Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UBB (ubiquitin B)

Identity

Alias_symbol (synonym)MGC8385
FLJ25987
Other aliasHEL-S-50
HGNC (Hugo) UBB
LocusID (NCBI) 7314
Atlas_Id 42742
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 16380793 and ends at 16382745 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DBI (2q14.2) / UBB (17p11.2)DUSP9 (Xq28) / UBB (17p11.2)MRPL23 (11p15.5) / UBB (17p11.2)
TUBA1C (12q13.12) / UBB (17p11.2)UBB (17p11.2) / HERC1 (15q22.31)UBB (17p11.2) / SMARCA4 (19p13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBB   12463
Cards
Entrez_Gene (NCBI)UBB  7314  ubiquitin B
AliasesHEL-S-50
GeneCards (Weizmann)UBB
Ensembl hg19 (Hinxton)ENSG00000170315 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170315 [Gene_View]  chr17:16380793-16382745 [Contig_View]  UBB [Vega]
ICGC DataPortalENSG00000170315
TCGA cBioPortalUBB
AceView (NCBI)UBB
Genatlas (Paris)UBB
WikiGenes7314
SOURCE (Princeton)UBB
Genetics Home Reference (NIH)UBB
Genomic and cartography
GoldenPath hg38 (UCSC)UBB  -     chr17:16380793-16382745 +  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBB  -     17p11.2   [Description]    (hg19-Feb_2009)
EnsemblUBB - 17p11.2 [CytoView hg19]  UBB - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIUBB [Mapview hg19]  UBB [Mapview hg38]
OMIM119540   191339   
Gene and transcription
Genbank (Entrez)AA659395 AK129498 AK300882 BC000379 BC009301
RefSeq transcript (Entrez)NM_001281716 NM_001281717 NM_001281718 NM_001281719 NM_001281720 NM_018955
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBB
Cluster EST : UnigeneHs.741549 [ NCBI ]
CGAP (NCI)Hs.741549
Alternative Splicing GalleryENSG00000170315
Gene ExpressionUBB [ NCBI-GEO ]   UBB [ EBI - ARRAY_EXPRESS ]   UBB [ SEEK ]   UBB [ MEM ]
Gene Expression Viewer (FireBrowse)UBB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7314
GTEX Portal (Tissue expression)UBB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0CG47   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0CG47  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0CG47
Splice isoforms : SwissVarP0CG47
PhosPhoSitePlusP0CG47
Domaine pattern : Prosite (Expaxy)UBIQUITIN_1 (PS00299)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Ubiquitin    Ubiquitin-rel_dom    Ubiquitin_CS    Ubiquitin_dom   
Domain families : Pfam (Sanger)ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)UBB
DMDM Disease mutations7314
Blocks (Seattle)UBB
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP0CG47
Human Protein AtlasENSG00000170315
Peptide AtlasP0CG47
HPRD06771
IPIIPI00719280   IPI01011805   
Protein Interaction databases
DIP (DOE-UCLA)P0CG47
IntAct (EBI)P0CG47
FunCoupENSG00000170315
BioGRIDUBB
STRING (EMBL)UBB
ZODIACUBB
Ontologies - Pathways
QuickGOP0CG47
Ontology : AmiGOG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  activation of MAPK activity  protein polyubiquitination  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein binding  extracellular space  nucleus  nucleoplasm  mitochondrion  mitochondrial outer membrane  cytosol  plasma membrane  glycogen biosynthetic process  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  protein folding  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  fibroblast growth factor receptor signaling pathway  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of G2/M transition of mitotic cell cycle  Wnt signaling pathway  endosomal transport  macroautophagy  protein ubiquitination  protein deubiquitination  viral life cycle  virion assembly  translesion synthesis  negative regulation of transforming growth factor beta receptor signaling pathway  endocytic vesicle membrane  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  vesicle  regulation of type I interferon production  negative regulation of type I interferon production  tumor necrosis factor-mediated signaling pathway  nucleotide-excision repair, DNA incision  ion transmembrane transport  entry of bacterium into host cell  TRIF-dependent toll-like receptor signaling pathway  interstrand cross-link repair  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  error-prone translesion synthesis  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuron projection  neuronal cell body  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  cellular protein metabolic process  endoplasmic reticulum quality control compartment  innate immune response  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription from RNA polymerase II promoter  mitochondrion transport along microtubule  neuron projection morphogenesis  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of mitochondrial membrane potential  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of necroptotic process  membrane organization  