [ MEM ]
Gene Expression Viewer (FireBrowse)UBA7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7318
GTEX Portal (Tissue expression)UBA7
Human Protein AtlasENSG00000182179-UBA7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41226   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41226  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41226
Splice isoforms : SwissVarP41226
PhosPhoSitePlusP41226
Domaine pattern : Prosite (Expaxy)UBIQUITIN_ACTIVAT_2 (PS00865)   
Domains : Interpro (EBI)E1_4HB    E1_FCCH    NAD(P)-bd_dom    ThiF_NAD_FAD-bd    Ub-activating_enz_E1_C    UBA_E1_Cys    UBQ-activ_enz_E1    UBQ-activ_enz_E1_Cys_AS    UBQ/SUMO-activ_enz_E1-like   
Domain families : Pfam (Sanger)E1_4HB (PF16191)    E1_FCCH (PF16190)    E1_UFD (PF09358)    ThiF (PF00899)    UBA_e1_thiolCys (PF10585)   
Domain families : Pfam (NCBI)pfam16191    pfam16190    pfam09358    pfam00899    pfam10585   
Domain families : Smart (EMBL)UBA_e1_C (SM00985)  
Conserved Domain (NCBI)UBA7
DMDM Disease mutations7318
Blocks (Seattle)UBA7
SuperfamilyP41226
Human Protein Atlas [tissue]ENSG00000182179-UBA7 [tissue]
Peptide AtlasP41226
HPRD01873
IPIIPI00013183   
Protein Interaction databases
DIP (DOE-UCLA)P41226
IntAct (EBI)P41226
FunCoupENSG00000182179
BioGRIDUBA7
STRING (EMBL)UBA7
ZODIACUBA7
Ontologies - Pathways
QuickGOP41226
Ontology : AmiGOubiquitin-protein transferase activity  protein binding  ATP binding  nucleoplasm  cytosol  cellular protein modification process  protein ubiquitination  ISG15 activating enzyme activity  modification-dependent protein catabolic process  translesion synthesis  ISG15-protein conjugation  negative regulation of type I interferon production  
Ontology : EGO-EBIubiquitin-protein transferase activity  protein binding  ATP binding  nucleoplasm  cytosol  cellular protein modification process  protein ubiquitination  ISG15 activating enzyme activity  modification-dependent protein catabolic process  translesion synthesis  ISG15-protein conjugation  negative regulation of type I interferon production  
Pathways : KEGGUbiquitin mediated proteolysis    Parkinson's disease   
NDEx NetworkUBA7
Atlas of Cancer Signalling NetworkUBA7
Wikipedia pathwaysUBA7
Orthology - Evolution
OrthoDB7318
GeneTree (enSembl)ENSG00000182179
Phylogenetic Trees/Animal Genes : TreeFamUBA7
HOVERGENP41226
HOGENOMP41226
Homologs : HomoloGeneUBA7
Homology/Alignments : Family Browser (UCSC)UBA7
Gene fusions - Rearrangements
Tumor Fusion PortalUBA7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBA7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBA7
dbVarUBA7
ClinVarUBA7
1000_GenomesUBA7 
Exome Variant ServerUBA7
ExAC (Exome Aggregation Consortium)ENSG00000182179
GNOMAD BrowserENSG00000182179
Genetic variants : HAPMAP7318
Genomic Variants (DGV)UBA7 [DGVbeta]
DECIPHERUBA7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBA7 
Mutations
ICGC Data PortalUBA7 
TCGA Data PortalUBA7 
Broad Tumor PortalUBA7
OASIS PortalUBA7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBA7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBA7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBA7
DgiDB (Drug Gene Interaction Database)UBA7
DoCM (Curated mutations)UBA7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBA7 (select a term)
intoGenUBA7
Cancer3DUBA7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191325   
Orphanet
DisGeNETUBA7
MedgenUBA7
Genetic Testing Registry UBA7
NextProtP41226 [Medical]
TSGene7318
GENETestsUBA7
Target ValidationUBA7
Huge Navigator UBA7 [HugePedia]
snp3D : Map Gene to Disease7318
BioCentury BCIQUBA7
ClinGenUBA7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7318
Chemical/Pharm GKB GenePA162407761
Clinical trialUBA7
Miscellaneous
canSAR (ICR)UBA7 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBA7
EVEXUBA7
GoPubMedUBA7
iHOPUBA7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:40:26 CET 2017

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