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UBE2A (ubiquitin-conjugating enzyme E2A)

Identity

Other namesHHR6A
MRXS30
MRXSN
RAD6A
UBC2
HGNC (Hugo) UBE2A
LocusID (NCBI) 7319
Location Xq24
Location_base_pair Starts at 118708430 and ends at 118718392 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)UBE2A   12472
Cards
Entrez_Gene (NCBI)UBE2A  7319  ubiquitin-conjugating enzyme E2A
GeneCards (Weizmann)UBE2A
Ensembl (Hinxton)ENSG00000077721 [Gene_View]  chrX:118708430-118718392 [Contig_View]  UBE2A [Vega]
ICGC DataPortalENSG00000077721
AceView (NCBI)UBE2A
Genatlas (Paris)UBE2A
WikiGenes7319
SOURCE (Princeton)NM_001282161 NM_003336 NM_181762 NM_181777
Genomic and cartography
GoldenPath (UCSC)UBE2A  -  Xq24   chrX:118708430-118718392 +  Xq24   [Description]    (hg19-Feb_2009)
EnsemblUBE2A - Xq24 [CytoView]
Mapping of homologs : NCBIUBE2A [Mapview]
OMIM300860   312180   
Gene and transcription
Genbank (Entrez)AI784380 AK223045 AK223064 AK297696 AK301675
RefSeq transcript (Entrez)NM_001282161 NM_003336 NM_181762 NM_181777
RefSeq genomic (Entrez)AC_000155 NC_000023 NC_018934 NG_009267 NT_011786 NW_001842395 NW_004929446
Consensus coding sequences : CCDS (NCBI)UBE2A
Cluster EST : UnigeneHs.379466 [ NCBI ]
CGAP (NCI)Hs.379466
Alternative Splicing : Fast-db (Paris)GSHG0031781
Alternative Splicing GalleryENSG00000077721
Gene ExpressionUBE2A [ NCBI-GEO ]     UBE2A [ SEEK ]   UBE2A [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49459 (Uniprot)
NextProtP49459  [Medical]
With graphics : InterProP49459
Splice isoforms : SwissVarP49459 (Swissvar)
Catalytic activity : Enzyme6.3.2.19 [ Enzyme-Expasy ]   6.3.2.196.3.2.19 [ IntEnz-EBI ]   6.3.2.19 [ BRENDA ]   6.3.2.19 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_CONJUGAT_1 (PS00183)    UBIQUITIN_CONJUGAT_2 (PS50127)   
Domains : Interpro (EBI)UBQ-conjugat_E2    UBQ-conjugating_AS    UBQ-conjugating_enzyme/RWD   
Related proteins : CluSTrP49459
Domain families : Pfam (Sanger)UQ_con (PF00179)   
Domain families : Pfam (NCBI)pfam00179   
DMDM Disease mutations7319
Blocks (Seattle)P49459
Human Protein AtlasENSG00000077721
Peptide AtlasP49459
HPRD02422
IPIIPI00746451   IPI00375549   IPI00843825   
Protein Interaction databases
DIP (DOE-UCLA)P49459
IntAct (EBI)P49459
FunCoupENSG00000077721
BioGRIDUBE2A
IntegromeDBUBE2A
STRING (EMBL)UBE2A
Ontologies - Pathways
QuickGOP49459
Ontology : AmiGOprotein polyubiquitination  chromatin  nuclear chromatin  in utero embryonic development  XY body  antigen processing and presentation of peptide antigen via MHC class I  ubiquitin-protein transferase activity  protein binding  ATP binding  cytosol  DNA repair  postreplication repair  ubiquitin-dependent protein catabolic process  positive regulation of cell proliferation  response to UV  acid-amino acid ligase activity  ubiquitin protein ligase binding  HULC complex  histone H2A ubiquitination  protein autoubiquitination  maternal process involved in female pregnancy  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Ontology : EGO-EBIprotein polyubiquitination  chromatin  nuclear chromatin  in utero embryonic development  XY body  antigen processing and presentation of peptide antigen via MHC class I  ubiquitin-protein transferase activity  protein binding  ATP binding  cytosol  DNA repair  postreplication repair  ubiquitin-dependent protein catabolic process  positive regulation of cell proliferation  response to UV  acid-amino acid ligase activity  ubiquitin protein ligase binding  HULC complex  histone H2A ubiquitination  protein autoubiquitination  maternal process involved in female pregnancy  protein K48-linked ubiquitination  protein K11-linked ubiquitination  
Pathways : KEGGUbiquitin mediated proteolysis   
Protein Interaction DatabaseUBE2A
Wikipedia pathwaysUBE2A
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)UBE2A
SNP (GeneSNP Utah)UBE2A
SNP : HGBaseUBE2A
Genetic variants : HAPMAPUBE2A
1000_GenomesUBE2A 
ICGC programENSG00000077721 
CONAN: Copy Number AnalysisUBE2A 
Somatic Mutations in Cancer : COSMICUBE2A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)X:118708430-118718392
Mutations and Diseases : HGMDUBE2A
OMIM300860    312180   
MedgenUBE2A
GENETestsUBE2A
Disease Genetic AssociationUBE2A
Huge Navigator UBE2A [HugePedia]  UBE2A [HugeCancerGEM]
Genomic VariantsUBE2A  UBE2A [DGVbeta]
Exome VariantUBE2A
dbVarUBE2A
ClinVarUBE2A
snp3D : Map Gene to Disease7319
General knowledge
Homologs : HomoloGeneUBE2A
Homology/Alignments : Family Browser (UCSC)UBE2A
Phylogenetic Trees/Animal Genes : TreeFamUBE2A
Chemical/Protein Interactions : CTD7319
Chemical/Pharm GKB GenePA37122
Clinical trialUBE2A
Cancer Resource (Charite)ENSG00000077721
Other databases
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
CoreMineUBE2A
GoPubMedUBE2A
iHOPUBE2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 18:04:09 CET 2014

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