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UBASH3B (ubiquitin associated and SH3 domain containing B)

Identity

Alias_namessuppressor of T-cell receptor signaling 1
nm23-phosphorylated unknown substrate
Alias_symbol (synonym)KIAA1959
STS-1
TULA2
Other aliasSTS1
TULA-2
p70
HGNC (Hugo) UBASH3B
LocusID (NCBI) 84959
Atlas_Id 45606
Location 11q24.1  [Link to chromosome band 11q24]
Location_base_pair Starts at 122655690 and ends at 122814479 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
SPRR1B (1q21.3) / UBASH3B (11q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBASH3B   29884
Cards
Entrez_Gene (NCBI)UBASH3B  84959  ubiquitin associated and SH3 domain containing B
AliasesSTS-1; STS1; TULA-2; TULA2; 
p70
GeneCards (Weizmann)UBASH3B
Ensembl hg19 (Hinxton)ENSG00000154127 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154127 [Gene_View]  chr11:122655690-122814479 [Contig_View]  UBASH3B [Vega]
ICGC DataPortalENSG00000154127
TCGA cBioPortalUBASH3B
AceView (NCBI)UBASH3B
Genatlas (Paris)UBASH3B
WikiGenes84959
SOURCE (Princeton)UBASH3B
Genetics Home Reference (NIH)UBASH3B
Genomic and cartography
GoldenPath hg38 (UCSC)UBASH3B  -     chr11:122655690-122814479 +  11q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBASH3B  -     11q24.1   [Description]    (hg19-Feb_2009)
EnsemblUBASH3B - 11q24.1 [CytoView hg19]  UBASH3B - 11q24.1 [CytoView hg38]
Mapping of homologs : NCBIUBASH3B [Mapview hg19]  UBASH3B [Mapview hg38]
OMIM609201   
Gene and transcription
Genbank (Entrez)AB075839 AF425252 AK075203 AK092011 AK222843
RefSeq transcript (Entrez)NM_032873
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBASH3B
Cluster EST : UnigeneHs.444075 [ NCBI ]
CGAP (NCI)Hs.444075
Alternative Splicing GalleryENSG00000154127
Gene ExpressionUBASH3B [ NCBI-GEO ]   UBASH3B [ EBI - ARRAY_EXPRESS ]   UBASH3B [ SEEK ]   UBASH3B [ MEM ]
Gene Expression Viewer (FireBrowse)UBASH3B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84959
GTEX Portal (Tissue expression)UBASH3B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TF42   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TF42  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TF42
Splice isoforms : SwissVarQ8TF42
Catalytic activity : Enzyme3.1.3.48 [ Enzyme-Expasy ]   3.1.3.483.1.3.48 [ IntEnz-EBI ]   3.1.3.48 [ BRENDA ]   3.1.3.48 [ KEGG ]   
PhosPhoSitePlusQ8TF42
Domaine pattern : Prosite (Expaxy)SH3 (PS50002)    UBA (PS50030)   
Domains : Interpro (EBI)cNuc_Pdiesterase    His_Pase_superF_clade-1    His_PPase_superfam    SH3_domain    UBA    UBA-like   
Domain families : Pfam (Sanger)His_Phos_1 (PF00300)    SH3_9 (PF14604)    UBA (PF00627)   
Domain families : Pfam (NCBI)pfam00300    pfam14604    pfam00627   
Domain families : Smart (EMBL)SH3 (SM00326)  UBA (SM00165)  
Conserved Domain (NCBI)UBASH3B
DMDM Disease mutations84959
Blocks (Seattle)UBASH3B
PDB (SRS)2CPW    2E5K   
PDB (PDBSum)2CPW    2E5K   
PDB (IMB)2CPW    2E5K   
PDB (RSDB)2CPW    2E5K   
Structural Biology KnowledgeBase2CPW    2E5K   
SCOP (Structural Classification of Proteins)2CPW    2E5K   
CATH (Classification of proteins structures)2CPW    2E5K   
SuperfamilyQ8TF42
Human Protein AtlasENSG00000154127
Peptide AtlasQ8TF42
HPRD16463
IPIIPI00154910   
Protein Interaction databases
DIP (DOE-UCLA)Q8TF42
IntAct (EBI)Q8TF42
FunCoupENSG00000154127
BioGRIDUBASH3B
STRING (EMBL)UBASH3B
ZODIACUBASH3B
Ontologies - Pathways
QuickGOQ8TF42
Ontology : AmiGOprotein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  negative regulation of protein kinase activity  negative regulation of signal transduction  ubiquitin protein ligase binding  peptidyl-tyrosine dephosphorylation  collagen-activated tyrosine kinase receptor signaling pathway  identical protein binding  regulation of protein binding  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphoprotein binding  regulation of release of sequestered calcium ion into cytosol  platelet aggregation  negative regulation of platelet aggregation  
Ontology : EGO-EBIprotein tyrosine phosphatase activity  protein binding  nucleus  cytoplasm  negative regulation of protein kinase activity  negative regulation of signal transduction  ubiquitin protein ligase binding  peptidyl-tyrosine dephosphorylation  collagen-activated tyrosine kinase receptor signaling pathway  identical protein binding  regulation of protein binding  negative regulation of osteoclast differentiation  negative regulation of bone resorption  phosphoprotein binding  regulation of release of sequestered calcium ion into cytosol  platelet aggregation  negative regulation of platelet aggregation  
NDEx NetworkUBASH3B
Atlas of Cancer Signalling NetworkUBASH3B
Wikipedia pathwaysUBASH3B
Orthology - Evolution
OrthoDB84959
GeneTree (enSembl)ENSG00000154127
Phylogenetic Trees/Animal Genes : TreeFamUBASH3B
HOVERGENQ8TF42
HOGENOMQ8TF42
Homologs : HomoloGeneUBASH3B
Homology/Alignments : Family Browser (UCSC)UBASH3B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBASH3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBASH3B
dbVarUBASH3B
ClinVarUBASH3B
1000_GenomesUBASH3B 
Exome Variant ServerUBASH3B
ExAC (Exome Aggregation Consortium)UBASH3B (select the gene name)
Genetic variants : HAPMAP84959
Genomic Variants (DGV)UBASH3B [DGVbeta]
DECIPHERUBASH3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBASH3B 
Mutations
ICGC Data PortalUBASH3B 
TCGA Data PortalUBASH3B 
Broad Tumor PortalUBASH3B
OASIS PortalUBASH3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBASH3B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBASH3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBASH3B
DgiDB (Drug Gene Interaction Database)UBASH3B
DoCM (Curated mutations)UBASH3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBASH3B (select a term)
intoGenUBASH3B
Cancer3DUBASH3B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609201   
Orphanet
MedgenUBASH3B
Genetic Testing Registry UBASH3B
NextProtQ8TF42 [Medical]
TSGene84959
GENETestsUBASH3B
Target ValidationUBASH3B
Huge Navigator UBASH3B [HugePedia]
snp3D : Map Gene to Disease84959
BioCentury BCIQUBASH3B
ClinGenUBASH3B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84959
Chemical/Pharm GKB GenePA162407840
Clinical trialUBASH3B
Miscellaneous
canSAR (ICR)UBASH3B (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBASH3B
EVEXUBASH3B
GoPubMedUBASH3B
iHOPUBASH3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:10:56 CEST 2017

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