Atlas of Genetics and Cytogenetics in Oncology and Haematology


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UBC (ubiquitin C)

Identity

Other aliasHMG20
HGNC (Hugo) UBC
LocusID (NCBI) 7316
Atlas_Id 42743
Location 12q24.31  [Link to chromosome band 12q24]
Location_base_pair Starts at 124911645 and ends at 124915041 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
AD_1 () / UBC (12q24.31)APBB1 (11p15.4) / UBC (12q24.31)FHIT (3p14.2) / UBC (12q24.31)
HPCAL4 (1p34.2) / UBC (12q24.31)LOC100507412 (-) / UBC (12q24.31)METRNL (17q25.3) / UBC (12q24.31)
PPP4R3B (2p16.1) / UBC (12q24.31)RBM10 (Xp11.23) / UBC (12q24.31)RPL23A (17q11.2) / UBC (12q24.31)
SCARB1 (12q24.31) / UBC (12q24.31)TLE4 (9q21.31) / UBC (12q24.31)UBA52 (19p13.11) / UBC (12q24.31)
UBC (12q24.31) / GNA12 (7p22.3)UBC (12q24.31) / LMNA (1q22)UBC (12q24.31) / MYC (8q24.21)
UBC (12q24.31) / SLC23A2 (20p13)UBC (12q24.31) / UBA52 (19p13.11)UBC (12q24.31) / UBC (12q24.31)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UBC   12468
Cards
Entrez_Gene (NCBI)UBC  7316  ubiquitin C
AliasesHMG20
GeneCards (Weizmann)UBC
Ensembl hg19 (Hinxton)ENSG00000150991 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000150991 [Gene_View]  chr12:124911645-124915041 [Contig_View]  UBC [Vega]
ICGC DataPortalENSG00000150991
TCGA cBioPortalUBC
AceView (NCBI)UBC
Genatlas (Paris)UBC
WikiGenes7316
SOURCE (Princeton)UBC
Genetics Home Reference (NIH)UBC
Genomic and cartography
GoldenPath hg38 (UCSC)UBC  -     chr12:124911645-124915041 -  12q24.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UBC  -     12q24.31   [Description]    (hg19-Feb_2009)
EnsemblUBC - 12q24.31 [CytoView hg19]  UBC - 12q24.31 [CytoView hg38]
Mapping of homologs : NCBIUBC [Mapview hg19]  UBC [Mapview hg38]
OMIM191340   
Gene and transcription
Genbank (Entrez)AB009010 AB209782 AF052164 AK026846 AK056939
RefSeq transcript (Entrez)NM_021009
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UBC
Cluster EST : UnigeneHs.731841 [ NCBI ]
CGAP (NCI)Hs.731841
Alternative Splicing GalleryENSG00000150991
Gene ExpressionUBC [ NCBI-GEO ]   UBC [ EBI - ARRAY_EXPRESS ]   UBC [ SEEK ]   UBC [ MEM ]
Gene Expression Viewer (FireBrowse)UBC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7316
GTEX Portal (Tissue expression)UBC
Protein : pattern, domain, 3D structure
UniProt/SwissProtP0CG48   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP0CG48  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP0CG48
Splice isoforms : SwissVarP0CG48
PhosPhoSitePlusP0CG48
Domaine pattern : Prosite (Expaxy)UBIQUITIN_1 (PS00299)    UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Ubiquitin    Ubiquitin-rel_dom    Ubiquitin_CS    Ubiquitin_dom   
Domain families : Pfam (Sanger)ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam00240   
Domain families : Smart (EMBL)UBQ (SM00213)  
Conserved Domain (NCBI)UBC
DMDM Disease mutations7316
Blocks (Seattle)UBC
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP0CG48
Human Protein AtlasENSG00000150991
Peptide AtlasP0CG48
HPRD07038
IPIIPI00969566   IPI00784990   IPI01011412   IPI00793729   IPI01010447   IPI01015749   IPI01010419   IPI01015985   IPI01009501   IPI01015113   IPI01015565   IPI01014205   IPI01014596   IPI01018966   IPI01015016   
Protein Interaction databases
DIP (DOE-UCLA)P0CG48
IntAct (EBI)P0CG48
FunCoupENSG00000150991
BioGRIDUBC
STRING (EMBL)UBC
ZODIACUBC
Ontologies - Pathways
QuickGOP0CG48
Ontology : AmiGOG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  activation of MAPK activity  protein polyubiquitination  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  protease binding  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  RNA binding  protein binding  extracellular space  nucleus  nucleoplasm  mitochondrial outer membrane  cytosol  plasma membrane  glycogen biosynthetic process  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  protein folding  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  fibroblast growth factor receptor signaling pathway  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of G2/M transition of mitotic cell cycle  ubiquitin homeostasis  Wnt signaling pathway  endosomal transport  macroautophagy  protein ubiquitination  protein deubiquitination  viral life cycle  virion assembly  translesion synthesis  negative regulation of transforming growth factor beta receptor signaling pathway  endocytic vesicle membrane  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  vesicle  regulation of type I interferon production  negative regulation of type I interferon production  tumor necrosis factor-mediated signaling pathway  nucleotide-excision repair, DNA incision  ion transmembrane transport  entry of bacterium into host cell  TRIF-dependent toll-like receptor signaling pathway  interstrand cross-link repair  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  error-prone translesion synthesis  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  myelin sheath  regulation of mRNA stability  cellular protein metabolic process  endoplasmic reticulum quality control compartment  innate immune response  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription from RNA polymerase II promoter  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of necroptotic process  membrane organization  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  global genome nucleotide-excision repair  error-free translesion synthesis  intracellular transport of virus  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of signal transduction by p53 class mediator  endoplasmic reticulum mannose trimming  