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  global genome nucleotide-excision repair  error-free translesion synthesis  intracellular transport of virus  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of neuron death  regulation of signal transduction by p53 class mediator  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  positive regulation of protein monoubiquitination  endoplasmic reticulum mannose trimming  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  activation of MAPK activity  protein polyubiquitination  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein binding  extracellular space  nucleus  nucleoplasm  mitochondrion  mitochondrial outer membrane  cytosol  plasma membrane  glycogen biosynthetic process  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  protein folding  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  fibroblast growth factor receptor signaling pathway  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of G2/M transition of mitotic cell cycle  Wnt signaling pathway  endosomal transport  macroautophagy  protein ubiquitination  protein deubiquitination  viral life cycle  virion assembly  translesion synthesis  negative regulation of transforming growth factor beta receptor signaling pathway  endocytic vesicle membrane  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  positive regulation of protein ubiquitination  vesicle  regulation of type I interferon production  negative regulation of type I interferon production  tumor necrosis factor-mediated signaling pathway  nucleotide-excision repair, DNA incision  ion transmembrane transport  entry of bacterium into host cell  TRIF-dependent toll-like receptor signaling pathway  interstrand cross-link repair  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  error-prone translesion synthesis  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  neuron projection  neuronal cell body  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  regulation of mRNA stability  cellular protein metabolic process  endoplasmic reticulum quality control compartment  innate immune response  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription from RNA polymerase II promoter  mitochondrion transport along microtubule  neuron projection morphogenesis  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  regulation of mitochondrial membrane potential  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of necroptotic process  membrane organization  regulation of proteasomal protein catabolic process  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  global genome nucleotide-excision repair  error-free translesion synthesis  intracellular transport of virus  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of neuron death  regulation of signal transduction by p53 class mediator  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  positive regulation of protein monoubiquitination  endoplasmic reticulum mannose trimming  
Pathways : KEGGParkinson's disease   
NDEx NetworkUBB
Atlas of Cancer Signalling NetworkUBB
Wikipedia pathwaysUBB
Orthology - Evolution
OrthoDB7314
GeneTree (enSembl)ENSG00000170315
Phylogenetic Trees/Animal Genes : TreeFamUBB
HOVERGENP0CG47
HOGENOMP0CG47
Homologs : HomoloGeneUBB
Homology/Alignments : Family Browser (UCSC)UBB
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBB
dbVarUBB
ClinVarUBB
1000_GenomesUBB 
Exome Variant ServerUBB
ExAC (Exome Aggregation Consortium)UBB (select the gene name)
Genetic variants : HAPMAP7314
Genomic Variants (DGV)UBB [DGVbeta]
DECIPHERUBB [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBB 
Mutations
ICGC Data PortalUBB 
TCGA Data PortalUBB 
Broad Tumor PortalUBB
OASIS PortalUBB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBB  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBB
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBB
DgiDB (Drug Gene Interaction Database)UBB
DoCM (Curated mutations)UBB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBB (select a term)
intoGenUBB
Cancer3DUBB(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM119540    191339   
Orphanet
MedgenUBB
Genetic Testing Registry UBB
NextProtP0CG47 [Medical]
TSGene7314
GENETestsUBB
Target ValidationUBB
Huge Navigator UBB [HugePedia]
snp3D : Map Gene to Disease7314
BioCentury BCIQUBB
ClinGenUBB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7314
Chemical/Pharm GKB GenePA37113
Clinical trialUBB
Miscellaneous
canSAR (ICR)UBB (select the gene name)
Probes
Litterature
PubMed223 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBB
EVEXUBB
GoPubMedUBB
iHOPUBB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 25 19:37:03 CEST 2017

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