Ontology : EGO-EBIG2/M transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  MAPK cascade  activation of MAPK activity  protein polyubiquitination  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  protease binding  stimulatory C-type lectin receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  RNA binding  protein binding  extracellular space  nucleus  nucleoplasm  mitochondrial outer membrane  cytosol  plasma membrane  glycogen biosynthetic process  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 5'-to lesion  nucleotide-excision repair, DNA gap filling  protein folding  DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest  transforming growth factor beta receptor signaling pathway  Notch signaling pathway  I-kappaB kinase/NF-kappaB signaling  JNK cascade  fibroblast growth factor receptor signaling pathway  endosome membrane  regulation of tumor necrosis factor-mediated signaling pathway  negative regulation of G2/M transition of mitotic cell cycle  ubiquitin homeostasis  Wnt signaling pathway  endosomal transport  macroautophagy  protein ubiquitination  protein deubiquitination  viral life cycle  virion assembly  translesion synthesis  negative regulation of transforming growth factor beta receptor signaling pathway  endocytic vesicle membrane  anaphase-promoting complex-dependent catabolic process  SCF-dependent proteasomal ubiquitin-dependent protein catabolic process  vesicle  regulation of type I interferon production  negative regulation of type I interferon production  tumor necrosis factor-mediated signaling pathway  nucleotide-excision repair, DNA incision  ion transmembrane transport  entry of bacterium into host cell  TRIF-dependent toll-like receptor signaling pathway  interstrand cross-link repair  NIK/NF-kappaB signaling  Fc-epsilon receptor signaling pathway  ERBB2 signaling pathway  negative regulation of epidermal growth factor receptor signaling pathway  error-prone translesion synthesis  DNA damage response, detection of DNA damage  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  positive regulation of apoptotic process  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  proteasome-mediated ubiquitin-dependent protein catabolic process  myelin sheath  regulation of mRNA stability  cellular protein metabolic process  endoplasmic reticulum quality control compartment  innate immune response  positive regulation of epidermal growth factor receptor signaling pathway  positive regulation of transcription from RNA polymerase II promoter  T cell receptor signaling pathway  positive regulation of NF-kappaB transcription factor activity  stress-activated MAPK cascade  negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle  positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition  transmembrane transport  Wnt signaling pathway, planar cell polarity pathway  regulation of necroptotic process  membrane organization  regulation of transcription from RNA polymerase II promoter in response to hypoxia  extracellular exosome  nucleotide-binding oligomerization domain containing signaling pathway  global genome nucleotide-excision repair  error-free translesion synthesis  intracellular transport of virus  negative regulation of canonical Wnt signaling pathway  positive regulation of canonical Wnt signaling pathway  regulation of signal transduction by p53 class mediator  endoplasmic reticulum mannose trimming  
Pathways : KEGGPPAR signaling pathway   
NDEx NetworkUBC
Atlas of Cancer Signalling NetworkUBC
Wikipedia pathwaysUBC
Orthology - Evolution
OrthoDB7316
GeneTree (enSembl)ENSG00000150991
Phylogenetic Trees/Animal Genes : TreeFamUBC
HOVERGENP0CG48
HOGENOMP0CG48
Homologs : HomoloGeneUBC
Homology/Alignments : Family Browser (UCSC)UBC
Gene fusions - Rearrangements
Fusion Cancer (Beijing)AD_1 [UBC]  -  12q24.31 [FUSC002932]
Fusion Cancer (Beijing)UBC [12q24.31]  -  UBA52 [19p13.11]  [FUSC001331]  [FUSC001331]  [FUSC001331]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUBC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UBC
dbVarUBC
ClinVarUBC
1000_GenomesUBC 
Exome Variant ServerUBC
ExAC (Exome Aggregation Consortium)UBC (select the gene name)
Genetic variants : HAPMAP7316
Genomic Variants (DGV)UBC [DGVbeta]
DECIPHERUBC [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUBC 
Mutations
ICGC Data PortalUBC 
TCGA Data PortalUBC 
Broad Tumor PortalUBC
OASIS PortalUBC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUBC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUBC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UBC
DgiDB (Drug Gene Interaction Database)UBC
DoCM (Curated mutations)UBC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UBC (select a term)
intoGenUBC
Cancer3DUBC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191340   
Orphanet
MedgenUBC
Genetic Testing Registry UBC
NextProtP0CG48 [Medical]
TSGene7316
GENETestsUBC
Target ValidationUBC
Huge Navigator UBC [HugePedia]
snp3D : Map Gene to Disease7316
BioCentury BCIQUBC
ClinGenUBC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7316
Chemical/Pharm GKB GenePA37118
Clinical trialUBC
Miscellaneous
canSAR (ICR)UBC (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUBC
EVEXUBC
GoPubMedUBC
iHOPUBC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:10:56 CEST 2017

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